DK280085D0 - 7alfa-acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner samt deresfremstilling og anvendelse - Google Patents

7alfa-acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner samt deresfremstilling og anvendelse

Info

Publication number
DK280085D0
DK280085D0 DK280085A DK280085A DK280085D0 DK 280085 D0 DK280085 D0 DK 280085D0 DK 280085 A DK280085 A DK 280085A DK 280085 A DK280085 A DK 280085A DK 280085 D0 DK280085 D0 DK 280085D0
Authority
DK
Denmark
Prior art keywords
9alfa
11alfa
7alfa
spirox
acylthio
Prior art date
Application number
DK280085A
Other languages
English (en)
Other versions
DK280085A (da
DK173854B1 (da
Inventor
Michel Biollaz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK280085D0 publication Critical patent/DK280085D0/da
Publication of DK280085A publication Critical patent/DK280085A/da
Application granted granted Critical
Publication of DK173854B1 publication Critical patent/DK173854B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198502800A 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater DK173854B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH300984 1984-06-21
CH300984 1984-06-21
CH464684 1984-09-28
CH464684 1984-09-28

Publications (3)

Publication Number Publication Date
DK280085D0 true DK280085D0 (da) 1985-06-20
DK280085A DK280085A (da) 1985-12-22
DK173854B1 DK173854B1 (da) 2001-12-27

Family

ID=25691934

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198502800A DK173854B1 (da) 1984-06-21 1985-06-20 7alfa-Acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner, fremgangsmåde til deres fremstilling, farmaceutiske præparater med indhold deraf samt deres anvendelse til fremstilling af farmaceutiske præparater

Country Status (16)

Country Link
US (1) US4670551A (da)
EP (1) EP0165902B1 (da)
AR (2) AR242036A1 (da)
AU (1) AU582754B2 (da)
CA (1) CA1239388A (da)
DE (1) DE3569540D1 (da)
DK (1) DK173854B1 (da)
ES (2) ES8704967A1 (da)
FI (1) FI83225C (da)
GR (1) GR851499B (da)
HU (1) HU192232B (da)
IE (1) IE58050B1 (da)
IL (1) IL75569A (da)
NO (1) NO165496C (da)
NZ (1) NZ212492A (da)
PT (1) PT80663B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100384866C (zh) 1995-12-11 2008-04-30 G·D·瑟尔公司 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法
EP1223174A3 (en) * 1996-12-11 2005-03-16 G.D. Searle & Co. Processes for preparation of 3-keto-7alpha-alkoxycarbonyl-delta-4,5- steroids and intermediates useful therein
PT944644E (pt) * 1996-12-11 2003-02-28 Searle & Co Processos para a preparacao de esteroides 9,11-epoxi e intermediarios uteis para esse efeito
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
EP1455795A1 (en) 2001-12-12 2004-09-15 Pharmacia Corporation Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
ATE51233T1 (de) * 1983-08-17 1990-04-15 Schering Ag 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.

Also Published As

Publication number Publication date
US4670551A (en) 1987-06-02
DE3569540D1 (en) 1989-05-24
FI852430A0 (fi) 1985-06-19
IL75569A0 (en) 1985-10-31
CA1239388A (en) 1988-07-19
IE851535L (en) 1985-12-21
PT80663B (en) 1987-05-08
NO165496B (no) 1990-11-12
NO165496C (no) 1991-02-20
DK280085A (da) 1985-12-22
EP0165902A2 (de) 1985-12-27
PT80663A (en) 1985-07-01
FI83225C (fi) 1991-06-10
ES8707737A1 (es) 1987-08-16
HU192232B (en) 1987-05-28
AR245731A1 (es) 1994-02-28
IL75569A (en) 1989-03-31
ES8704967A1 (es) 1987-04-16
IE58050B1 (en) 1993-06-16
FI852430L (fi) 1985-12-22
AU582754B2 (en) 1989-04-13
DK173854B1 (da) 2001-12-27
ES557112A0 (es) 1987-08-16
GR851499B (da) 1985-11-25
ES544387A0 (es) 1987-04-16
AU4397185A (en) 1986-01-02
HUT38367A (en) 1986-05-28
NO852501L (no) 1985-12-23
AR242036A1 (es) 1993-02-26
NZ212492A (en) 1989-02-24
EP0165902A3 (en) 1986-10-22
FI83225B (fi) 1991-02-28
EP0165902B1 (de) 1989-04-19

Similar Documents

Publication Publication Date Title
DK129386A (da) Iodpropargylethere, deres fremstilling og anvendelse
DK416985D0 (da) Substitueret 1,4-dihydropyridincarbonyl-piperidinoforbindelser samt deres fremstilling og anvendelse
DK420785D0 (da) 13-halogen- eller 13-hydroxymilbemyciner samt deres fremstilling og anvendelse
DK158522C (da) Beta-amylase, samt fremstilling og anvendelse deraf
DK519586A (da) 1-aryl-4-nitro-pyrazoler, deres fremstilling og anvendelse
DK280085A (da) 7alfa-acylthio-9alfa,11alfa-epoxy-20-spirox-4-en-3,21-dioner samt deresfremstilling og anvendelse
DK451786A (da) Transglucosidase, fremstilling og anvendelse deraf
NO854968L (no) Alkosymetyleter- og alkoksymetylesterderivater.
DK514382A (da) Azolylvinyldithioacetaler, deres fremstilling og anvendelse
DK380286A (da) Sulfonamider, deres fremstilling og anvendelse
DK295785A (da) 1,8-diacyloxy-10-acyl-anthroner, deres fremstilling og anvendelse
DK289287D0 (da) 1-phenylalkylimidazol-4- og/eller -5-carboxamider samt deres fremstiling og anvendelse
DK393285D0 (da) Substituerede carbonylphenylsulfonylguanidiner samt deres fremstilling og anvendelse
DK396886D0 (da) Gem-dihalogen-1,8-diamino-4-azaoctaner, deres fremstilling og anvendelse
DK617886D0 (da) 1-aryl-pyrazoler, deres fremstilling og anvendelse
DK119585A (da) 1,2,4-triazacycloalkadienderivater samt deres fremstilling og anvendelse
DK162979C (da) Polyfluoralkylestere, deres fremstilling og anvendelse
DK8887A (da) Substituerede 1,3,5-oxadiazin-2-oner samt deres fremstilling og anvendelse
DK538382A (da) P-oxooxazolidinylbenzensulfonamider, deres fremstilling og anvendelse
DK377786D0 (da) 1-aryl-5-hydrazino-pyrazoler, deres fremstilling og anvendelse
DK516982A (da) P-phenylendiaminer, deres fremstilling og anvendelse
DK181485D0 (da) 3-substituerede thiopyroner samt deres fremstilling og anvendelse
DK393986D0 (da) Lactamamider, deres fremstilling og anvendelse
DK421485A (da) Substituerede 1,1-bis-azolyl-butan-2-oner og -oler samt deres fremstilling og anvendelse
DK451486A (da) Alkenylazoler, deres fremstilling og anvendelse

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK