NL191308C - Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. - Google Patents

Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Info

Publication number
NL191308C
NL191308C NL8502869A NL8502869A NL191308C NL 191308 C NL191308 C NL 191308C NL 8502869 A NL8502869 A NL 8502869A NL 8502869 A NL8502869 A NL 8502869A NL 191308 C NL191308 C NL 191308C
Authority
NL
Netherlands
Prior art keywords
solution
injectable
anthracycline glycoside
preparation
preparation containing
Prior art date
Application number
NL8502869A
Other languages
English (en)
Dutch (nl)
Other versions
NL191308B (nl
NL8502869A (nl
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NL8502869A publication Critical patent/NL8502869A/nl
Publication of NL191308B publication Critical patent/NL191308B/xx
Application granted granted Critical
Publication of NL191308C publication Critical patent/NL191308C/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8502869A 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. NL191308C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8426672 1984-10-22
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions

Publications (3)

Publication Number Publication Date
NL8502869A NL8502869A (nl) 1986-05-16
NL191308B NL191308B (nl) 1994-12-16
NL191308C true NL191308C (nl) 1995-05-16

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502869A NL191308C (nl) 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Country Status (35)

Country Link
US (4) US4675311A (enExample)
JP (1) JPH0611700B2 (enExample)
KR (1) KR920005813B1 (enExample)
CN (1) CN85107562B (enExample)
AT (1) AT401345B (enExample)
AU (1) AU572003B2 (enExample)
BE (1) BE903484A (enExample)
BG (1) BG60934B2 (enExample)
CA (1) CA1248453A (enExample)
CH (1) CH667594A5 (enExample)
CS (1) CS270421B2 (enExample)
DE (1) DE3536896C2 (enExample)
DK (1) DK165620C (enExample)
ES (1) ES8605374A1 (enExample)
FI (2) FI853913A7 (enExample)
FR (1) FR2571966B1 (enExample)
GB (2) GB8426672D0 (enExample)
GR (1) GR852549B (enExample)
HK (1) HK94390A (enExample)
HU (1) HU197988B (enExample)
IE (1) IE56992B1 (enExample)
IL (1) IL76732A (enExample)
IT (1) IT1186779B (enExample)
MY (1) MY103956A (enExample)
NL (1) NL191308C (enExample)
NO (1) NO170616C (enExample)
NZ (1) NZ213885A (enExample)
PH (1) PH23982A (enExample)
PT (1) PT81347B (enExample)
RU (2) RU1836088C (enExample)
SE (1) SE467520B (enExample)
SG (1) SG80290G (enExample)
UA (2) UA34419C2 (enExample)
YU (1) YU46160B (enExample)
ZA (1) ZA858033B (enExample)

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US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB2200047B (en) * 1986-12-05 1990-11-21 Erba Carlo Spa Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
DE3801178A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung
US6300361B1 (en) 1990-07-25 2001-10-09 Novartis Ag Stabilized pharmaceutical compositions comprising acid donors
NZ336381A (en) 1996-12-30 2000-11-24 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5942508A (en) * 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
CN100346784C (zh) 2002-02-22 2007-11-07 先灵公司 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
WO2005004805A2 (en) * 2003-07-02 2005-01-20 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
DE602004027824D1 (de) * 2003-09-25 2010-08-05 Astellas Pharma Inc Antitumorales mittel mit einem histon-deacetylase-hemmer und einem topoisomerase-ii-hemmer
RU2262923C2 (ru) * 2003-12-25 2005-10-27 Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации Иммобилизованная форма доксорубицина
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
BRPI0605832A2 (pt) * 2005-05-11 2009-05-26 Sicor Inc glicosìdeos de antraciclina liofilizados estáveis
CN106075449A (zh) 2005-07-14 2016-11-09 尼奥塞蒂克斯公司 用于局部脂肪组织治疗的持续释放的增强性脂肪分解性制剂
DE06848583T1 (de) * 2005-12-13 2011-03-17 Solux Corporation, San Diego Verfahren zur herstellung von 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
EP2152312B1 (en) * 2007-05-16 2014-12-31 KTB Tumorforschungsgesellschaft mbH Low-viscous anthracycline formulation
BRPI0816364B8 (pt) * 2007-09-04 2021-05-25 Meiji Seika Kaisha solução de injeção, preparação de kit de injeção e injetável para preparar solução de injeção
US20100234314A1 (en) * 2007-10-26 2010-09-16 Pfizer Inc. Idarubicin for the treatment of lymphoma in a dog
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
GB2487868B (en) * 2010-01-15 2014-12-10 Neothetics Inc Lyophilized cake formulations
BR112013012994A2 (pt) 2010-11-24 2016-09-13 Lithera Inc formulações monoterapêuticas de beta-agonista de longa duração, lipofílicas e seletivas e métodos para o tratamento cosmético da adiposidade e saliência de contorno
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
DE102011111991A1 (de) * 2011-08-30 2013-02-28 Lead Discovery Center Gmbh Neue Cyclosporin-Derivate
JP6433913B2 (ja) 2012-12-13 2018-12-05 サイトレックス コーポレイション アントラサイクリン製剤
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US4039663A (en) * 1975-03-19 1977-08-02 Societa' Farmaceutici Italia S.P.A. Daunomycins, process for their uses and intermediates
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GB1567456A (en) * 1976-11-16 1980-05-14 Farmaceutici Italia Daunomycin derivatives
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US4438105A (en) * 1982-04-19 1984-03-20 Farmaitalia Carlo Erba S.P.A 4'-Iododerivatives of anthracycline glycosides
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Also Published As

Publication number Publication date
DK165620B (da) 1992-12-28
SG80290G (en) 1990-11-23
ES547578A0 (es) 1986-03-16
PT81347B (pt) 1987-11-11
GB8426672D0 (en) 1984-11-28
FI854035A0 (fi) 1985-10-16
DE3536896A1 (de) 1986-04-24
YU46160B (sh) 1993-05-28
GR852549B (enExample) 1986-02-24
NO170616B (no) 1992-08-03
AU4880585A (en) 1986-05-01
DK481585D0 (da) 1985-10-21
SE8504945D0 (sv) 1985-10-21
US5091373A (en) 1992-02-25
MY103956A (en) 1993-10-30
SE8504945L (sv) 1986-04-23
DK165620C (da) 1993-06-01
ZA858033B (en) 1986-06-25
NO170616C (no) 1992-11-11
US4840938A (en) 1989-06-20
CA1248453A (en) 1989-01-10
NL191308B (nl) 1994-12-16
AU572003B2 (en) 1988-04-28
ES8605374A1 (es) 1986-03-16
DK481585A (da) 1986-04-23
FI853913A0 (fi) 1985-10-08
NO854194L (no) 1986-04-23
JPH0611700B2 (ja) 1994-02-16
IL76732A (en) 1989-07-31
UA19169A (uk) 1997-12-25
US4675311A (en) 1987-06-23
FI854035L (fi) 1986-04-23
IT1186779B (it) 1987-12-16
FI86252B (fi) 1992-04-30
HUT40759A (en) 1987-02-27
KR860003014A (ko) 1986-05-19
HK94390A (en) 1990-11-23
PT81347A (en) 1985-11-01
SE467520B (sv) 1992-08-03
IE56992B1 (en) 1992-02-26
IE852593L (en) 1986-04-22
UA34419C2 (uk) 2001-03-15
CH667594A5 (de) 1988-10-31
AT401345B (de) 1996-08-26
JPS61246129A (ja) 1986-11-01
GB2165751B (en) 1988-08-17
CN85107562A (zh) 1986-07-23
IT8522507A0 (it) 1985-10-16
FI853913A7 (fi) 1986-04-23
ATA303285A (de) 1996-01-15
CN85107562B (zh) 1988-06-01
RU1836088C (ru) 1993-08-23
RU2101018C1 (ru) 1998-01-10
NL8502869A (nl) 1986-05-16
FR2571966A1 (fr) 1986-04-25
CS756585A2 (en) 1989-11-14
HU197988B (en) 1989-07-28
FR2571966B1 (fr) 1988-04-15
FI86252C (fi) 1992-08-10
NZ213885A (en) 1988-05-30
BE903484A (fr) 1986-04-21
KR920005813B1 (ko) 1992-07-20
IL76732A0 (en) 1986-02-28
US5091372A (en) 1992-02-25
DE3536896C2 (de) 1996-11-14
YU164485A (en) 1987-10-31
PH23982A (en) 1990-02-09
CS270421B2 (en) 1990-06-13
BG60934B2 (bg) 1996-06-28
GB2165751A (en) 1986-04-23
GB8525709D0 (en) 1985-11-20

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BB A search report has been drawn up
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: ERBAMONT INDUSTRIALE S.R.L.

DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

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BC A request for examination has been filed
SNR Assignments of patents or rights arising from examined patent applications

Owner name: PHARMACIA S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA & UPJOHN S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA ITALIA S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20051021