FI102172B1 - Menetelmä terapeuttisesti aktiivisten, isoindoli-, isokinoliini- ja indolijohdannaisten ja meripihkahappojohdannaisten muodostamien amidien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisten, isoindoli-, isokinoliini- ja indolijohdannaisten ja meripihkahappojohdannaisten muodostamien amidien valmistamiseksi

Info

Publication number
FI102172B1
FI102172B1 FI921392A FI921392A FI102172B1 FI 102172 B1 FI102172 B1 FI 102172B1 FI 921392 A FI921392 A FI 921392A FI 921392 A FI921392 A FI 921392A FI 102172 B1 FI102172 B1 FI 102172B1
Authority
FI
Finland
Prior art keywords
group
isomers
carbon atoms
atom
succinic acid
Prior art date
Application number
FI921392A
Other languages
English (en)
Swedish (sv)
Other versions
FI102172B (fi
FI921392A (fi
FI921392A0 (fi
Inventor
Fumiyasu Sato
Atsushi Tsubaki
Hiroshi Hokari
Nobuyuki Tanaka
Masaru Saito
Kenji Akahane
Michihiro Kobayashi
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3142275A external-priority patent/JP2686861B2/ja
Priority claimed from JP3188416A external-priority patent/JP2686863B2/ja
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of FI921392A0 publication Critical patent/FI921392A0/fi
Publication of FI921392A publication Critical patent/FI921392A/fi
Application granted granted Critical
Publication of FI102172B publication Critical patent/FI102172B/fi
Publication of FI102172B1 publication Critical patent/FI102172B1/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04Polysiloxanes
    • C08G77/06Preparatory processes
    • C08G77/08Preparatory processes characterised by the catalysts used
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI921392A 1991-03-30 1992-03-30 Menetelmä terapeuttisesti aktiivisten, isoindoli-, isokinoliini- ja indolijohdannaisten ja meripihkahappojohdannaisten muodostamien amidien valmistamiseksi FI102172B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP3142275A JP2686861B2 (ja) 1991-03-30 1991-03-30 新規なベンジリデンコハク酸誘導体
JP14227591 1991-03-30
JP3188416A JP2686863B2 (ja) 1991-04-25 1991-04-25 新規なベンジルコハク酸誘導体
JP18841691 1991-04-25
JP36151991 1991-12-27
JP36151991 1991-12-27

Publications (4)

Publication Number Publication Date
FI921392A0 FI921392A0 (fi) 1992-03-30
FI921392A FI921392A (fi) 1992-10-01
FI102172B FI102172B (fi) 1998-10-30
FI102172B1 true FI102172B1 (fi) 1998-10-30

Family

ID=27318415

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921392A FI102172B1 (fi) 1991-03-30 1992-03-30 Menetelmä terapeuttisesti aktiivisten, isoindoli-, isokinoliini- ja indolijohdannaisten ja meripihkahappojohdannaisten muodostamien amidien valmistamiseksi

Country Status (12)

Country Link
US (1) US5202335A (fi)
EP (1) EP0507534B1 (fi)
KR (1) KR100192530B1 (fi)
AT (1) ATE134615T1 (fi)
AU (1) AU654331B2 (fi)
CA (1) CA2062877C (fi)
DE (1) DE69208496T2 (fi)
DK (1) DK170973B1 (fi)
ES (1) ES2084275T3 (fi)
FI (1) FI102172B1 (fi)
HK (1) HK1005449A1 (fi)
NO (1) NO178371C (fi)

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WO1998032736A1 (fr) * 1997-01-29 1998-07-30 Kissei Pharmaceutical Co., Ltd. Procede de production de derives d'acide benzylsuccinique
FR2765578B1 (fr) * 1997-07-03 1999-09-10 Adir Procede de preparation d'un perhydroisoindole substitue
JP3277320B2 (ja) * 1997-08-28 2002-04-22 有機合成薬品工業株式会社 シス−ヘキサヒドロイソインドリン誘導体の製造方法
FR2777566B1 (fr) 1998-04-15 2003-02-21 Synthelabo Derives d'azacycloalcanes, leur preparation et leur application en therapeutique
FR2779428B1 (fr) * 1998-06-03 2001-05-18 Synthelabo Derives d'oxo-azacycloalcanes, leurs preparations et leurs applications en therapeutique
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
FR2793411B1 (fr) * 1999-05-11 2001-06-29 Synthelabo Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation
AU782005B2 (en) * 1999-05-21 2005-06-30 Kissei Pharmaceutical Co. Ltd. Immediate release medicinal compositions for oral use
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
KR20020092060A (ko) * 2001-06-01 2002-12-11 김정균 알콕시 작용성 그룹을 포함한 폴리실록산 화합물
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
CN1976696B (zh) * 2004-05-11 2010-10-06 橘生药品工业株式会社 用于预防或治疗脂质代谢异常的医药组合物
JP4955392B2 (ja) * 2004-07-01 2012-06-20 キッセイ薬品工業株式会社 血管内膜過増殖疾患の予防または治療剤
US20060193845A1 (en) * 2004-09-14 2006-08-31 Elixir Pharmaceuticals, Inc. Combination therapy for controlled carbohydrate digestion
CN1634885B (zh) * 2004-11-09 2011-05-04 北京乐力健生物科技有限公司 米格列奈晶型及其制备方法
CN1324010C (zh) * 2005-01-12 2007-07-04 江苏省药物研究所 一种米格列奈的制备方法
KR20070102694A (ko) * 2005-01-31 2007-10-19 아지노모토 가부시키가이샤 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
AU2006311601A1 (en) * 2005-11-07 2007-05-18 Elixir Pharmaceuticals, Inc. Combinations of metformin and meglitinide
WO2009047797A2 (en) * 2007-10-08 2009-04-16 Ind-Swift Laboratories Limited Process for the preparation of perhydroisoindole derivative
KR20110074614A (ko) * 2009-03-19 2011-06-30 고쿠리츠 다이가쿠 호진 교토 다이가쿠 췌도 이미징용 분자 프로브 전구체 및 그 사용
BRPI1010600A2 (pt) 2009-05-15 2016-03-15 Novartis Ag aril piridina como inibidores de aldosterona sintase
CN102459247B (zh) 2009-05-15 2014-09-17 诺华股份有限公司 作为醛固酮合酶抑制剂的苯并噁唑酮衍生物
KR101442897B1 (ko) 2009-05-28 2014-09-23 노파르티스 아게 네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체
SG176010A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
US8519134B2 (en) 2009-11-17 2013-08-27 Novartis Ag Aryl-pyridine derivatives as aldosterone synthase inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
WO2011064376A1 (en) 2009-11-30 2011-06-03 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
CN101973926B (zh) * 2010-11-05 2012-09-19 威海迪素制药有限公司 R-米格列奈钙的制备方法
US8673974B2 (en) 2010-11-16 2014-03-18 Novartis Ag Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
US8877815B2 (en) 2010-11-16 2014-11-04 Novartis Ag Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
ES2546362B1 (es) 2012-06-22 2016-07-07 Laboratorios Lesvi, S. L. PROCEDIMIENTO DE OBTENCIÓN DEL ÁCIDO (S) -2 BENCIL 4 - ((3aR, 7aS) -HEXAHIDRO-1H-ISOINDOL-2 (3H) IL) -4-OXOBUTANOICO Y SUS SALES
UY35144A (es) 2012-11-20 2014-06-30 Novartis Ag Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
NZ710574A (en) 2013-02-14 2017-11-24 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
WO2015013168A1 (en) 2013-07-25 2015-01-29 Novartis Ag Cyclic polypeptides for the treatment of heart failure
US9340582B2 (en) 2013-07-25 2016-05-17 Novartis Ag Bioconjugates of synthetic apelin polypeptides
CA2972871A1 (en) 2015-01-23 2016-07-28 Novartis Ag Synthetic apelin fatty acid conjugates with improved half-life
CN106631978B (zh) * 2016-12-29 2020-03-24 千辉药业(安徽)有限责任公司 一种米格列奈中间体的合成工艺
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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US4303662A (en) * 1980-11-24 1981-12-01 E. R. Squibb & Sons, Inc. Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds
US4479963A (en) * 1981-02-17 1984-10-30 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
DE3689506D1 (de) * 1985-10-09 1994-02-17 Shell Int Research Neue Acrylsäureamide.
FR2672598A1 (fr) * 1991-02-11 1992-08-14 Adir Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ES2084275T3 (es) 1996-05-01
NO921200L (no) 1992-10-01
AU1280992A (en) 1992-10-01
EP0507534A1 (en) 1992-10-07
FI102172B (fi) 1998-10-30
CA2062877A1 (en) 1992-10-01
FI921392A (fi) 1992-10-01
EP0507534B1 (en) 1996-02-28
DE69208496T2 (de) 1996-10-17
ATE134615T1 (de) 1996-03-15
DK170973B1 (da) 1996-04-09
DE69208496D1 (de) 1996-04-04
DK41592D0 (da) 1992-03-27
FI921392A0 (fi) 1992-03-30
DK41592A (da) 1992-10-01
KR930019682A (ko) 1993-10-18
CA2062877C (en) 2002-07-02
AU654331B2 (en) 1994-11-03
KR100192530B1 (ko) 1999-06-15
NO921200D0 (no) 1992-03-27
HK1005449A1 (en) 1999-01-08
US5202335A (en) 1993-04-13
NO178371B (no) 1995-12-04
NO178371C (no) 1996-03-13

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