DK151884C - Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK151884C
DK151884C DK042580A DK42580A DK151884C DK 151884 C DK151884 C DK 151884C DK 042580 A DK042580 A DK 042580A DK 42580 A DK42580 A DK 42580A DK 151884 C DK151884 C DK 151884C
Authority
DK
Denmark
Prior art keywords
imidazolylalkyl
incidental
analogue
preparation
acid addition
Prior art date
Application number
DK042580A
Other languages
Danish (da)
English (en)
Other versions
DK151884B (da
DK42580A (da
Inventor
Peter Edward Cross
Roger Peter Dickinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK42580A publication Critical patent/DK42580A/da
Publication of DK151884B publication Critical patent/DK151884B/da
Application granted granted Critical
Publication of DK151884C publication Critical patent/DK151884C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK042580A 1979-03-07 1980-01-31 Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf DK151884C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07
GB7908123 1979-03-07

Publications (3)

Publication Number Publication Date
DK42580A DK42580A (da) 1980-09-08
DK151884B DK151884B (da) 1988-01-11
DK151884C true DK151884C (da) 1988-06-13

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
DK042580A DK151884C (da) 1979-03-07 1980-01-31 Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (36)

Country Link
US (1) US4273782A (cs)
JP (1) JPS55133380A (cs)
KR (1) KR850000760B1 (cs)
AR (1) AR227015A1 (cs)
AT (1) AT375366B (cs)
AU (1) AU516957B2 (cs)
BE (1) BE882113A (cs)
CA (1) CA1120479A (cs)
CH (1) CH649546A5 (cs)
CS (1) CS253702B2 (cs)
DD (1) DD149525A5 (cs)
DE (1) DE3008632A1 (cs)
DK (1) DK151884C (cs)
ES (2) ES8104278A1 (cs)
FI (1) FI66860C (cs)
FR (1) FR2450832A1 (cs)
GR (1) GR67237B (cs)
HK (1) HK89884A (cs)
HU (1) HU184727B (cs)
IE (1) IE49542B1 (cs)
IL (1) IL59524A (cs)
IT (1) IT1218420B (cs)
KE (1) KE3467A (cs)
LU (1) LU82224A1 (cs)
MY (1) MY8500285A (cs)
NL (1) NL182959C (cs)
NO (1) NO152217C (cs)
NZ (1) NZ193052A (cs)
PH (1) PH15198A (cs)
PL (1) PL128296B1 (cs)
PT (1) PT70914A (cs)
SE (1) SE440778B (cs)
SG (1) SG67284G (cs)
SU (1) SU1277894A3 (cs)
YU (1) YU41911B (cs)
ZA (1) ZA801328B (cs)

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ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
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US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
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AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
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JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 Ｎ―フタルイシド誘導体及びその製造法
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
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ES2104708T3 (es) * 1990-06-07 1997-10-16 Zeneca Ltd Compuestos heterociclicos terapeuticos.
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
IE913204A1 (en) * 1990-09-13 1992-02-25 Beecham Group Plc Novel compounds
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US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
ES2090956T3 (es) * 1991-12-18 1996-10-16 Schering Corp Imidazolil o imidazolilalquil sustituido con un anillo heterociclico de cuatro o cinco miembros que contiene nitrogeno.
EP0597112A4 (en) * 1992-03-27 1994-06-22 Kyoto Pharma Ind Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor.
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
EE200000573A (et) * 1998-03-31 2002-04-15 The Institutes For Pharmaceutical Discovery, Llc Asendatud indoolalkaanhapped
JP4286782B2 (ja) * 2002-09-12 2009-07-01 エフ．ホフマン−ラ ロシュ アーゲー 糖尿病の治療に有用な、ｐｐａｒアゴニストとしてのｎ−置換−１ｈ−インドール−５−プロピオン酸化合物
PL377320A1 (pl) * 2002-11-25 2006-01-23 F. Hoffmann-La Roche Ag Pochodne indolilowe
CA2509170A1 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
MXPA06012683A (es) * 2004-05-03 2007-01-16 Hoffmann La Roche Derivados de indolilo como moduladores de receptor x del higado.
DE602005026553D1 (de) * 2004-10-12 2011-04-07 Decode Genetics Ehf Peri-substituierte bicyclische sulfonamide gegen arterielle verschlusskrankheit
ATE517883T1 (de) * 2005-08-25 2011-08-15 Schering Corp Imidazolderivate als funktionelle selektive agonisten des alpha2c-adrenorezeptors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
KR20090018934A (ko) * 2006-05-16 2009-02-24 디코드 제네틱스 이에이치에프 7-(아크릴로일)인돌의 제조방법
KR20090042808A (ko) 2006-07-22 2009-04-30 옥사겐 리미티드 씨알티에이치2 길항제 활성을 갖는 화합물
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US3621027A (en) * 1968-03-18 1971-11-16 Endo Lab 1-aminoalkyl-2,6-diaryl 4,5,6,7 tetrahydro-4-oxindales
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Also Published As

Publication number Publication date
ATA125780A (de) 1983-12-15
IL59524A (en) 1982-11-30
PL222470A1 (cs) 1980-12-01
FI800672A7 (fi) 1980-09-08
DE3008632A1 (de) 1980-10-16
PT70914A (en) 1980-04-01
FI66860C (fi) 1984-12-10
ES8205789A1 (es) 1982-08-01
FR2450832B1 (cs) 1983-04-22
US4273782A (en) 1981-06-16
AU5623180A (en) 1980-09-11
SU1277894A3 (ru) 1986-12-15
KR850000760B1 (ko) 1985-05-25
KR830001928A (ko) 1983-05-19
ES489220A0 (es) 1981-04-01
ES496889A0 (es) 1982-08-01
CA1120479A (en) 1982-03-23
DD149525A5 (de) 1981-07-15
IT8020399A0 (it) 1980-03-06
IT1218420B (it) 1990-04-19
NO152217B (no) 1985-05-13
FI66860B (fi) 1984-08-31
AU516957B2 (en) 1981-07-02
AT375366B (de) 1984-07-25
YU41911B (en) 1988-02-29
YU61480A (en) 1983-12-31
NO152217C (no) 1985-08-21
SE440778B (sv) 1985-08-19
JPS6141513B2 (cs) 1986-09-16
AR227015A1 (es) 1982-09-15
FR2450832A1 (fr) 1980-10-03
HK89884A (en) 1984-11-23
SE8001736L (sv) 1980-09-08
PL128296B1 (en) 1984-01-31
DE3008632C2 (cs) 1988-02-25
IL59524A0 (en) 1980-06-30
ES8104278A1 (es) 1981-04-01
DK151884B (da) 1988-01-11
IE800453L (en) 1980-09-07
CS253702B2 (en) 1987-12-17
ZA801328B (en) 1981-03-25
NO800650L (no) 1980-09-08
BE882113A (fr) 1980-09-08
JPS55133380A (en) 1980-10-17
NL8001351A (nl) 1980-09-09
MY8500285A (en) 1985-12-31
CH649546A5 (de) 1985-05-31
KE3467A (en) 1984-11-09
NZ193052A (en) 1984-07-06
DK42580A (da) 1980-09-08
NL182959C (nl) 1988-06-16
SG67284G (en) 1985-03-15
PH15198A (en) 1982-09-17
HU184727B (en) 1984-10-29
LU82224A1 (fr) 1980-06-06
IE49542B1 (en) 1985-10-30
GR67237B (cs) 1981-06-25

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