NL182959C - N-1 gesubstitueerde 3-(imidazol-1-ylmethyl)-indolen, deze verbindingen bevattende farmaceutische voorwerpen, en werkwijze voor het bereiden van voornoemde verbindingen. - Google Patents

N-1 gesubstitueerde 3-(imidazol-1-ylmethyl)-indolen, deze verbindingen bevattende farmaceutische voorwerpen, en werkwijze voor het bereiden van voornoemde verbindingen.

Info

Publication number
NL182959C
NL182959C NLAANVRAGE8001351,A NL8001351A NL182959C NL 182959 C NL182959 C NL 182959C NL 8001351 A NL8001351 A NL 8001351A NL 182959 C NL182959 C NL 182959C
Authority
NL
Netherlands
Prior art keywords
compounds
indols
imidazol
ylmethyl
substituted
Prior art date
Application number
NLAANVRAGE8001351,A
Other languages
English (en)
Dutch (nl)
Other versions
NL8001351A (nl
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NL8001351A publication Critical patent/NL8001351A/nl
Application granted granted Critical
Publication of NL182959C publication Critical patent/NL182959C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NLAANVRAGE8001351,A 1979-03-07 1980-03-06 N-1 gesubstitueerde 3-(imidazol-1-ylmethyl)-indolen, deze verbindingen bevattende farmaceutische voorwerpen, en werkwijze voor het bereiden van voornoemde verbindingen. NL182959C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7908123 1979-03-07
GB7908123 1979-03-07

Publications (2)

Publication Number Publication Date
NL8001351A NL8001351A (nl) 1980-09-09
NL182959C true NL182959C (nl) 1988-06-16

Family

ID=10503707

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE8001351,A NL182959C (nl) 1979-03-07 1980-03-06 N-1 gesubstitueerde 3-(imidazol-1-ylmethyl)-indolen, deze verbindingen bevattende farmaceutische voorwerpen, en werkwijze voor het bereiden van voornoemde verbindingen.

Country Status (36)

Country Link
US (1) US4273782A (cs)
JP (1) JPS55133380A (cs)
KR (1) KR850000760B1 (cs)
AR (1) AR227015A1 (cs)
AT (1) AT375366B (cs)
AU (1) AU516957B2 (cs)
BE (1) BE882113A (cs)
CA (1) CA1120479A (cs)
CH (1) CH649546A5 (cs)
CS (1) CS253702B2 (cs)
DD (1) DD149525A5 (cs)
DE (1) DE3008632A1 (cs)
DK (1) DK151884C (cs)
ES (2) ES489220A0 (cs)
FI (1) FI66860C (cs)
FR (1) FR2450832A1 (cs)
GR (1) GR67237B (cs)
HK (1) HK89884A (cs)
HU (1) HU184727B (cs)
IE (1) IE49542B1 (cs)
IL (1) IL59524A (cs)
IT (1) IT1218420B (cs)
KE (1) KE3467A (cs)
LU (1) LU82224A1 (cs)
MY (1) MY8500285A (cs)
NL (1) NL182959C (cs)
NO (1) NO152217C (cs)
NZ (1) NZ193052A (cs)
PH (1) PH15198A (cs)
PL (1) PL128296B1 (cs)
PT (1) PT70914A (cs)
SE (1) SE440778B (cs)
SG (1) SG67284G (cs)
SU (1) SU1277894A3 (cs)
YU (1) YU41911B (cs)
ZA (1) ZA801328B (cs)

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US4539410A (en) * 1982-09-30 1985-09-03 Ciba-Geigy Corporation N-Substituted-2-(1-imidazolyl)indoles
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US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
JPH0832679B2 (ja) * 1986-09-05 1996-03-29 理化学研究所 Ｎ―フタルイシド誘導体及びその製造法
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WO1990012009A1 (en) * 1989-03-31 1990-10-18 Kyoto Pharmaceutical Industries, Ltd. New imidazole derivatives, production thereof, and uses thereof as medicines
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
DE4023215A1 (de) * 1990-07-21 1992-01-23 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung
WO1992005170A1 (en) * 1990-09-13 1992-04-02 Beecham Group Plc Indole ureas as 5 ht receptor antagonist
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
US5120749A (en) * 1991-02-20 1992-06-09 Abbott Laboratories Platelet activating antagonists
ZA929788B (en) * 1991-12-18 1993-06-22 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring.
US5538973A (en) * 1992-03-27 1996-07-23 Kyoto Pharmaceutical Industries, Ltd. Imidazole derivative, pharmaceutical use thereof, and intermediate therefor
EP0597112A4 (en) * 1992-03-27 1994-06-22 Kyoto Pharma Ind Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor.
JPH0632913U (ja) * 1992-09-18 1994-04-28 三洋電機株式会社 床暖房用パネル
IL138711A0 (en) * 1998-03-31 2001-10-31 Inst Pharmaceutical Discovery Substituted indolealkanoic acids
ATE345340T1 (de) * 2002-09-12 2006-12-15 Hoffmann La Roche N-substituierte-1h-indol-5-propansäure verbindungen als ppar-agonisten zur behandlung von diabetis
JP4384052B2 (ja) * 2002-11-25 2009-12-16 エフ．ホフマン−ラ ロシュ アーゲー インドリル誘導体
WO2004052853A2 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
KR100893449B1 (ko) * 2004-05-03 2009-04-17 에프. 호프만-라 로슈 아게 간-ｘ-수용체 조절제로서의 인돌일 유도체
NZ554491A (en) * 2004-10-12 2009-07-31 Decode Genetics Ehf Sulfonamide peri-substituted bicyclics for occlusive artery disease
SG165314A1 (en) * 2005-08-25 2010-10-28 Schering Corp Imidazole derivatives as functionally selective alpha2c adrenoreceptor agonists
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
CA2652152A1 (en) * 2006-05-16 2007-11-29 Decode Genetics Ehf Process for preparing 7-(acryloyl)indoles
PL2046740T3 (pl) 2006-07-22 2012-10-31 Oxagen Ltd Związki o aktywności antagonisty CRTH2
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
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DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US20100022613A1 (en) * 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
JP2011509991A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
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US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
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DE2960547D1 (en) * 1978-02-24 1981-11-05 Pfizer Ltd 3-(imidazol-1-ylalkyl)indoles as selective inhibitors of thromboxane synthetase,pharmaceutical compositions thereof, and methods for preparing them

Also Published As

Publication number Publication date
DK151884B (da) 1988-01-11
KR830001928A (ko) 1983-05-19
CS253702B2 (en) 1987-12-17
CA1120479A (en) 1982-03-23
JPS6141513B2 (cs) 1986-09-16
HK89884A (en) 1984-11-23
DD149525A5 (de) 1981-07-15
AU5623180A (en) 1980-09-11
ES8104278A1 (es) 1981-04-01
YU61480A (en) 1983-12-31
FR2450832A1 (fr) 1980-10-03
PL128296B1 (en) 1984-01-31
IE800453L (en) 1980-09-07
SE8001736L (sv) 1980-09-08
DE3008632A1 (de) 1980-10-16
KR850000760B1 (ko) 1985-05-25
KE3467A (en) 1984-11-09
IL59524A0 (en) 1980-06-30
IT8020399A0 (it) 1980-03-06
SU1277894A3 (ru) 1986-12-15
ZA801328B (en) 1981-03-25
PL222470A1 (cs) 1980-12-01
BE882113A (fr) 1980-09-08
DK42580A (da) 1980-09-08
GR67237B (cs) 1981-06-25
PH15198A (en) 1982-09-17
ES8205789A1 (es) 1982-08-01
IL59524A (en) 1982-11-30
US4273782A (en) 1981-06-16
FI800672A7 (fi) 1980-09-08
AR227015A1 (es) 1982-09-15
HU184727B (en) 1984-10-29
NO152217C (no) 1985-08-21
IE49542B1 (en) 1985-10-30
FI66860B (fi) 1984-08-31
IT1218420B (it) 1990-04-19
AT375366B (de) 1984-07-25
NO800650L (no) 1980-09-08
SE440778B (sv) 1985-08-19
CH649546A5 (de) 1985-05-31
YU41911B (en) 1988-02-29
NZ193052A (en) 1984-07-06
NL8001351A (nl) 1980-09-09
PT70914A (en) 1980-04-01
MY8500285A (en) 1985-12-31
ATA125780A (de) 1983-12-15
LU82224A1 (fr) 1980-06-06
ES489220A0 (es) 1981-04-01
FR2450832B1 (cs) 1983-04-22
SG67284G (en) 1985-03-15
JPS55133380A (en) 1980-10-17
DE3008632C2 (cs) 1988-02-25
ES496889A0 (es) 1982-08-01
FI66860C (fi) 1984-12-10
AU516957B2 (en) 1981-07-02
DK151884C (da) 1988-06-13
NO152217B (no) 1985-05-13

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A1A A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed
A85 Still pending on 85-01-01
V1 Lapsed because of non-payment of the annual fee

Effective date: 19951001