DK171989B1 - Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler - Google Patents

Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler Download PDF

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Publication number
DK171989B1
DK171989B1 DK428188A DK428188A DK171989B1 DK 171989 B1 DK171989 B1 DK 171989B1 DK 428188 A DK428188 A DK 428188A DK 428188 A DK428188 A DK 428188A DK 171989 B1 DK171989 B1 DK 171989B1
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Denmark
Prior art keywords
alkyl
alkoxy
compound
vanadium
process according
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DK428188A
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Danish (da)
English (en)
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DK428188A (da
DK428188D0 (da
Inventor
Masayasu Kato
Yoshio Toyoshima
Norio Iwano
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Takeda Chemical Industries Ltd
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Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK428188D0 publication Critical patent/DK428188D0/da
Publication of DK428188A publication Critical patent/DK428188A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK428188A 1987-08-04 1988-08-01 Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler DK171989B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19480987 1987-08-04
JP19480987 1987-08-04

Publications (3)

Publication Number Publication Date
DK428188D0 DK428188D0 (da) 1988-08-01
DK428188A DK428188A (da) 1989-02-05
DK171989B1 true DK171989B1 (da) 1997-09-08

Family

ID=16330618

Family Applications (1)

Application Number Title Priority Date Filing Date
DK428188A DK171989B1 (da) 1987-08-04 1988-08-01 Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

Country Status (11)

Country Link
US (1) US5578732A (de)
EP (1) EP0302720B1 (de)
KR (1) KR960000047B1 (de)
AT (1) ATE82283T1 (de)
CA (1) CA1263119A (de)
DE (1) DE3875848T2 (de)
DK (1) DK171989B1 (de)
ES (1) ES2052728T3 (de)
GR (1) GR3006974T3 (de)
HU (1) HU199828B (de)
IE (1) IE61717B1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
KR100362947B1 (ko) * 1999-09-21 2002-11-30 주식회사 대웅 설폭시드 화합물의 제조방법
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KR101035534B1 (ko) 2000-05-15 2011-05-23 다케다 야쿠힌 고교 가부시키가이샤 결정의 제조방법
KR100887912B1 (ko) 2000-12-01 2009-03-12 다케다 야쿠힌 고교 가부시키가이샤 (ｒ)- 또는 (ｓ)-란소프라졸의 결정화 방법
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KR100430575B1 (ko) * 2001-02-21 2004-05-10 주식회사 씨트리 란소프라졸 및 그 중간체의 제조방법
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
EP1437352A4 (de) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd Benzimidazolverbindung, verfahren zu deren herstellung und deren verwendung
KR20040093187A (ko) * 2002-03-27 2004-11-04 테바 파마슈티컬 인더스트리즈 리미티드 란소프라졸 다형 및 그것의 제조 방법
KR100873419B1 (ko) * 2002-06-18 2008-12-11 페어차일드코리아반도체 주식회사 높은 항복 전압, 낮은 온 저항 및 작은 스위칭 손실을갖는 전력용 반도체 소자
AU2003268034A1 (en) * 2002-07-26 2004-02-16 Teva Pharmaceutical Industries Ltd. Preparation of lansoprazole and related compounds
EP1837335A1 (de) * 2002-08-21 2007-09-26 Teva Pharmaceutical Industries Ltd Verfahren zur Reinigung von Lansoprazol
PT1501824E (pt) * 2002-08-21 2007-11-28 Teva Pharma Método para purificação de lansoprazole
US8697094B2 (en) 2002-10-16 2014-04-15 Takeda Pharmaceutical Company Limited Stable solid preparations
DE03789888T1 (de) * 2002-11-18 2005-08-18 Teva Pharmaceutical Industries Ltd. Stabiles lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm wasser und mehr als 200 ppm bis zu 5000 ppm alkohol
JP2006514108A (ja) 2002-12-19 2006-04-27 テバ ファーマシューティカル インダストリーズ リミティド パントプラゾールナトリウムの固体状態、それらの調製方法、及び公知のパントプラゾールナトリウム水和物の調製方法
US7678816B2 (en) * 2003-02-05 2010-03-16 Teva Pharmaceutical Industries Ltd. Method of stabilizing lansoprazole
CA2520157A1 (fr) * 2003-03-28 2004-10-14 Sidem Pharma Procede de preparation enantioselective de derives de sulfoxydes
FR2852956B1 (fr) * 2003-03-28 2006-08-04 Negma Gild Procede de preparation enantioselective de derives de sulfoxydes
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
JP5563735B2 (ja) 2004-06-16 2014-07-30 タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド Ｐｐｉ多回剤形
JP5173191B2 (ja) 2004-09-13 2013-03-27 武田薬品工業株式会社 酸化化合物の製造方法及び製造装置
EP1681056A1 (de) * 2005-01-14 2006-07-19 Krka Tovarna Zdravil, D.D., Novo Mesto Verfahren zur Herstellung von Lansoprazol
KR100758600B1 (ko) * 2006-01-05 2007-09-13 주식회사 대웅제약 란소프라졸 결정형 ａ의 제조방법
US8129536B2 (en) * 2006-09-22 2012-03-06 Orchid Chemicals & Pharmaceuticals Limited Method for the purification of lansoprazole
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
WO2009066309A2 (en) * 2007-07-12 2009-05-28 Cadila Healthcare Limited Process for preparation of omeprazole
US8173158B2 (en) 2007-10-12 2012-05-08 Takeda Pharmaceuticals U.S.A., Inc. Methods of treating gastrointestinal disorders independent of the intake of food
EP2262790B1 (de) 2008-03-10 2017-06-07 Takeda Pharmaceutical Company Limited Kristall einer benzimidazolverbindung
ES2343935B1 (es) * 2008-12-29 2011-04-28 Laboratorios Viñas S.A. Intermedios utiles para la obtencion de 2-(2-piridinilmetilsulfinil)-1h-benzimidazoles y procedimientos correspondientes.
KR20100101405A (ko) * 2009-03-09 2010-09-17 한미홀딩스 주식회사 비결정형의 (+)-란소프라졸 제조방법 및 이에 사용되는 (+)-란소프라졸 알코올레이트
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CN102180865B (zh) * 2011-03-17 2013-01-16 浙江工业大学 一种兰索拉唑的合成方法
US9119769B2 (en) 2011-12-30 2015-09-01 The Curators Of The University Of Missouri Method for transforming pharmaceutical crystal forms
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
CN103724325B (zh) * 2013-12-10 2016-04-13 南京工业大学 制备亚磺酰基-1-氢-苯并咪唑衍生物的方法
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺

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US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
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DK171989B1 (da) * 1987-08-04 1997-09-08 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

Also Published As

Publication number Publication date
IE882376L (en) 1989-02-04
KR890003738A (ko) 1989-04-17
ATE82283T1 (de) 1992-11-15
HUT49346A (en) 1989-09-28
US5578732A (en) 1996-11-26
KR960000047B1 (ko) 1996-01-03
DE3875848T2 (de) 1993-03-25
IE61717B1 (en) 1994-11-30
DK428188A (da) 1989-02-05
EP0302720A1 (de) 1989-02-08
GR3006974T3 (de) 1993-06-30
DK428188D0 (da) 1988-08-01
HU199828B (en) 1990-03-28
DE3875848D1 (de) 1992-12-17
ES2052728T3 (es) 1994-07-16
EP0302720B1 (de) 1992-11-11
CA1263119A (en) 1989-11-21

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