ES8402875A1 - Procedimiento para la substitucion enzimatica de insulinas. - Google Patents

Procedimiento para la substitucion enzimatica de insulinas.

Info

Publication number
ES8402875A1
ES8402875A1 ES519127A ES519127A ES8402875A1 ES 8402875 A1 ES8402875 A1 ES 8402875A1 ES 519127 A ES519127 A ES 519127A ES 519127 A ES519127 A ES 519127A ES 8402875 A1 ES8402875 A1 ES 8402875A1
Authority
ES
Spain
Prior art keywords
amino acid
insulins
enzymatic
residue
replacement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519127A
Other languages
English (en)
Other versions
ES519127A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
De Forenede Bryggerier AS
Original Assignee
De Forenede Bryggerier AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by De Forenede Bryggerier AS filed Critical De Forenede Bryggerier AS
Publication of ES519127A0 publication Critical patent/ES519127A0/es
Publication of ES8402875A1 publication Critical patent/ES8402875A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA SUSTITUCION ENZIMATICA DE INSULINAS, EN PARTICULAR, PARA EL REEMPLAZAMIENTO ENZIMATICO DEL AMINOACIDO B-30 DE LAS INSULINAS.CONSISTE EN HACER REACCIONAR, COMO COMPONENTE SUSTRATO, LA INSULINA ELEGIDA INS-X, EN DONDE X REPRESENTA EL AMINOACIDO B-30, CON UN COMPONENTE AMINA ELEGIDO EN EL GRUPO FORMADO POR UN L-AMINOACIDOS DE FORMULA: H - B - OH, EN LA QUE B ES UN RESIDUO DE L-AMINOACIDO, POR AMIDAS DE L-AMINOACIDO OPCIONALMENTE N-SUSTITUIDAS DE FORMULA: H - B - NR1R2, EN LA QUE B ES UN RESIDUO DE L-AMINOACIDO.DE APLICACION EN LA CONVERSIONDE LA INSULINA PORCINA EN INSULINA HUMANA.
ES519127A 1982-01-22 1983-01-20 Procedimiento para la substitucion enzimatica de insulinas. Expired ES8402875A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK27782A DK149824C (da) 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner

Publications (2)

Publication Number Publication Date
ES519127A0 ES519127A0 (es) 1984-03-16
ES8402875A1 true ES8402875A1 (es) 1984-03-16

Family

ID=8091736

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519127A Expired ES8402875A1 (es) 1982-01-22 1983-01-20 Procedimiento para la substitucion enzimatica de insulinas.

Country Status (8)

Country Link
US (1) US4579820A (es)
EP (1) EP0085516B1 (es)
AT (1) ATE19790T1 (es)
AU (1) AU549272B2 (es)
CA (1) CA1195940A (es)
DE (1) DE3363449D1 (es)
DK (1) DK149824C (es)
ES (1) ES8402875A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
CA1339955C (en) * 1986-10-14 1998-07-14 Richard Eugene Heiney Process for transforming a human insulin precursor to human insulin
BR8803346A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
US5279954A (en) * 1989-06-30 1994-01-18 Board Of Regents Of The University Of Nebraska And Bionebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US5234820A (en) * 1989-06-30 1993-08-10 Board Of Regents Of The University Of Nebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US6187579B1 (en) 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5985627A (en) * 1997-02-28 1999-11-16 Carlsberg Laboratory Modified carboxypeptidase
KR100925381B1 (ko) 2001-11-19 2009-11-09 노보 노르디스크 에이/에스 인슐린 화합물의 제조 방법
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4086136A (en) * 1975-10-23 1978-04-25 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide using a serine or thiol proteinase
BR8008024A (pt) * 1979-04-06 1981-03-31 Forenede Bryggerier As Processo para a producao enzimatica de peptideos
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof

Also Published As

Publication number Publication date
AU1060883A (en) 1983-07-28
EP0085516A2 (en) 1983-08-10
EP0085516A3 (en) 1983-09-07
DE3363449D1 (en) 1986-06-19
US4579820A (en) 1986-04-01
DK149824C (da) 1987-03-16
DK149824B (da) 1986-10-06
ES519127A0 (es) 1984-03-16
DK27782A (da) 1983-07-23
EP0085516B1 (en) 1986-05-14
AU549272B2 (en) 1986-01-23
ATE19790T1 (de) 1986-05-15
CA1195940A (en) 1985-10-29

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