ES8506749A1 - Procedimiento para la produccion de 1-n -(l-3-amino-2-hidroxipropionilo)- o 1-n-(l-4-amino-2-hidroxibutirilo)-2',3'-dideoxikanamicina a - Google Patents
Procedimiento para la produccion de 1-n -(l-3-amino-2-hidroxipropionilo)- o 1-n-(l-4-amino-2-hidroxibutirilo)-2',3'-dideoxikanamicina aInfo
- Publication number
- ES8506749A1 ES8506749A1 ES535038A ES535038A ES8506749A1 ES 8506749 A1 ES8506749 A1 ES 8506749A1 ES 535038 A ES535038 A ES 535038A ES 535038 A ES535038 A ES 535038A ES 8506749 A1 ES8506749 A1 ES 8506749A1
- Authority
- ES
- Spain
- Prior art keywords
- amino
- production
- same
- general formula
- dideoxykanamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DE 1-N-(L-3-AMINO-2-HIDROXIPROPIONIL) O 1-N-(L-4-AMINO-2-HIDROXIBUTIRIL)-2K, 3K-DIDESOXIKANAMICINA A.CONSISTE EN LA ACILACION DEL GRUPO 1-AMINO DE 2K,3K-DIDESOXIKANAMICINA A O UN DERIVADO PARCIALMENTE N-PROTEGIDO DE LA MISMA, DE FORMULA GENERAL (I), EN LA QUE A ES UN ATOMO DE HIDROGENO Y AL MENOS UNA B ES UN GRUPO MONOVALENTE AMINO-PROTECTOR, MEDIANTE REACCION CON ACIDO L-3-AMINO-2-HIDROXIPROPIONICO O L-4-AMINO-2-HIDROXIBUTIRICO O UN DERIVADO AMINO PROTEGIDO DEL MISMO, DE FORMULA GENERAL (II), PARA LA OBTENCION DEL PRODUCTO 1-N-ACILADO DE FORMULAGENERAL (III), Y EN RETIRAR A CONTINUACION LOS GRUPOS AMINO-PROTECTORES.DE APLICACION COMO ANTIBIOTICOS PARA EL TRATAMIENTO TERAPEUTICO DE VARIAS CLASES DE INFECCIONES BACTERIASNAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58147965A JPS6041692A (ja) | 1983-08-15 | 1983-08-15 | 2′,3′−ジデオキシカナマイシンa誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8506749A1 true ES8506749A1 (es) | 1985-07-16 |
ES535038A0 ES535038A0 (es) | 1985-07-16 |
Family
ID=15442092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535038A Granted ES535038A0 (es) | 1983-08-15 | 1984-08-09 | Procedimiento para la produccion de 1-n -(l-3-amino-2-hidroxipropionilo)- o 1-n-(l-4-amino-2-hidroxibutirilo)-2',3'-dideoxikanamicina a |
Country Status (6)
Country | Link |
---|---|
US (1) | US4547492A (es) |
EP (1) | EP0139553A3 (es) |
JP (1) | JPS6041692A (es) |
KR (1) | KR920003838B1 (es) |
CA (1) | CA1212941A (es) |
ES (1) | ES535038A0 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4656160A (en) * | 1984-11-29 | 1987-04-07 | Fujisawa Pharmaceutical Co., Ltd. | Aminoglycoside derivatives |
JPS6253997A (ja) * | 1985-09-03 | 1987-03-09 | Kowa Co | 新規なアミノ配糖体及びこれを含有する製剤 |
IT1225484B (it) * | 1987-11-27 | 1990-11-14 | Pierrel Spa | Procedimento di sintesi dell'amikacina |
IT1237490B (it) * | 1989-09-22 | 1993-06-07 | Chementecno S R L Monza Milano | Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico |
JP3045527B2 (ja) * | 1990-08-24 | 2000-05-29 | 財団法人微生物化学研究会 | 4―0―(アミノグリコシル)―又は4,6―ジー0―(アミノグリコシル)―2,5―ジデオキシ―5,5―ジフルオロストレプタミン誘導体とその製造法 |
KR20000044978A (ko) * | 1998-12-30 | 2000-07-15 | 성재갑 | 각질 박리 촉진용 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51127045A (en) * | 1975-04-24 | 1976-11-05 | Microbial Chem Res Found | A process for preparing 3'- deoxykanamycin a derivatives. |
US4160082A (en) * | 1976-04-14 | 1979-07-03 | Pfizer Inc. | Intermediates for aminoglycoside antibiotics |
US4171356A (en) * | 1976-10-28 | 1979-10-16 | Schering Corporation | 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor |
JPS55105699A (en) * | 1979-02-05 | 1980-08-13 | Microbial Chem Res Found | 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative |
JPS5953498A (ja) * | 1982-09-20 | 1984-03-28 | Microbial Chem Res Found | 5,2′,3′,4′,4″,6″−ヘキサデオキシカナマイシンおよびその1−n−アシル誘導体 |
-
1983
- 1983-08-15 JP JP58147965A patent/JPS6041692A/ja active Pending
-
1984
- 1984-08-09 ES ES535038A patent/ES535038A0/es active Granted
- 1984-08-10 US US06/639,392 patent/US4547492A/en not_active Expired - Fee Related
- 1984-08-13 CA CA000460899A patent/CA1212941A/en not_active Expired
- 1984-08-13 EP EP84401666A patent/EP0139553A3/en not_active Withdrawn
- 1984-08-14 KR KR1019840004937A patent/KR920003838B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR920003838B1 (ko) | 1992-05-15 |
KR850001765A (ko) | 1985-04-01 |
ES535038A0 (es) | 1985-07-16 |
US4547492A (en) | 1985-10-15 |
EP0139553A3 (en) | 1986-08-13 |
JPS6041692A (ja) | 1985-03-05 |
EP0139553A2 (en) | 1985-05-02 |
CA1212941A (en) | 1986-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970612 |