ATE19790T1 - Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen. - Google Patents

Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen.

Info

Publication number
ATE19790T1
ATE19790T1 AT83300309T AT83300309T ATE19790T1 AT E19790 T1 ATE19790 T1 AT E19790T1 AT 83300309 T AT83300309 T AT 83300309T AT 83300309 T AT83300309 T AT 83300309T AT E19790 T1 ATE19790 T1 AT E19790T1
Authority
AT
Austria
Prior art keywords
amino acid
ins
group
insulin
formula
Prior art date
Application number
AT83300309T
Other languages
English (en)
Inventor
Klaus Breddam
Jack Taaning Johansen
Original Assignee
Carlsberg Biotechnology As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsberg Biotechnology As filed Critical Carlsberg Biotechnology As
Application granted granted Critical
Publication of ATE19790T1 publication Critical patent/ATE19790T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT83300309T 1982-01-22 1983-01-21 Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen. ATE19790T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK27782A DK149824C (da) 1982-01-22 1982-01-22 Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP83300309A EP0085516B1 (de) 1982-01-22 1983-01-21 Verfahren zum enzymatischen Ersetzen von B-30 Aminosäuren in Insulinen

Publications (1)

Publication Number Publication Date
ATE19790T1 true ATE19790T1 (de) 1986-05-15

Family

ID=8091736

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83300309T ATE19790T1 (de) 1982-01-22 1983-01-21 Verfahren zum enzymatischen ersetzen von b-30 aminosaeuren in insulinen.

Country Status (8)

Country Link
US (1) US4579820A (de)
EP (1) EP0085516B1 (de)
AT (1) ATE19790T1 (de)
AU (1) AU549272B2 (de)
CA (1) CA1195940A (de)
DE (1) DE3363449D1 (de)
DK (1) DK149824C (de)
ES (1) ES8402875A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
CA1339955C (en) * 1986-10-14 1998-07-14 Richard Eugene Heiney Process for transforming a human insulin precursor to human insulin
BR8803346A (pt) * 1988-06-30 1990-02-13 Biobras Bioquimica Do Brasil S Processo aperfeicoado para producao em larga escala de cristais de insulina purificada
US5279954A (en) * 1989-06-30 1994-01-18 Board Of Regents Of The University Of Nebraska And Bionebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US5234820A (en) * 1989-06-30 1993-08-10 Board Of Regents Of The University Of Nebraska Exopeptidase catalyzed site-specific bonding of supports, labels and bioactive agents to proteins
US6187579B1 (en) 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5985627A (en) * 1997-02-28 1999-11-16 Carlsberg Laboratory Modified carboxypeptidase
KR100925381B1 (ko) 2001-11-19 2009-11-09 노보 노르디스크 에이/에스 인슐린 화합물의 제조 방법
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US4086136A (en) * 1975-10-23 1978-04-25 (Zaidanhojin) Sagami Chemical Research Center Process for producing a peptide using a serine or thiol proteinase
BR8008024A (pt) * 1979-04-06 1981-03-31 Forenede Bryggerier As Processo para a producao enzimatica de peptideos
DE3064479D1 (en) * 1979-04-13 1983-09-08 Shionogi & Co Process for preparing a b30-threonine insulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof

Also Published As

Publication number Publication date
AU1060883A (en) 1983-07-28
EP0085516A2 (de) 1983-08-10
EP0085516A3 (en) 1983-09-07
DE3363449D1 (en) 1986-06-19
US4579820A (en) 1986-04-01
DK149824C (da) 1987-03-16
DK149824B (da) 1986-10-06
ES519127A0 (es) 1984-03-16
DK27782A (da) 1983-07-23
EP0085516B1 (de) 1986-05-14
AU549272B2 (en) 1986-01-23
CA1195940A (en) 1985-10-29
ES8402875A1 (es) 1984-03-16

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