DE69903329D1 - Verfahren zur herstellung einer eisen-dextran verbindung - Google Patents

Verfahren zur herstellung einer eisen-dextran verbindung

Info

Publication number
DE69903329D1
DE69903329D1 DE69903329T DE69903329T DE69903329D1 DE 69903329 D1 DE69903329 D1 DE 69903329D1 DE 69903329 T DE69903329 T DE 69903329T DE 69903329 T DE69903329 T DE 69903329T DE 69903329 D1 DE69903329 D1 DE 69903329D1
Authority
DE
Germany
Prior art keywords
dextrane
iron
producing
connection
iron dextrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903329T
Other languages
English (en)
Other versions
DE69903329T2 (de
Inventor
Berg Andreasen
Lars Christensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacosmos Holding AS
Original Assignee
Pharmacosmos Holding AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacosmos Holding AS filed Critical Pharmacosmos Holding AS
Publication of DE69903329D1 publication Critical patent/DE69903329D1/de
Application granted granted Critical
Publication of DE69903329T2 publication Critical patent/DE69903329T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
DE69903329T 1998-11-20 1999-07-29 Verfahren zur herstellung einer eisen-dextran verbindung Expired - Fee Related DE69903329T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
PCT/DK1999/000425 WO2000030657A1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound

Publications (2)

Publication Number Publication Date
DE69903329D1 true DE69903329D1 (de) 2002-11-07
DE69903329T2 DE69903329T2 (de) 2003-07-10

Family

ID=8105751

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903329T Expired - Fee Related DE69903329T2 (de) 1998-11-20 1999-07-29 Verfahren zur herstellung einer eisen-dextran verbindung

Country Status (26)

