DK165620C - Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet - Google Patents
Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatetInfo
- Publication number
- DK165620C DK165620C DK481585A DK481585A DK165620C DK 165620 C DK165620 C DK 165620C DK 481585 A DK481585 A DK 481585A DK 481585 A DK481585 A DK 481585A DK 165620 C DK165620 C DK 165620C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- anthracycliclycoside
- annostation
- cosolubilizing
- freeze
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8426672 | 1984-10-22 | ||
| GB848426672A GB8426672D0 (en) | 1984-10-22 | 1984-10-22 | Pharmaceutical compositions |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK481585D0 DK481585D0 (da) | 1985-10-21 |
| DK481585A DK481585A (da) | 1986-04-23 |
| DK165620B DK165620B (da) | 1992-12-28 |
| DK165620C true DK165620C (da) | 1993-06-01 |
Family
ID=10568553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK481585A DK165620C (da) | 1984-10-22 | 1985-10-21 | Frysetoerret farmaceutisk praeparat indeholdende anthracyclinglycosider og et cosolubiliserende middel og fremgangsmaade til fremstilling heraf, anvendelse af praeparatet til fremstilling af et tumormiddel samt fremgangsmaade til fremstilling af en rekonstitueret injicerbar oploesning af praeparatet |
Country Status (35)
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5124318A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.R.L. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| DE3741037A1 (de) * | 1986-12-05 | 1988-06-09 | Erba Farmitalia | Injizierbare, gebrauchsfertige loesungen, welche ein antitumor-anthracyclinglycosid enthalten |
| JP2603480B2 (ja) * | 1987-08-05 | 1997-04-23 | 住友製薬株式会社 | 安定化されたアンスラサイクリン系製剤 |
| DE3801178A1 (de) * | 1988-01-18 | 1989-07-27 | Hoechst Ag | Stabilisierte trockenzubereitung zytostatisch wirksamer anthracyclin-antibiotika und verfahren zu ihrer herstellung |
| US6300362B1 (en) | 1990-07-25 | 2001-10-09 | Novartis Ag (Formerly Sandoz Ltd.) | Stabilized pharmaceutical compositions comprising acid donors |
| DE69737510T2 (de) | 1996-12-30 | 2007-12-06 | Battelle Memorial Institute, Columbus | Verwendung eines unverkapselten Antikrebs-Arzneimittels zur Herstellung einer Zubereitung zur Behandlung von Neoplasmen durch Inhalation |
| US5942508A (en) * | 1997-02-04 | 1999-08-24 | Senju Pharmaceutical Co., Ltd. | Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid |
| RU2292216C2 (ru) * | 2000-10-31 | 2007-01-27 | Фарма Мар, С.А. | Кахалалид f |
| KR100970528B1 (ko) | 2002-02-22 | 2010-07-16 | 쉐링 코포레이션 | 항신생물제, 특히 테모졸로마이드의 약제학적 제형, 이의제조 및 사용 방법 |
| DK1474995T3 (da) * | 2003-05-06 | 2013-02-18 | Gumlink As | Fremgangsmåde til fremstilling af tyggegummigranulater, et gummisammensætningsekstruder- og granuleringssystem og et tyggegummiprodukt |
| US20090099346A1 (en) * | 2003-07-02 | 2009-04-16 | Victor Matvienko | Thermally stable crystalline epirubicin hydrochloride |
| CN100412084C (zh) * | 2003-07-02 | 2008-08-20 | 獀洛克斯股份有限公司 | 热稳定的结晶盐酸表柔比星及其制造方法 |
| SI2263694T1 (sl) * | 2003-09-25 | 2013-09-30 | Astellas Pharma Inc. | Antitumorsko sredstvo, ki obsega inhibitor histon-deacetilaze FK228 in inhibitor topoizomeraze II doksorubicin |
| RU2262923C2 (ru) * | 2003-12-25 | 2005-10-27 | Государственное образовательное учреждение высшего профессионального образования Курский государственный медицинский университет Министерства здравоохранения Российской Федерации | Иммобилизованная форма доксорубицина |
| US7388083B2 (en) * | 2005-03-07 | 2008-06-17 | Solux Corporation | Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics |
| JP2008513519A (ja) * | 2005-05-11 | 2008-05-01 | シコール インコーポレイティド | 安定した凍結乾燥されたアントラサイクリングリコシド |
| EP1921919B1 (en) | 2005-07-14 | 2012-04-04 | Lithera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
| CN101331147B (zh) * | 2005-12-13 | 2011-11-30 | 苏洛克股份有限公司 | 用于制备4-脱甲基柔红霉素的方法 |
| US8802830B2 (en) * | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8148338B2 (en) * | 2006-02-22 | 2012-04-03 | Supratek Pharma Inc. | Doxorubicin formulations for anti-cancer use |
| US7470672B2 (en) * | 2006-07-31 | 2008-12-30 | Savvipharm Inc. | Compositions and methods of reducing tissue levels of drugs when given as orotate derivatives |
| EP2152312B1 (en) * | 2007-05-16 | 2014-12-31 | KTB Tumorforschungsgesellschaft mbH | Low-viscous anthracycline formulation |
| US8227430B2 (en) | 2007-09-04 | 2012-07-24 | Meiji Seika Pharma Co., Ltd | Injectable, injection solution, and injection kit preparation |
| US20100234314A1 (en) * | 2007-10-26 | 2010-09-16 | Pfizer Inc. | Idarubicin for the treatment of lymphoma in a dog |
| US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US9132084B2 (en) | 2009-05-27 | 2015-09-15 | Neothetics, Inc. | Methods for administration and formulations for the treatment of regional adipose tissue |
| CN102869363A (zh) * | 2010-01-15 | 2013-01-09 | 利赛拉公司 | 冻干的块状制剂 |
| UA111822C2 (uk) | 2010-11-24 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Новамедіка" | Монотерапевтичий препарат селективного ліпофільного бета-агоніста тривалої дії і спосіб косметичного лікування ожиріння і контурного випинання |
| DE102011103751A1 (de) | 2011-05-31 | 2012-12-06 | Heraeus Precious Metals Gmbh & Co. Kg | Kristallisierung von Epirubicinhydrochlorid |
| DE102011111991A1 (de) * | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
| DK2931042T3 (da) | 2012-12-13 | 2021-06-07 | Cytrx Corp | Anthracyclinformuleringer |
| CA2912908C (en) | 2013-06-05 | 2021-06-08 | Cytrx Corporation | Cytotoxic agents comprising covalently protein binding groups for treating brain cancer |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU33730B (en) * | 1967-04-18 | 1978-02-28 | Farmaceutici Italia | Process for preparing a novel antibiotic substance and salts thereof |
| US4039663A (en) * | 1975-03-19 | 1977-08-02 | Societa' Farmaceutici Italia S.P.A. | Daunomycins, process for their uses and intermediates |
| GB1506200A (en) * | 1975-04-30 | 1978-04-05 | Farmaceutici Italia | Glycosides |
| GB1567456A (en) * | 1976-11-16 | 1980-05-14 | Farmaceutici Italia | Daunomycin derivatives |
| US4177264A (en) * | 1977-10-17 | 1979-12-04 | Sri International | N-benzyl anthracyclines |
| GB2007645B (en) * | 1977-10-17 | 1982-05-12 | Stanford Res Inst Int | Benzyl anthracyclines and pharmaceutical compositions containing them |
| JPS563851A (en) * | 1979-06-22 | 1981-01-16 | Matsushita Electric Works Ltd | Fireplace in floor |
| JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
| US4325947A (en) * | 1981-05-12 | 1982-04-20 | Farmitalia Carlo Erba S.P.A. | 4-Demethoxy-4'-deoxydoxorubicin |
| IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
| US4438105A (en) * | 1982-04-19 | 1984-03-20 | Farmaitalia Carlo Erba S.P.A | 4'-Iododerivatives of anthracycline glycosides |
| FI75834C (fi) * | 1982-05-24 | 1988-08-08 | Erba Farmitalia | Foerfarande foer framstaellning av antracyklinglykosidfoereningar. |
| US4464529A (en) * | 1982-07-20 | 1984-08-07 | Sri International | Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin |
| CA1248944A (en) * | 1982-09-28 | 1989-01-17 | Gareth J. Thomas | Anthracycline glycosides |
| JPS5982395A (ja) * | 1982-11-02 | 1984-05-12 | Microbial Chem Res Found | アントラサイクリン化合物、その製造法およびその用途 |
| GR79729B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1982-12-20 | 1984-10-31 | Univ Ohio State Res Found | |
| JPS6092212A (ja) * | 1983-10-26 | 1985-05-23 | Kyowa Hakko Kogyo Co Ltd | ドキソルビシン塩の製剤 |
| US4537882A (en) * | 1984-05-10 | 1985-08-27 | Ohio State University | 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same |
-
1984
- 1984-10-22 GB GB848426672A patent/GB8426672D0/en active Pending
-
1985
- 1985-10-03 ES ES547578A patent/ES8605374A1/es not_active Expired
- 1985-10-08 FI FI853913A patent/FI853913A7/fi not_active Application Discontinuation
- 1985-10-15 HU HU853988A patent/HU197988B/hu unknown
- 1985-10-15 CN CN85107562A patent/CN85107562B/zh not_active Expired
- 1985-10-16 US US06/788,158 patent/US4675311A/en not_active Expired - Lifetime
- 1985-10-16 IT IT22507/85A patent/IT1186779B/it active Protection Beyond IP Right Term
- 1985-10-16 FI FI854035A patent/FI86252C/fi not_active IP Right Cessation
- 1985-10-16 DE DE3536896A patent/DE3536896C2/de not_active Expired - Lifetime
- 1985-10-16 YU YU164485A patent/YU46160B/sh unknown
- 1985-10-17 AU AU48805/85A patent/AU572003B2/en not_active Expired
- 1985-10-17 JP JP60230055A patent/JPH0611700B2/ja not_active Expired - Lifetime
- 1985-10-17 IL IL76732A patent/IL76732A/xx not_active IP Right Cessation
- 1985-10-17 CH CH4476/85A patent/CH667594A5/de not_active IP Right Cessation
- 1985-10-18 GB GB08525709A patent/GB2165751B/en not_active Expired
- 1985-10-18 PH PH32947A patent/PH23982A/en unknown
- 1985-10-18 RU SU853964940A patent/RU1836088C/ru active
- 1985-10-18 UA UA3964940A patent/UA19169A/uk unknown
- 1985-10-18 UA UA5010680A patent/UA34419C2/uk unknown
- 1985-10-18 ZA ZA858033A patent/ZA858033B/xx unknown
- 1985-10-18 AT AT0303285A patent/AT401345B/de not_active IP Right Cessation
- 1985-10-18 NZ NZ213885A patent/NZ213885A/en unknown
- 1985-10-21 KR KR1019850007740A patent/KR920005813B1/ko not_active Expired
- 1985-10-21 NO NO854194A patent/NO170616C/no not_active IP Right Cessation
- 1985-10-21 CA CA000493459A patent/CA1248453A/en not_active Expired
- 1985-10-21 PT PT81347A patent/PT81347B/pt unknown
- 1985-10-21 DK DK481585A patent/DK165620C/da not_active IP Right Cessation
- 1985-10-21 IE IE2593/85A patent/IE56992B1/en not_active IP Right Cessation
- 1985-10-21 BE BE0/215752A patent/BE903484A/fr not_active IP Right Cessation
- 1985-10-21 FR FR8515596A patent/FR2571966B1/fr not_active Expired
- 1985-10-21 NL NL8502869A patent/NL191308C/xx not_active IP Right Cessation
- 1985-10-21 SE SE8504945A patent/SE467520B/sv not_active IP Right Cessation
- 1985-10-22 CS CS857565A patent/CS270421B2/cs not_active IP Right Cessation
- 1985-10-22 GR GR852549A patent/GR852549B/el unknown
-
1986
- 1986-08-06 US US06/893,613 patent/US4840938A/en not_active Expired - Lifetime
-
1988
- 1988-12-30 MY MYPI88001588A patent/MY103956A/en unknown
-
1990
- 1990-09-26 US US07/588,526 patent/US5091372A/en not_active Expired - Lifetime
- 1990-09-28 US US07/590,536 patent/US5091373A/en not_active Expired - Lifetime
- 1990-10-03 SG SG802/90A patent/SG80290G/en unknown
- 1990-11-15 HK HK943/90A patent/HK94390A/xx not_active IP Right Cessation
-
1992
- 1992-01-30 RU SU5010680A patent/RU2101018C1/ru active
-
1994
- 1994-02-23 BG BG098530A patent/BG60934B2/bg unknown
Also Published As
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