NL191308C - Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. - Google Patents

Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Info

Publication number
NL191308C
NL191308C NL8502869A NL8502869A NL191308C NL 191308 C NL191308 C NL 191308C NL 8502869 A NL8502869 A NL 8502869A NL 8502869 A NL8502869 A NL 8502869A NL 191308 C NL191308 C NL 191308C
Authority
NL
Netherlands
Prior art keywords
solution
injectable
anthracycline glycoside
preparation
preparation containing
Prior art date
Application number
NL8502869A
Other languages
English (en)
Dutch (nl)
Other versions
NL191308B (nl
NL8502869A (nl
Inventor
Gaetano Gatti
Diego Oldani
Carlo Confalonieri
Luciano Gambini
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of NL8502869A publication Critical patent/NL8502869A/nl
Publication of NL191308B publication Critical patent/NL191308B/xx
Application granted granted Critical
Publication of NL191308C publication Critical patent/NL191308C/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL8502869A 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside. NL191308C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848426672A GB8426672D0 (en) 1984-10-22 1984-10-22 Pharmaceutical compositions
GB8426672 1984-10-22

Publications (3)

Publication Number Publication Date
NL8502869A NL8502869A (nl) 1986-05-16
NL191308B NL191308B (nl) 1994-12-16
NL191308C true NL191308C (nl) 1995-05-16

Family

ID=10568553

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8502869A NL191308C (nl) 1984-10-22 1985-10-21 Gelyofiliseerd, na oplossing injecteerbaar preparaat dat een antracycline-glycoside bevat, alsmede werkwijze voor de bereiding van een injecteerbare oplossing van een antracycline-glycoside.

Country Status (35)

Country Link
US (4) US4675311A (enExample)
JP (1) JPH0611700B2 (enExample)
KR (1) KR920005813B1 (enExample)
CN (1) CN85107562B (enExample)
AT (1) AT401345B (enExample)
AU (1) AU572003B2 (enExample)
BE (1) BE903484A (enExample)
BG (1) BG60934B2 (enExample)
CA (1) CA1248453A (enExample)
CH (1) CH667594A5 (enExample)
CS (1) CS270421B2 (enExample)
DE (1) DE3536896C2 (enExample)
DK (1) DK165620C (enExample)
ES (1) ES8605374A1 (enExample)
FI (2) FI853913A7 (enExample)
FR (1) FR2571966B1 (enExample)
GB (2) GB8426672D0 (enExample)
GR (1) GR852549B (enExample)
HK (1) HK94390A (enExample)
HU (1) HU197988B (enExample)
IE (1) IE56992B1 (enExample)
IL (1) IL76732A (enExample)
IT (1) IT1186779B (enExample)
MY (1) MY103956A (enExample)
NL (1) NL191308C (enExample)
NO (1) NO170616C (enExample)
NZ (1) NZ213885A (enExample)
PH (1) PH23982A (enExample)
PT (1) PT81347B (enExample)
RU (2) RU1836088C (enExample)
SE (1) SE467520B (enExample)
SG (1) SG80290G (enExample)
UA (2) UA34419C2 (enExample)
YU (1) YU46160B (enExample)
ZA (1) ZA858033B (enExample)

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RU2292216C2 (ru) * 2000-10-31 2007-01-27 Фарма Мар, С.А. Кахалалид f
CN101172104B (zh) 2002-02-22 2013-04-03 默沙东公司 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途
EP1474995B1 (en) * 2003-05-06 2012-11-14 Gumlink A/S A method for producing chewing gum granules, a gum composition extruder and granulating system, and a chewing gum product
US7485707B2 (en) * 2003-07-02 2009-02-03 Solux Corporation Thermally stable crystalline epirubicin hydrochloride and method of making the same
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
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US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
WO2006122309A2 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
ATE552032T1 (de) 2005-07-14 2012-04-15 Lithera Inc Verbesserte lipolytikum-formulierung mit hinhaltender wirkstofffreigabe für die arealbehandlung von fettgewebe
EP1976858B1 (en) * 2005-12-13 2016-01-06 Solux Corporation Method for preparing 4-demethyldaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8148338B2 (en) * 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
US7470672B2 (en) * 2006-07-31 2008-12-30 Savvipharm Inc. Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives
MX2009012370A (es) * 2007-05-16 2010-04-22 Ktb Tumorforschungs Gmbh Formulacion de antraciclina de baja viscosidad.
JP4456177B2 (ja) * 2007-09-04 2010-04-28 明治製菓株式会社 注射剤、注射液および注射用キット製剤
WO2009053804A2 (en) * 2007-10-26 2009-04-30 Pfizer Products Inc. Idarubicin for the treatment of lymphoma in a dog
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US9132084B2 (en) 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
SG2014014351A (en) * 2010-01-15 2014-07-30 Lithera Inc Lyophilized cake formulations
JP2013543897A (ja) 2010-11-24 2013-12-09 リセラ，インク． 脂肪症及び輪郭の膨れの美容処置のための、選択的な、親油性の、及び長時間作用性のベータアゴニストの単剤療法製剤、及び方法
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US20150342975A1 (en) 2012-12-13 2015-12-03 Cytrx Corporation Anthracycline formulations
KR102257647B1 (ko) 2013-06-05 2021-05-31 싸이트알엑스 코포레이션 암 치료용 세포독성제

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Also Published As

Publication number Publication date
BG60934B2 (bg) 1996-06-28
YU164485A (en) 1987-10-31
DK165620B (da) 1992-12-28
JPH0611700B2 (ja) 1994-02-16
SE8504945L (sv) 1986-04-23
AU572003B2 (en) 1988-04-28
FI86252C (fi) 1992-08-10
DE3536896A1 (de) 1986-04-24
NZ213885A (en) 1988-05-30
IL76732A (en) 1989-07-31
FR2571966B1 (fr) 1988-04-15
US4840938A (en) 1989-06-20
US5091372A (en) 1992-02-25
GB2165751B (en) 1988-08-17
CN85107562B (zh) 1988-06-01
GB2165751A (en) 1986-04-23
HU197988B (en) 1989-07-28
NO170616B (no) 1992-08-03
ZA858033B (en) 1986-06-25
DK481585A (da) 1986-04-23
DE3536896C2 (de) 1996-11-14
PH23982A (en) 1990-02-09
CS756585A2 (en) 1989-11-14
FI854035L (fi) 1986-04-23
SE8504945D0 (sv) 1985-10-21
GR852549B (enExample) 1986-02-24
FR2571966A1 (fr) 1986-04-25
AU4880585A (en) 1986-05-01
RU1836088C (ru) 1993-08-23
AT401345B (de) 1996-08-26
MY103956A (en) 1993-10-30
YU46160B (sh) 1993-05-28
GB8525709D0 (en) 1985-11-20
CN85107562A (zh) 1986-07-23
DK481585D0 (da) 1985-10-21
NO854194L (no) 1986-04-23
FI854035A0 (fi) 1985-10-16
UA34419C2 (uk) 2001-03-15
SG80290G (en) 1990-11-23
IT1186779B (it) 1987-12-16
ES8605374A1 (es) 1986-03-16
CS270421B2 (en) 1990-06-13
ES547578A0 (es) 1986-03-16
PT81347A (en) 1985-11-01
KR920005813B1 (ko) 1992-07-20
FI86252B (fi) 1992-04-30
KR860003014A (ko) 1986-05-19
RU2101018C1 (ru) 1998-01-10
US5091373A (en) 1992-02-25
SE467520B (sv) 1992-08-03
CH667594A5 (de) 1988-10-31
US4675311A (en) 1987-06-23
NL191308B (nl) 1994-12-16
PT81347B (pt) 1987-11-11
IT8522507A0 (it) 1985-10-16
UA19169A (uk) 1997-12-25
FI853913A0 (fi) 1985-10-08
GB8426672D0 (en) 1984-11-28
IE852593L (en) 1986-04-22
HUT40759A (en) 1987-02-27
FI853913A7 (fi) 1986-04-23
ATA303285A (de) 1996-01-15
HK94390A (en) 1990-11-23
NO170616C (no) 1992-11-11
DK165620C (da) 1993-06-01
CA1248453A (en) 1989-01-10
NL8502869A (nl) 1986-05-16
IE56992B1 (en) 1992-02-26
JPS61246129A (ja) 1986-11-01
BE903484A (fr) 1986-04-21
IL76732A0 (en) 1986-02-28

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BB A search report has been drawn up
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: ERBAMONT INDUSTRIALE S.R.L.

DNT Communications of changes of names of applicants whose applications have been laid open to public inspection

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BC A request for examination has been filed
SNR Assignments of patents or rights arising from examined patent applications

Owner name: PHARMACIA S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA & UPJOHN S.P.A.

TNT Modifications of names of proprietors of patents or applicants of examined patent applications

Owner name: PHARMACIA ITALIA S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20051021