DK155945C - Analogifremgangsmaade til fremstilling af 7-beta-oealfa-syn--methoxyimino-alfa-(2-aminothiazol-4-yl)acetamidoaa-3-oe(1,2,3-thiadiazol-5-ylthio)methylaa-3-cephem-4-carboxylsyre samt i thiadiazolringens 4-stilling substituerede c1-c6-alkylderivater og fysiologisk acceptable salte deraf. - Google Patents

Analogifremgangsmaade til fremstilling af 7-beta-oealfa-syn--methoxyimino-alfa-(2-aminothiazol-4-yl)acetamidoaa-3-oe(1,2,3-thiadiazol-5-ylthio)methylaa-3-cephem-4-carboxylsyre samt i thiadiazolringens 4-stilling substituerede c1-c6-alkylderivater og fysiologisk acceptable salte deraf.

Info

Publication number
DK155945C
DK155945C DK355081A DK355081A DK155945C DK 155945 C DK155945 C DK 155945C DK 355081 A DK355081 A DK 355081A DK 355081 A DK355081 A DK 355081A DK 155945 C DK155945 C DK 155945C
Authority
DK
Denmark
Prior art keywords
thiadiazol
oealfa
methylaa
alkylde
acetamidoaa
Prior art date
Application number
DK355081A
Other languages
English (en)
Other versions
DK155945B (da
DK355081A (da
Inventor
William Vincent Curran
Adma Schneller Ross
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK355081A publication Critical patent/DK355081A/da
Publication of DK155945B publication Critical patent/DK155945B/da
Application granted granted Critical
Publication of DK155945C publication Critical patent/DK155945C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK355081A 1980-08-11 1981-08-10 Analogifremgangsmaade til fremstilling af 7-beta-oealfa-syn--methoxyimino-alfa-(2-aminothiazol-4-yl)acetamidoaa-3-oe(1,2,3-thiadiazol-5-ylthio)methylaa-3-cephem-4-carboxylsyre samt i thiadiazolringens 4-stilling substituerede c1-c6-alkylderivater og fysiologisk acceptable salte deraf. DK155945C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17688980A 1980-08-11 1980-08-11
US17688980 1980-08-11
US28143881 1981-07-08
US06/281,438 US4399132A (en) 1980-08-11 1981-07-08 7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-acetamido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C1 -C6 alkyl derivatives thereof

Publications (3)

Publication Number Publication Date
DK355081A DK355081A (da) 1982-02-12
DK155945B DK155945B (da) 1989-06-05
DK155945C true DK155945C (da) 1989-12-04

Family

ID=26872715

Family Applications (1)

Application Number Title Priority Date Filing Date
DK355081A DK155945C (da) 1980-08-11 1981-08-10 Analogifremgangsmaade til fremstilling af 7-beta-oealfa-syn--methoxyimino-alfa-(2-aminothiazol-4-yl)acetamidoaa-3-oe(1,2,3-thiadiazol-5-ylthio)methylaa-3-cephem-4-carboxylsyre samt i thiadiazolringens 4-stilling substituerede c1-c6-alkylderivater og fysiologisk acceptable salte deraf.

Country Status (25)

Country Link
US (1) US4399132A (da)
JP (1) JPS5759895A (da)
KR (1) KR840002163B1 (da)
AR (1) AR228869A1 (da)
AT (1) AT389639B (da)
AU (1) AU545895B2 (da)
BE (1) BE889913A (da)
CA (1) CA1175417A (da)
CH (1) CH648561A5 (da)
DD (1) DD202164A5 (da)
DE (1) DE3130404A1 (da)
DK (1) DK155945C (da)
FI (1) FI74020C (da)
FR (1) FR2488258A1 (da)
GB (1) GB2083461B (da)
GR (1) GR75676B (da)
HK (1) HK52089A (da)
HU (1) HU185644B (da)
IE (1) IE51486B1 (da)
IL (1) IL63531A (da)
NL (1) NL8103751A (da)
NO (1) NO161566C (da)
NZ (1) NZ197965A (da)
PL (1) PL131457B1 (da)
SE (1) SE452324B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60120886A (ja) * 1983-12-02 1985-06-28 Takeda Chem Ind Ltd セフェムカルボン酸のナトリウム塩の結晶
US4914091A (en) * 1984-04-02 1990-04-03 American Cyanamid Company Esters of cephalosporin derivitives
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
US4927922A (en) * 1986-07-08 1990-05-22 American Cyanamid Company 7β-(substituted)amino-3-substituted cephalosporanic acids and esters
EP0252473A3 (en) * 1986-07-08 1989-07-05 American Cyanamid Company 7 beta-(substituted) amino-3-substituted cephalosporanic acids and esters
EP0257275A3 (en) * 1986-07-28 1990-05-23 American Cyanamid Company Cephalosporin and penicillin derivatives
US5066799A (en) * 1986-07-28 1991-11-19 American Cyanamid Company Intermediates for the preparation of aminothiazoloximino cephalosporins
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
AT394196B (de) * 1990-01-22 1992-02-10 Biochemie Gmbh (6r,7r)-7-((2-(2-amino-4-thiazolyl) -2oxoacetamido)-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carbons|urenitrat
CN105646538B (zh) * 2016-03-09 2018-04-24 上海宁瑞生化技术有限公司 一种头孢唑南的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2856404A1 (de) * 1978-12-28 1980-07-17 Dynamit Nobel Ag 1,2,3-thiadiazol-5-yl-thioglycolsaeure, deren derivate sowie verfahren zu deren herstellung

Also Published As

Publication number Publication date
NO161566C (no) 1989-08-30
SE8104771L (sv) 1982-02-12
IL63531A0 (en) 1981-11-30
PL131457B1 (en) 1984-11-30
HU185644B (en) 1985-03-28
HK52089A (en) 1989-07-07
FR2488258A1 (fr) 1982-02-12
CA1175417A (en) 1984-10-02
FR2488258B1 (da) 1984-08-24
US4399132A (en) 1983-08-16
SE452324B (sv) 1987-11-23
DK155945B (da) 1989-06-05
KR830006311A (ko) 1983-09-20
FI74020C (fi) 1987-12-10
BE889913A (fr) 1982-02-10
DE3130404C2 (da) 1990-07-19
NO161566B (no) 1989-05-22
GB2083461A (en) 1982-03-24
IE51486B1 (en) 1987-01-07
DE3130404A1 (de) 1982-06-16
NO812701L (no) 1982-02-12
PL232568A1 (en) 1983-06-06
JPS5759895A (en) 1982-04-10
JPS6141517B2 (da) 1986-09-16
NL8103751A (nl) 1982-03-01
CH648561A5 (da) 1985-03-29
NZ197965A (en) 1984-03-16
DD202164A5 (de) 1983-08-31
AR228869A1 (es) 1983-04-29
IE811811L (en) 1982-02-11
AU545895B2 (en) 1985-08-08
IL63531A (en) 1985-07-31
KR840002163B1 (ko) 1984-11-24
GB2083461B (en) 1984-04-11
FI812470L (fi) 1982-02-12
GR75676B (da) 1984-08-02
AT389639B (de) 1990-01-10
FI74020B (fi) 1987-08-31
DK355081A (da) 1982-02-12
AU7384881A (en) 1982-02-18
ATA307683A (de) 1989-06-15

Similar Documents

Publication Publication Date Title
DK490482A (da) Derivater af cis,endo-2-azabicyclo-(3.3.0)-octan-3-carboxylsyren, fremgangsmaade til deres fremstilling, midler med indhold deraf samt deres anvendelse
DK160250C (da) Analogifremgangsmaade til fremstilling af 4-substituerede piperidinoalkanon-derivater eller farmaceutisk acceptable salte deraf
DK163244C (da) Analogifremgangsmaade til fremstilling af 7-oe2-(2-aminothiazol-4-yl)-2-oxyimino-acetamidoaa-ceph-3-em-4-carboxylsyrederivater eller fysiologisk acceptable salte deraf
NO167810C (no) Analogifremgangsmaate til fremstilling av insulinderivater.
DK284078A (da) 1,2,3-thiadiazol-5-carboxylsyrederivater midler med herbicid og vaekstregulerende virkning med indhold af disse forbindelser samt fremgangsmaade til fremstilling heraf
DK397387A (da) Carbostyrilderivater og salte deraf samt fremgangsmaade til fremstilling af saadanne forbindelser
NO822932L (no) Analogifremgangsmaate for fremstilling av heterocykliske benzoforbindelser.
DK258078A (da) Fremgangsmaade til fremstilling af 7alfa-methoxy-7beta-(1,3-dithiethan-2-carboxamido) cephalosporansyre-derivater
DK157022C (da) Analogifremgangsmaade til fremstilling af 9-hydrazono-6,7,8,9-tetrahydro-4h-pyrido oe1,2-aaapyrimidinderivater eller farmaceutisk acceptable salte, hydrater, stereoisomere, optisk aktive isomere, geometriske isomere og tautomere deraf
DK155945C (da) Analogifremgangsmaade til fremstilling af 7-beta-oealfa-syn--methoxyimino-alfa-(2-aminothiazol-4-yl)acetamidoaa-3-oe(1,2,3-thiadiazol-5-ylthio)methylaa-3-cephem-4-carboxylsyre samt i thiadiazolringens 4-stilling substituerede c1-c6-alkylderivater og fysiologisk acceptable salte deraf.
DK143183C (da) Analogifremgangsmaade til fremstilling af 1h-pyrazolo(3,4-b)pyridiner eller fysiologisk acceptable salte deraf
NO883833L (no) Fremgangsmaate for fremstilling av isoxazol-betacarbolinderivater.
DK165005C (da) Analogifremgangsmaade til fremstilling af 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater eller terapeutisk acceptable salte deraf
DK152115C (da) Analogifremgangsmaade til fremstilling af fluorerede 2,5-diamino-3-pentenderivater og farmaceutisk acceptable salte deraf
DK158227C (da) Analogifremgangsmaade til fremstilling af substituerede imidazooe1,5-aaapyridiner eller 5,6,7,8-tetrahydroderivater deraf eller salte deraf
DK147337C (da) Krystallinsk 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carboxylsyre-1,1-dioxid til anvendelse som mellemprodukt ved fremstilling af 3,4-dihydro-2-methyl-4-oxo-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og fremgangsmaade til fremstilling af syren
DK423284A (da) Naphthalenylimidazopyridin og derivater heraf samt fremgangsmaade til fremstilling af saadanne forbindelser
DK152754C (da) Analogifremgangsmaade til fremstilling af 1-acyl-8-(3-amino-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinoliner eller farmaceutisk acceptable syreadditionssalte deraf
DK160875C (da) Analogifremgangsmaade til fremstilling af 3,7-diazabicyklooe3.3.1aa-nonanforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK163512C (da) Substituerede azacyclohexylderivater af rifamyciner og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt en fremgangsmaade til fremstilling af forbindelserne
DK164786C (da) Analogifremgangsmaade til fremstilling af benzazolderivater eller salte deraf
DK152843C (da) Analogifremgangsmaade til fremstilling af n-substituerede 4-(3-trifluormethylphenyl)-1,2,3,6-tetrahydropyridiner og farmaceutisk acceptable salte deraf
DK150517C (da) Analogifremgangsmaade til fremstilling af 2,5-dihydro-1,2-thiazino(5,6-b)indol-3-carboxamid-1,1-dioxider eller fysiologisk acceptable salte deraf
DK7483A (da) Fremgangsmaade til fremstilling af 6-aminoalkylpencillansyre-1,1-dioxider samt derivater deraf
DK66980A (da) Fremgangsmaade til fremstilling af azacyclyl (thio) ureidoacetamidocphem-forbindelser og salte deraf samt anvendelse deraf

Legal Events

Date Code Title Description
PBP Patent lapsed