DK375784A - Fremgangsmaade til fremstilling af insulinderivater - Google Patents
Fremgangsmaade til fremstilling af insulinderivater Download PDFInfo
- Publication number
- DK375784A DK375784A DK375784A DK375784A DK375784A DK 375784 A DK375784 A DK 375784A DK 375784 A DK375784 A DK 375784A DK 375784 A DK375784 A DK 375784A DK 375784 A DK375784 A DK 375784A
- Authority
- DK
- Denmark
- Prior art keywords
- insulin derivatives
- preparation
- procedure
- formula
- amino acid
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000008575 L-amino acids Chemical class 0.000 abstract 2
- QJPWUUJVYOJNMH-VKHMYHEASA-N L-homoserine lactone Chemical compound N[C@H]1CCOC1=O QJPWUUJVYOJNMH-VKHMYHEASA-N 0.000 abstract 1
- 108010076181 Proinsulin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- -1 aromatic hydroxy compound Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 108010066381 preproinsulin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3327928 | 1983-08-03 | ||
| DE19833327928 DE3327928A1 (de) | 1983-08-03 | 1983-08-03 | Verfahren zur herstellung von insulin-derivaten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK375784D0 DK375784D0 (da) | 1984-08-02 |
| DK375784A true DK375784A (da) | 1985-02-04 |
| DK172242B1 DK172242B1 (da) | 1998-02-02 |
Family
ID=6205606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK375784A DK172242B1 (da) | 1983-08-03 | 1984-08-02 | Fremgangsmåde til fremstilling af insulinderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4639332A (da) |
| EP (1) | EP0135720B1 (da) |
| JP (1) | JPH0696597B2 (da) |
| KR (1) | KR920008710B1 (da) |
| AT (1) | ATE41162T1 (da) |
| AU (1) | AU568866B2 (da) |
| CA (1) | CA1229588A (da) |
| DE (2) | DE3327928A1 (da) |
| DK (1) | DK172242B1 (da) |
| ES (1) | ES534798A0 (da) |
| FI (1) | FI79853C (da) |
| GR (1) | GR80008B (da) |
| HU (1) | HU202886B (da) |
| IE (1) | IE57666B1 (da) |
| IL (1) | IL72568A (da) |
| NO (1) | NO167036C (da) |
| NZ (1) | NZ209074A (da) |
| PH (1) | PH21160A (da) |
| PT (1) | PT79013B (da) |
| ZA (1) | ZA845980B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8201650A (nl) * | 1982-04-21 | 1983-11-16 | Akzo Nv | Semisynthetische bereiding van humane insuline. |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
| DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| JP4246795B2 (ja) | 1995-07-25 | 2009-04-02 | ノバルティス アクチエンゲゼルシャフト | β型トランスフォーミング増殖因子の結晶 |
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
| US6323311B1 (en) | 1999-09-22 | 2001-11-27 | University Of Utah Research Foundation | Synthesis of insulin derivatives |
| KR100520616B1 (ko) * | 2002-12-05 | 2005-10-10 | 태양금속공업주식회사 | 보울트 머리 성형용 트리밍 다이스 |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| US7741281B2 (en) * | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1072410A (fr) * | 1951-11-15 | 1954-09-13 | Novo Terapeutisk Labor As | Perfectionnements apportés au procédé de préparation d'insuline sous une forme cristallisée |
| DK78069C (da) * | 1952-06-23 | 1954-09-06 | Novo Terapeutisk Labor As | Fremgangsmåde til fremstilling af krystallinsk insulin. |
| DE952208C (de) * | 1953-11-13 | 1956-11-15 | Novo Terapeutisk Labor As | Verfahren zur Herstellung von kristallinem Insulin |
| DE2214405A1 (de) * | 1972-03-24 | 1973-10-04 | Hoechst Ag | Verfahren zur herstellung von insulin und insulinanalogen |
| NL7314766A (da) * | 1972-10-31 | 1974-05-02 | ||
| DE2428412A1 (de) * | 1974-06-12 | 1976-01-15 | Hoechst Ag | Verfahren zur herstellung von insulin, insulin-analogen und -derivaten |
| DE3033127A1 (de) * | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | Neue analoga des insulins |
| DE3326472A1 (de) * | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
| DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
| DE3334407A1 (de) * | 1983-09-23 | 1985-04-04 | Hoechst Ag, 6230 Frankfurt | In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
-
1983
- 1983-08-03 DE DE19833327928 patent/DE3327928A1/de not_active Withdrawn
-
1984
- 1984-07-27 HU HU842890A patent/HU202886B/hu not_active IP Right Cessation
- 1984-08-01 DE DE8484109067T patent/DE3477004D1/de not_active Expired
- 1984-08-01 EP EP84109067A patent/EP0135720B1/de not_active Expired
- 1984-08-01 GR GR80008A patent/GR80008B/el unknown
- 1984-08-01 ES ES534798A patent/ES534798A0/es active Granted
- 1984-08-01 PH PH31054A patent/PH21160A/en unknown
- 1984-08-01 NZ NZ209074A patent/NZ209074A/xx unknown
- 1984-08-01 FI FI843045A patent/FI79853C/fi not_active IP Right Cessation
- 1984-08-01 US US06/636,672 patent/US4639332A/en not_active Expired - Lifetime
- 1984-08-01 AT AT84109067T patent/ATE41162T1/de not_active IP Right Cessation
- 1984-08-02 IL IL72568A patent/IL72568A/xx not_active IP Right Cessation
- 1984-08-02 DK DK375784A patent/DK172242B1/da not_active IP Right Cessation
- 1984-08-02 JP JP59161643A patent/JPH0696597B2/ja not_active Expired - Lifetime
- 1984-08-02 NO NO843109A patent/NO167036C/no not_active IP Right Cessation
- 1984-08-02 KR KR1019840004611A patent/KR920008710B1/ko not_active Expired
- 1984-08-02 CA CA000460239A patent/CA1229588A/en not_active Expired
- 1984-08-02 AU AU31460/84A patent/AU568866B2/en not_active Ceased
- 1984-08-02 ZA ZA845980A patent/ZA845980B/xx unknown
- 1984-08-02 IE IE1995/84A patent/IE57666B1/en not_active IP Right Cessation
- 1984-08-02 PT PT79013A patent/PT79013B/pt not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
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