DK167904B1 - Farmaceutisk praeparat indeholdende en kombination af angiotensin-converting-enzyme-inhibitorer calciumantagonister samt fremgangsmaade til fremstilling af praeparatet - Google Patents

Farmaceutisk praeparat indeholdende en kombination af angiotensin-converting-enzyme-inhibitorer calciumantagonister samt fremgangsmaade til fremstilling af praeparatet Download PDF

Info

Publication number
DK167904B1
DK167904B1 DK516487A DK516487A DK167904B1 DK 167904 B1 DK167904 B1 DK 167904B1 DK 516487 A DK516487 A DK 516487A DK 516487 A DK516487 A DK 516487A DK 167904 B1 DK167904 B1 DK 167904B1
Authority
DK
Denmark
Prior art keywords
alkyl
physiologically acceptable
aryl
preparation
amino
Prior art date
Application number
DK516487A
Other languages
Danish (da)
English (en)
Other versions
DK516487A (da
DK516487D0 (da
Inventor
Reinhard Becker
Rainer Henning
Wolfgang Rueger
Volker Teetz
Hansjoerg Urbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36747182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK167904(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK516487D0 publication Critical patent/DK516487D0/da
Publication of DK516487A publication Critical patent/DK516487A/da
Application granted granted Critical
Publication of DK167904B1 publication Critical patent/DK167904B1/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK516487A 1986-10-02 1987-10-01 Farmaceutisk praeparat indeholdende en kombination af angiotensin-converting-enzyme-inhibitorer calciumantagonister samt fremgangsmaade til fremstilling af praeparatet DK167904B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19863633496 DE3633496A1 (de) 1986-10-02 1986-10-02 Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3633496 1986-10-02
AT0260087A AT402894B (de) 1986-10-02 1987-10-08 Kombination von angiotensin-converting-enzyme- hemmern mit calciumantagonisten sowie ein erzeugnis, das diese enthält, zur anwendung bei der behandlung des bluthochdrucks
AT260087 1987-10-08

Publications (3)

Publication Number Publication Date
DK516487D0 DK516487D0 (da) 1987-10-01
DK516487A DK516487A (da) 1988-04-03
DK167904B1 true DK167904B1 (da) 1994-01-03

Family

ID=36747182

Family Applications (1)

Application Number Title Priority Date Filing Date
DK516487A DK167904B1 (da) 1986-10-02 1987-10-01 Farmaceutisk praeparat indeholdende en kombination af angiotensin-converting-enzyme-inhibitorer calciumantagonister samt fremgangsmaade til fremstilling af praeparatet

Country Status (26)

Country Link
US (3) US5098910A (ja)
EP (1) EP0265685B1 (ja)
JP (2) JP2752043B2 (ja)
KR (1) KR970005838B1 (ja)
AR (1) AR243083A1 (ja)
AT (2) ATE78697T1 (ja)
AU (1) AU611863B2 (ja)
CA (1) CA1317545C (ja)
DD (1) DD272035A5 (ja)
DE (3) DE3633496A1 (ja)
DK (1) DK167904B1 (ja)
EG (1) EG18081A (ja)
ES (1) ES2043626T3 (ja)
FI (1) FI874281A (ja)
GR (1) GR3006042T3 (ja)
HU (1) HU199302B (ja)
IE (1) IE59975B1 (ja)
IL (1) IL84054A (ja)
LU (1) LU90345I2 (ja)
MA (1) MA21072A1 (ja)
MX (1) MX8639A (ja)
NL (1) NL980030I2 (ja)
NO (2) NO175621C (ja)
NZ (1) NZ221989A (ja)
PT (1) PT85843B (ja)
ZA (1) ZA877385B (ja)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
NL8702502A (nl) * 1986-11-03 1988-06-01 Sandoz Ag Farmaceutisch preparaat voor toepassing tegen hypertensie en congestieve cardiale insufficientie.
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
USH734H (en) * 1988-03-07 1990-02-06 E. R. Squibb & Sons, Inc. Method for inhibiting onset of or treating migraine headaches employing an ACE inhibitor
JPH01275529A (ja) * 1988-03-21 1989-11-06 E R Squibb & Sons Inc 晩発性運動障害の抑制治療剤
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
EP0391462A1 (en) * 1989-04-05 1990-10-10 Janssen Pharmaceutica N.V. Synergistic compositions containing ketanserin
TW197945B (ja) * 1990-11-27 1993-01-11 Hoechst Ag
DE4109134A1 (de) * 1991-03-20 1992-09-24 Knoll Ag Erzeugnisse, enthaltend verapamil und trandolapril
US6162802A (en) * 1992-03-10 2000-12-19 Papa; Joseph Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor
DE4314962A1 (de) * 1993-05-06 1994-11-10 Bayer Ag Substituierte Piperazine
JP3057471B2 (ja) 1993-06-07 2000-06-26 武田薬品工業株式会社 アンジオテンシンii介在性諸疾患の予防または治療剤
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
US5658832A (en) * 1994-10-17 1997-08-19 Regents Of The University Of California Method of forming a spacer for field emission flat panel displays
DE69626958T2 (de) 1995-03-16 2004-03-18 Pfizer Inc. Verwendung von amlodipin, eines seiner salze oder felodipin in kombination mit einem ace-hemmer zur herstellung eines arzneimittels zur behandlung von nicht ischämischer kongestiver herzinsuffizienz
FR2733911B1 (fr) * 1995-05-09 1998-05-29 Takeda Chemical Industries Ltd Composition pharmaceutique pour maladies renales ou cardio-vasculaires
EP0795327A1 (en) * 1996-03-13 1997-09-17 Pfizer Inc. Use of Amlodipine for the treatment and prophylaxis of congestive cardiac failure of non-ischaemic origin
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
ES2246894T3 (es) * 1999-08-30 2006-03-01 Sanofi-Aventis Deutschland Gmbh Ramipril para la prevencion de sucesos cardiovasculares.
US20040005359A1 (en) * 2002-06-27 2004-01-08 Cheng Xiu Xiu Controlled release oral dosage form
US20040147566A1 (en) * 2002-10-16 2004-07-29 Amedeo Leonardi Lisinopril/lercanidipine combination therapy
US20050101640A1 (en) * 2002-10-16 2005-05-12 Recordati Ireland Limited Lisinopril/lercanidipine combination therapy
US20050032784A1 (en) * 2003-04-01 2005-02-10 University Of Florida Research Foundation, Inc. Combination drug therapy for treating hypertension
KR100546710B1 (ko) 2003-07-02 2006-01-26 엘지.필립스 엘시디 주식회사 액정표시장치의 아날로그 버퍼회로
AU2005301989A1 (en) * 2004-11-05 2006-05-11 King Pharmaceuticals Research & Development, Inc. Stabilized individually coated ramipril particles, compositions and methods
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
WO2009125944A2 (ko) * 2008-04-10 2009-10-15 한올제약주식회사 비디히드로피리딘계 칼슘 채널 차단제 및 안지오텐신-2 수용체 차단제를 포함하는 약제학적 제제
SI2538924T1 (sl) 2010-02-24 2014-09-30 Sanofi-Aventis Deutschland Gmbh Trdne farmacevtske formulacije ramiprila in amlodipin bezilata in njihova priprava
RU2543637C2 (ru) * 2012-12-06 2015-03-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здавоохранения Российской Федерации Пролонгированная фармацевтическая композиция гипотензивного действия и способ ее изготовления

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
AT358908B (de) * 1979-02-20 1980-10-10 Heinzle August Stickmaschine
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2491469A1 (fr) * 1980-10-02 1982-04-09 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
DE3032709A1 (de) * 1980-08-30 1982-04-29 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3134933A1 (de) * 1981-09-03 1983-03-31 Hoechst Ag, 6230 Frankfurt "harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente sowie deren verwendung"
SU1327787A3 (ru) * 1981-11-05 1987-07-30 Хехст Аг (Фирма) Способ получени цис,эндо-2-азабицикло-/3,3,0/-октан-3-карбоновых кислот или их кислотно-аддитивных солей
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4634716A (en) * 1982-09-30 1987-01-06 Merck & Co., Inc. Substituted N-carboxymethyl-aminoacylaminoalkanoic acids useful as antihypertensive agents
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
DE3437917A1 (de) * 1984-10-17 1986-04-17 Bayer Ag, 5090 Leverkusen Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
IL77843A (en) * 1985-02-11 1989-07-31 Syntex Inc Dihydropyridine derivatives,process and novel intermediates for their preparation and pharmaceutical compositions containing them
US5256687A (en) * 1985-09-09 1993-10-26 Hoechst Aktiengesellschaft Pharmaceutical composition for the treatment of high blood pressure
US4761420A (en) * 1986-06-13 1988-08-02 Laboratoires Syntex S.A. Antihypertensive dihydropyridine derivatives
DE3629060A1 (de) * 1986-08-27 1988-03-03 Bayer Ag Kombination von positiv inotrop wirkenden dihydropyridinen mit ace-hemmern, sowie ihre verwendung in arzneimitteln
DE3633496A1 (de) * 1986-10-02 1988-04-14 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
US4882894A (en) * 1986-10-14 1989-11-28 W. R. Grace & Co.-Conn. Agent for imparting antistatic characteristics to a thermoplastic polymer and a thermoplastic polymer composition containing the agent
FR2607004B1 (fr) * 1986-11-20 1990-06-01 Synthelabo Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine

Also Published As

Publication number Publication date
PT85843B (pt) 1991-02-08
GR3006042T3 (ja) 1993-06-21
ZA877385B (en) 1988-05-25
ES2043626T3 (es) 1994-01-01
JPH10182456A (ja) 1998-07-07
NZ221989A (en) 1990-11-27
HUT47030A (en) 1989-01-30
FI874281A (fi) 1988-04-03
AU7928087A (en) 1988-04-14
IL84054A0 (en) 1988-03-31
US5721244A (en) 1998-02-24
AU611863B2 (en) 1991-06-27
CA1317545C (en) 1993-05-11
JP2752043B2 (ja) 1998-05-18
KR880005150A (ko) 1988-06-28
NL980030I2 (nl) 1999-10-01
FI874281A0 (fi) 1987-09-30
DK516487A (da) 1988-04-03
EP0265685B1 (de) 1992-07-29
LU90345I2 (fr) 1999-04-06
US5500434A (en) 1996-03-19
JP3003995B2 (ja) 2000-01-31
NO1998022I1 (no) 1998-10-12
DE19975008I2 (de) 2004-07-01
IE59975B1 (en) 1994-05-04
PT85843A (de) 1987-11-01
DE3780753D1 (de) 1992-09-03
MA21072A1 (fr) 1988-07-01
JPS6396136A (ja) 1988-04-27
IL84054A (en) 1993-01-31
NO874141D0 (no) 1987-10-01
AT402894B (de) 1997-09-25
EP0265685A2 (de) 1988-05-04
EP0265685A3 (en) 1989-10-11
US5098910A (en) 1992-03-24
AR243083A1 (es) 1993-07-30
IE872636L (en) 1988-04-02
DE3633496A1 (de) 1988-04-14
ATA260087A (de) 1997-02-15
DD272035A5 (de) 1989-09-27
HU199302B (en) 1990-02-28
NO175621B (ja) 1994-08-01
NO874141L (no) 1988-04-05
EG18081A (en) 1991-08-30
ATE78697T1 (de) 1992-08-15
MX8639A (es) 1993-11-01
NL980030I1 (nl) 1999-01-04
DK516487D0 (da) 1987-10-01
KR970005838B1 (ko) 1997-04-21
NO175621C (no) 1994-11-09

Similar Documents

Publication Publication Date Title
DK167904B1 (da) Farmaceutisk praeparat indeholdende en kombination af angiotensin-converting-enzyme-inhibitorer calciumantagonister samt fremgangsmaade til fremstilling af praeparatet
US5256687A (en) Pharmaceutical composition for the treatment of high blood pressure
KR930008094B1 (ko) 안기오텐신 전환효소 억제제의 제조방법
US5366994A (en) Use of a combination of angiotensin-converting enzyme inhibitor and calcium antagonist for the treatment of proteinuria
CS277644B6 (en) Pharmaceutical preparation for treating cardial and vascular hypertrophy and hyperplasia
JPH0219326A (ja) アンジオテンシン変換酵素阻害剤とカリウムチャンネルモジユレーターとの組み合わせ物
JPH021444A (ja) 向精神作用を有するアミノ酸アミド
US5939430A (en) Combinations of retroviral inhibitors
JPH089549B2 (ja) 高血圧治療用医薬組成物
AU679497B2 (en) Combinations of retroviral inhibitors
JPS6391326A (ja) 高血圧治療用医薬組成物

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1998 00022, 19980910, EXPIRES: 20120919

CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: FELODIPIN, RAMIPRIL

Spc suppl protection certif: CA 1998 00022

Filing date: 19980910

PUP Patent expired