DK166545B1 - 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling - Google Patents

17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling Download PDF

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Publication number
DK166545B1
DK166545B1 DK212184A DK212184A DK166545B1 DK 166545 B1 DK166545 B1 DK 166545B1 DK 212184 A DK212184 A DK 212184A DK 212184 A DK212184 A DK 212184A DK 166545 B1 DK166545 B1 DK 166545B1
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DK
Denmark
Prior art keywords
group
groups
steroids
alkyl
mmol
Prior art date
Application number
DK212184A
Other languages
Danish (da)
English (en)
Other versions
DK212184D0 (da
DK212184A (da
Inventor
Albert Mattheus Van Leusen
Adriaan Marinus Van Leusen
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of DK212184D0 publication Critical patent/DK212184D0/da
Publication of DK212184A publication Critical patent/DK212184A/da
Application granted granted Critical
Publication of DK166545B1 publication Critical patent/DK166545B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK212184A 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling DK166545B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP83200616A EP0123734A1 (en) 1983-04-29 1983-04-29 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation
EP83200616 1983-04-29

Publications (3)

Publication Number Publication Date
DK212184D0 DK212184D0 (da) 1984-04-27
DK212184A DK212184A (da) 1984-10-30
DK166545B1 true DK166545B1 (da) 1993-06-07

Family

ID=8190949

Family Applications (2)

Application Number Title Priority Date Filing Date
DK212184A DK166545B1 (da) 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling
DK022192A DK166831B1 (da) 1983-04-29 1992-02-21 17-(formamido-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK022192A DK166831B1 (da) 1983-04-29 1992-02-21 17-(formamido-sulfonylmethylen)-steroider og fremgangsmaade til deres fremstilling

Country Status (17)

Country Link
US (1) US4647410A (enExample)
EP (2) EP0123734A1 (enExample)
JP (2) JPS59206399A (enExample)
KR (1) KR860001469B1 (enExample)
AU (1) AU568643B2 (enExample)
CA (1) CA1257249A (enExample)
DE (1) DE3461381D1 (enExample)
DK (2) DK166545B1 (enExample)
ES (2) ES8608537A1 (enExample)
FI (1) FI82061C (enExample)
GR (1) GR81997B (enExample)
HU (2) HU193207B (enExample)
IE (1) IE57328B1 (enExample)
IL (1) IL71658A (enExample)
NO (1) NO167093C (enExample)
NZ (1) NZ207985A (enExample)
PT (1) PT78503B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
HU208437B (en) * 1988-04-08 1993-10-28 Roussel Uclaf Process for producing 9-alpha-hydroxy- -17-methylene-steroides for synthetizing corticosteroides
HU226413B1 (en) * 1991-06-25 2008-11-28 Aventis Pharma Sa Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
WO1997021720A2 (en) 1995-12-11 1997-06-19 G.D. Searle And Co. Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
EP2287721A3 (en) 1999-11-02 2011-04-06 Canon Kabushiki Kaisha Print control method and apparatus
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN105481924B (zh) * 2015-11-24 2017-08-15 浙江省诸暨合力化学对外贸易有限公司 一种黄体酮的制备方法
US20240368212A1 (en) * 2021-08-26 2024-11-07 Brandeis University Selective isonitrile inhibitors of cytochrome p450 subtypes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807631A (nl) * 1978-07-17 1980-01-21 Gist Brocades Nv Isocyanoderivaten en hun bereiding.
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto

Also Published As

Publication number Publication date
JPH0559097A (ja) 1993-03-09
GR81997B (enExample) 1984-12-12
DK166831B1 (da) 1993-07-19
IL71658A0 (en) 1984-07-31
PT78503A (en) 1984-05-01
HU193207B (en) 1987-08-28
AU2713384A (en) 1984-11-01
PT78503B (en) 1986-05-20
DK22192D0 (da) 1992-02-21
EP0123734A1 (en) 1984-11-07
JPH053478B2 (enExample) 1993-01-14
FI841679A7 (fi) 1984-10-30
ES8608537A1 (es) 1986-07-16
DK212184D0 (da) 1984-04-27
NO167093B (no) 1991-06-24
IE841038L (en) 1984-10-29
US4647410A (en) 1987-03-03
FI82061B (fi) 1990-09-28
DK212184A (da) 1984-10-30
EP0124934B1 (en) 1986-11-20
DE3461381D1 (en) 1987-01-08
ES553609A0 (es) 1987-11-01
DK22192A (da) 1992-02-21
CA1257249A (en) 1989-07-11
FI841679A0 (fi) 1984-04-27
JPS59206399A (ja) 1984-11-22
HU194277B (en) 1988-01-28
EP0124934A1 (en) 1984-11-14
ES8800263A1 (es) 1987-11-01
FI82061C (fi) 1991-01-10
AU568643B2 (en) 1988-01-07
IE57328B1 (en) 1992-07-29
NO841700L (no) 1984-10-30
HUT34220A (en) 1985-02-28
JPH0717673B2 (ja) 1995-03-01
NZ207985A (en) 1986-11-12
ES532029A0 (es) 1986-07-16
KR860001469B1 (ko) 1986-09-26
KR840008461A (ko) 1984-12-15
IL71658A (en) 1988-03-31
NO167093C (no) 1991-10-02

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed