DK169029B1 - Collagenaseinhibitorderivater baseret på hydroxamsyre, og farmaceutisk præparat deraf - Google Patents
Collagenaseinhibitorderivater baseret på hydroxamsyre, og farmaceutisk præparat deraf Download PDFInfo
- Publication number
- DK169029B1 DK169029B1 DK427686A DK427686A DK169029B1 DK 169029 B1 DK169029 B1 DK 169029B1 DK 427686 A DK427686 A DK 427686A DK 427686 A DK427686 A DK 427686A DK 169029 B1 DK169029 B1 DK 169029B1
- Authority
- DK
- Denmark
- Prior art keywords
- compound according
- methyl
- alkyl
- nhoh
- nhch
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/774,491 US4599361A (en) | 1985-09-10 | 1985-09-10 | Hydroxamic acid based collagenase inhibitors |
US77449185 | 1985-09-10 | ||
US88013086 | 1986-07-07 | ||
US06/880,130 US4743587A (en) | 1985-09-10 | 1986-07-07 | Hydroxamic acid based collagenase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
DK427686D0 DK427686D0 (da) | 1986-09-08 |
DK427686A DK427686A (da) | 1987-03-11 |
DK169029B1 true DK169029B1 (da) | 1994-08-01 |
Family
ID=27118893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK427686A DK169029B1 (da) | 1985-09-10 | 1986-09-08 | Collagenaseinhibitorderivater baseret på hydroxamsyre, og farmaceutisk præparat deraf |
Country Status (14)
Country | Link |
---|---|
US (1) | US4743587A (fi) |
EP (1) | EP0214639B1 (fi) |
JP (1) | JPH0764800B2 (fi) |
CA (1) | CA1329397C (fi) |
DE (1) | DE3671891D1 (fi) |
DK (1) | DK169029B1 (fi) |
FI (1) | FI84472C (fi) |
GR (1) | GR862286B (fi) |
IE (1) | IE58770B1 (fi) |
IL (1) | IL79971A (fi) |
NO (1) | NO164092C (fi) |
NZ (1) | NZ217491A (fi) |
PH (1) | PH24182A (fi) |
PT (1) | PT83328B (fi) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0225292A3 (en) * | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Certain n-substituted butyramide derivatives |
US5166212A (en) * | 1985-12-06 | 1992-11-24 | Ciba-Geigy Corporation | Certain n-substituted butyramide derivatives |
US4939299A (en) * | 1986-12-04 | 1990-07-03 | Monsanto Company | Succinyl dihydroxamic acids |
FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
US5686422A (en) * | 1987-03-17 | 1997-11-11 | Research Corporation Technologies, Inc. | Synthetic inhibitors of mammalian collagenase |
JP2573006B2 (ja) * | 1987-12-17 | 1997-01-16 | 富士薬品工業株式会社 | 新規なヒドロキサム酸誘導体 |
GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8827308D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
ES2093699T3 (es) * | 1990-01-25 | 1997-01-01 | Childrens Hosp Medical Center | Metodo y composiciones para inhibir la angiogenesis. |
US5189178A (en) * | 1990-11-21 | 1993-02-23 | Galardy Richard E | Matrix metalloprotease inhibitors |
US5892112A (en) * | 1990-11-21 | 1999-04-06 | Glycomed Incorporated | Process for preparing synthetic matrix metalloprotease inhibitors |
US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
US5114953A (en) * | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
US5183900A (en) * | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
DE69108363T2 (de) * | 1990-12-03 | 1995-08-31 | Celltech Ltd | Peptidylderivate. |
US5889058A (en) * | 1990-12-03 | 1999-03-30 | Celltech Limited | Peptidyl derivatives |
CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
AU2228292A (en) * | 1991-06-14 | 1993-01-12 | Research Corporation Technologies, Inc. | Peptide derivatives of collagenase inhibitor |
US5530161A (en) * | 1991-07-08 | 1996-06-25 | British Bio-Technology Limited | Hydroxamic acid based collagenase inhibitors |
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
GB9211706D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
GB9211707D0 (en) * | 1992-06-03 | 1992-07-15 | Celltech Ltd | Peptidyl derivatives |
US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
AU666727B2 (en) * | 1992-06-25 | 1996-02-22 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives |
GB9220845D0 (en) * | 1992-10-03 | 1992-11-18 | British Bio Technology | Vasoactive peptide inhibition |
US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
US5403824A (en) * | 1993-03-19 | 1995-04-04 | The Procter & Gamble Company | Methods for the treatment of osteoporosis |
US5795891A (en) * | 1993-08-09 | 1998-08-18 | Kanebo Ltd. | Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient |
GB9501737D0 (en) * | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
JPH10500986A (ja) * | 1994-05-28 | 1998-01-27 | ブリテッシュ バイオテック ファーマシューティカルズ リミテッド | 金属タンパク質分解酵素阻害剤 |
GB9411088D0 (en) * | 1994-06-03 | 1994-07-27 | Hoffmann La Roche | Hydroxylamine derivatives |
US5831004A (en) | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5840698A (en) * | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
GB9601041D0 (en) * | 1996-01-17 | 1996-03-20 | Smithkline Beecham Plc | Novel compounds |
EP0925278B1 (en) * | 1996-09-10 | 2002-07-17 | British Biotech Pharmaceuticals Limited | Cytostatic hydroxamic acid derivatives |
EP0911319A1 (en) * | 1997-09-01 | 1999-04-28 | Roche Diagnostics GmbH | Malonic acid based matrix metalloproteinase inhibitors |
GB9804504D0 (en) | 1998-03-03 | 1998-04-29 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
US6696456B1 (en) * | 1999-10-14 | 2004-02-24 | The Procter & Gamble Company | Beta disubstituted metalloprotease inhibitors |
US6797820B2 (en) | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
IL151250A0 (en) * | 2000-03-21 | 2003-04-10 | Procter & Gamble | Difluorobutyric acid metalloprotease inhibitors |
WO2001070682A2 (en) * | 2000-03-21 | 2001-09-27 | The Procter & Gamble Company | Carbocyclic side chain containing metalloprotease inhibitors |
MXPA02009311A (es) | 2000-03-21 | 2003-03-12 | Procter & Gamble | Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas. |
US20030229113A1 (en) * | 2000-03-24 | 2003-12-11 | Koji Hashimoto | Keratinocyte growth inhibitors and hydroxamic acid derivatives |
ES2369498T3 (es) | 2003-04-04 | 2011-12-01 | Yeda Research And Development Co., Ltd. | Anticuerpos para inhibir la actividad de mmp-2 y mmp-9. |
US20060112494A1 (en) * | 2004-12-01 | 2006-06-01 | David Oppong | Method of protecting an animal skin product from metalloproteinase activity |
GB0722484D0 (en) * | 2007-11-15 | 2007-12-27 | Ucl Business Plc | Solid compositions |
GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
NZ596304A (en) | 2009-05-28 | 2014-01-31 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
CA2787311C (en) | 2010-01-27 | 2017-08-15 | Yeda Research And Development Co. Ltd. | Antibodies that inhibit metalloproteins |
CN103370337B (zh) | 2010-10-28 | 2015-12-09 | 耶达研究及发展有限公司 | 用于产生针对金属酶的抗体的方法 |
EP2956445A1 (en) | 2013-02-14 | 2015-12-23 | Novartis AG | Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy |
LT2956464T (lt) | 2013-02-14 | 2018-07-10 | Novartis Ag | Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai |
IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
US3471476A (en) * | 1964-05-18 | 1969-10-07 | Tino Gaeumann | Trihydroxamic acids |
US4077998A (en) * | 1975-10-28 | 1978-03-07 | Morton-Norwich Products, Inc. | Phthaloyl amino acid hydroxamic acids |
US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
US4028401A (en) * | 1976-07-01 | 1977-06-07 | Morton-Norwich Products, Inc. | (Substituted)ureidoacetohydroxamic acids |
NZ201010A (en) * | 1981-06-19 | 1986-02-21 | Ciba Geigy Ag | The treatment of inflammation diseases using desferrioxamine |
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
-
1986
- 1986-07-07 US US06/880,130 patent/US4743587A/en not_active Expired - Lifetime
- 1986-09-08 IL IL79971A patent/IL79971A/xx not_active IP Right Cessation
- 1986-09-08 GR GR862286A patent/GR862286B/el unknown
- 1986-09-08 CA CA000517713A patent/CA1329397C/en not_active Expired - Fee Related
- 1986-09-08 PH PH34231A patent/PH24182A/en unknown
- 1986-09-08 EP EP86112386A patent/EP0214639B1/en not_active Expired - Lifetime
- 1986-09-08 NZ NZ217491A patent/NZ217491A/xx unknown
- 1986-09-08 DE DE8686112386T patent/DE3671891D1/de not_active Expired - Lifetime
- 1986-09-08 DK DK427686A patent/DK169029B1/da not_active IP Right Cessation
- 1986-09-08 FI FI863607A patent/FI84472C/fi not_active IP Right Cessation
- 1986-09-08 PT PT83328A patent/PT83328B/pt unknown
- 1986-09-08 NO NO863581A patent/NO164092C/no not_active IP Right Cessation
- 1986-09-09 JP JP61212539A patent/JPH0764800B2/ja not_active Expired - Fee Related
- 1986-09-09 IE IE240486A patent/IE58770B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0214639A2 (en) | 1987-03-18 |
NZ217491A (en) | 1989-10-27 |
CA1329397C (en) | 1994-05-10 |
JPH0764800B2 (ja) | 1995-07-12 |
FI863607A (fi) | 1987-03-11 |
NO164092B (no) | 1990-05-21 |
FI84472C (fi) | 1991-12-10 |
GR862286B (en) | 1987-01-12 |
IE862404L (en) | 1987-03-10 |
NO164092C (no) | 1990-08-29 |
PH24182A (en) | 1990-03-22 |
US4743587A (en) | 1988-05-10 |
IL79971A (en) | 1990-11-05 |
IE58770B1 (en) | 1993-11-03 |
DK427686D0 (da) | 1986-09-08 |
PT83328B (pt) | 1988-07-29 |
EP0214639A3 (en) | 1988-02-17 |
FI84472B (fi) | 1991-08-30 |
DE3671891D1 (de) | 1990-07-19 |
DK427686A (da) | 1987-03-11 |
AU588362B2 (en) | 1989-09-14 |
JPS62103052A (ja) | 1987-05-13 |
NO863581D0 (no) | 1986-09-08 |
NO863581L (no) | 1987-03-11 |
IL79971A0 (en) | 1986-12-31 |
AU6240886A (en) | 1987-03-12 |
PT83328A (pt) | 1986-10-01 |
FI863607A0 (fi) | 1986-09-08 |
EP0214639B1 (en) | 1990-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |