DK170973B1 - Ravsyreforbindelser og farmaceutiske præparater indeholdende dem - Google Patents
Ravsyreforbindelser og farmaceutiske præparater indeholdende dem Download PDFInfo
- Publication number
- DK170973B1 DK170973B1 DK041592A DK41592A DK170973B1 DK 170973 B1 DK170973 B1 DK 170973B1 DK 041592 A DK041592 A DK 041592A DK 41592 A DK41592 A DK 41592A DK 170973 B1 DK170973 B1 DK 170973B1
- Authority
- DK
- Denmark
- Prior art keywords
- cis
- hexahydro
- group
- propionic acid
- isoindolinylcarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/06—Preparatory processes
- C08G77/08—Preparatory processes characterised by the catalysts used
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14227591 | 1991-03-30 | ||
JP3142275A JP2686861B2 (ja) | 1991-03-30 | 1991-03-30 | 新規なベンジリデンコハク酸誘導体 |
JP18841691 | 1991-04-25 | ||
JP3188416A JP2686863B2 (ja) | 1991-04-25 | 1991-04-25 | 新規なベンジルコハク酸誘導体 |
JP36151991 | 1991-12-27 | ||
JP36151991 | 1991-12-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK41592D0 DK41592D0 (da) | 1992-03-27 |
DK41592A DK41592A (da) | 1992-10-01 |
DK170973B1 true DK170973B1 (da) | 1996-04-09 |
Family
ID=27318415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK041592A DK170973B1 (da) | 1991-03-30 | 1992-03-27 | Ravsyreforbindelser og farmaceutiske præparater indeholdende dem |
Country Status (12)
Country | Link |
---|---|
US (1) | US5202335A (fr) |
EP (1) | EP0507534B1 (fr) |
KR (1) | KR100192530B1 (fr) |
AT (1) | ATE134615T1 (fr) |
AU (1) | AU654331B2 (fr) |
CA (1) | CA2062877C (fr) |
DE (1) | DE69208496T2 (fr) |
DK (1) | DK170973B1 (fr) |
ES (1) | ES2084275T3 (fr) |
FI (1) | FI102172B1 (fr) |
HK (1) | HK1005449A1 (fr) |
NO (1) | NO178371C (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998032736A1 (fr) * | 1997-01-29 | 1998-07-30 | Kissei Pharmaceutical Co., Ltd. | Procede de production de derives d'acide benzylsuccinique |
FR2765578B1 (fr) * | 1997-07-03 | 1999-09-10 | Adir | Procede de preparation d'un perhydroisoindole substitue |
JP3277320B2 (ja) * | 1997-08-28 | 2002-04-22 | 有機合成薬品工業株式会社 | シス−ヘキサヒドロイソインドリン誘導体の製造方法 |
FR2777566B1 (fr) * | 1998-04-15 | 2003-02-21 | Synthelabo | Derives d'azacycloalcanes, leur preparation et leur application en therapeutique |
FR2779428B1 (fr) * | 1998-06-03 | 2001-05-18 | Synthelabo | Derives d'oxo-azacycloalcanes, leurs preparations et leurs applications en therapeutique |
TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
FR2793411B1 (fr) * | 1999-05-11 | 2001-06-29 | Synthelabo | Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation |
AU782005B2 (en) * | 1999-05-21 | 2005-06-30 | Kissei Pharmaceutical Co. Ltd. | Immediate release medicinal compositions for oral use |
AR033390A1 (es) | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
KR20020092060A (ko) * | 2001-06-01 | 2002-12-11 | 김정균 | 알콕시 작용성 그룹을 포함한 폴리실록산 화합물 |
EP2316468A1 (fr) | 2002-02-22 | 2011-05-04 | Shire LLC | Système de distribution et méthodes de protection et d'administration de dextroamphetamine |
WO2005107746A1 (fr) * | 2004-05-11 | 2005-11-17 | Kissei Pharmaceutical Co., Ltd. | Composition pharmaceutique pour la prévention ou le traitement de maladies liées au métabolisme des lipides |
JP4955392B2 (ja) * | 2004-07-01 | 2012-06-20 | キッセイ薬品工業株式会社 | 血管内膜過増殖疾患の予防または治療剤 |
JP2008514549A (ja) * | 2004-09-14 | 2008-05-08 | エリクシアー ファーマシューティカルズ, インコーポレイテッド | 制御された炭水化物消化のための併用療法 |
CN1634885B (zh) * | 2004-11-09 | 2011-05-04 | 北京乐力健生物科技有限公司 | 米格列奈晶型及其制备方法 |
CN1324010C (zh) * | 2005-01-12 | 2007-07-04 | 江苏省药物研究所 | 一种米格列奈的制备方法 |
KR20070102694A (ko) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물 |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US20090221652A1 (en) * | 2005-11-07 | 2009-09-03 | Geesaman Bard J | Combinations of metformin and meglitinide |
WO2009047797A2 (fr) * | 2007-10-08 | 2009-04-16 | Ind-Swift Laboratories Limited | Procédé de préparation d'un dérivé du perhydroisoindole |
WO2010107029A1 (fr) * | 2009-03-19 | 2010-09-23 | 国立大学法人京都大学 | Précurseur de sonde moléculaire pour l'imagerie d'îlots pancréatiques et son utilisation |
JP5654572B2 (ja) | 2009-05-15 | 2015-01-14 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのベンズオキサゾロン誘導体 |
MA33358B1 (fr) | 2009-05-15 | 2012-06-01 | Novartis Ag | Arylpyridine en tant qu'inhibiteurs de l'aldostérone synthase |
ES2602826T3 (es) | 2009-05-28 | 2017-02-22 | Novartis Ag | Derivados aminobutíricos sustituidos como inhibidores de neprilisina |
MA33364B1 (fr) | 2009-05-28 | 2012-06-01 | Novartis Ag | Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine |
US8519134B2 (en) | 2009-11-17 | 2013-08-27 | Novartis Ag | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
EP2507234B1 (fr) | 2009-11-30 | 2014-03-12 | Novartis AG | Dérivés d'imidazole en tant qu'inhibiteurs de l'aldostérone synthase |
CN101973926B (zh) * | 2010-11-05 | 2012-09-19 | 威海迪素制药有限公司 | R-米格列奈钙的制备方法 |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
ES2546362B1 (es) | 2012-06-22 | 2016-07-07 | Laboratorios Lesvi, S. L. | PROCEDIMIENTO DE OBTENCIÓN DEL ÁCIDO (S) -2 BENCIL 4 - ((3aR, 7aS) -HEXAHIDRO-1H-ISOINDOL-2 (3H) IL) -4-OXOBUTANOICO Y SUS SALES |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
AP2015008621A0 (en) | 2013-02-14 | 2015-07-31 | Novartis Ag | Substituted bisphenyl butanoic nep 'neutral endopeptidase' inhibitors |
UY35670A (es) | 2013-07-25 | 2015-02-27 | Novartis Ag | Polipéptidos cíclicos para el tratamiento de insuficiencia cardíaca |
JP2016527249A (ja) | 2013-07-25 | 2016-09-08 | ノバルティス アーゲー | 合成アペリンポリペプチドのバイオコンジュゲート |
KR20170103970A (ko) | 2015-01-23 | 2017-09-13 | 노파르티스 아게 | 개선된 반감기를 갖는 합성 아펠린 지방산 접합체 |
CN106631978B (zh) * | 2016-12-29 | 2020-03-24 | 千辉药业(安徽)有限责任公司 | 一种米格列奈中间体的合成工艺 |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4303662A (en) * | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
US4479963A (en) * | 1981-02-17 | 1984-10-30 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
EP0219756B1 (fr) * | 1985-10-09 | 1994-01-05 | Shell Internationale Researchmaatschappij B.V. | Amides de l'acide acrylique |
FR2672598A1 (fr) * | 1991-02-11 | 1992-08-14 | Adir | Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1992
- 1992-03-11 AU AU12809/92A patent/AU654331B2/en not_active Expired
- 1992-03-12 CA CA002062877A patent/CA2062877C/fr not_active Expired - Lifetime
- 1992-03-27 DK DK041592A patent/DK170973B1/da not_active IP Right Cessation
- 1992-03-27 NO NO921200A patent/NO178371C/no unknown
- 1992-03-30 ES ES92302786T patent/ES2084275T3/es not_active Expired - Lifetime
- 1992-03-30 KR KR1019920005274A patent/KR100192530B1/ko not_active IP Right Cessation
- 1992-03-30 EP EP92302786A patent/EP0507534B1/fr not_active Expired - Lifetime
- 1992-03-30 FI FI921392A patent/FI102172B1/fi active
- 1992-03-30 AT AT92302786T patent/ATE134615T1/de not_active IP Right Cessation
- 1992-03-30 DE DE69208496T patent/DE69208496T2/de not_active Expired - Lifetime
- 1992-03-30 US US07/860,023 patent/US5202335A/en not_active Expired - Lifetime
-
1998
- 1998-05-27 HK HK98104547A patent/HK1005449A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK41592A (da) | 1992-10-01 |
EP0507534B1 (fr) | 1996-02-28 |
DE69208496T2 (de) | 1996-10-17 |
FI102172B (fi) | 1998-10-30 |
NO178371B (no) | 1995-12-04 |
NO921200D0 (no) | 1992-03-27 |
CA2062877A1 (fr) | 1992-10-01 |
FI102172B1 (fi) | 1998-10-30 |
CA2062877C (fr) | 2002-07-02 |
EP0507534A1 (fr) | 1992-10-07 |
ATE134615T1 (de) | 1996-03-15 |
DK41592D0 (da) | 1992-03-27 |
KR100192530B1 (ko) | 1999-06-15 |
HK1005449A1 (en) | 1999-01-08 |
KR930019682A (ko) | 1993-10-18 |
NO921200L (no) | 1992-10-01 |
FI921392A0 (fi) | 1992-03-30 |
US5202335A (en) | 1993-04-13 |
AU654331B2 (en) | 1994-11-03 |
FI921392A (fi) | 1992-10-01 |
NO178371C (no) | 1996-03-13 |
DE69208496D1 (de) | 1996-04-04 |
ES2084275T3 (es) | 1996-05-01 |
AU1280992A (en) | 1992-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
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