DK170973B1 - Ravsyreforbindelser og farmaceutiske præparater indeholdende dem - Google Patents
Ravsyreforbindelser og farmaceutiske præparater indeholdende dem Download PDFInfo
- Publication number
- DK170973B1 DK170973B1 DK041592A DK41592A DK170973B1 DK 170973 B1 DK170973 B1 DK 170973B1 DK 041592 A DK041592 A DK 041592A DK 41592 A DK41592 A DK 41592A DK 170973 B1 DK170973 B1 DK 170973B1
- Authority
- DK
- Denmark
- Prior art keywords
- cis
- hexahydro
- group
- propionic acid
- isoindolinylcarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/06—Preparatory processes
- C08G77/08—Preparatory processes characterised by the catalysts used
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14227591 | 1991-03-30 | ||
| JP3142275A JP2686861B2 (ja) | 1991-03-30 | 1991-03-30 | 新規なベンジリデンコハク酸誘導体 |
| JP3188416A JP2686863B2 (ja) | 1991-04-25 | 1991-04-25 | 新規なベンジルコハク酸誘導体 |
| JP18841691 | 1991-04-25 | ||
| JP36151991 | 1991-12-27 | ||
| JP36151991 | 1991-12-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK41592D0 DK41592D0 (da) | 1992-03-27 |
| DK41592A DK41592A (da) | 1992-10-01 |
| DK170973B1 true DK170973B1 (da) | 1996-04-09 |
Family
ID=27318415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK041592A DK170973B1 (da) | 1991-03-30 | 1992-03-27 | Ravsyreforbindelser og farmaceutiske præparater indeholdende dem |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5202335A (es) |
| EP (1) | EP0507534B1 (es) |
| KR (1) | KR100192530B1 (es) |
| AT (1) | ATE134615T1 (es) |
| AU (1) | AU654331B2 (es) |
| CA (1) | CA2062877C (es) |
| DE (1) | DE69208496T2 (es) |
| DK (1) | DK170973B1 (es) |
| ES (1) | ES2084275T3 (es) |
| FI (1) | FI102172B1 (es) |
| HK (1) | HK1005449A1 (es) |
| NO (1) | NO178371C (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0967204A4 (en) * | 1997-01-29 | 2000-11-29 | Kissei Pharmaceutical | METHOD FOR THE PRODUCTION OF BENZYL succinic acid ester derivatives |
| FR2765578B1 (fr) * | 1997-07-03 | 1999-09-10 | Adir | Procede de preparation d'un perhydroisoindole substitue |
| JP3277320B2 (ja) * | 1997-08-28 | 2002-04-22 | 有機合成薬品工業株式会社 | シス−ヘキサヒドロイソインドリン誘導体の製造方法 |
| FR2777566B1 (fr) * | 1998-04-15 | 2003-02-21 | Synthelabo | Derives d'azacycloalcanes, leur preparation et leur application en therapeutique |
| FR2779428B1 (fr) * | 1998-06-03 | 2001-05-18 | Synthelabo | Derives d'oxo-azacycloalcanes, leurs preparations et leurs applications en therapeutique |
| TW568788B (en) * | 1998-10-12 | 2004-01-01 | Chugai Pharmaceutical Co Ltd | Polymer combining with phosphoric acid and preparation containing the same |
| FR2793411B1 (fr) * | 1999-05-11 | 2001-06-29 | Synthelabo | Utilisation de derives de l'acide succinique pour obtenir un medicament destine au traitement de l'inflammation |
| US7166301B1 (en) * | 1999-05-21 | 2007-01-23 | Kissei Pharmaceutical Co., Ltd. | Immediate release medicinal compositions for oral use |
| PE20020617A1 (es) | 2000-08-22 | 2002-08-05 | Novartis Ag | Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina |
| KR20020092060A (ko) * | 2001-06-01 | 2002-12-11 | 김정균 | 알콕시 작용성 그룹을 포함한 폴리실록산 화합물 |
| JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
| CA2565878A1 (en) * | 2004-05-11 | 2005-11-17 | Kissei Pharmaceutical Co., Ltd. | Pharmaceutical composition for prevention or treatment of lipid metabolism disorder |
| WO2006003907A1 (ja) * | 2004-07-01 | 2006-01-12 | Kissei Pharmaceutical Co., Ltd. | 血管内膜過増殖疾患の予防または治療剤 |
| JP2008514549A (ja) * | 2004-09-14 | 2008-05-08 | エリクシアー ファーマシューティカルズ， インコーポレイテッド | 制御された炭水化物消化のための併用療法 |
| CN1634885B (zh) * | 2004-11-09 | 2011-05-04 | 北京乐力健生物科技有限公司 | 米格列奈晶型及其制备方法 |
| CN1324010C (zh) * | 2005-01-12 | 2007-07-04 | 江苏省药物研究所 | 一种米格列奈的制备方法 |
| KR20070102694A (ko) * | 2005-01-31 | 2007-10-19 | 아지노모토 가부시키가이샤 | 혈당 강하제를 함유하는, 내당능 이상, 경계형 당뇨병,인슐린 저항성 및 고인슐린혈증 개선 또는 치료용 의약조성물 |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| AU2006311601A1 (en) * | 2005-11-07 | 2007-05-18 | Elixir Pharmaceuticals, Inc. | Combinations of metformin and meglitinide |
| WO2009047797A2 (en) * | 2007-10-08 | 2009-04-16 | Ind-Swift Laboratories Limited | Process for the preparation of perhydroisoindole derivative |
| KR20110074614A (ko) * | 2009-03-19 | 2011-06-30 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 췌도 이미징용 분자 프로브 전구체 및 그 사용 |
| SI2429995T1 (sl) | 2009-05-15 | 2014-05-30 | Novartis Ag | Arilpiridini kot inhibitorji aldosteron sintaze |
| BRPI1012852A2 (pt) | 2009-05-15 | 2018-06-19 | Novartis Ag | derivados de benzoxazolona como inibidores da sintase de aldoesterona |
| NZ596304A (en) | 2009-05-28 | 2014-01-31 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
| EP2993169B1 (en) | 2009-11-17 | 2017-12-20 | Novartis AG | Aryl-pyridine derivatives as aldosterone synthase inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| US8575160B2 (en) | 2009-11-30 | 2013-11-05 | Novartis Ag | Imidazole derivatives as aldosterone synthase inhibitors |
| CN101973926B (zh) * | 2010-11-05 | 2012-09-19 | 威海迪素制药有限公司 | R-米格列奈钙的制备方法 |
| US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
| US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
| WO2013189829A1 (en) | 2012-06-22 | 2013-12-27 | Laboratorios Lesvi, S. L. | Process for obtaining (s)-2-benzyl-4-((3ar,7as)-hexahydro-1 h-isoindol- 2(3h)-yl)-4-oxobutanoic acid and salts thereof |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| LT2956464T (lt) | 2013-02-14 | 2018-07-10 | Novartis Ag | Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai |
| MX2016001021A (es) | 2013-07-25 | 2016-08-03 | Novartis Ag | Bioconjugados de polipeptidos de apelina sinteticos. |
| KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
| SG11201704758XA (en) | 2015-01-23 | 2017-08-30 | Novartis Ag | Synthetic apelin fatty acid conjugates with improved half-life |
| CN106631978B (zh) * | 2016-12-29 | 2020-03-24 | 千辉药业（安徽）有限责任公司 | 一种米格列奈中间体的合成工艺 |
| UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4303662A (en) * | 1980-11-24 | 1981-12-01 | E. R. Squibb & Sons, Inc. | Carboxyacyl, mercapto and acylmercapto derivatives of heterobicyclo compounds |
| US4479963A (en) * | 1981-02-17 | 1984-10-30 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
| DE3689506D1 (de) * | 1985-10-09 | 1994-02-17 | Shell Int Research | Neue Acrylsäureamide. |
| FR2672598A1 (fr) * | 1991-02-11 | 1992-08-14 | Adir | Nouveaux inhibiteurs de n-myristoyltransferase, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1992
- 1992-03-11 AU AU12809/92A patent/AU654331B2/en not_active Expired
- 1992-03-12 CA CA002062877A patent/CA2062877C/en not_active Expired - Lifetime
- 1992-03-27 NO NO921200A patent/NO178371C/no unknown
- 1992-03-27 DK DK041592A patent/DK170973B1/da not_active IP Right Cessation
- 1992-03-30 US US07/860,023 patent/US5202335A/en not_active Expired - Lifetime
- 1992-03-30 AT AT92302786T patent/ATE134615T1/de not_active IP Right Cessation
- 1992-03-30 ES ES92302786T patent/ES2084275T3/es not_active Expired - Lifetime
- 1992-03-30 EP EP92302786A patent/EP0507534B1/en not_active Expired - Lifetime
- 1992-03-30 DE DE69208496T patent/DE69208496T2/de not_active Expired - Lifetime
- 1992-03-30 KR KR1019920005274A patent/KR100192530B1/ko not_active IP Right Cessation
- 1992-03-30 FI FI921392A patent/FI102172B1/fi active
-
1998
- 1998-05-27 HK HK98104547A patent/HK1005449A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK41592D0 (da) | 1992-03-27 |
| NO921200L (no) | 1992-10-01 |
| US5202335A (en) | 1993-04-13 |
| DE69208496D1 (de) | 1996-04-04 |
| DE69208496T2 (de) | 1996-10-17 |
| ES2084275T3 (es) | 1996-05-01 |
| FI921392A (fi) | 1992-10-01 |
| ATE134615T1 (de) | 1996-03-15 |
| FI102172B (fi) | 1998-10-30 |
| NO178371C (no) | 1996-03-13 |
| DK41592A (da) | 1992-10-01 |
| AU1280992A (en) | 1992-10-01 |
| HK1005449A1 (en) | 1999-01-08 |
| CA2062877C (en) | 2002-07-02 |
| CA2062877A1 (en) | 1992-10-01 |
| KR100192530B1 (ko) | 1999-06-15 |
| KR930019682A (ko) | 1993-10-18 |
| EP0507534A1 (en) | 1992-10-07 |
| NO921200D0 (no) | 1992-03-27 |
| NO178371B (no) | 1995-12-04 |
| FI921392A0 (fi) | 1992-03-30 |
| FI102172B1 (fi) | 1998-10-30 |
| EP0507534B1 (en) | 1996-02-28 |
| AU654331B2 (en) | 1994-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK170973B1 (da) | Ravsyreforbindelser og farmaceutiske præparater indeholdende dem | |
| US4977180A (en) | Novel prolinal derivatives | |
| EP0268190B1 (en) | Prolinal derivatives | |
| MXPA04004869A (es) | Compuestos heterociclicos y metodos de uso. | |
| NO327957B1 (no) | Substituert fenylpropansyrederivater som agonister for human peroksisom proliferantaktivert reseptor (PPAR)<alfa> | |
| NO312064B1 (no) | D-prolinderivater, fremgangsmåte for fremstilling og anvendelse derav, samt medikamenter inneholdende disseforbindelsene | |
| DK157851B (da) | Analogifremgangsmaade til fremstilling af en octa-hydro-1-(omega-mercaptoalkanoyl)-1h-indol-2-carboxylsyreforbindelse | |
| WO2006090244A1 (en) | New adamantane derivatives as dipeptidyl, peptidase iv inhibitors, processes for their preparation, and pharmaceutical compositions containing them | |
| BRPI0714885A2 (pt) | compostos terapÊuticos | |
| KR950009359B1 (ko) | 프롤리날 유도체 및 이의 제조방법 | |
| EP0965585A1 (en) | Anti-amnesic thiazolidine derivatives | |
| US5254550A (en) | Prolinal derivatives and pharmaceutical compositions thereof | |
| KR100469028B1 (ko) | 선택적트롬빈억제제로유용한방향족아미딘유도체 | |
| FR2703050A1 (fr) | Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| US5262431A (en) | Prolinal derivatives and pharmaceutical compositions thereof | |
| JPS59130863A (ja) | ５―ビニル―２―ピロリジノンの製法 | |
| EP0238319A1 (en) | Pyrrolidine derivatives | |
| EP0443498A1 (en) | Isoindoline derivatives | |
| JP3647451B2 (ja) | ベンゾラクタム誘導体 | |
| JPS5829950B2 (ja) | 環状イミノカルボン酸誘導体およびその塩類 | |
| JPH07157459A (ja) | ビフェニルメチル置換バレリルアミド誘導体 | |
| CA2079185A1 (fr) | Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| FR2758329A1 (fr) | Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique | |
| CA2400537A1 (fr) | Derives d'aminoacides et leur utilisation en tant qu'inhibiteurs de la nep, l'ace et l'ece | |
| US5151437A (en) | Benzofurancarboxamides having basic substituents and therapeutic agents containing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |
Country of ref document: DK |