DK167794B1 - Fremgangsmaade til fremstilling af en krystalform af ranitidinhydrochlorid - Google Patents
Fremgangsmaade til fremstilling af en krystalform af ranitidinhydrochlorid Download PDFInfo
- Publication number
- DK167794B1 DK167794B1 DK436281A DK436281A DK167794B1 DK 167794 B1 DK167794 B1 DK 167794B1 DK 436281 A DK436281 A DK 436281A DK 436281 A DK436281 A DK 436281A DK 167794 B1 DK167794 B1 DK 167794B1
- Authority
- DK
- Denmark
- Prior art keywords
- ranitidine hydrochloride
- ranitidine
- solvent
- process according
- crystallization
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8031634 | 1980-10-01 | ||
GB8031634 | 1980-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK436281A DK436281A (da) | 1982-04-02 |
DK167794B1 true DK167794B1 (da) | 1993-12-13 |
Family
ID=10516407
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK436281A DK167794B1 (da) | 1980-10-01 | 1981-10-01 | Fremgangsmaade til fremstilling af en krystalform af ranitidinhydrochlorid |
DK033792A DK167923B1 (da) | 1980-10-01 | 1992-03-12 | Ranitidinhydrochlorid i form 2 og anvendelsen deraf ved fremstilling af et farmaceutisk praeparat |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK033792A DK167923B1 (da) | 1980-10-01 | 1992-03-12 | Ranitidinhydrochlorid i form 2 og anvendelsen deraf ved fremstilling af et farmaceutisk praeparat |
Country Status (29)
Country | Link |
---|---|
US (2) | US4521431A (de) |
JP (1) | JPS5791983A (de) |
KR (1) | KR870001431B1 (de) |
AT (1) | AT389696B (de) |
AU (1) | AU549119B2 (de) |
BE (1) | BE890574A (de) |
CA (1) | CA1202638A (de) |
CH (1) | CH652122A5 (de) |
CZ (1) | CZ280885B6 (de) |
DE (1) | DE3139134A1 (de) |
DK (2) | DK167794B1 (de) |
ES (1) | ES505951A0 (de) |
FR (1) | FR2491067A1 (de) |
GR (1) | GR72499B (de) |
HK (1) | HK97985A (de) |
IE (1) | IE51604B1 (de) |
IL (1) | IL63968A (de) |
IT (1) | IT1143237B (de) |
KE (1) | KE3549A (de) |
LU (1) | LU83661A1 (de) |
MY (1) | MY8500747A (de) |
NL (1) | NL8104482A (de) |
NZ (1) | NZ198522A (de) |
PH (2) | PH19489A (de) |
PT (1) | PT73744B (de) |
SE (1) | SE453500B (de) |
SK (1) | SK403591A3 (de) |
ZA (1) | ZA816809B (de) |
ZW (1) | ZW24481A1 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK162525C (da) * | 1983-07-15 | 1992-03-30 | Richter Gedeon Vegyeszet | Fremgangsmaade til fremstilling af ranitidin-hydroklorid |
GB8629781D0 (en) * | 1986-12-12 | 1987-01-21 | Glaxo Group Ltd | Pharmaceutical compositions |
SE8704436D0 (sv) * | 1987-11-13 | 1987-11-13 | Pm Konsult Handelsbolag | Anvendning av antisekretoriska substanser for nya indikationer |
IL90245A (en) * | 1988-05-11 | 1994-04-12 | Glaxo Group Ltd | Resin adsorption containing ranitidine together with synthetic resin replaces cations, its preparation and pharmaceutical preparations containing it |
GB8904182D0 (en) * | 1989-02-23 | 1989-04-05 | Glaxo Canada | Pharmaceutical compositions |
US5169864A (en) * | 1991-11-15 | 1992-12-08 | Baxter International Inc. | Unbuffered premixed ranitidine formulation |
CN1048984C (zh) * | 1991-12-20 | 2000-02-02 | 多坎化学有限公司 | 晶形1呋喃硝胺氢氯化物的制备 |
US5338871A (en) * | 1991-12-20 | 1994-08-16 | Torcan Chemical Ltd. | Preparation of form 1 ranitidine hydrochloride |
WO1994020505A1 (en) * | 1993-03-12 | 1994-09-15 | The Upjohn Company | Crystalline ceftiofur free acid |
DE4341310A1 (de) * | 1993-12-03 | 1995-06-08 | Hexal Pharma Gmbh | Tablette oder Kapsel mit einem Gehalt an stabilem Ranitidinhydrochlorid Form 1 |
US5407687A (en) * | 1994-02-22 | 1995-04-18 | Glaxo Inc. | Ranitidine solid dosage form |
CA2120874E (en) * | 1994-04-08 | 2002-01-08 | Keshava Murthy | Form of form 1 ranitidine |
EP0754182A1 (de) * | 1994-04-08 | 1997-01-22 | Brantford Chemicals Inc. | Form 1 rantidinhydrochlorid mit erhöhter dichte |
EP0755393B1 (de) | 1994-04-15 | 2001-10-24 | PHARMACIA & UPJOHN COMPANY | Kristallformen von 1-[5-methansulfonamidoindolyl-2-carbonyl]-4-[3-[1-methylethylamino]-2-pyridinyl] piperazin |
IN181698B (de) * | 1994-05-13 | 1998-09-05 | Ranbaxy Lab Ltd | |
IN181699B (de) * | 1994-05-13 | 1998-09-05 | Ranbaxy Lab Ltd | |
NZ272054A (en) * | 1994-05-13 | 1996-05-28 | Ranbaxy Lab Ltd | Process for producing form 1 ranitidine hydrochloride |
EP2354125A1 (de) * | 1994-05-18 | 2011-08-10 | Aventisub II Inc. | Wasserfreien und Hydrat-Polymorphen von antihistaminische Piperidinderivate |
US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
DE69504156T2 (de) | 1994-06-24 | 1998-12-24 | Ranbaxy Lab Ltd | Verfahren zur Herstellung von Ranitidinhydrochlorid in der Kristallform 1 |
AU709057B2 (en) * | 1994-11-18 | 1999-08-19 | Pharmacia & Upjohn Company | A new physically stable solid form of a fluoroquinolone |
US5538737A (en) * | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
US5663381A (en) * | 1995-04-21 | 1997-09-02 | Hexal Pharmaceuticals, Inc. | Process for preparing form 1 ranitidine hydrochloride |
US5686588A (en) * | 1995-08-16 | 1997-11-11 | Yoo; Seo Hong | Amine acid salt compounds and process for the production thereof |
AU1972097A (en) * | 1996-03-25 | 1997-10-17 | Hoechst Marion Roussel, Inc. | Process for the preparation of form 1 ranitidine hydrochloride |
ATE207065T1 (de) * | 1997-08-08 | 2001-11-15 | Aventis Pharma Gmbh | Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid |
US6287693B1 (en) | 1998-02-25 | 2001-09-11 | John Claude Savoir | Stable shaped particles of crystalline organic compounds |
IT1317858B1 (it) * | 2000-02-29 | 2003-07-15 | Pharmexcel S R L | Allomorfo del cloridrato dell'isomero z di derivato dialchilamminofurano, procedimento per la sua produzione e composizione |
GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
US20020183553A1 (en) * | 2000-10-19 | 2002-12-05 | Ben-Zion Dolitzky | Crystalline venlafaxine base and novel polymorphs of venlafaxine hydrochloride, processes for preparing thereof |
US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
US20060173064A1 (en) * | 2001-08-24 | 2006-08-03 | Lippa Arnold S | (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders |
US7235655B2 (en) * | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
TW200409746A (en) * | 2002-07-26 | 2004-06-16 | Theravance Inc | Crystalline β2 adrenergic receptor agonist |
US20080081834A1 (en) | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
US7166641B2 (en) * | 2002-10-02 | 2007-01-23 | Yung Shin Pharmaceutical Industrial Co., Ltd. | Pharmaceutically acceptable salts containing local anesthetic and anti-inflammatory activities and methods for preparing the same |
AU2003286889A1 (en) * | 2002-11-08 | 2004-06-03 | Dov Pharmaceutical, Inc. | Polymorphs of bicifadine hydrochloride |
TW200510277A (en) * | 2003-05-27 | 2005-03-16 | Theravance Inc | Crystalline form of β2-adrenergic receptor agonist |
US7384557B2 (en) * | 2003-07-14 | 2008-06-10 | Applied Ambient Extraction Process Consultants, Llc | Method and apparatus for removing solute from a solid solute-bearing product |
TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
US20070043100A1 (en) * | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
US20060100263A1 (en) * | 2004-11-05 | 2006-05-11 | Anthony Basile | Antipyretic compositions and methods |
US20060100271A1 (en) * | 2004-11-08 | 2006-05-11 | Keith Whitehead | Stabilized aqueous ranitidine compositions |
KR20170005888A (ko) | 2005-07-27 | 2017-01-16 | 뉴로반스, 인크. | 신규 1-아릴-3-아자바이사이클로[3.1.0]헥산:제조 방법 및 신경 정신 질환 치료를 위한 용도 |
DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
US20080045725A1 (en) * | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
AR063347A1 (es) * | 2006-10-20 | 2009-01-21 | Scinopharm Singapore Pte Ltd | Formas cristalinas de docetaxel y proceso para su preparacion |
US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
US20090069374A1 (en) * | 2007-06-06 | 2009-03-12 | Phil Skolnick | Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments |
US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
TW201011043A (en) | 2008-06-20 | 2010-03-16 | Chugai Pharmaceutical Co Ltd | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives |
UA111213C2 (uk) | 2011-06-30 | 2016-04-11 | Торей Індастріз, Інк. | Кристалічна форма похідного гліцину (варіанти), фармацевтична композиція та терапевтичний або профілактичний засіб |
CN106432149B (zh) * | 2015-05-26 | 2018-04-17 | 烟台市华文欣欣医药科技有限公司 | 一种制备治疗胃病的药物盐酸雷尼替丁化合物的方法 |
CN105030694A (zh) * | 2015-08-04 | 2015-11-11 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗胃溃疡的药物盐酸雷尼替丁组合物干混悬剂 |
CN104971053A (zh) * | 2015-08-05 | 2015-10-14 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗消化系统疾病的药物盐酸雷尼替丁组合物片剂 |
CN105055331A (zh) * | 2015-08-31 | 2015-11-18 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗消化性溃疡的药物盐酸雷尼替丁组合物颗粒剂 |
WO2021079183A1 (en) * | 2019-10-21 | 2021-04-29 | Sms Pharmaceuticals Limited | Isopropyl alcohol solvent free crystalline ranitidine hydrochloride form-2 which is free of nitrosamine (ndma) impurity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1565966A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
US4233302A (en) * | 1977-12-23 | 1980-11-11 | Glaxo Group Limited | Amine derivatives and pharmaceutical compositions containing them |
-
1981
- 1981-09-28 IL IL63968A patent/IL63968A/xx unknown
- 1981-09-29 PT PT73744A patent/PT73744B/pt unknown
- 1981-10-01 FR FR8118528A patent/FR2491067A1/fr active Granted
- 1981-10-01 DE DE19813139134 patent/DE3139134A1/de active Granted
- 1981-10-01 ZA ZA816809A patent/ZA816809B/xx unknown
- 1981-10-01 JP JP56154887A patent/JPS5791983A/ja active Granted
- 1981-10-01 ZW ZW244/81A patent/ZW24481A1/xx unknown
- 1981-10-01 LU LU83661A patent/LU83661A1/fr unknown
- 1981-10-01 CH CH6322/81A patent/CH652122A5/fr not_active IP Right Cessation
- 1981-10-01 ES ES505951A patent/ES505951A0/es active Granted
- 1981-10-01 AT AT0422281A patent/AT389696B/de not_active IP Right Cessation
- 1981-10-01 DK DK436281A patent/DK167794B1/da not_active IP Right Cessation
- 1981-10-01 GR GR66187A patent/GR72499B/el unknown
- 1981-10-01 NL NL8104482A patent/NL8104482A/nl active Search and Examination
- 1981-10-01 NZ NZ198522A patent/NZ198522A/en unknown
- 1981-10-01 PH PH26300A patent/PH19489A/en unknown
- 1981-10-01 BE BE0/206126A patent/BE890574A/fr not_active IP Right Cessation
- 1981-10-01 CA CA000387135A patent/CA1202638A/en not_active Expired
- 1981-10-01 AU AU75955/81A patent/AU549119B2/en not_active Expired
- 1981-10-01 SE SE8105812A patent/SE453500B/sv not_active IP Right Cessation
- 1981-10-01 IE IE2287/81A patent/IE51604B1/en not_active IP Right Cessation
- 1981-10-01 IT IT49407/81A patent/IT1143237B/it active
- 1981-10-01 KR KR1019810003689A patent/KR870001431B1/ko not_active IP Right Cessation
-
1982
- 1982-08-09 US US06/406,710 patent/US4521431A/en not_active Expired - Lifetime
-
1985
- 1985-03-18 US US06/712,610 patent/US4672133A/en not_active Expired - Lifetime
- 1985-07-17 KE KE3549A patent/KE3549A/xx unknown
- 1985-12-05 HK HK979/85A patent/HK97985A/xx not_active IP Right Cessation
- 1985-12-20 PH PH33229A patent/PH21761A/en unknown
- 1985-12-30 MY MY747/85A patent/MY8500747A/xx unknown
-
1991
- 1991-12-23 SK SK4035-91A patent/SK403591A3/sk unknown
- 1991-12-23 CZ CS914035A patent/CZ280885B6/cs unknown
-
1992
- 1992-03-12 DK DK033792A patent/DK167923B1/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |