DK169918B1 - Bicykliske sulfonamidderivater - Google Patents
Bicykliske sulfonamidderivater Download PDFInfo
- Publication number
- DK169918B1 DK169918B1 DK549086A DK549086A DK169918B1 DK 169918 B1 DK169918 B1 DK 169918B1 DK 549086 A DK549086 A DK 549086A DK 549086 A DK549086 A DK 549086A DK 169918 B1 DK169918 B1 DK 169918B1
- Authority
- DK
- Denmark
- Prior art keywords
- acid
- compound
- reaction
- mixture
- chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25915485 | 1985-11-18 | ||
JP25915485 | 1985-11-18 | ||
JP3013086 | 1986-02-13 | ||
JP3013086 | 1986-02-13 | ||
JP11559986 | 1986-05-19 | ||
JP11559986 | 1986-05-19 | ||
JP12901186 | 1986-06-03 | ||
JP12901186 | 1986-06-03 | ||
JP16925786 | 1986-07-17 | ||
JP16925786 | 1986-07-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK549086D0 DK549086D0 (da) | 1986-11-17 |
DK549086A DK549086A (da) | 1987-05-19 |
DK169918B1 true DK169918B1 (da) | 1995-04-03 |
Family
ID=27521199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK549086A DK169918B1 (da) | 1985-11-18 | 1986-11-17 | Bicykliske sulfonamidderivater |
Country Status (20)
Country | Link |
---|---|
US (6) | US4861913A (de) |
EP (1) | EP0226346B1 (de) |
JP (1) | JPS63139161A (de) |
CN (1) | CN1019194B (de) |
AR (1) | AR245102A1 (de) |
AT (1) | ATE66207T1 (de) |
AU (1) | AU595554B2 (de) |
CA (1) | CA1278577C (de) |
DE (1) | DE3680884D1 (de) |
DK (1) | DK169918B1 (de) |
ES (1) | ES2051693T3 (de) |
FI (1) | FI90064C (de) |
GB (1) | GB2184118B (de) |
GR (1) | GR3002489T3 (de) |
HU (1) | HU203078B (de) |
IE (1) | IE58988B1 (de) |
IL (1) | IL80670A (de) |
NO (1) | NO165442C (de) |
NZ (1) | NZ218115A (de) |
PT (1) | PT83744B (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
EP0516181A1 (de) * | 1987-10-23 | 1992-12-02 | Ono Pharmaceutical Co., Ltd. | Sulfonamidderivate |
EP0312906A3 (de) * | 1987-10-23 | 1990-09-05 | Ono Pharmaceutical Co., Ltd. | Sulfonamidderivate |
JP2565746B2 (ja) * | 1987-10-23 | 1996-12-18 | 小野薬品工業株式会社 | 新規な炭素環系スルホンアミド誘導体 |
EP0516180A1 (de) * | 1988-04-19 | 1992-12-02 | Ono Pharmaceutical Co., Ltd. | Sulfonamidderivate |
CA1332607C (en) * | 1988-07-19 | 1994-10-18 | Masayuki Narisada | Alkenyltetrazole derivatives |
US5047574A (en) * | 1988-12-14 | 1991-09-10 | Shionogi & Co., Ltd. | Certain optically active mono esters of dicarboxylic acids |
KR0138528B1 (en) * | 1988-12-14 | 1998-05-01 | Shionogi Seiyaku Kk | Preparation of 2,3-trans-1,4-bridged cyclohexane sulfonamide derivatives |
US5117039A (en) * | 1988-12-14 | 1992-05-26 | Shionogi & Co., Ltd. | Monoesters of arylacetic acid and the process thereof |
US5008409A (en) * | 1988-12-14 | 1991-04-16 | Shionogi & Co., Ltd. | Process for preparing 1,4-bridged cyclohexane carboxylic acid derivatives |
US5241104A (en) * | 1988-12-14 | 1993-08-31 | Shionogi & Co., Ltd. | Mono ester of dicarboxylic acid and process thereof |
JP2756689B2 (ja) * | 1989-02-20 | 1998-05-25 | 塩野義製薬株式会社 | 置換ヘキセン酸誘導体 |
DE69030884T2 (de) * | 1989-10-18 | 1997-12-18 | Shionogi & Co | Verfahren zur herstellung von norbornan-sulfonamidderivat |
US5763647A (en) * | 1990-03-30 | 1998-06-09 | Shionogi & Co., Ltd. | Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives |
JP2891740B2 (ja) * | 1990-03-30 | 1999-05-17 | 塩野義製薬株式会社 | 光学活性ノルボルナン系アミン誘導体の製造方法 |
JP2984077B2 (ja) * | 1990-04-19 | 1999-11-29 | 塩野義製薬株式会社 | スルホニルアミノ置換ビシクロ環系ヒドロキサム酸誘導体 |
FR2665440B1 (fr) * | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
US5550248A (en) * | 1990-11-29 | 1996-08-27 | E.R. Squibb & Sons, Inc. | Substituted stryl heterocyclic amido prostaglandin analogs |
US5334369A (en) * | 1991-06-11 | 1994-08-02 | Medical University Of South Carolina | Platelet receptor antagonists useful in detecting intravascular platelet aggregation |
US5827868A (en) * | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
CA2113787A1 (en) * | 1993-01-29 | 1994-07-30 | Nobuyuki Hamanaka | Carbocyclic sulfonamides |
MX9710256A (es) * | 1995-06-21 | 1998-03-31 | Shionogi & Co | Derivados de amino biciclicos y antagonistas pgd2 que contienen los mismos. |
IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
JP2000500752A (ja) * | 1995-11-16 | 2000-01-25 | イーライ・リリー・アンド・カンパニー | 興奮性アミノ酸受容体アンタゴニスト |
ZA969485B (en) * | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
ES2188928T3 (es) * | 1996-04-26 | 2003-07-01 | Shionogi & Co | Pastilla de liberador-rapido s1452. |
JP4120993B2 (ja) * | 1996-12-12 | 2008-07-16 | 塩野義製薬株式会社 | ヘテロ環縮合ベンゼンカルボン酸アミド誘導体およびそれを含有するpgd2拮抗剤 |
ATE223911T1 (de) * | 1996-12-13 | 2002-09-15 | Shionogi & Co | Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten |
ZA984040B (en) | 1997-05-15 | 1998-11-20 | Ono Pharmaceutical Co | Benzenesulfonamide compounds |
AU8998298A (en) | 1997-09-19 | 1999-04-12 | Shionogi & Co., Ltd. | Compounds having (2.2.1)bicyclo skeleton |
AU745129B2 (en) * | 1998-03-31 | 2002-03-14 | Shionogi & Co., Ltd. | Process for producing 5-hydroxybenzo(b)thiophene-3- carboxylic acid derivatives |
PA8469401A1 (es) * | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
WO2000030683A1 (fr) * | 1998-11-19 | 2000-06-02 | Shionogi & C0., Ltd. | Composes prophylactiques et/ou therapeutiques destines a des maladies du systeme nerveux central et possedant des composes antagonistes du recepteur de txa2 et/ou inhibiteurs de la txa2 synthase |
JP2000351729A (ja) * | 1999-06-08 | 2000-12-19 | Shionogi & Co Ltd | トロンボキサンa2受容体拮抗剤の経皮吸収製剤 |
EP1249233B9 (de) | 1999-11-26 | 2009-08-05 | Shionogi & Co., Ltd. | Npyy5-antagonisten |
US7365196B2 (en) * | 2000-03-20 | 2008-04-29 | Merck Sharp & Dohme Ltd. | Sulphonamido-substituted bridged bicycloalkyl derivatives |
US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
JP5861884B2 (ja) * | 2012-03-29 | 2016-02-16 | 荒川化学工業株式会社 | エキソ型ノルボルネン化合物の製造方法 |
CN110563006A (zh) * | 2019-09-25 | 2019-12-13 | 新乡市锦源化工有限公司 | 一种对位酯生产中亚硫酸氢钠处理方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL33813A (en) * | 1969-02-14 | 1973-10-25 | Sparamedica Ag | Bornanocarboxamides and their salts,and their preparation |
US3988362A (en) * | 1972-08-10 | 1976-10-26 | Hoffmann-La Roche Inc. | Intermediates for preparation of 2,2,3-endotrimethyl-7-anti-amino-norbornanes |
EP0013607B1 (de) * | 1979-01-05 | 1983-03-23 | National Research Development Corporation | Substituierte Bicyclo (2,2,1)Heptane und Bicyclo (2,2,1) Hept-2-ene und ihre pharmazeutischen Zusammensetzungen |
EP0044711B1 (de) * | 1980-07-22 | 1984-03-14 | Ono Pharmaceutical Co., Ltd. | Analoge von 9,11-Methano-13-aza-11a-carbathromban-Säure und deren pharmazeutische Verwendung |
JPS5813551A (ja) | 1981-07-16 | 1983-01-26 | Ono Pharmaceut Co Ltd | 13−アザトロンボキサン類似化合物、その製造方法及びその化合物を有効成分として含有するトロンボキサン起因疾患治療剤 |
DE3280020D1 (en) * | 1981-12-23 | 1989-12-21 | Nat Res Dev | Prostaglandins |
US4456615A (en) * | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4456616A (en) * | 1982-12-27 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
US4647585A (en) * | 1984-11-08 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted ethers |
US4663336A (en) * | 1985-07-01 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease |
US4654357A (en) * | 1985-08-09 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs |
CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
US4734424A (en) * | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted diamide and its congener prostaglandin analogs |
CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
-
1986
- 1986-10-30 CA CA000521812A patent/CA1278577C/en not_active Expired - Fee Related
- 1986-10-30 NZ NZ218115A patent/NZ218115A/xx unknown
- 1986-11-05 US US06/927,823 patent/US4861913A/en not_active Expired - Lifetime
- 1986-11-13 IE IE300286A patent/IE58988B1/en not_active IP Right Cessation
- 1986-11-14 PT PT83744A patent/PT83744B/pt not_active IP Right Cessation
- 1986-11-14 NO NO864542A patent/NO165442C/no not_active IP Right Cessation
- 1986-11-16 AR AR86305933A patent/AR245102A1/es active
- 1986-11-17 JP JP61273372A patent/JPS63139161A/ja active Granted
- 1986-11-17 DK DK549086A patent/DK169918B1/da not_active IP Right Cessation
- 1986-11-17 HU HU864742A patent/HU203078B/hu not_active IP Right Cessation
- 1986-11-17 IL IL80670A patent/IL80670A/xx unknown
- 1986-11-17 FI FI864675A patent/FI90064C/fi not_active IP Right Cessation
- 1986-11-18 AT AT86309016T patent/ATE66207T1/de not_active IP Right Cessation
- 1986-11-18 EP EP86309016A patent/EP0226346B1/de not_active Expired - Lifetime
- 1986-11-18 DE DE8686309016T patent/DE3680884D1/de not_active Expired - Fee Related
- 1986-11-18 CN CN86108584A patent/CN1019194B/zh not_active Expired
- 1986-11-18 AU AU65360/86A patent/AU595554B2/en not_active Ceased
- 1986-11-18 GB GB8627561A patent/GB2184118B/en not_active Expired - Fee Related
- 1986-11-18 ES ES86309016T patent/ES2051693T3/es not_active Expired - Lifetime
-
1989
- 1989-03-23 US US07/327,772 patent/US4960909A/en not_active Expired - Lifetime
- 1989-03-23 US US07/327,778 patent/US4976891A/en not_active Expired - Lifetime
-
1990
- 1990-04-27 US US07/516,140 patent/US5043451A/en not_active Expired - Lifetime
- 1990-04-27 US US07/516,141 patent/US5043456A/en not_active Expired - Lifetime
- 1990-06-20 US US07/541,491 patent/US5041635A/en not_active Expired - Lifetime
-
1991
- 1991-08-16 GR GR91401163T patent/GR3002489T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
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