ES8706167A1 - Un procedimiento para preparar nuevos peptidos hipotensivos. - Google Patents
Un procedimiento para preparar nuevos peptidos hipotensivos.Info
- Publication number
- ES8706167A1 ES8706167A1 ES540110A ES540110A ES8706167A1 ES 8706167 A1 ES8706167 A1 ES 8706167A1 ES 540110 A ES540110 A ES 540110A ES 540110 A ES540110 A ES 540110A ES 8706167 A1 ES8706167 A1 ES 8706167A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- groups
- substituted
- carbazoyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010026906 renin inhibitory peptide Proteins 0.000 title 1
- -1 N-substituted carbamoyl group Chemical group 0.000 abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002461 renin inhibitor Substances 0.000 abstract 1
- 229940086526 renin-inhibitors Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
METODO DE PREPARAR NUEVOS PEPTIDOS HIPOTENSIVOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE C50 Y 50JC, DURANTE UN PERIODO DE TIEMPO ENTRE 3 HORAS Y 5 DIAS, PARA OBTENER NUEVOS PEPTIDOS HIPOTENSIVOS DE FORMULA (I), DONDE R1 ES UN GRUPO DE C 1 A 4, UN SUSTITUYENTE AMINO O AMINO PROTEGIDO EN SU ATOMO DE CARBONO A, Y UN SUSTITUYENTE AROMATICO CARBOCICLICO, UN SUSTITUYENTE HETEROCICLICO Y OTROS; R2 ES H, UN GRUPO ALQUILO DE C 1 A 18, UN GRUPO ALQUENILO DE C 2 A 5 Y OTROS; R3 ES UN GRUPO ISOBUTILO, SEC-BUTILO Y OTROS; Y X REPRESENTA UN GRUPO DE FORMULA -CH(-A-R4)-Y.TIENEN UTILIDAD PARA EL TRATAMIENTO DE LA HIPERTENSION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59019100A JPS60163899A (ja) | 1984-02-03 | 1984-02-03 | レニン阻害ペプチド類 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8706167A1 true ES8706167A1 (es) | 1987-06-01 |
| ES540110A0 ES540110A0 (es) | 1987-06-01 |
Family
ID=11990054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES540110A Expired ES8706167A1 (es) | 1984-02-03 | 1985-02-01 | Un procedimiento para preparar nuevos peptidos hipotensivos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4698329A (es) |
| EP (1) | EP0152255A3 (es) |
| JP (1) | JPS60163899A (es) |
| KR (1) | KR910007576B1 (es) |
| CA (1) | CA1267498A (es) |
| DK (1) | DK47285A (es) |
| ES (1) | ES8706167A1 (es) |
| FI (1) | FI850429L (es) |
| HU (1) | HU198951B (es) |
| NO (1) | NO167744C (es) |
| PT (1) | PT79917B (es) |
| SU (1) | SU1739852A3 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
| EP0181110A3 (en) * | 1984-10-22 | 1988-05-11 | Kissei Pharmaceutical Co. Ltd. | Histidine derivatives as renin inhibitors |
| US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
| EP0184855A3 (en) * | 1984-12-14 | 1989-05-03 | Abbott Laboratories | Resin inhibiting compounds |
| EP0190891A3 (en) * | 1985-01-31 | 1988-04-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
| EP0206807A3 (en) * | 1985-06-28 | 1988-01-20 | Kissei Pharmaceutical Co. Ltd. | Novel amino acid derivatives |
| US4853463A (en) * | 1985-09-04 | 1989-08-01 | Kissei Pharmaceutical Co., Ltd. | Amino acid derivatives |
| US4894437A (en) * | 1985-11-15 | 1990-01-16 | The Upjohn Company | Novel renin inhibiting polypeptide analogs containing S-aryl-D- or L- or DL-cysteinyl, 3-(arylthio)lactic acid or 3-(arylthio)alkyl moieties |
| KR870005013A (ko) * | 1985-11-29 | 1987-06-04 | 가와무라 요시부미 | 레닌-억제 올리고펩티드, 그의 제조방법 및 용도 |
| US4885292A (en) * | 1986-02-03 | 1989-12-05 | E. R. Squibb & Sons, Inc. | N-heterocyclic alcohol renin inhibitors |
| FI870474A (fi) * | 1986-02-07 | 1987-08-08 | Ciba Geigy Ag | Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat. |
| US4727062A (en) * | 1986-03-17 | 1988-02-23 | Merck & Co., Inc. | 3-Halovinylglycine antibacterial agents |
| JPS6322081A (ja) * | 1986-07-11 | 1988-01-29 | Kissei Pharmaceut Co Ltd | 新規なアミノ酸誘導体 |
| DE3627877A1 (de) * | 1986-07-30 | 1988-02-04 | Hoechst Ag | Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung |
| US4814342A (en) * | 1986-10-31 | 1989-03-21 | Pfizer Inc. | Nor-statine and nor-cyclostatine polypeptides |
| DE3640535A1 (de) * | 1986-11-27 | 1988-06-01 | Merck Patent Gmbh | Peptide |
| ZW23187A1 (en) * | 1986-12-15 | 1988-06-29 | Hoffmann La Roche | Phosphinic acid derivatives |
| DE3789101T2 (de) * | 1986-12-19 | 1994-07-21 | Sankyo Co | Renin inhibierende Oligopeptide, ihre Präparation und ihre Anwendung. |
| US5032577A (en) * | 1986-12-31 | 1991-07-16 | Abbott Laboratories | Peptidylaminodiols |
| NL8800100A (nl) * | 1987-01-21 | 1988-08-16 | Sandoz Ag | Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
| US4758584A (en) * | 1987-02-05 | 1988-07-19 | Ciba-Geigy Corporation | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
| GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
| US4921855A (en) * | 1987-06-22 | 1990-05-01 | Fujisawa Pharmaceutical Co., Ltd. | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same |
| US4859654A (en) * | 1987-07-01 | 1989-08-22 | Pfizer Inc. | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents |
| DE68916271T2 (de) * | 1988-01-26 | 1995-02-23 | Sankyo Co | Renin inhibierende Polypeptide, ihre Herstellung und Anwendung. |
| JPH0819153B2 (ja) * | 1988-10-04 | 1996-02-28 | キッセイ薬品工業株式会社 | ペプチド誘導体 |
| KR900012945A (ko) * | 1989-02-16 | 1990-09-03 | 가와무라 요시부미 | 렌닌 억제활성을 갖는 펩타이트, 그 제조방법 및 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO812612L (no) * | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| CA1245217A (en) * | 1981-12-10 | 1988-11-22 | Joshua S. Boger | Renin inhibitory peptides having phe su13 xx deletion |
| DE3377497D1 (en) * | 1982-09-15 | 1988-09-01 | Haessle Ab | Enzyme inhibitors |
| AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
| JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
| US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
| DK110285A (da) * | 1984-03-12 | 1985-09-13 | Pfizer | Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater |
| EP0163237A3 (en) * | 1984-05-29 | 1988-04-27 | Merck & Co. Inc. | Di- and tri-peptidal renin inhibitors |
| EP0486478A3 (en) * | 1984-08-06 | 1992-08-12 | The Upjohn Company | Renin-inhibiting peptides |
| SU1676454A3 (ru) * | 1984-11-30 | 1991-09-07 | Санкио Компани Лимитед (Фирма) | Способ получени пептидов или их фармацевтически приемлемых солей |
-
1984
- 1984-02-03 JP JP59019100A patent/JPS60163899A/ja active Pending
-
1985
- 1985-01-30 US US06/696,334 patent/US4698329A/en not_active Expired - Fee Related
- 1985-02-01 PT PT79917A patent/PT79917B/pt not_active IP Right Cessation
- 1985-02-01 SU SU853860201A patent/SU1739852A3/ru active
- 1985-02-01 NO NO850397A patent/NO167744C/no unknown
- 1985-02-01 ES ES540110A patent/ES8706167A1/es not_active Expired
- 1985-02-01 FI FI850429A patent/FI850429L/fi not_active Application Discontinuation
- 1985-02-01 HU HU85398A patent/HU198951B/hu not_active IP Right Cessation
- 1985-02-01 DK DK47285A patent/DK47285A/da not_active Application Discontinuation
- 1985-02-02 KR KR1019850000661A patent/KR910007576B1/ko active IP Right Grant
- 1985-02-04 CA CA000473519A patent/CA1267498A/en not_active Expired - Fee Related
- 1985-02-04 EP EP85300738A patent/EP0152255A3/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HU198951B (en) | 1989-12-28 |
| JPS60163899A (ja) | 1985-08-26 |
| KR850006008A (ko) | 1985-09-28 |
| NO167744C (no) | 1991-12-04 |
| SU1739852A3 (ru) | 1992-06-07 |
| FI850429L (fi) | 1985-08-04 |
| KR910007576B1 (ko) | 1991-09-28 |
| DK47285D0 (da) | 1985-02-01 |
| NO167744B (no) | 1991-08-26 |
| PT79917B (en) | 1987-02-05 |
| EP0152255A2 (en) | 1985-08-21 |
| EP0152255A3 (en) | 1987-06-16 |
| CA1267498A (en) | 1990-04-03 |
| PT79917A (en) | 1985-03-01 |
| FI850429A0 (fi) | 1985-02-01 |
| US4698329A (en) | 1987-10-06 |
| DK47285A (da) | 1985-08-04 |
| NO850397L (no) | 1985-08-05 |
| HUT38105A (en) | 1986-04-28 |
| ES540110A0 (es) | 1987-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |