DK172242B1 - Fremgangsmåde til fremstilling af insulinderivater - Google Patents

Fremgangsmåde til fremstilling af insulinderivater Download PDF

Info

Publication number
DK172242B1
DK172242B1 DK375784A DK375784A DK172242B1 DK 172242 B1 DK172242 B1 DK 172242B1 DK 375784 A DK375784 A DK 375784A DK 375784 A DK375784 A DK 375784A DK 172242 B1 DK172242 B1 DK 172242B1
Authority
DK
Denmark
Prior art keywords
insulin
cleavage
process according
reaction
formula
Prior art date
Application number
DK375784A
Other languages
Danish (da)
English (en)
Other versions
DK375784A (da
DK375784D0 (da
Inventor
Ulrich Grau
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK375784D0 publication Critical patent/DK375784D0/da
Publication of DK375784A publication Critical patent/DK375784A/da
Application granted granted Critical
Publication of DK172242B1 publication Critical patent/DK172242B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/26Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK375784A 1983-08-03 1984-08-02 Fremgangsmåde til fremstilling af insulinderivater DK172242B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833327928 DE3327928A1 (de) 1983-08-03 1983-08-03 Verfahren zur herstellung von insulin-derivaten
DE3327928 1983-08-03

Publications (3)

Publication Number Publication Date
DK375784D0 DK375784D0 (da) 1984-08-02
DK375784A DK375784A (da) 1985-02-04
DK172242B1 true DK172242B1 (da) 1998-02-02

Family

ID=6205606

Family Applications (1)

Application Number Title Priority Date Filing Date
DK375784A DK172242B1 (da) 1983-08-03 1984-08-02 Fremgangsmåde til fremstilling af insulinderivater

Country Status (20)

Country Link
US (1) US4639332A (ja)
EP (1) EP0135720B1 (ja)
JP (1) JPH0696597B2 (ja)
KR (1) KR920008710B1 (ja)
AT (1) ATE41162T1 (ja)
AU (1) AU568866B2 (ja)
CA (1) CA1229588A (ja)
DE (2) DE3327928A1 (ja)
DK (1) DK172242B1 (ja)
ES (1) ES534798A0 (ja)
FI (1) FI79853C (ja)
GR (1) GR80008B (ja)
HU (1) HU202886B (ja)
IE (1) IE57666B1 (ja)
IL (1) IL72568A (ja)
NO (1) NO167036C (ja)
NZ (1) NZ209074A (ja)
PH (1) PH21160A (ja)
PT (1) PT79013B (ja)
ZA (1) ZA845980B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
CA2225963C (en) 1995-07-25 2008-02-05 Novartis Ag Transforming growth factor beta crystals
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
WO1998042749A1 (en) * 1997-03-20 1998-10-01 Novo Nordisk A/S Zinc free insulin crystals for use in pulmonary compositions
US6323311B1 (en) 1999-09-22 2001-11-27 University Of Utah Research Foundation Synthesis of insulin derivatives
KR100520616B1 (ko) * 2002-12-05 2005-10-10 태양금속공업주식회사 보울트 머리 성형용 트리밍 다이스
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7714025B2 (en) * 2006-05-10 2010-05-11 Arizona Biomedical Research Commission Modified chalcone compounds as antimitotic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1072410A (fr) * 1951-11-15 1954-09-13 Novo Terapeutisk Labor As Perfectionnements apportés au procédé de préparation d'insuline sous une forme cristallisée
DK78069C (da) * 1952-06-23 1954-09-06 Novo Terapeutisk Labor As Fremgangsmåde til fremstilling af krystallinsk insulin.
DE952208C (de) * 1953-11-13 1956-11-15 Novo Terapeutisk Labor As Verfahren zur Herstellung von kristallinem Insulin
DE2214405A1 (de) * 1972-03-24 1973-10-04 Hoechst Ag Verfahren zur herstellung von insulin und insulinanalogen
NL7314766A (ja) * 1972-10-31 1974-05-02
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE3033127A1 (de) * 1980-09-03 1982-04-08 Hoechst Ag, 6000 Frankfurt Neue analoga des insulins
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus

Also Published As

Publication number Publication date
FI79853B (fi) 1989-11-30
FI79853C (fi) 1990-03-12
NO167036B (no) 1991-06-17
IL72568A0 (en) 1984-11-30
NO167036C (no) 1991-09-25
FI843045A (fi) 1985-02-04
ES8504679A1 (es) 1985-04-16
GR80008B (en) 1984-12-11
KR920008710B1 (ko) 1992-10-08
DE3327928A1 (de) 1985-02-21
EP0135720A2 (de) 1985-04-03
PT79013B (de) 1986-09-08
AU568866B2 (en) 1988-01-14
IE841995L (en) 1985-02-03
IL72568A (en) 1989-08-15
HUT35002A (en) 1985-05-28
DE3477004D1 (en) 1989-04-13
US4639332A (en) 1987-01-27
NZ209074A (en) 1989-02-24
PT79013A (de) 1984-09-01
IE57666B1 (en) 1993-02-24
EP0135720A3 (en) 1987-04-08
EP0135720B1 (de) 1989-03-08
ZA845980B (en) 1985-03-27
DK375784A (da) 1985-02-04
DK375784D0 (da) 1984-08-02
PH21160A (en) 1987-08-05
JPS6064997A (ja) 1985-04-13
ES534798A0 (es) 1985-04-16
FI843045A0 (fi) 1984-08-01
HU202886B (en) 1991-04-29
KR850001775A (ko) 1985-04-01
JPH0696597B2 (ja) 1994-11-30
AU3146084A (en) 1985-02-07
ATE41162T1 (de) 1989-03-15
NO843109L (no) 1985-02-04
CA1229588A (en) 1987-11-24

Similar Documents

Publication Publication Date Title
US5986048A (en) Process for obtaining insulin precursors having correctly bonded cystine bridges
DK172242B1 (da) Fremgangsmåde til fremstilling af insulinderivater
US5698669A (en) Tri-arginine insulins
EP0216832B1 (en) Novel insulin derivatives and pharmaceutical preparations containing these derivatives
US20100210815A1 (en) Insulin production methods and pro-insulin constructs
NO167207B (no) Fremgangsmaate til fremstilling av insulinderivat-krystallsuspensjoner.
NO318424B1 (no) Fremgangsmate for isolering av insulin med korrekt koblede cysteinbroer
JPH0691834B2 (ja) インシュリン誘導体の製法
KR880001107B1 (ko) 인체 인슐린 및 그의 유도체의 제조방법
JPH03169895A (ja) 新規インスリン誘導体
NO304743B1 (no) FremgangsmÕte for fremstilling av insulinholdige oppl÷sninger
FI73239C (fi) Foerfarande foer framstaellning av ett insulinderivat.
HUT53677A (en) Process for selective splitting of fusion proteins
Shang-quan Studies on structure and biological activity of insulin
NO156132B (no) Fremgangsmaate ved fremstilling av et insulinderivat.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK