JPS57155997A - Insulin derivative - Google Patents

Insulin derivative

Info

Publication number
JPS57155997A
JPS57155997A JP56175030A JP17503081A JPS57155997A JP S57155997 A JPS57155997 A JP S57155997A JP 56175030 A JP56175030 A JP 56175030A JP 17503081 A JP17503081 A JP 17503081A JP S57155997 A JPS57155997 A JP S57155997A
Authority
JP
Japan
Prior art keywords
insulin
protecting group
enzyme
basicity
trypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56175030A
Other languages
Japanese (ja)
Other versions
JPS6312480B2 (en
Inventor
Kazuyuki Morihara
Tatsu Oka
Hiroshige Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP56175030A priority Critical patent/JPS57155997A/en
Publication of JPS57155997A publication Critical patent/JPS57155997A/en
Priority to JP61266447A priority patent/JPS62116598A/en
Publication of JPS6312480B2 publication Critical patent/JPS6312480B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: To synthesize human insulin using swine insulin as a raw material, by reacting des-B30-insulin with large excess of a threonine derivative by the action of an enzyme exhibiting specificity on an amino acid having basicity on the carboxyl side, followed by removing a protecting group.
CONSTITUTION: Des-B30-insulin is reacted with large excess of a threonine derivative shown by the formula (Thr is L-threonine residue, R1 is a H-protecting group, R2 is a carboxyl-protecting group) by the action of an enzyme such as trypsin or enzyme like trypsin, etc., exhibiting specificity on an amino acid derived from various kinds of animals and microorganisms, having basicity on the carboxyl side. The reaction solution is subjected to gel filtration, the rest is subjected to chromatography to give insulin containing a protecting group, which is eliminated by common elimination of protecting group, and prepared insulin is used as a remedy for diabetes.
COPYRIGHT: (C)1982,JPO&Japio
JP56175030A 1981-10-30 1981-10-30 Insulin derivative Granted JPS57155997A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP56175030A JPS57155997A (en) 1981-10-30 1981-10-30 Insulin derivative
JP61266447A JPS62116598A (en) 1981-10-30 1986-11-07 Production of insulin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56175030A JPS57155997A (en) 1981-10-30 1981-10-30 Insulin derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP4571079A Division JPS55138393A (en) 1979-04-13 1979-04-13 Semisynthesis of insulin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61266447A Division JPS62116598A (en) 1981-10-30 1986-11-07 Production of insulin derivative

Publications (2)

Publication Number Publication Date
JPS57155997A true JPS57155997A (en) 1982-09-27
JPS6312480B2 JPS6312480B2 (en) 1988-03-18

Family

ID=15988985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56175030A Granted JPS57155997A (en) 1981-10-30 1981-10-30 Insulin derivative

Country Status (1)

Country Link
JP (1) JPS57155997A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135789A (en) * 1978-04-13 1979-10-22 Nippon Soda Co Ltd Preparation of human insulin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54135789A (en) * 1978-04-13 1979-10-22 Nippon Soda Co Ltd Preparation of human insulin

Also Published As

Publication number Publication date
JPS6312480B2 (en) 1988-03-18

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