Country Link
US (2) US6977249B1 (de)
EP (1) EP1123103B1 (de)
JP (1) JP2002530345A (de)
KR (1) KR20010071767A (de)
CN (1) CN1308539A (de)
AR (1) AR019403A1 (de)
AT (1) ATE225180T1 (de)
AU (1) AU756555B2 (de)
BR (1) BR9910834A (de)
CA (1) CA2332882A1 (de)
DE (1) DE69903329T2 (de)
DK (2) DK173138B1 (de)
EA (1) EA003278B1 (de)
ES (1) ES2183582T3 (de)
HU (1) HUP0101802A3 (de)
ID (1) ID26997A (de)
NO (1) NO20006021D0 (de)
NZ (1) NZ508225A (de)
PL (1) PL345125A1 (de)
PT (1) PT1123103E (de)
SI (1) SI1123103T1 (de)
SK (1) SK19432000A3 (de)
TR (1) TR200003648T2 (de)
UA (1) UA57140C2 (de)
WO (1) WO2000030657A1 (de)
ZA (1) ZA200006878B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6104802A (en) 1997-02-10 2000-08-15 Genesys Telecommunications Laboratories, Inc. In-band signaling for routing
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
WO2000061191A2 (en) 1999-04-09 2000-10-19 Advanced Magnetics, Inc. Heat stable coated colloidal iron oxides
EP1522318A3 (de) * 1999-04-09 2005-07-06 Advanced Magnetics Incorporated Hitzebeständige umhüllte kolloidale Eisenoxide
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US20050191246A1 (en) * 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
ITMO20050056A1 (it) 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
KR101905340B1 (ko) 2006-01-06 2018-10-05 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
DE102007054794A1 (de) * 2007-11-13 2009-05-14 Agilan Gmbh Wässrige Eisen-Dextran-Zubereitung mit ein oder mehreren Verbindungen der para-Hydroxy-Benzoesäureester und/oder deren Salzen
LT2411053T (lt) * 2009-03-25 2017-04-10 Pharmacosmos Holding A/S Stabilus geležies oligosacharido junginys
EP2537866A1 (de) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethylstärke-Derivate, Verfahren zu ihrer Herstellung und therapeutische Verwendungen dafür
PL2934109T3 (pl) 2012-11-30 2022-03-21 Pharmacosmos Holding A/S Środek krioprotekcyjny, kompozycje krioprotekcyjne i kriokonserwo-wane, ich zastosowania i sposoby kriokonserwacji
WO2015150394A1 (en) 2014-04-01 2015-10-08 Pharmacosmos A/S Cryoprotective agent, cryoprotective and cryopreserved compositions, uses thereof, and methods of cryopreservation
WO2015198304A1 (en) 2014-06-22 2015-12-30 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
MX2017005784A (es) 2014-11-05 2017-07-28 Du Pont Dextranos gelificantes enzimaticamente polimerizados.
JP2018511684A (ja) 2015-04-03 2018-04-26 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ ゲル化デキストランエーテル
US10787524B2 (en) 2015-04-03 2020-09-29 Dupont Industrial Biosciences Usa, Llc Oxidized dextran
WO2018198135A1 (en) 2017-04-26 2018-11-01 Mylan Laboratories Ltd. Improved process for the preparation of iron complex
JP7426927B2 (ja) * 2017-09-11 2024-02-02 ファーマコスモス ホールディング エー／エス 治療的使用のための鉄錯体化合
CN109646454A (zh) * 2018-12-29 2019-04-19 博瑞生物医药（苏州）股份有限公司 异麦芽糖酐铁1000的制备方法
CN110183548B (zh) * 2019-06-28 2021-05-18 瑞普（天津）生物药业有限公司 一种低分子葡聚糖铁的制备方法及其应用
CN110551019A (zh) * 2019-09-12 2019-12-10 天津医科大学 一种亚铁糖(ⅱ)复合物、制备方法及其应用
CN110804107B (zh) * 2019-09-29 2021-08-31 山东金洋药业有限公司 一种使用右旋糖酐制备右旋糖酐铁水溶液的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE24642E (en) 1959-04-28 Therapeutic preparations of iron
DK117730A (de)
US2885393A (en) 1956-02-24 1959-05-05 R K Laros Company Dextran-iron complex and process for making same
US3093545A (en) 1960-08-29 1963-06-11 Armour Pharma Therapeutic iron-dextran preparations
US3234209A (en) 1963-09-13 1966-02-08 Chemicals Inc Process for making iron hydrogenated dextran
GB1200902A (en) 1967-05-13 1970-08-05 Fisons Pharmaceuticals Ltd Iron-dextran complexes
US3549614A (en) * 1967-07-13 1970-12-22 Jan Zbigniew Mioduszewski Method of manufacture of mixed complex compounds of ferric iron with hydrogenated dextran and citric acid or sodium citrate
SU364625A1 (ru) * 1968-07-12 1972-12-28 Способ получения комплексных соединений
US3697502A (en) 1969-11-03 1972-10-10 Christensen Henry M Method of making iron dextran-preparations
HU176073B (hu) 1978-03-08 1980-12-28 Chinoin Gyogyszer Es Vegyeszet Eljárás nagy vastartalmú vasdextrán előállítására
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
US4788281A (en) 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
US4827945A (en) 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5075885A (en) * 1988-12-21 1991-12-24 National Semiconductor Corporation Ecl eprom with cmos programming
SU1797196A1 (ru) * 1991-03-29 1996-02-10 Научно-исследовательский ветеринарный институт Нечерноземной зоны РСФСР Препарат для профилактики алиментарной анемии поросят
EP0634174A1 (de) * 1993-07-13 1995-01-18 Takeda Chemical Industries, Ltd. Antianämische Zusammensetzung zur veterinären Verwendung
US5624668A (en) 1995-09-29 1997-04-29 Luitpold Pharmaceuticals, Inc. Iron dextran formulations
EP0859795B1 (de) * 1995-11-09 2003-04-02 Abbott Laboratories Verfahren zur herstellung eines kristallinen eisendextrans
DK172860B1 (da) 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman

Also Published As

Publication number Publication date
ATE225180T1 (de) 2002-10-15
WO2000030657A1 (en) 2000-06-02
UA57140C2 (uk) 2003-06-16
SI1123103T1 (en) 2003-04-30
ES2183582T3 (es) 2003-03-16
EA003278B1 (ru) 2003-04-24
NO20006021L (no) 2000-11-28
ID26997A (id) 2001-02-22
TR200003648T2 (tr) 2001-08-21
AR019403A1 (es) 2002-02-20
NO20006021D0 (no) 2000-11-28
DK199801526A (da) 2000-02-07
BR9910834A (pt) 2001-02-13
CN1308539A (zh) 2001-08-15
KR20010071767A (ko) 2001-07-31
NZ508225A (en) 2003-10-31
AU756555B2 (en) 2003-01-16
SK19432000A3 (sk) 2001-06-11
DK1123103T3 (da) 2002-11-25
US6977249B1 (en) 2005-12-20
PL345125A1 (en) 2001-12-03
AU5027399A (en) 2000-06-13
EP1123103B1 (de) 2002-10-02
EA200001086A1 (ru) 2001-06-25
HUP0101802A2 (hu) 2001-10-28
HUP0101802A3 (en) 2003-07-28
DE69903329T2 (de) 2003-07-10
JP2002530345A (ja) 2002-09-17
US20030083310A1 (en) 2003-05-01
ZA200006878B (en) 2001-05-10
EP1123103A1 (de) 2001-08-16
DK173138B1 (da) 2000-02-07
CA2332882A1 (en) 2000-06-02
PT1123103E (pt) 2003-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee