DK1532152T3 - Ny polymorf af N-methyl-N- (3- (3- [2-thienylcarbonyl]-pyrazol- [1,5-alfa]-pyrimidin-7-yl) phenyl) acetamid og beslægtede sammensætninger og metoder - Google Patents
Ny polymorf af N-methyl-N- (3- (3- [2-thienylcarbonyl]-pyrazol- [1,5-alfa]-pyrimidin-7-yl) phenyl) acetamid og beslægtede sammensætninger og metoderInfo
- Publication number
- DK1532152T3 DK1532152T3 DK03749163T DK03749163T DK1532152T3 DK 1532152 T3 DK1532152 T3 DK 1532152T3 DK 03749163 T DK03749163 T DK 03749163T DK 03749163 T DK03749163 T DK 03749163T DK 1532152 T3 DK1532152 T3 DK 1532152T3
- Authority
- DK
- Denmark
- Prior art keywords
- thienylcarbonyl
- pyrimidin
- pyrazole
- acetamide
- alpha
- Prior art date
Links
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40607202P | 2002-08-26 | 2002-08-26 | |
| PCT/US2003/026870 WO2004018476A1 (en) | 2002-08-26 | 2003-08-26 | Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1532152T3 true DK1532152T3 (da) | 2007-02-26 |
Family
ID=31946959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03749163T DK1532152T3 (da) | 2002-08-26 | 2003-08-26 | Ny polymorf af N-methyl-N- (3- (3- [2-thienylcarbonyl]-pyrazol- [1,5-alfa]-pyrimidin-7-yl) phenyl) acetamid og beslægtede sammensætninger og metoder |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6903106B2 (da) |
| EP (1) | EP1532152B1 (da) |
| JP (2) | JP4522859B2 (da) |
| KR (1) | KR101063033B1 (da) |
| CN (1) | CN1319974C (da) |
| AP (1) | AP2005003220A0 (da) |
| AR (1) | AR044191A1 (da) |
| AT (1) | ATE343581T1 (da) |
| AU (1) | AU2003268212B2 (da) |
| BR (1) | BR0313695A (da) |
| CA (1) | CA2493359C (da) |
| DE (1) | DE60309332T2 (da) |
| DK (1) | DK1532152T3 (da) |
| EA (1) | EA200500421A1 (da) |
| EC (1) | ECSP055703A (da) |
| ES (1) | ES2274260T3 (da) |
| HK (1) | HK1071373A1 (da) |
| HR (1) | HRP20050288A2 (da) |
| IL (2) | IL166621A0 (da) |
| IS (1) | IS7769A (da) |
| MA (1) | MA27519A1 (da) |
| MX (1) | MXPA05002251A (da) |
| NO (1) | NO20050615L (da) |
| NZ (1) | NZ538027A (da) |
| OA (1) | OA12917A (da) |
| PE (1) | PE20040979A1 (da) |
| PL (1) | PL374436A1 (da) |
| PT (1) | PT1532152E (da) |
| TN (1) | TNSN05058A1 (da) |
| TW (1) | TWI288135B (da) |
| WO (1) | WO2004018476A1 (da) |
| ZA (1) | ZA200501125B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003268212B2 (en) * | 2002-08-26 | 2008-08-14 | Neurocrine Biosciences, Inc. | Novel polymorph of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-YL}phenyl)acetamide and compositions and methods related thereto |
| US7429596B2 (en) * | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| JP5156381B2 (ja) * | 2004-10-18 | 2013-03-06 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | Ｎ−メチル−Ｎ−（３−｛３−［２−チエニルカルボニル］−ピラゾール−［１，５−α］−ピリミジン−７−イル｝フェニル）アセトアミドの水和物ならびにそれに関連するプロセスおよび方法 |
| CN100528875C (zh) * | 2005-02-18 | 2009-08-19 | 美德（江西）生物科技有限公司 | 无结晶型态的印地普隆及其制备方法 |
| EP1918290A1 (en) * | 2006-10-11 | 2008-05-07 | Ferrer Internacional, S.A. | Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide |
| EP1956021A1 (en) * | 2006-10-11 | 2008-08-13 | Ferrer Internacional, S.A. | Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound |
| CN101177427B (zh) * | 2006-11-09 | 2011-07-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物 |
| CN102180879B (zh) * | 2006-11-09 | 2013-05-01 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种催眠药的多晶型α的乙酸溶剂化物 |
| BR112012023656A2 (pt) | 2010-03-25 | 2017-10-10 | Yazaki Corp | conector e método para identificação de padrão de barramento em conector |
| ES2581452T3 (es) * | 2010-04-16 | 2016-09-05 | Ivoclar Vivadent Ag | Vitrocerámica y vidrio de silicato de litio con óxido de metal de transición |
| AT510837B1 (de) | 2011-07-27 | 2012-07-15 | Helmut Dr Buchberger | Inhalatorkomponente |
| EP2672847B1 (de) | 2011-02-11 | 2015-04-22 | Batmark Limited | Inhalatorkomponente |
| CN102174048B (zh) * | 2011-03-08 | 2014-09-17 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种催眠药的新多晶型β |
| KR102060691B1 (ko) | 2011-09-06 | 2020-02-11 | 브리티시 아메리칸 토바코 (인베스트먼츠) 리미티드 | 가열식 흡연가능 재료 |
| GB201207039D0 (en) | 2012-04-23 | 2012-06-06 | British American Tobacco Co | Heating smokeable material |
| GB2533135B (en) | 2014-12-11 | 2020-11-11 | Nicoventures Holdings Ltd | Aerosol provision systems |
| GB201511349D0 (en) | 2015-06-29 | 2015-08-12 | Nicoventures Holdings Ltd | Electronic aerosol provision systems |
| US11924930B2 (en) | 2015-08-31 | 2024-03-05 | Nicoventures Trading Limited | Article for use with apparatus for heating smokable material |
| US20170055584A1 (en) | 2015-08-31 | 2017-03-02 | British American Tobacco (Investments) Limited | Article for use with apparatus for heating smokable material |
| US20170119046A1 (en) | 2015-10-30 | 2017-05-04 | British American Tobacco (Investments) Limited | Apparatus for Heating Smokable Material |
| MY192211A (en) | 2016-04-27 | 2022-08-08 | Nicoventures Trading Ltd | Electronic aerosol provision system and vaporizer therefor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399621B1 (en) | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| US6472528B1 (en) | 1999-08-10 | 2002-10-29 | Neurocrine Biosciences, Inc. | Synthesis of substituted pyrazolopyrimidines |
| US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
| CN1198824C (zh) * | 1999-09-02 | 2005-04-27 | 纽罗克里恩生物科学有限公司 | N－甲基－N－(3－{3－[2－噻吩基羰基]－吡唑－[1,5－α]－嘧啶－7－基}苯基)乙酰胺的多晶型 |
| US6384221B1 (en) * | 1999-09-02 | 2002-05-07 | Neurocrine Biosciences, Inc. | Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| JP2001177971A (ja) * | 1999-12-20 | 2001-06-29 | Auto Network Gijutsu Kenkyusho:Kk | 回転接続装置 |
| AU2003268212B2 (en) * | 2002-08-26 | 2008-08-14 | Neurocrine Biosciences, Inc. | Novel polymorph of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-YL}phenyl)acetamide and compositions and methods related thereto |
-
2003
- 2003-08-26 AU AU2003268212A patent/AU2003268212B2/en not_active Ceased
- 2003-08-26 BR BR0313695-7A patent/BR0313695A/pt not_active Application Discontinuation
- 2003-08-26 ES ES03749163T patent/ES2274260T3/es not_active Expired - Lifetime
- 2003-08-26 PT PT03749163T patent/PT1532152E/pt unknown
- 2003-08-26 OA OA1200500060A patent/OA12917A/en unknown
- 2003-08-26 DE DE60309332T patent/DE60309332T2/de not_active Expired - Lifetime
- 2003-08-26 CN CNB03820245XA patent/CN1319974C/zh not_active Expired - Fee Related
- 2003-08-26 KR KR1020057003193A patent/KR101063033B1/ko active IP Right Grant
- 2003-08-26 US US10/648,812 patent/US6903106B2/en not_active Expired - Lifetime
- 2003-08-26 JP JP2004531248A patent/JP4522859B2/ja not_active Expired - Fee Related
- 2003-08-26 PE PE2003000867A patent/PE20040979A1/es not_active Application Discontinuation
- 2003-08-26 AP AP2005003220A patent/AP2005003220A0/xx unknown
- 2003-08-26 MX MXPA05002251A patent/MXPA05002251A/es active IP Right Grant
- 2003-08-26 DK DK03749163T patent/DK1532152T3/da active
- 2003-08-26 CA CA002493359A patent/CA2493359C/en not_active Expired - Lifetime
- 2003-08-26 IL IL16662103A patent/IL166621A0/xx unknown
- 2003-08-26 AT AT03749163T patent/ATE343581T1/de active
- 2003-08-26 EP EP03749163A patent/EP1532152B1/en not_active Expired - Lifetime
- 2003-08-26 WO PCT/US2003/026870 patent/WO2004018476A1/en active IP Right Grant
- 2003-08-26 EA EA200500421A patent/EA200500421A1/ru unknown
- 2003-08-26 NZ NZ538027A patent/NZ538027A/en not_active IP Right Cessation
- 2003-08-26 PL PL03374436A patent/PL374436A1/xx not_active Application Discontinuation
- 2003-08-26 TW TW092123478A patent/TWI288135B/zh not_active IP Right Cessation
- 2003-08-27 AR ARP030103086A patent/AR044191A1/es not_active Application Discontinuation
-
2004
- 2004-12-15 US US11/013,308 patent/US7459458B2/en not_active Expired - Lifetime
-
2005
- 2005-02-01 IL IL166621A patent/IL166621A/en active IP Right Review Request
- 2005-02-03 NO NO20050615A patent/NO20050615L/no not_active Application Discontinuation
- 2005-02-08 ZA ZA200501125A patent/ZA200501125B/en unknown
- 2005-02-25 MA MA28122A patent/MA27519A1/fr unknown
- 2005-02-25 TN TNP2005000058A patent/TNSN05058A1/en unknown
- 2005-03-23 IS IS7769A patent/IS7769A/is unknown
- 2005-03-23 EC EC2005005703A patent/ECSP055703A/es unknown
- 2005-03-24 HR HR20050288A patent/HRP20050288A2/xx not_active Application Discontinuation
- 2005-05-26 HK HK05104433A patent/HK1071373A1/xx not_active IP Right Cessation
-
2009
- 2009-12-22 JP JP2009291164A patent/JP2010070561A/ja not_active Withdrawn
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