DK168093B1 - Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse - Google Patents

Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse Download PDF

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Publication number
DK168093B1
DK168093B1 DK324985A DK324985A DK168093B1 DK 168093 B1 DK168093 B1 DK 168093B1 DK 324985 A DK324985 A DK 324985A DK 324985 A DK324985 A DK 324985A DK 168093 B1 DK168093 B1 DK 168093B1
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DK
Denmark
Prior art keywords
compound
bis
mixture
isoquinolinium
formula
Prior art date
Application number
DK324985A
Other languages
Danish (da)
English (en)
Other versions
DK324985D0 (da
DK324985A (da
Inventor
Roy Archibald Swaringen Jr
Hassan Ali El-Sayad
David Arthur Yeowell
John Joseph Savarese
Original Assignee
Wellcome Found
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found, Gen Hospital Corp filed Critical Wellcome Found
Publication of DK324985D0 publication Critical patent/DK324985D0/da
Publication of DK324985A publication Critical patent/DK324985A/da
Application granted granted Critical
Publication of DK168093B1 publication Critical patent/DK168093B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Jib Cranes (AREA)
  • Medicinal Preparation (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Fats And Perfumes (AREA)
  • Cosmetics (AREA)
  • Cephalosporin Compounds (AREA)
DK324985A 1984-07-18 1985-07-17 Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse DK168093B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848418303A GB8418303D0 (en) 1984-07-18 1984-07-18 Compounds
GB8418303 1984-07-18

Publications (3)

Publication Number Publication Date
DK324985D0 DK324985D0 (da) 1985-07-17
DK324985A DK324985A (da) 1986-01-19
DK168093B1 true DK168093B1 (da) 1994-02-07

Family

ID=10564058

Family Applications (1)

Application Number Title Priority Date Filing Date
DK324985A DK168093B1 (da) 1984-07-18 1985-07-17 Isoquinoliniumderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat indeholdende disse samt deres anvendelse

Country Status (30)

Country Link
US (1) US4761418A (fi)
EP (1) EP0181055B1 (fi)
JP (1) JPH0662568B2 (fi)
AT (1) ATE60759T1 (fi)
AU (1) AU574481B2 (fi)
BG (1) BG60411B2 (fi)
CA (1) CA1273341A (fi)
CY (1) CY1687A (fi)
DD (1) DD235638A5 (fi)
DE (2) DE3581699D1 (fi)
DK (1) DK168093B1 (fi)
ES (1) ES8609260A1 (fi)
FI (1) FI85019C (fi)
GB (1) GB8418303D0 (fi)
GE (1) GEP19960468B (fi)
HK (1) HK47593A (fi)
HU (1) HU193996B (fi)
IE (1) IE58138B1 (fi)
IL (1) IL75833A (fi)
LT (1) LT2078B (fi)
LU (1) LU88801I2 (fi)
LV (1) LV5483A3 (fi)
MC (1) MC1690A1 (fi)
MX (1) MX9203667A (fi)
NL (1) NL940023I2 (fi)
NZ (1) NZ212766A (fi)
PL (1) PL146066B1 (fi)
SG (1) SG3493G (fi)
SU (1) SU1468414A3 (fi)
ZA (1) ZA855407B (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
MY121316A (en) * 1997-03-25 2006-01-28 Cornell Res Foundation Inc Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
WO2005041960A2 (en) * 2003-10-28 2005-05-12 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
US7872137B2 (en) * 2006-06-20 2011-01-18 Farmabios S.P.A. Process for the preparation of mivacurium chloride
CN101588803B (zh) * 2006-12-06 2013-03-20 康乃尔研究基金会有限公司 中等持续时间神经肌肉阻断剂及其拮抗剂
CA2680277A1 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
WO2008117271A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008243749B2 (en) * 2007-05-01 2012-05-03 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
AU2008273724B2 (en) * 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
AU2008264802A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
EP2176227A1 (en) * 2007-07-09 2010-04-21 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
BRPI0816519A2 (pt) * 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
ITMI20080319A1 (it) * 2008-02-28 2009-08-29 Recordati Chem Pharm Processo per la risoluzione di derivati isochinolinici
AU2009241211A1 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
WO2010107488A1 (en) 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
WO2013021398A2 (en) * 2011-08-05 2013-02-14 Sequent Scientific Limited A process for preparation of mivacurium chloride
US9156826B2 (en) 2012-06-29 2015-10-13 Cornell University Asymmetrical reversible neuromuscular blocking agents of ultra-short, short, or intermediate duration
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
CN107778237A (zh) * 2016-08-26 2018-03-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的新晶型及其制备方法和用途
CN107782821B (zh) * 2016-08-26 2021-11-09 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN108503564A (zh) * 2017-09-30 2018-09-07 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体及利用该中间体合成米库氯铵的方法
CN110361472B (zh) * 2019-07-29 2022-04-29 武汉嘉诺康医药技术有限公司 一种米库氯铵中间体miv-g异构体的hplc检测方法
CN111004179B (zh) * 2019-11-11 2021-03-09 武汉大安制药有限公司 一种5’-甲氧基劳丹素的拆分方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863717A (en) * 1958-07-03 1961-03-22 Allen & Hanburys Ltd Tetrahydropapaverine derivatives and their preparation
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
DD143254A5 (de) * 1977-08-01 1980-08-13 Massachusetts Gen Hospital Verfahren zur herstellung von tetrahydroisochinolin-derivaten
US4192877A (en) * 1977-08-01 1980-03-11 Massachusetts General Hospital Neuromuscular blocking agents
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) * 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
CA1153380A (en) * 1979-10-19 1983-09-06 Hassan A. El-Sayad Neuromuscular blocking tetrahydroisoquinolinium salts
DE3165714D1 (en) * 1980-12-17 1984-09-27 Wellcome Found Long duration neuromuscular blocking agents, pharmaceutical compositions containing them and processes for their preparation
JPS5899465A (ja) * 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体

Also Published As

Publication number Publication date
HUT40626A (en) 1987-01-28
US4761418A (en) 1988-08-02
DD235638A5 (de) 1986-05-14
PL146066B1 (en) 1988-12-31
AU574481B2 (en) 1988-07-07
MC1690A1 (fr) 1986-07-18
GB8418303D0 (en) 1984-08-22
MX9203667A (es) 1992-07-31
BG60411B2 (bg) 1995-02-28
ZA855407B (en) 1986-04-30
PL254571A1 (en) 1986-07-15
DE3581699D1 (de) 1991-03-14
NL940023I2 (nl) 1998-06-02
SU1468414A3 (ru) 1989-03-23
CA1273341A (en) 1990-08-28
AU4510885A (en) 1986-01-23
IE851791L (en) 1986-01-18
SG3493G (en) 1993-03-12
HU193996B (en) 1987-12-28
ES8609260A1 (es) 1986-09-01
EP0181055A1 (en) 1986-05-14
FI85019C (fi) 1992-02-25
JPH0662568B2 (ja) 1994-08-17
DK324985D0 (da) 1985-07-17
LT2078B (lt) 1993-06-15
LV5483A3 (lv) 1994-03-10
FI852807A0 (fi) 1985-07-17
DK324985A (da) 1986-01-19
FI852807L (fi) 1986-01-19
HK47593A (en) 1993-05-21
ATE60759T1 (de) 1991-02-15
IE58138B1 (en) 1993-07-14
GEP19960468B (en) 1996-08-29
CY1687A (en) 1993-10-10
IL75833A0 (en) 1985-11-29
NL940023I1 (nl) 1995-01-02
EP0181055B1 (en) 1991-02-06
FI85019B (fi) 1991-11-15
LU88801I2 (fr) 1996-11-05
JPS6187666A (ja) 1986-05-06
ES545319A0 (es) 1986-09-01
IL75833A (en) 1988-11-30
DE19675039I2 (de) 2003-01-09
NZ212766A (en) 1988-03-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1994 00013, 941215

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1994 00013, 941215, EXPIRES: 20071208

PUP Patent expired