DE3461381D1 - 17-(isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation - Google Patents

17-(isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation

Info

Publication number
DE3461381D1
DE3461381D1 DE8484200595T DE3461381T DE3461381D1 DE 3461381 D1 DE3461381 D1 DE 3461381D1 DE 8484200595 T DE8484200595 T DE 8484200595T DE 3461381 T DE3461381 T DE 3461381T DE 3461381 D1 DE3461381 D1 DE 3461381D1
Authority
DE
Germany
Prior art keywords
sulfonylmethylene
steroids
formamido
isocyano
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484200595T
Other languages
German (de)
English (en)
Inventor
Leusen Albert Mattheus Van
Leusen Adriaan Marinus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Application granted granted Critical
Publication of DE3461381D1 publication Critical patent/DE3461381D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8484200595T 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation Expired DE3461381D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP83200616A EP0123734A1 (en) 1983-04-29 1983-04-29 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation

Publications (1)

Publication Number Publication Date
DE3461381D1 true DE3461381D1 (en) 1987-01-08

Family

ID=8190949

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484200595T Expired DE3461381D1 (en) 1983-04-29 1984-04-27 17-(isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation

Country Status (17)

Country Link
US (1) US4647410A (enExample)
EP (2) EP0123734A1 (enExample)
JP (2) JPS59206399A (enExample)
KR (1) KR860001469B1 (enExample)
AU (1) AU568643B2 (enExample)
CA (1) CA1257249A (enExample)
DE (1) DE3461381D1 (enExample)
DK (2) DK166545B1 (enExample)
ES (2) ES8608537A1 (enExample)
FI (1) FI82061C (enExample)
GR (1) GR81997B (enExample)
HU (2) HU193207B (enExample)
IE (1) IE57328B1 (enExample)
IL (1) IL71658A (enExample)
NO (1) NO167093C (enExample)
NZ (1) NZ207985A (enExample)
PT (1) PT78503B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
HU208437B (en) * 1988-04-08 1993-10-28 Roussel Uclaf Process for producing 9-alpha-hydroxy- -17-methylene-steroides for synthetizing corticosteroides
HU226413B1 (en) * 1991-06-25 2008-11-28 Aventis Pharma Sa Novel 16-(nitro-substituted methyl)pregna-1,4-dien-3,20-dion derivatives and process for producing them
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
WO1997021720A2 (en) 1995-12-11 1997-06-19 G.D. Searle And Co. Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
EP2287721A3 (en) 1999-11-02 2011-04-06 Canon Kabushiki Kaisha Print control method and apparatus
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN105481924B (zh) * 2015-11-24 2017-08-15 浙江省诸暨合力化学对外贸易有限公司 一种黄体酮的制备方法
US20240368212A1 (en) * 2021-08-26 2024-11-07 Brandeis University Selective isonitrile inhibitors of cytochrome p450 subtypes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807631A (nl) * 1978-07-17 1980-01-21 Gist Brocades Nv Isocyanoderivaten en hun bereiding.
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2486947A1 (fr) * 1980-07-15 1982-01-22 Roussel Uclaf Nouveaux derives steroides 20-isonitriles 17(20) insatures, leur procede de preparation et leur application a la preparation des steroides 17a-hydroxy 20-ceto

Also Published As

Publication number Publication date
JPH0559097A (ja) 1993-03-09
GR81997B (enExample) 1984-12-12
DK166831B1 (da) 1993-07-19
IL71658A0 (en) 1984-07-31
PT78503A (en) 1984-05-01
HU193207B (en) 1987-08-28
AU2713384A (en) 1984-11-01
PT78503B (en) 1986-05-20
DK22192D0 (da) 1992-02-21
EP0123734A1 (en) 1984-11-07
JPH053478B2 (enExample) 1993-01-14
FI841679A7 (fi) 1984-10-30
ES8608537A1 (es) 1986-07-16
DK212184D0 (da) 1984-04-27
NO167093B (no) 1991-06-24
IE841038L (en) 1984-10-29
US4647410A (en) 1987-03-03
FI82061B (fi) 1990-09-28
DK212184A (da) 1984-10-30
EP0124934B1 (en) 1986-11-20
ES553609A0 (es) 1987-11-01
DK22192A (da) 1992-02-21
CA1257249A (en) 1989-07-11
FI841679A0 (fi) 1984-04-27
JPS59206399A (ja) 1984-11-22
HU194277B (en) 1988-01-28
EP0124934A1 (en) 1984-11-14
ES8800263A1 (es) 1987-11-01
FI82061C (fi) 1991-01-10
AU568643B2 (en) 1988-01-07
DK166545B1 (da) 1993-06-07
IE57328B1 (en) 1992-07-29
NO841700L (no) 1984-10-30
HUT34220A (en) 1985-02-28
JPH0717673B2 (ja) 1995-03-01
NZ207985A (en) 1986-11-12
ES532029A0 (es) 1986-07-16
KR860001469B1 (ko) 1986-09-26
KR840008461A (ko) 1984-12-15
IL71658A (en) 1988-03-31
NO167093C (no) 1991-10-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ROUSSEL UCLAF, PARIS, FR

8328 Change in the person/name/address of the agent

Free format text: ZUMSTEIN, F., DIPL.-CHEM. DR.RER.NAT. KLINGSEISEN, F., DIPL.-ING., PAT.-ANWAELTE, 8000 MUENCHEN

8339 Ceased/non-payment of the annual fee