AR044191A1 - Polimorfo del n- metil -n (3(3-(2-tienil carbonil)-pirazol-(1,5-a)- primidina-7- il) fenil) acetamida y compuestos y metodos relacionados - Google Patents

Polimorfo del n- metil -n (3(3-(2-tienil carbonil)-pirazol-(1,5-a)- primidina-7- il) fenil) acetamida y compuestos y metodos relacionados

Info

Publication number
AR044191A1
AR044191A1 ARP030103086A ARP030103086A AR044191A1 AR 044191 A1 AR044191 A1 AR 044191A1 AR P030103086 A ARP030103086 A AR P030103086A AR P030103086 A ARP030103086 A AR P030103086A AR 044191 A1 AR044191 A1 AR 044191A1
Authority
AR
Argentina
Prior art keywords
acetamide
phenyl
methyl
methods
related compounds
Prior art date
Application number
ARP030103086A
Other languages
English (en)
Original Assignee
Neurocrine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Inc filed Critical Neurocrine Inc
Publication of AR044191A1 publication Critical patent/AR044191A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Polimorfo Forma (III) del N-metil-N-(3-{3-[2-tienilcarbonil]-pirazol-[1,5-a]-pirimidina-7-yl}fenil)acetamida, y su uso como sedante-hipnótico, ansiolítico, anticonvulsivante, y/o agente relajante de los músculos asociados al esqueleto. También se divulgan compuestos relacionados y métodos, particularmente en cuanto al tratamiento del insomnio.
ARP030103086A 2002-08-26 2003-08-27 Polimorfo del n- metil -n (3(3-(2-tienil carbonil)-pirazol-(1,5-a)- primidina-7- il) fenil) acetamida y compuestos y metodos relacionados AR044191A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40607202P 2002-08-26 2002-08-26

Publications (1)

Publication Number Publication Date
AR044191A1 true AR044191A1 (es) 2005-09-07

Family

ID=31946959

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103086A AR044191A1 (es) 2002-08-26 2003-08-27 Polimorfo del n- metil -n (3(3-(2-tienil carbonil)-pirazol-(1,5-a)- primidina-7- il) fenil) acetamida y compuestos y metodos relacionados

Country Status (32)

Country Link
US (2) US6903106B2 (es)
EP (1) EP1532152B1 (es)
JP (2) JP4522859B2 (es)
KR (1) KR101063033B1 (es)
CN (1) CN1319974C (es)
AP (1) AP2005003220A0 (es)
AR (1) AR044191A1 (es)
AT (1) ATE343581T1 (es)
AU (1) AU2003268212B2 (es)
BR (1) BR0313695A (es)
CA (1) CA2493359C (es)
DE (1) DE60309332T2 (es)
DK (1) DK1532152T3 (es)
EA (1) EA200500421A1 (es)
EC (1) ECSP055703A (es)
ES (1) ES2274260T3 (es)
HK (1) HK1071373A1 (es)
HR (1) HRP20050288A2 (es)
IL (2) IL166621A0 (es)
IS (1) IS7769A (es)
MA (1) MA27519A1 (es)
MX (1) MXPA05002251A (es)
NO (1) NO20050615L (es)
NZ (1) NZ538027A (es)
OA (1) OA12917A (es)
PE (1) PE20040979A1 (es)
PL (1) PL374436A1 (es)
PT (1) PT1532152E (es)
TN (1) TNSN05058A1 (es)
TW (1) TWI288135B (es)
WO (1) WO2004018476A1 (es)
ZA (1) ZA200501125B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4522859B2 (ja) * 2002-08-26 2010-08-11 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｎ−メチル−Ｎ−（３−｛３−［２−チエニルカルボニル］−ピラゾール−［１，５−α］−ピリミジン−７−イル｝フェニル）アセトアミドの新規の多形ならびにそれに関連した組成物および方法
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
EP1844047A1 (en) 2004-10-18 2007-10-17 Neurocrine Biosciences, Inc. Hydrate of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]- pyramidin-7-yl}phenyl)acetamide and processes and methods related thereto
CN100528875C (zh) * 2005-02-18 2009-08-19 美德（江西）生物科技有限公司 无结晶型态的印地普隆及其制备方法
EP1918290A1 (en) 2006-10-11 2008-05-07 Ferrer Internacional, S.A. Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
CN102180879B (zh) * 2006-11-09 2013-05-01 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的多晶型α的乙酸溶剂化物
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
BR112012023656A2 (pt) 2010-03-25 2017-10-10 Yazaki Corp conector e método para identificação de padrão de barramento em conector
ES2581452T3 (es) * 2010-04-16 2016-09-05 Ivoclar Vivadent Ag Vitrocerámica y vidrio de silicato de litio con óxido de metal de transición
ES2543312T3 (es) 2011-02-11 2015-08-18 Batmark Limited Componente para inhalador
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
CN102174048B (zh) * 2011-03-08 2014-09-17 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的新多晶型β
KR102196913B1 (ko) 2011-09-06 2020-12-30 니코벤처스 트레이딩 리미티드 가열식 흡연가능 재료
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
WO2017187148A1 (en) 2016-04-27 2017-11-02 Nicoventures Holdings Limited Electronic aerosol provision system and vaporizer therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6472528B1 (en) 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
ATE269082T1 (de) 1999-09-02 2004-07-15 Neurocrine Biosciences Inc Polymorphe des n-methyl-n-(3-(2-thienylcarbonyl)- pyrazol(1,5-a)pyrimidin-7-yl phenyl)acetamid und zusammenstellungen und diesbezügliche methoden
JP2001177971A (ja) * 1999-12-20 2001-06-29 Auto Network Gijutsu Kenkyusho:Kk 回転接続装置
JP4522859B2 (ja) * 2002-08-26 2010-08-11 ニューロクライン バイオサイエンシーズ，インコーポレイテッド Ｎ−メチル−Ｎ−（３−｛３−［２−チエニルカルボニル］−ピラゾール−［１，５−α］−ピリミジン−７−イル｝フェニル）アセトアミドの新規の多形ならびにそれに関連した組成物および方法

Also Published As

Publication number Publication date
IS7769A (is) 2005-03-23
US6903106B2 (en) 2005-06-07
CN1319974C (zh) 2007-06-06
AU2003268212B2 (en) 2008-08-14
AP2005003220A0 (en) 2005-03-31
MA27519A1 (fr) 2005-09-01
OA12917A (en) 2006-10-13
TW200406404A (en) 2004-05-01
BR0313695A (pt) 2005-06-21
KR20050059082A (ko) 2005-06-17
JP2010070561A (ja) 2010-04-02
DK1532152T3 (da) 2007-02-26
TNSN05058A1 (en) 2007-05-14
EP1532152A1 (en) 2005-05-25
JP2005538149A (ja) 2005-12-15
AU2003268212A1 (en) 2004-03-11
NZ538027A (en) 2007-08-31
US20050153988A1 (en) 2005-07-14
PE20040979A1 (es) 2005-01-07
PL374436A1 (en) 2005-10-17
ATE343581T1 (de) 2006-11-15
HK1071373A1 (en) 2005-07-15
CA2493359C (en) 2009-10-27
ES2274260T3 (es) 2007-05-16
EP1532152B1 (en) 2006-10-25
IL166621A0 (en) 2006-01-15
MXPA05002251A (es) 2005-06-08
CN1678614A (zh) 2005-10-05
JP4522859B2 (ja) 2010-08-11
US20040116446A1 (en) 2004-06-17
KR101063033B1 (ko) 2011-09-07
US7459458B2 (en) 2008-12-02
DE60309332T2 (de) 2007-05-24
ECSP055703A (es) 2005-05-30
NO20050615L (no) 2005-03-22
WO2004018476A1 (en) 2004-03-04
ZA200501125B (en) 2006-07-26
IL166621A (en) 2012-02-29
PT1532152E (pt) 2007-02-28
EA200500421A1 (ru) 2005-08-25
DE60309332D1 (de) 2006-12-07
TWI288135B (en) 2007-10-11
CA2493359A1 (en) 2004-03-04
HRP20050288A2 (en) 2006-10-31

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