NO20050615L - NY POLYMORF AV N-METYL-N-(3-{3-[2-TIENYLKARBONYL]-PYRAZOL-[1,5-alfa]-PYRIMIDIN-7-YL}FENYL)ACETAMID OG PREPARAT OG ANVENDELSER RELATERT DERTIL - Google Patents

NY POLYMORF AV N-METYL-N-(3-{3-[2-TIENYLKARBONYL]-PYRAZOL-[1,5-alfa]-PYRIMIDIN-7-YL}FENYL)ACETAMID OG PREPARAT OG ANVENDELSER RELATERT DERTIL

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Publication number
NO20050615L
NO20050615L NO20050615A NO20050615A NO20050615L NO 20050615 L NO20050615 L NO 20050615L NO 20050615 A NO20050615 A NO 20050615A NO 20050615 A NO20050615 A NO 20050615A NO 20050615 L NO20050615 L NO 20050615L
Authority
NO
Norway
Prior art keywords
pyrimidin
acetamide
phenyl
methyl
pyrazol
Prior art date
Application number
NO20050615A
Other languages
English (en)
Inventor
Scott E Zook
Donald Hettinger
Iii Henry R Dubois
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of NO20050615L publication Critical patent/NO20050615L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Polymorf Form III av N-metyl-N-(3-(3-[2-tienylkarbonyl]-pyrazol-[1,5-(]pyrimidin-7-yl)fenyl)acetamid og anvendelse derav som et sedativ-hypnotisk, angstdempende, antikonvulsivt og/eller skjelettmuskelavspennende middel. Relaterte preparater og metoder er også beskrevet, spesielt med hensyn til behandling av søvnløshet.
NO20050615A 2002-08-26 2005-02-03 NY POLYMORF AV N-METYL-N-(3-{3-[2-TIENYLKARBONYL]-PYRAZOL-[1,5-alfa]-PYRIMIDIN-7-YL}FENYL)ACETAMID OG PREPARAT OG ANVENDELSER RELATERT DERTIL NO20050615L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40607202P 2002-08-26 2002-08-26
PCT/US2003/026870 WO2004018476A1 (en) 2002-08-26 2003-08-26 Novel polymorph of n-methyl-n-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-alpha]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Publications (1)

Publication Number Publication Date
NO20050615L true NO20050615L (no) 2005-03-22

Family

ID=31946959

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050615A NO20050615L (no) 2002-08-26 2005-02-03 NY POLYMORF AV N-METYL-N-(3-{3-[2-TIENYLKARBONYL]-PYRAZOL-[1,5-alfa]-PYRIMIDIN-7-YL}FENYL)ACETAMID OG PREPARAT OG ANVENDELSER RELATERT DERTIL

Country Status (32)

Country Link
US (2) US6903106B2 (no)
EP (1) EP1532152B1 (no)
JP (2) JP4522859B2 (no)
KR (1) KR101063033B1 (no)
CN (1) CN1319974C (no)
AP (1) AP2005003220A0 (no)
AR (1) AR044191A1 (no)
AT (1) ATE343581T1 (no)
AU (1) AU2003268212B2 (no)
BR (1) BR0313695A (no)
CA (1) CA2493359C (no)
DE (1) DE60309332T2 (no)
DK (1) DK1532152T3 (no)
EA (1) EA200500421A1 (no)
EC (1) ECSP055703A (no)
ES (1) ES2274260T3 (no)
HK (1) HK1071373A1 (no)
HR (1) HRP20050288A2 (no)
IL (2) IL166621A0 (no)
IS (1) IS7769A (no)
MA (1) MA27519A1 (no)
MX (1) MXPA05002251A (no)
NO (1) NO20050615L (no)
NZ (1) NZ538027A (no)
OA (1) OA12917A (no)
PE (1) PE20040979A1 (no)
PL (1) PL374436A1 (no)
PT (1) PT1532152E (no)
TN (1) TNSN05058A1 (no)
TW (1) TWI288135B (no)
WO (1) WO2004018476A1 (no)
ZA (1) ZA200501125B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2274260T3 (es) * 2002-08-26 2007-05-16 Neurocrine Biosciences, Inc. Nuevo polimorfo de n-metil-n-(3-(3-((2-tienilcarbonil))pirazol-((1,5-alfa))pirimidin-7-il))fenil)acetamida y composiciones y metodos relacionados.
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
TW200630368A (en) * 2004-10-18 2006-09-01 Neurocrine Biosciences Inc Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto
CN100528875C (zh) * 2005-02-18 2009-08-19 美德（江西）生物科技有限公司 无结晶型态的印地普隆及其制备方法
EP1918290A1 (en) 2006-10-11 2008-05-07 Ferrer Internacional, S.A. Polymorph B of N-{2-Fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
EP1956021A1 (en) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
CN102180879B (zh) * 2006-11-09 2013-05-01 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的多晶型α的乙酸溶剂化物
CN102834987B (zh) 2010-03-25 2015-04-15 矢崎总业株式会社 接头连接器和用于识别接头连接器中的汇流条图案的方法
ES2581452T3 (es) * 2010-04-16 2016-09-05 Ivoclar Vivadent Ag Vitrocerámica y vidrio de silicato de litio con óxido de metal de transición
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
PL2672847T3 (pl) 2011-02-11 2015-10-30 Batmark Ltd Część składowa inhalatora
CN102174048B (zh) * 2011-03-08 2014-09-17 中国人民解放军军事医学科学院放射与辐射医学研究所 一种催眠药的新多晶型β
EP2753202B1 (en) 2011-09-06 2016-04-27 British American Tobacco (Investments) Ltd Heating smokeable material
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201511361D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic vapour provision system
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
BR112018071824B1 (pt) 2016-04-27 2023-01-10 Nicoventures Trading Limited Subconjunto, sistema, método para fabricar um vaporizador e dispositivo de fornecimento de vapor eletrônico

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US6472528B1 (en) 1999-08-10 2002-10-29 Neurocrine Biosciences, Inc. Synthesis of substituted pyrazolopyrimidines
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
AU769856B2 (en) 1999-09-02 2004-02-05 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-(3-(2-thienylcarbonyl)-pyrazol-(1,5-alpha)- pyrimidin-7-yl)phenyl)acetamide and compositions and methods related thereto
JP2001177971A (ja) * 1999-12-20 2001-06-29 Auto Network Gijutsu Kenkyusho:Kk 回転接続装置
ES2274260T3 (es) * 2002-08-26 2007-05-16 Neurocrine Biosciences, Inc. Nuevo polimorfo de n-metil-n-(3-(3-((2-tienilcarbonil))pirazol-((1,5-alfa))pirimidin-7-il))fenil)acetamida y composiciones y metodos relacionados.

Also Published As

Publication number Publication date
OA12917A (en) 2006-10-13
DE60309332D1 (de) 2006-12-07
CN1678614A (zh) 2005-10-05
HK1071373A1 (en) 2005-07-15
CA2493359A1 (en) 2004-03-04
IL166621A0 (en) 2006-01-15
US7459458B2 (en) 2008-12-02
WO2004018476A1 (en) 2004-03-04
EP1532152B1 (en) 2006-10-25
US6903106B2 (en) 2005-06-07
CA2493359C (en) 2009-10-27
TWI288135B (en) 2007-10-11
KR20050059082A (ko) 2005-06-17
AU2003268212B2 (en) 2008-08-14
TNSN05058A1 (en) 2007-05-14
ATE343581T1 (de) 2006-11-15
JP4522859B2 (ja) 2010-08-11
US20050153988A1 (en) 2005-07-14
MA27519A1 (fr) 2005-09-01
PT1532152E (pt) 2007-02-28
PL374436A1 (en) 2005-10-17
ES2274260T3 (es) 2007-05-16
MXPA05002251A (es) 2005-06-08
TW200406404A (en) 2004-05-01
AP2005003220A0 (en) 2005-03-31
EA200500421A1 (ru) 2005-08-25
AR044191A1 (es) 2005-09-07
HRP20050288A2 (en) 2006-10-31
IS7769A (is) 2005-03-23
KR101063033B1 (ko) 2011-09-07
EP1532152A1 (en) 2005-05-25
AU2003268212A1 (en) 2004-03-11
PE20040979A1 (es) 2005-01-07
JP2010070561A (ja) 2010-04-02
DE60309332T2 (de) 2007-05-24
ECSP055703A (es) 2005-05-30
US20040116446A1 (en) 2004-06-17
JP2005538149A (ja) 2005-12-15
DK1532152T3 (da) 2007-02-26
CN1319974C (zh) 2007-06-06
ZA200501125B (en) 2006-07-26
IL166621A (en) 2012-02-29
BR0313695A (pt) 2005-06-21
NZ538027A (en) 2007-08-31

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