DK165620C - Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet - Google Patents

Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Info

Publication number
DK165620C
DK165620C DK481585A DK481585A DK165620C DK 165620 C DK165620 C DK 165620C DK 481585 A DK481585 A DK 481585A DK 481585 A DK481585 A DK 481585A DK 165620 C DK165620 C DK 165620C
Authority
DK
Denmark
Prior art keywords
preparation
anthracycliclycoside
annostation
cosolubilizing
freeze
Prior art date
Application number
DK481585A
Other languages
Danish (da)
English (en)
Other versions
DK481585D0 (da
DK165620B (da
DK481585A (da
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of DK481585D0 publication Critical patent/DK481585D0/da
Publication of DK481585A publication Critical patent/DK481585A/da
Publication of DK165620B publication Critical patent/DK165620B/da
Application granted granted Critical
Publication of DK165620C publication Critical patent/DK165620C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK481585A 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet DK165620C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8426672 1984-10-22
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (4)

Publication Number Publication Date
DK481585D0 DK481585D0 (da) 1985-10-21
DK481585A DK481585A (da) 1986-04-23
DK165620B DK165620B (da) 1992-12-28
DK165620C true DK165620C (da) 1993-06-01

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
DK481585A DK165620C (da) 1984-10-22 1985-10-21 Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet

Country Status (35)

Country Link
US (4) US4675311A (enExample)
JP (1) JPH0611700B2 (enExample)
KR (1) KR920005813B1 (enExample)
CN (1) CN85107562B (enExample)
AT (1) AT401345B (enExample)
AU (1) AU572003B2 (enExample)
BE (1) BE903484A (enExample)
BG (1) BG60934B2 (enExample)
CA (1) CA1248453A (enExample)
CH (1) CH667594A5 (enExample)
CS (1) CS270421B2 (enExample)
DE (1) DE3536896C2 (enExample)
DK (1) DK165620C (enExample)
ES (1) ES8605374A1 (enExample)
FI (2) FI853913A7 (enExample)
FR (1) FR2571966B1 (enExample)
GB (2) GB8426672D0 (enExample)
GR (1) GR852549B (enExample)
HK (1) HK94390A (enExample)
HU (1) HU197988B (enExample)
IE (1) IE56992B1 (enExample)
IL (1) IL76732A (enExample)
IT (1) IT1186779B (enExample)
MY (1) MY103956A (enExample)
NL (1) NL191308C (enExample)
NO (1) NO170616C (enExample)
NZ (1) NZ213885A (enExample)
PH (1) PH23982A (enExample)
PT (1) PT81347B (enExample)
RU (2) RU1836088C (enExample)
SE (1) SE467520B (enExample)
SG (1) SG80290G (enExample)
UA (2) UA34419C2 (enExample)
YU (1) YU46160B (enExample)
ZA (1) ZA858033B (enExample)

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JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
AU741439B2 (en) 1996-12-30 2001-11-29 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
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RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
CN101172104B (zh) 2002-02-22 2013-04-03 默沙东公司 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
ES2425083T3 (es) * 2003-09-25 2013-10-11 Astellas Pharma Inc. Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
BRPI0605832A2 (pt) * 2005-05-11 2009-05-26 Sicor Inc glicosìdeos de antraciclina liofilizados estáveis
CA2615173C (en) 2005-07-14 2012-01-03 Lipothera, Inc. Sustained release enhanced lipolytic formulation for regional adipose tissue treatment
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
CN101743020A (zh) * 2007-05-16 2010-06-16 Ktb肿瘤研究有限责任公司 低粘度蒽环制剂
EP2184066B1 (en) * 2007-09-04 2013-11-06 Meiji Seika Pharma Co., Ltd. Injection, injection solution and injection kit preparation
KR20100058662A (ko) * 2007-10-26 2010-06-03 화이자 프로덕츠 인코포레이티드 개에게서 림프종을 치료하기 위한 이다루비신
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
GB2487868B (en) * 2010-01-15 2014-12-10 Neothetics Inc Lyophilized cake formulations
UA111822C2 (uk) 2010-11-24 2016-06-24 Общєство С Огранічєнной Отвєтствєнностью "Новамедіка" Монотерапевтичий препарат селективного ліпофільного бета-агоніста тривалої дії і спосіб косметичного лікування ожиріння і контурного випинання
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
CA2894548C (en) 2012-12-13 2021-01-12 Cytrx Corporation Anthracycline formulations
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Also Published As

Publication number Publication date
NO854194L (no) 1986-04-23
AT401345B (de) 1996-08-26
GB2165751A (en) 1986-04-23
RU1836088C (ru) 1993-08-23
DE3536896A1 (de) 1986-04-24
JPS61246129A (ja) 1986-11-01
DK481585D0 (da) 1985-10-21
DE3536896C2 (de) 1996-11-14
IL76732A (en) 1989-07-31
IL76732A0 (en) 1986-02-28
NL191308B (nl) 1994-12-16
AU4880585A (en) 1986-05-01
NO170616C (no) 1992-11-11
IE56992B1 (en) 1992-02-26
MY103956A (en) 1993-10-30
GB8426672D0 (en) 1984-11-28
YU46160B (sh) 1993-05-28
BG60934B2 (bg) 1996-06-28
RU2101018C1 (ru) 1998-01-10
GB2165751B (en) 1988-08-17
CS756585A2 (en) 1989-11-14
SE8504945D0 (sv) 1985-10-21
CH667594A5 (de) 1988-10-31
SE467520B (sv) 1992-08-03
US5091373A (en) 1992-02-25
FR2571966A1 (fr) 1986-04-25
CN85107562A (zh) 1986-07-23
HU197988B (en) 1989-07-28
DK165620B (da) 1992-12-28
SE8504945L (sv) 1986-04-23
ES547578A0 (es) 1986-03-16
PT81347A (en) 1985-11-01
NZ213885A (en) 1988-05-30
HUT40759A (en) 1987-02-27
FI86252B (fi) 1992-04-30
GB8525709D0 (en) 1985-11-20
YU164485A (en) 1987-10-31
UA19169A (uk) 1997-12-25
GR852549B (enExample) 1986-02-24
IE852593L (en) 1986-04-22
CN85107562B (zh) 1988-06-01
DK481585A (da) 1986-04-23
ES8605374A1 (es) 1986-03-16
PT81347B (pt) 1987-11-11
FI854035L (fi) 1986-04-23
FR2571966B1 (fr) 1988-04-15
IT8522507A0 (it) 1985-10-16
US4675311A (en) 1987-06-23
BE903484A (fr) 1986-04-21
PH23982A (en) 1990-02-09
FI853913A7 (fi) 1986-04-23
JPH0611700B2 (ja) 1994-02-16
UA34419C2 (uk) 2001-03-15
NL8502869A (nl) 1986-05-16
NL191308C (nl) 1995-05-16
US4840938A (en) 1989-06-20
HK94390A (en) 1990-11-23
ZA858033B (en) 1986-06-25
US5091372A (en) 1992-02-25
AU572003B2 (en) 1988-04-28
KR860003014A (ko) 1986-05-19
IT1186779B (it) 1987-12-16
ATA303285A (de) 1996-01-15
KR920005813B1 (ko) 1992-07-20
FI854035A0 (fi) 1985-10-16
FI86252C (fi) 1992-08-10
CS270421B2 (en) 1990-06-13
CA1248453A (en) 1989-01-10
NO170616B (no) 1992-08-03
FI853913A0 (fi) 1985-10-08
SG80290G (en) 1990-11-23

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