DK171846B1 - Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener - Google Patents

Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener Download PDF

Info

Publication number
DK171846B1
DK171846B1 DK016487A DK16487A DK171846B1 DK 171846 B1 DK171846 B1 DK 171846B1 DK 016487 A DK016487 A DK 016487A DK 16487 A DK16487 A DK 16487A DK 171846 B1 DK171846 B1 DK 171846B1
Authority
DK
Denmark
Prior art keywords
immunogen
complex
molecule
carrier molecule
carrier
Prior art date
Application number
DK016487A
Other languages
Danish (da)
English (en)
Other versions
DK16487A (da
DK16487D0 (da
Inventor
Gregory John Russell-Jones
Henry James De Aizpurua
Peter Howe
Keith Norman Rand
Original Assignee
Biotech Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25642944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK171846(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotech Australia Pty Ltd filed Critical Biotech Australia Pty Ltd
Publication of DK16487D0 publication Critical patent/DK16487D0/da
Publication of DK16487A publication Critical patent/DK16487A/da
Application granted granted Critical
Publication of DK171846B1 publication Critical patent/DK171846B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0006Contraceptive vaccins; Vaccines against sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK016487A 1985-05-15 1987-01-14 Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener DK171846B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AUPH056685 1985-05-15
AUPH056685 1985-05-15
AUPH310485 1985-10-25
AUPH310485 1985-10-25
PCT/AU1986/000135 WO1986006635A1 (en) 1985-05-15 1986-05-14 Oral vaccines
AU8600135 1986-05-14

Publications (3)

Publication Number Publication Date
DK16487D0 DK16487D0 (da) 1987-01-14
DK16487A DK16487A (da) 1987-03-16
DK171846B1 true DK171846B1 (da) 1997-06-30

Family

ID=25642944

Family Applications (1)

Application Number Title Priority Date Filing Date
DK016487A DK171846B1 (da) 1985-05-15 1987-01-14 Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener

Country Status (12)

Country Link
EP (1) EP0222835B2 (ja)
JP (1) JP2761849B2 (ja)
CN (1) CN86103835A (ja)
CA (1) CA1340555C (ja)
DE (1) DE3650082T3 (ja)
DK (1) DK171846B1 (ja)
ES (1) ES8900006A1 (ja)
FI (1) FI870140A0 (ja)
HK (1) HK29896A (ja)
IL (1) IL78775A (ja)
NZ (1) NZ216162A (ja)
WO (1) WO1986006635A1 (ja)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
US4822611A (en) * 1986-12-09 1989-04-18 Immunotec, Inc. Oral hyposensitization in the treatment of allergies
US5112749A (en) * 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5135918A (en) * 1988-03-21 1992-08-04 Broncorp Method for decreasing reaginic antibody levels
EP0396653A1 (en) * 1988-08-30 1990-11-14 Applied Research Systems ARS Holding N.V. Recombinant fusion proteins for altering hormone secretion
DE68929405T2 (de) * 1988-09-06 2003-02-06 Univ St Louis Orale-immunisierung durch verwendung von transgenen pflanzen
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
FR2636842B1 (fr) * 1988-09-27 1994-06-10 Liege Universite Etat Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion
PT92511A (pt) * 1988-12-07 1990-06-29 Univ Leicester Processo de preparacao de um hospedeiro transformado e de proteinas de fusao da subunidade b de toxina labil ao calor
WO1990007525A1 (en) * 1989-01-06 1990-07-12 The Regents Of The University Of California Keratoconjunctivitis cytotoxin and methods for its use and production
US6413523B1 (en) * 1989-06-02 2002-07-02 The United States Of America As Represented By The Secretary Of The Navy Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use
EP0418626B1 (en) * 1989-09-08 1993-12-29 Takeda Chemical Industries, Ltd. Fused proteins and production thereof
US5032405A (en) * 1989-09-27 1991-07-16 Warner-Lambert Company Oral pharmaceutical composition for acid sensitive proteinaceous agents
US5378815A (en) * 1989-10-20 1995-01-03 National Research Council Canada Process for indirect targeted immunocytolysis
CA2050425A1 (en) * 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
US5241053A (en) * 1990-09-05 1993-08-31 Takeda Chemical Industries, Ltd. Fused proteins comprising glycoprotein gD of HSV-1 and LTB
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
ES2131066T3 (es) * 1990-12-21 1999-07-16 Antex Biolog Inc Vacuna de conjugacion de oligosacarido con adhesina para hi(haemophilus influenzae).
PL296623A1 (en) * 1991-03-01 1993-09-20 Rhone Merieux Method of improving organoleptic properties of male slaughter animal meat
CA2084194C (en) * 1991-04-02 2003-05-20 Gregory John Russell-Jones Oral delivery systems for microparticles
GB9112553D0 (en) * 1991-06-11 1991-07-31 Wellcome Found Fusion proteins
ZA934199B (en) * 1992-06-18 1994-01-10 Akzo Nv Carrier system against gnrh
DE69305313T3 (de) * 1992-12-22 2001-06-21 Univ Cincinnati Cincinnati Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen Proteinen
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
US5688506A (en) 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6030613A (en) * 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
EP1323346B1 (en) * 1995-01-17 2006-06-28 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
EP0840796A2 (en) * 1995-07-26 1998-05-13 Maxim Pharmaceuticals Mucosal delivery of polynucleotides
DE19534579C2 (de) * 1995-09-18 2000-06-08 Max Planck Gesellschaft Nucleinsäure-Moleküle codierend Proteine, die die Adhäsion von Neisseria-Zellen an humane Zellen vermitteln
AU734532B2 (en) 1996-04-19 2001-06-14 Henry M. Jackson Foundation For The Advancement Of Military Medicine Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
CA2252439C (en) 1996-04-19 2014-09-30 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
KR20010043441A (ko) 1998-05-08 2001-05-25 더 유니버시티 오브 브리스톨 백신용 면역조절제
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
ES2233284T3 (es) 1999-02-17 2005-06-16 Pfizer Products Inc. Proteinas de fusion que comprenden portadores que pueden inducir una bdoble respuesta inmune.
FR2791895B1 (fr) * 1999-03-23 2001-06-15 Pasteur Merieux Serums Vacc Utilisation de trehalose pour stabiliser un vaccin liquide
EP1242122B1 (en) * 1999-10-22 2009-09-30 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Delivery of proteins across polar epithelial cell layers
US6863896B1 (en) 1999-10-26 2005-03-08 Chiron Corporation Plant lectins as mucosal adjuvants
CA2389080C (en) * 1999-10-26 2012-02-21 Chiron Corporation Mistletoe lectins as mucosal adjuvants
JP2001335510A (ja) * 2000-05-23 2001-12-04 Masanori Baba エイズワクチン
NZ561879A (en) * 2003-03-07 2009-05-31 Wyeth Corp Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
WO2006007853A2 (en) * 2004-07-20 2006-01-26 Symphogen A/S A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
WO2006044205A2 (en) 2004-10-04 2006-04-27 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of macromolecules
ES2370040T3 (es) 2005-10-07 2011-12-12 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. Vacuna de metaloproteinasa 11 de la matriz.
WO2007067596A2 (en) 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of antibodies
CA2638760A1 (en) 2006-03-07 2007-09-13 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
CN104080475A (zh) 2008-04-18 2014-10-01 法克斯因内特公司 鞭毛蛋白的缺失突变体以及使用方法
SI2445522T1 (sl) 2009-06-22 2017-10-30 Wyeth Llc Imunogeni sestavki antigenov Staphylococcusa aureusa
US9125951B2 (en) 2009-06-22 2015-09-08 Wyeth Llc Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
CN101921726B (zh) * 2010-07-27 2012-08-22 浙江大学 一种口服免疫阻断鸡抑制素作用的转化子及其应用
CN102178699B (zh) * 2011-04-20 2013-03-20 威海康博尔生物药业有限公司 一种用于增强人体免疫力、促进生长发育的制剂
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
WO2017066134A1 (en) 2015-10-16 2017-04-20 Merck Sharp & Dohme Corp. Processes for preparing formulations for gastrointestinal-targeted therapies

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2547224A1 (de) * 1974-11-01 1976-05-13 Sandoz Ag Organische verbindungen, ihre verwendung und herstellung
FR2306684A1 (fr) * 1975-04-11 1976-11-05 Crinex Lab Nouvelle composition a action immunostimulante
GB1553664A (en) * 1975-06-12 1979-09-26 Unilever Ltd Antigenic compositions
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
JPS5639022A (en) * 1979-09-05 1981-04-14 Hayashibara Biochem Lab Inc Preparation of vaccine
DE3110031A1 (de) * 1980-03-17 1982-01-07 President And Fellows Of Harvard College, Cambridge, Mass. Verschmolzene gene, ihre herstellung und verwendung derselben
EP0049945A3 (en) * 1980-09-15 1982-12-01 Bactex Incorporated Determining a hierarchy of piliated organisms and a vaccine prepared from such organisms
GB2094314A (en) * 1981-02-05 1982-09-15 Wellcome Found Recombinant DNA
WO1982003088A1 (en) * 1981-03-09 1982-09-16 Corp Cetus Vaccines
US4593002A (en) * 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
CA1203164A (en) * 1982-03-09 1986-04-15 Thomas J. Mckearn Antibody conjugates
IT1203672B (it) * 1982-05-12 1989-02-15 Harvard College Proteina ibrida comprendente frammenti proteici collegati da legami peptidici e relativo gene di fusione composizione contenente tale proteina
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
DE3382547D1 (de) * 1983-01-12 1992-05-27 Chiron Corp Sekretorische expression in eukaryoten.
DK219084D0 (da) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
AU582358B2 (en) * 1984-04-06 1989-03-23 Scripps Clinic And Research Foundation A peptide vaccine or diagnostic, and a polypeptide useful therefor
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
DE3586386T2 (de) * 1984-10-05 1993-01-14 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
NZ213759A (en) * 1984-10-19 1989-01-27 Genentech Inc Lhrh-ctp protein conjugates influencing prolactin fsh and lh release
US4556555A (en) * 1985-01-25 1985-12-03 North Carolina State University Process for the immunological neutering of animals

Also Published As

Publication number Publication date
EP0222835B1 (en) 1994-09-28
JP2761849B2 (ja) 1998-06-04
ES8900006A1 (es) 1988-10-16
ES554969A0 (es) 1988-10-16
CN86103835A (zh) 1987-04-08
EP0222835B2 (en) 2000-04-19
FI870140A (fi) 1987-01-14
WO1986006635A1 (en) 1986-11-20
NZ216162A (en) 1989-04-26
DE3650082D1 (de) 1994-11-03
IL78775A0 (en) 1986-08-31
DK16487A (da) 1987-03-16
JPH07213290A (ja) 1995-08-15
EP0222835A1 (en) 1987-05-27
HK29896A (en) 1996-02-23
DE3650082T3 (de) 2000-12-21
CA1340555C (en) 1999-05-25
AU594059B2 (en) 1990-03-01
DK16487D0 (da) 1987-01-14
FI870140A0 (fi) 1987-01-14
AU5861286A (en) 1986-12-04
DE3650082T2 (de) 1995-05-04
IL78775A (en) 1992-06-21
EP0222835A4 (en) 1988-02-01

Similar Documents

Publication Publication Date Title
DK171846B1 (da) Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener
De Aizpurua et al. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding.
US6103243A (en) Oral vaccines
Ellis Vaccines: New approaches to immunological problems
US7960535B2 (en) Recombinant lipidated PsaA protein, methods of preparation and use
US20050244425A1 (en) Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
Oaks et al. Development and evaluation of a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine
JP2012139221A (ja) 肺炎球菌感染を治療または予防するための組成物および方法
KR20010021953A (ko) B군 수막염균 포린 및 에이치.인플루엔자 다당류를포함하는 면역원성 접합체
US9011871B2 (en) Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease
LEVINE et al. Pediatric diarrhea: the challenge of prevention
EP0682950B1 (en) Mucosal administration of pneumococcal antigens
CZ281556B6 (cs) Způsob výroby kompozitní vakcíny proti střevní infekci způsobené enterotexigenickými bakteriemi E. coli
JPH05503420A (ja) キメラタンパク質
EP0365646A1 (en) SYNTHETIC PEPTIDES FROM STREPTOCOCCAL PROTEINS M AND VACCINES PREPARED FROM SUCH PEPTIDES.
Lasaro et al. Prime-boost vaccine regimen confers protective immunity to human-derived enterotoxigenic Escherichia coli
AU594059C (en) Oral vaccines
Jacob et al. Identification of a 33 kDa antigen associated with an adhesive and colonizing strain of Vibrio cholerae El Tor and its role in protection
Klipstein et al. Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin
NO870148L (no) Orale vaksiner.
JP2660511B2 (ja) 経口ワクチン
Svennerholm et al. Immunity to enterotoxin-producing bacteria
Freytag Effect of gene location on in vitro and in vivo stability, immunogenicity and expression of foreign antigens in bacterial vaccine fectors
Dickinson Construction and characterization of a non-toxic mutant of the Escherichia coli heat-labile enterotoxin effective as an oral adjuvant
Guinée et al. Infection and immunity to Vibrio cholerae, Salmonella typhimurium and Escherichia coli in a rabbit model

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed