DK1652857T3 - Fusionsprotein af HIV-regulator/hjælpeproteiner - Google Patents

Fusionsprotein af HIV-regulator/hjælpeproteiner

Info

Publication number
DK1652857T3
DK1652857T3 DK05017695T DK05017695T DK1652857T3 DK 1652857 T3 DK1652857 T3 DK 1652857T3 DK 05017695 T DK05017695 T DK 05017695T DK 05017695 T DK05017695 T DK 05017695T DK 1652857 T3 DK1652857 T3 DK 1652857T3
Authority
DK
Denmark
Prior art keywords
proteins
fusion protein
hiv
nucleic acids
auxiliary proteins
Prior art date
Application number
DK05017695T
Other languages
Danish (da)
English (en)
Inventor
Paul Howley
Sonja Leyrer
Eva Dr Felder
Original Assignee
Bavarian Nordic As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bavarian Nordic As filed Critical Bavarian Nordic As
Application granted granted Critical
Publication of DK1652857T3 publication Critical patent/DK1652857T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/21Retroviridae, e.g. equine infectious anemia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16HIV-1 ; HIV-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/24011Poxviridae
    • C12N2710/24111Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16311Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK05017695T 2002-05-16 2003-05-14 Fusionsprotein af HIV-regulator/hjælpeproteiner DK1652857T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200754 2002-05-16
PCT/EP2003/005039 WO2003097675A1 (fr) 2002-05-16 2003-05-14 Proteine hybride des proteines regulateurs de vih/accessoires

Publications (1)

Publication Number Publication Date
DK1652857T3 true DK1652857T3 (da) 2009-01-05

Family

ID=29433046

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05017695T DK1652857T3 (da) 2002-05-16 2003-05-14 Fusionsprotein af HIV-regulator/hjælpeproteiner
DK03730029T DK1506223T3 (da) 2002-05-16 2003-05-14 Fusionsprotein af regulatoriske/accessoriske HIV-proteiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK03730029T DK1506223T3 (da) 2002-05-16 2003-05-14 Fusionsprotein af regulatoriske/accessoriske HIV-proteiner

Country Status (24)

Country Link
US (7) US20050222388A1 (fr)
EP (2) EP1652857B9 (fr)
JP (3) JP2006502704A (fr)
KR (4) KR100996330B1 (fr)
CN (3) CN1325512C (fr)
AT (2) ATE407143T1 (fr)
AU (2) AU2003240638B2 (fr)
BR (1) BR0309963A (fr)
CA (1) CA2483640A1 (fr)
CY (1) CY1108638T1 (fr)
DE (2) DE60302356T2 (fr)
DK (2) DK1652857T3 (fr)
EA (1) EA007154B1 (fr)
ES (2) ES2253675T3 (fr)
HK (1) HK1076822A1 (fr)
IL (3) IL164178A0 (fr)
MX (1) MXPA04010683A (fr)
NO (1) NO20045229L (fr)
NZ (2) NZ556144A (fr)
PL (2) PL397252A1 (fr)
PT (1) PT1652857E (fr)
SI (2) SI1506223T1 (fr)
UA (3) UA92788C2 (fr)
WO (1) WO2003097675A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501127B2 (en) 2002-05-16 2009-03-10 Bavarian Nordic A/S Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara
KR100996330B1 (ko) * 2002-05-16 2010-11-23 버베리안 노딕 에이/에스 Hiv 조절/부속 단백질의 융합 단백질
WO2004085466A2 (fr) 2003-03-28 2004-10-07 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Produits de recombinaison hiv-1 multiclade immunogenes et multivalents, et methodes d'utilisation de ceux-ci
CN101330830B (zh) * 2005-10-18 2016-01-20 国家犹太健康中心 条件无限增殖化长期干细胞和制备和使用所述细胞的方法
US20100047266A1 (en) * 2006-07-27 2010-02-25 Ligocyte Pharmaceuticals, Inc. Chimeric virus-like particles
AU2007345768B2 (en) * 2006-07-27 2013-08-01 Ligocyte Pharmaceuticals, Inc. Chimeric influenza virus-like particles
EP2285832B1 (fr) 2008-05-16 2020-08-26 Taiga Biotechnologies, Inc. Anticorps et leurs procédés de préparation
CA2731767C (fr) 2008-07-21 2016-12-06 Taiga Biotechnologies, Inc. Cellules anucleees differenciees et leur procede de fabrication
DK2966084T3 (en) 2008-08-28 2018-08-06 Taiga Biotechnologies Inc MODULATORS OF MYC, PROCEDURES FOR USING SAME AND PROCEDURES FOR IDENTIFYING SUBSTANCES MODULATING MYC
WO2011042180A1 (fr) 2009-10-08 2011-04-14 Bavarian Nordic A/S Génération d'une large réponse des lymphocytes t contre le vih chez les humains
WO2011043830A2 (fr) * 2009-10-09 2011-04-14 New York University Procédés, agents et peptides destinés à induire une réponse immunitaire innée dans la vaccination contre le vih
EP2496609A4 (fr) 2009-11-03 2013-05-08 Ligocyte Pharmaceuticals Inc Particules de type viral (vlp) chimériques à base de gag de polypeptide rsv-f et de lentivirus ou alpharétrovirus
EP2620446A1 (fr) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogènes pour la vaccination contre le VIH
ES2856179T3 (es) 2012-07-20 2021-09-27 Taiga Biotechnologies Inc Reconstitución y autorreconstitución potenciadas del compartimento hematopoyético
US10272115B2 (en) 2013-03-11 2019-04-30 Taiga Biotechnologies, Inc. Production and use of red blood cells
US9365825B2 (en) 2013-03-11 2016-06-14 Taiga Biotechnologies, Inc. Expansion of adult stem cells in vitro
WO2015192339A1 (fr) * 2014-06-18 2015-12-23 中山大学 Vecteur chimère et son procédé de préparation et son utilisation
CN104130331B (zh) * 2014-06-19 2017-06-06 中山大学 一种抗hiv‑1病毒药物及其制备和应用
FR3042121A1 (fr) 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
CN105330729A (zh) * 2015-11-18 2016-02-17 南京医科大学 一种人类免疫缺陷病毒Vpr蛋白的制备方法
AU2017367730A1 (en) 2016-12-02 2019-06-06 Taiga Biotechnologies, Inc. Nanoparticle formulations
US10149898B2 (en) 2017-08-03 2018-12-11 Taiga Biotechnologies, Inc. Methods and compositions for the treatment of melanoma
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines

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WO1998008539A1 (fr) * 1996-08-26 1998-03-05 Chiron Corporation Therapie de vaccination apres l'infection par le virus de l'immunodeficience humaine (vih)
GB9720585D0 (en) * 1997-09-26 1997-11-26 Smithkline Beecham Biolog Vaccine
IT1297090B1 (it) 1997-12-01 1999-08-03 Barbara Ensoli Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le
FR2773156B1 (fr) * 1997-12-26 2000-03-31 Biovacs Inc Nouveaux immunogenes anti-retroviraux (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida
FI105105B (fi) 1998-02-27 2000-06-15 Finnish Immunotechnology Ltd O Itsereplikoiva DNA-vektori immunisoimiseksi HIV:ta vastaan
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
HUP0204250A3 (en) 2000-01-31 2005-06-28 Smithkline Beecham Biolog Use of hiv-protein or -polynucleotide for vaccine produce
CA2401974C (fr) * 2000-03-02 2013-07-02 Emory University Vecteurs d'expression d'adn et procedes d'utilisation
US6544780B1 (en) * 2000-06-02 2003-04-08 Genphar, Inc. Adenovirus vector with multiple expression cassettes
DE60134408D1 (de) * 2000-07-14 2008-07-24 Univ Pennsylvania Für akzessorische hiv proteine kodierende dna impfstoffe
AU2872202A (en) * 2000-11-01 2002-05-15 Us Gov Health & Human Serv Expression vectors able to elicit improved immune response and methods of using same
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
KR100996330B1 (ko) * 2002-05-16 2010-11-23 버베리안 노딕 에이/에스 Hiv 조절/부속 단백질의 융합 단백질

Also Published As

Publication number Publication date
EP1652857B1 (fr) 2008-09-03
KR100996330B1 (ko) 2010-11-23
NZ556144A (en) 2008-04-30
MXPA04010683A (es) 2005-02-17
CN1653085A (zh) 2005-08-10
US8147839B2 (en) 2012-04-03
US20060257974A1 (en) 2006-11-16
US8389275B2 (en) 2013-03-05
PT1652857E (pt) 2008-12-12
KR20050010000A (ko) 2005-01-26
IL197304A0 (en) 2011-07-31
EP1506223B1 (fr) 2005-11-16
KR20120106894A (ko) 2012-09-26
KR20100063126A (ko) 2010-06-10
US20120142096A1 (en) 2012-06-07
DE60302356D1 (de) 2005-12-22
EP1652857A3 (fr) 2007-03-14
US8435535B2 (en) 2013-05-07
BR0309963A (pt) 2005-02-22
KR101196178B1 (ko) 2012-11-01
ATE407143T1 (de) 2008-09-15
US20100047871A1 (en) 2010-02-25
JP2010099084A (ja) 2010-05-06
DE60302356T2 (de) 2006-08-03
EP1506223A1 (fr) 2005-02-16
ES2253675T3 (es) 2006-06-01
AU2008252074A1 (en) 2009-01-08
CA2483640A1 (fr) 2003-11-27
IL164178A (en) 2011-01-31
EP1652857A2 (fr) 2006-05-03
EA007154B1 (ru) 2006-08-25
NO20045229L (no) 2004-11-29
CN1325512C (zh) 2007-07-11
PL372092A1 (en) 2005-07-11
IL164178A0 (en) 2005-12-18
JP2009178165A (ja) 2009-08-13
US20120142097A1 (en) 2012-06-07
CY1108638T1 (el) 2014-04-09
AU2008252074B2 (en) 2012-02-16
ATE310016T1 (de) 2005-12-15
CN101108882A (zh) 2008-01-23
JP2006502704A (ja) 2006-01-26
EA200401504A1 (ru) 2005-04-28
SI1652857T1 (sl) 2009-02-28
CN1982332A (zh) 2007-06-20
SI1506223T1 (sl) 2006-04-30
PL397252A1 (pl) 2012-04-10
AU2003240638B2 (en) 2008-05-15
US20090280561A1 (en) 2009-11-12
NZ536499A (en) 2008-04-30
US8137931B2 (en) 2012-03-20
US20100047268A1 (en) 2010-02-25
EP1652857B9 (fr) 2009-10-14
UA85373C2 (ru) 2009-01-26
UA92788C2 (ru) 2010-12-10
US8143054B2 (en) 2012-03-27
US7569228B2 (en) 2009-08-04
AU2003240638A1 (en) 2003-12-02
US20050222388A1 (en) 2005-10-06
ES2313166T3 (es) 2009-03-01
KR20110099058A (ko) 2011-09-05
DK1506223T3 (da) 2006-04-10
HK1076822A1 (en) 2006-01-27
WO2003097675A1 (fr) 2003-11-27
UA82998C2 (ru) 2008-06-10
DE60323407D1 (de) 2008-10-16

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