ES8704967A1 - Procedimiento para la obtencion de un 9alfa, 11alfa-epoxiesteroide. - Google Patents

Procedimiento para la obtencion de un 9alfa, 11alfa-epoxiesteroide.

Info

Publication number
ES8704967A1
ES8704967A1 ES544387A ES544387A ES8704967A1 ES 8704967 A1 ES8704967 A1 ES 8704967A1 ES 544387 A ES544387 A ES 544387A ES 544387 A ES544387 A ES 544387A ES 8704967 A1 ES8704967 A1 ES 8704967A1
Authority
ES
Spain
Prior art keywords
alpha
epoxy
epoxy steroids
spirox
hyperaldosteronism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544387A
Other languages
English (en)
Other versions
ES544387A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES8704967A1 publication Critical patent/ES8704967A1/es
Publication of ES544387A0 publication Critical patent/ES544387A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 91,11-A-EPOXIESTEROIDES, DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO 9-A,11-A-EPOXI-6,7-INSATURADO, DE FORMULA (II), CON UN TIOACIDO INFERIOR DE RSH, PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LA QUE R REPRESENTA ALCANOILO INFERIOR Y -A-A- ES RADICAL ETILENO O CICLOPROPILENO. LA REACCION SE EFECTUA EN UN ALCANOL INFERIOR, EN PRESENCIA DE UN CATALIZADOR ACIDO O BAJO RADIACION ULTRAVIOLETA, A UNA TEMPERATURA COMPRENDIDA ENTRE LA AMBIENTE Y 100º C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO DIURETICOS AHORRADORES DEL POTASIO.
ES544387A 1984-06-21 1985-06-20 Procedimiento para la obtencion de un 9alfa, 11alfa-epoxiesteroide. Expired ES8704967A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH300984 1984-06-21
CH464684 1984-09-28

Publications (2)

Publication Number Publication Date
ES8704967A1 true ES8704967A1 (es) 1987-04-16
ES544387A0 ES544387A0 (es) 1987-04-16

Family

ID=25691934

Family Applications (2)

Application Number Title Priority Date Filing Date
ES544387A Expired ES8704967A1 (es) 1984-06-21 1985-06-20 Procedimiento para la obtencion de un 9alfa, 11alfa-epoxiesteroide.
ES557112A Expired ES8707737A1 (es) 1984-06-21 1986-10-01 Procedimiento para la obtencion de una 9 l 11 l epoxiesteroide

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557112A Expired ES8707737A1 (es) 1984-06-21 1986-10-01 Procedimiento para la obtencion de una 9 l 11 l epoxiesteroide

Country Status (16)

Country Link
US (1) US4670551A (es)
EP (1) EP0165902B1 (es)
AR (2) AR242036A1 (es)
AU (1) AU582754B2 (es)
CA (1) CA1239388A (es)
DE (1) DE3569540D1 (es)
DK (1) DK173854B1 (es)
ES (2) ES8704967A1 (es)
FI (1) FI83225C (es)
GR (1) GR851499B (es)
HU (1) HU192232B (es)
IE (1) IE58050B1 (es)
IL (1) IL75569A (es)
NO (1) NO165496C (es)
NZ (1) NZ212492A (es)
PT (1) PT80663B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE365171T1 (de) * 1995-12-11 2007-07-15 Searle Llc Verfahren zur herstellung einer epoxyverbindung
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
EP1148061B1 (en) * 1996-12-11 2007-10-17 G.D. Searle LLC. Epoxidation process
ATE375992T1 (de) * 1996-12-11 2007-11-15 Searle Llc Epoxidierungsverfahren
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
JP2005516914A (ja) 2001-12-12 2005-06-09 ファルマシア・コーポレーション エポキシ−ステロイド系アルドステロン受容体アンタゴニストで眼病を治療する方法
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
WO2007025780A2 (en) * 2005-09-02 2007-03-08 Recordati Ireland Limited Aldosterone receptor antagonists
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013012A (en) * 1960-12-22 1961-12-12 Searle & Co Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones
US3095412A (en) * 1961-12-19 1963-06-25 Searle & Co 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
DE2652761C2 (de) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US4559332A (en) * 1983-04-13 1985-12-17 Ciba Geigy Corporation 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof
EP0134529B1 (de) * 1983-08-17 1990-03-21 Schering Aktiengesellschaft 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
AU582754B2 (en) 1989-04-13
IL75569A0 (en) 1985-10-31
FI852430A0 (fi) 1985-06-19
DK280085A (da) 1985-12-22
EP0165902A3 (en) 1986-10-22
AR245731A1 (es) 1994-02-28
EP0165902B1 (de) 1989-04-19
NO165496C (no) 1991-02-20
DK173854B1 (da) 2001-12-27
CA1239388A (en) 1988-07-19
IE851535L (en) 1985-12-21
PT80663B (en) 1987-05-08
ES544387A0 (es) 1987-04-16
US4670551A (en) 1987-06-02
EP0165902A2 (de) 1985-12-27
ES8707737A1 (es) 1987-08-16
DE3569540D1 (en) 1989-05-24
HU192232B (en) 1987-05-28
AR242036A1 (es) 1993-02-26
GR851499B (es) 1985-11-25
IE58050B1 (en) 1993-06-16
NZ212492A (en) 1989-02-24
FI83225B (fi) 1991-02-28
PT80663A (en) 1985-07-01
AU4397185A (en) 1986-01-02
FI83225C (fi) 1991-06-10
NO852501L (no) 1985-12-23
HUT38367A (en) 1986-05-28
NO165496B (no) 1990-11-12
DK280085D0 (da) 1985-06-20
IL75569A (en) 1989-03-31
FI852430L (fi) 1985-12-22
ES557112A0 (es) 1987-08-16

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20041004