DE3671891D1 - Hydroxamsaeure enthaltende collagenase-inhibitoren. - Google Patents

Hydroxamsaeure enthaltende collagenase-inhibitoren.

Info

Publication number
DE3671891D1
DE3671891D1 DE8686112386T DE3671891T DE3671891D1 DE 3671891 D1 DE3671891 D1 DE 3671891D1 DE 8686112386 T DE8686112386 T DE 8686112386T DE 3671891 T DE3671891 T DE 3671891T DE 3671891 D1 DE3671891 D1 DE 3671891D1
Authority
DE
Germany
Prior art keywords
hydroxamic acid
inhibitors containing
collagenase inhibitors
containing hydroxamic
collagenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686112386T
Other languages
English (en)
Inventor
Jonathan Philip Dickens
David Keith Donald
Geoffrey Kneen
William Roger Mckay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/774,491 external-priority patent/US4599361A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE3671891D1 publication Critical patent/DE3671891D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686112386T 1985-09-10 1986-09-08 Hydroxamsaeure enthaltende collagenase-inhibitoren. Expired - Lifetime DE3671891D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/774,491 US4599361A (en) 1985-09-10 1985-09-10 Hydroxamic acid based collagenase inhibitors
US06/880,130 US4743587A (en) 1985-09-10 1986-07-07 Hydroxamic acid based collagenase inhibitors

Publications (1)

Publication Number Publication Date
DE3671891D1 true DE3671891D1 (de) 1990-07-19

Family

ID=27118893

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686112386T Expired - Lifetime DE3671891D1 (de) 1985-09-10 1986-09-08 Hydroxamsaeure enthaltende collagenase-inhibitoren.

Country Status (14)

Country Link
US (1) US4743587A (de)
EP (1) EP0214639B1 (de)
JP (1) JPH0764800B2 (de)
CA (1) CA1329397C (de)
DE (1) DE3671891D1 (de)
DK (1) DK169029B1 (de)
FI (1) FI84472C (de)
GR (1) GR862286B (de)
IE (1) IE58770B1 (de)
IL (1) IL79971A (de)
NO (1) NO164092C (de)
NZ (1) NZ217491A (de)
PH (1) PH24182A (de)
PT (1) PT83328B (de)

Families Citing this family (63)

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US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0225292A3 (de) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Einige N-substituierte Buttersäureamidderivate
US4939299A (en) * 1986-12-04 1990-07-03 Monsanto Company Succinyl dihydroxamic acids
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
JP2573006B2 (ja) * 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
DE69122956T2 (de) * 1990-01-25 1997-05-22 Childrens Hosp Medical Center Verfahren und zusammensetzungen zur hemmung der angiogenese
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5239078A (en) * 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
US5114953A (en) * 1990-11-21 1992-05-19 University Of Florida Treatment for tissue ulceration
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5889058A (en) * 1990-12-03 1999-03-30 Celltech Limited Peptidyl derivatives
AU652596B2 (en) * 1990-12-03 1994-09-01 Celltech Limited Peptidyl derivatives
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
AU2228292A (en) * 1991-06-14 1993-01-12 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
US5530161A (en) * 1991-07-08 1996-06-25 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211706D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5318964A (en) * 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
GB9220845D0 (en) * 1992-10-03 1992-11-18 British Bio Technology Vasoactive peptide inhibition
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5403824A (en) * 1993-03-19 1995-04-04 The Procter & Gamble Company Methods for the treatment of osteoporosis
ATE172959T1 (de) * 1993-08-09 1998-11-15 Kanebo Ltd Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
DE69510198T2 (de) * 1994-05-28 1999-10-28 British Biotech Pharm Succinyl hydroxamsäure-, n-formyl-n-hydroxy-aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease-inhibitoren
GB9411088D0 (en) * 1994-06-03 1994-07-27 Hoffmann La Roche Hydroxylamine derivatives
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5831004A (en) 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
GB9601041D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Novel compounds
CA2265666C (en) * 1996-09-10 2008-01-15 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives
EP0911319A1 (de) * 1997-09-01 1999-04-28 Roche Diagnostics GmbH Matrix-metalloproteinase-inhibitoren auf Malonsäure-Basis
GB9804504D0 (en) 1998-03-03 1998-04-29 Leo Pharm Prod Ltd Matrix metalloproteinase inhibitors
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
IL151126A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Carbocyclic side chain containing metalloprotease inhibitors
MXPA02009311A (es) * 2000-03-21 2003-03-12 Procter & Gamble Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas.
JP2003528082A (ja) * 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
WO2001070269A1 (fr) * 2000-03-24 2001-09-27 Akzo Nobel N.V. Inhibiteurs de la croissance des keratinocytes et derives d'acide hydroxamique
DK2330132T3 (da) 2003-04-04 2013-11-04 Yeda Res & Dev Antistoffer mod MMP2 eller MMP9 og farmaceutiske sammensætninger deraf til hæmning af deres metalloproteinaktivitet
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
GB0722484D0 (en) * 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
MY156270A (en) 2009-05-28 2016-01-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
UY32660A (es) 2009-05-28 2010-12-31 Novartis Ag Derivados aminobutricos sustituidos como inhibidores de neprilisina
EP2528949A1 (de) 2010-01-27 2012-12-05 Yeda Research And Development Co. Ltd. Antikörper zur hemmung von metalloproteinen
WO2012056455A1 (en) 2010-10-28 2012-05-03 Yeda Research And Development Co. Ltd. Methods of generating antibodies to metalloenzymes
MA38330B1 (fr) 2013-02-14 2016-09-30 Novartis Ag Dérivés d'acide phosphonique butanoïque de bisphénol substitués en qualité d'inhibiteurs de nep (endopeptidase neutre)
EA026989B1 (ru) 2013-02-14 2017-06-30 Новартис Аг Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью
IL264768A (en) 2019-02-10 2020-08-31 Sagi Irit ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH438351A (de) * 1959-09-25 1967-06-30 Ciba Geigy Verfahren zur Herstellung neuer Wuchsstoffe
US3471476A (en) * 1964-05-18 1969-10-07 Tino Gaeumann Trihydroxamic acids
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4028401A (en) * 1976-07-01 1977-06-07 Morton-Norwich Products, Inc. (Substituted)ureidoacetohydroxamic acids
NZ201010A (en) * 1981-06-19 1986-02-21 Ciba Geigy Ag The treatment of inflammation diseases using desferrioxamine
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
US4419365A (en) * 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease

Also Published As

Publication number Publication date
PH24182A (en) 1990-03-22
NO863581D0 (no) 1986-09-08
FI863607A (fi) 1987-03-11
NO164092C (no) 1990-08-29
CA1329397C (en) 1994-05-10
FI863607A0 (fi) 1986-09-08
IL79971A (en) 1990-11-05
DK169029B1 (da) 1994-08-01
FI84472C (fi) 1991-12-10
JPH0764800B2 (ja) 1995-07-12
AU588362B2 (en) 1989-09-14
EP0214639B1 (de) 1990-06-13
IE58770B1 (en) 1993-11-03
PT83328B (pt) 1988-07-29
DK427686D0 (da) 1986-09-08
EP0214639A3 (en) 1988-02-17
FI84472B (fi) 1991-08-30
IE862404L (en) 1987-03-10
NZ217491A (en) 1989-10-27
JPS62103052A (ja) 1987-05-13
NO164092B (no) 1990-05-21
AU6240886A (en) 1987-03-12
DK427686A (da) 1987-03-11
GR862286B (en) 1987-01-12
NO863581L (no) 1987-03-11
PT83328A (pt) 1986-10-01
EP0214639A2 (de) 1987-03-18
US4743587A (en) 1988-05-10
IL79971A0 (en) 1986-12-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition