DK1648518T3 - Konjugerede biologiske molekyler og deres fremstilling - Google Patents
Konjugerede biologiske molekyler og deres fremstillingInfo
- Publication number
- DK1648518T3 DK1648518T3 DK04743335T DK04743335T DK1648518T3 DK 1648518 T3 DK1648518 T3 DK 1648518T3 DK 04743335 T DK04743335 T DK 04743335T DK 04743335 T DK04743335 T DK 04743335T DK 1648518 T3 DK1648518 T3 DK 1648518T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- general formula
- protein
- compound
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316294.8A GB0316294D0 (en) | 2003-07-11 | 2003-07-11 | Conjugated biological molecules and their preparation |
| PCT/GB2004/002994 WO2005007197A2 (fr) | 2003-07-11 | 2004-07-12 | Molecules biologiques conjuguees et leur preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1648518T3 true DK1648518T3 (da) | 2009-11-09 |
Family
ID=27742023
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09167191.7T DK2133099T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| DK04743335T DK1648518T3 (da) | 2003-07-11 | 2004-07-12 | Konjugerede biologiske molekyler og deres fremstilling |
| DK10175140.2T DK2253330T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| DK10175143.6T DK2277550T3 (en) | 2003-07-11 | 2004-07-12 | A process for the preparation of conjugated biological molecules |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09167191.7T DK2133099T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10175140.2T DK2253330T3 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| DK10175143.6T DK2277550T3 (en) | 2003-07-11 | 2004-07-12 | A process for the preparation of conjugated biological molecules |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7595292B2 (fr) |
| EP (4) | EP2253330B1 (fr) |
| JP (2) | JP4958549B2 (fr) |
| KR (1) | KR101152500B1 (fr) |
| CN (2) | CN101792525B (fr) |
| AT (1) | ATE440620T1 (fr) |
| AU (2) | AU2004257448B2 (fr) |
| DE (1) | DE602004022824D1 (fr) |
| DK (4) | DK2133099T3 (fr) |
| ES (4) | ES2549427T3 (fr) |
| GB (1) | GB0316294D0 (fr) |
| PL (2) | PL1648518T3 (fr) |
| WO (1) | WO2005007197A2 (fr) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003303635B2 (en) | 2002-12-26 | 2009-07-23 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of interferon-beta with enhanced biological potency |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US7046714B2 (en) * | 2003-09-10 | 2006-05-16 | Intel Corporation | Method and apparatus for Raman ring resonator based laser/wavelength converter |
| JP4942643B2 (ja) * | 2004-03-02 | 2012-05-30 | シアトル ジェネティックス， インコーポレイテッド | 部分的に付加された抗体およびそれらの結合体化方法 |
| RU2008110060A (ru) * | 2005-08-15 | 2009-09-27 | Арана Терапьютикс Лимитед (Au) | Сконструированные антитела с каркасными участками приматов нового света |
| US7846439B2 (en) * | 2006-02-01 | 2010-12-07 | Cephalon Australia Pty Ltd | Domain antibody construct |
| US20080139790A1 (en) * | 2006-12-08 | 2008-06-12 | Jennings Philip A | Chimeric antibodies |
| US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| TWI360535B (en) * | 2007-08-30 | 2012-03-21 | Univ Nat Sun Yat Sen | Sulfur-containing compound, method of preparation |
| US20100239517A1 (en) * | 2007-10-09 | 2010-09-23 | Stephen Brocchini | Novel conjugated proteins and peptides |
| KR20110016440A (ko) * | 2008-04-24 | 2011-02-17 | 셀틱 파르마 피이지 엘티디. | 연장된 반감기를 가진 제 ⅰⅹ 인자 접합체 |
| EP2304033B1 (fr) | 2008-06-30 | 2016-09-07 | ESBATech, an Alcon Biomedical Research Unit LLC | Polypeptides fonctionnalisés |
| KR20110031373A (ko) | 2008-07-10 | 2011-03-25 | 에스바테크, 언 알콘 바이오메디칼 리서치 유닛 엘엘씨 | 마크로분자 전달을 증강하는 방법 및 조성물 |
| ES2536882T3 (es) * | 2008-07-21 | 2015-05-29 | Polytherics Limited | Nuevos reactivos y procedimiento de conjugación de moléculas biológicas |
| GB0817978D0 (en) * | 2008-10-01 | 2008-11-05 | Imp Innovations Ltd | Peptides |
| KR20110091720A (ko) * | 2008-11-04 | 2011-08-12 | 얀센 파마슈티카 엔.브이. | Ｃｒｈｒ2 펩티드 작용제 및 이의 용도 |
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| GB0922354D0 (en) | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| WO2011005540A1 (fr) | 2009-06-22 | 2011-01-13 | Burnham Institute For Medical Research | Procédés et compositions utilisant des peptides et des protéines dotés déléments c-terminaux |
| GB0916578D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| GB0916576D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| FI124016B (fi) * | 2009-10-26 | 2014-01-31 | Vapo Oy | Menetelmä biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi välipiirinesteen avulla sekä vesi-glykoliseoksen tai sitä vastaavan jäätymättömän välipiirinesteen käyttö biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi |
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| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| WO2012118778A1 (fr) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Peptides car tronqués, procédés et compositions les utilisant |
| GB2490655A (en) | 2011-04-28 | 2012-11-14 | Univ Aston | Modulators of tissue transglutaminase |
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| US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
| AP2014008049A0 (en) | 2012-04-16 | 2014-11-30 | Cantab Biopharmaceuticals Patents Ltd | Optimised subcuraneous therapeutic agents |
| WO2013177481A1 (fr) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazépines et leurs conjugués |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
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| KR20150023027A (ko) * | 2012-06-19 | 2015-03-04 | 폴리테릭스 리미티드 | 항체 접합체의 제조를 위한 신규한 공정 및 신규한 항체 접합체 |
| NO2789793T3 (fr) | 2012-10-24 | 2018-01-27 | ||
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| AU4934299A (en) * | 1999-07-15 | 2001-02-05 | Kuhnil Pharm. Co., Ltd. | Novel water soluble-cyclosporine conjugated compounds |
| AU7346400A (en) | 1999-09-03 | 2001-04-10 | School Of Pharmacy, University Of London, The | Degradable polymers |
| US6828412B1 (en) | 1999-09-03 | 2004-12-07 | School Of Pharmacy, University Of London | Degradable polymers |
| EP1222217B1 (fr) | 1999-09-08 | 2005-06-15 | Polytherics Limited | Polymeres de poids moleculaire uniforme |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| GB0400264D0 (en) * | 2004-01-07 | 2004-02-11 | Polytherics Ltd | Complexes |
| US8575397B2 (en) * | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| US20100239517A1 (en) * | 2007-10-09 | 2010-09-23 | Stephen Brocchini | Novel conjugated proteins and peptides |
| ES2536882T3 (es) * | 2008-07-21 | 2015-05-29 | Polytherics Limited | Nuevos reactivos y procedimiento de conjugación de moléculas biológicas |
| WO2010100430A1 (fr) * | 2009-03-04 | 2010-09-10 | Polytherics Limited | Protéines et peptides conjugués |
| GB0912485D0 (en) * | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
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2003
- 2003-07-11 GB GBGB0316294.8A patent/GB0316294D0/en not_active Ceased
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2004
- 2004-07-12 ES ES10175140.2T patent/ES2549427T3/es not_active Expired - Lifetime
- 2004-07-12 AT AT04743335T patent/ATE440620T1/de active
- 2004-07-12 ES ES09167191.7T patent/ES2632515T3/es not_active Expired - Lifetime
- 2004-07-12 JP JP2006518372A patent/JP4958549B2/ja not_active Expired - Lifetime
- 2004-07-12 EP EP10175140.2A patent/EP2253330B1/fr not_active Expired - Lifetime
- 2004-07-12 US US10/564,340 patent/US7595292B2/en active Active
- 2004-07-12 AU AU2004257448A patent/AU2004257448B2/en not_active Expired
- 2004-07-12 PL PL04743335T patent/PL1648518T3/pl unknown
- 2004-07-12 DE DE602004022824T patent/DE602004022824D1/de not_active Expired - Lifetime
- 2004-07-12 ES ES04743335T patent/ES2331004T3/es not_active Expired - Lifetime
- 2004-07-12 EP EP09167191.7A patent/EP2133099B1/fr not_active Expired - Lifetime
- 2004-07-12 DK DK09167191.7T patent/DK2133099T3/en active
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- 2004-07-12 DK DK04743335T patent/DK1648518T3/da active
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- 2004-07-12 DK DK10175140.2T patent/DK2253330T3/en active
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- 2004-07-12 WO PCT/GB2004/002994 patent/WO2005007197A2/fr active Application Filing
- 2004-07-12 ES ES10175143.6T patent/ES2542531T3/es not_active Expired - Lifetime
- 2004-07-12 EP EP20100175143 patent/EP2277550B1/fr not_active Expired - Lifetime
- 2004-07-12 KR KR1020067000278A patent/KR101152500B1/ko active IP Right Grant
- 2004-07-12 EP EP04743335A patent/EP1648518B1/fr not_active Expired - Lifetime
- 2004-07-12 CN CN2004800198144A patent/CN1822860B/zh not_active Expired - Lifetime
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