DK1470114T3 - Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner - Google Patents

Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner

Info

Publication number
DK1470114T3
DK1470114T3 DK03700408T DK03700408T DK1470114T3 DK 1470114 T3 DK1470114 T3 DK 1470114T3 DK 03700408 T DK03700408 T DK 03700408T DK 03700408 T DK03700408 T DK 03700408T DK 1470114 T3 DK1470114 T3 DK 1470114T3
Authority
DK
Denmark
Prior art keywords
sub
nucleobase
oligomers
side chain
peptide nucleic
Prior art date
Application number
DK03700408T
Other languages
Danish (da)
English (en)
Inventor
Sung Kee Kim
Hyunil Lee
Jong Chan Lim
Hoon Choi
Jae Hoon Jeon
Sung Hee Lee
Sang Youl Ahn
Original Assignee
Panagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panagene Inc filed Critical Panagene Inc
Application granted granted Critical
Publication of DK1470114T3 publication Critical patent/DK1470114T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003Peptide-nucleic acids (PNAs)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03700408T 2002-01-24 2003-01-23 Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner DK1470114T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0004194A KR100464261B1 (ko) 2002-01-24 2002-01-24 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
PCT/IB2003/000164 WO2003062212A1 (en) 2002-01-24 2003-01-23 Peptide nucleic acid oligomers from 1-benzenesulfonyl-3-amino acid side chain-4-(2-nucleobase(acetyl))-piperazin-2-ones

Publications (1)

Publication Number Publication Date
DK1470114T3 true DK1470114T3 (da) 2009-11-02

Family

ID=27607011

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03700408T DK1470114T3 (da) 2002-01-24 2003-01-23 Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner

Country Status (9)

Country Link
US (1) US7022851B2 (zh)
EP (1) EP1470114B1 (zh)
JP (1) JP4394952B2 (zh)
KR (1) KR100464261B1 (zh)
CN (1) CN100351243C (zh)
AT (1) ATE440089T1 (zh)
DE (1) DE60328866D1 (zh)
DK (1) DK1470114T3 (zh)
WO (1) WO2003062212A1 (zh)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100464264B1 (ko) * 2002-03-21 2005-01-03 주식회사 파나진 광분해 보호기를 갖는 신규한 pna 단량체
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7211668B2 (en) * 2003-07-28 2007-05-01 Panagene, Inc. PNA monomer and precursor
EP1722792A1 (de) * 2004-03-03 2006-11-22 Boehringer Ingelheim International GmbH Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
CA2596506C (en) 2005-02-09 2021-04-06 Avi Biopharma, Inc. Antisense composition and method for treating muscle atrophy
WO2006130872A2 (en) 2005-06-02 2006-12-07 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
KR101072899B1 (ko) 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
US20110111416A1 (en) * 2008-05-06 2011-05-12 Panagene Inc. Peptide Nucleic Acid Probes, Kits and Methods for Expression Profiling of Micrornas
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
CA2764158A1 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
EP2499248B1 (en) 2009-11-13 2017-01-04 Sarepta Therapeutics, Inc. Antisense antiviral compound and method for treating influenza viral infection
US20120309684A1 (en) 2009-11-30 2012-12-06 Isis Innovation Limited Conjugates for delivery of biologically active compounds
WO2011112516A1 (en) 2010-03-08 2011-09-15 Ico Therapeutics Inc. Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
EP2545173A2 (en) 2010-03-12 2013-01-16 Sarepta Therapeutics, Inc. Antisense modulation of nuclear hormone receptors
CN103118692A (zh) 2010-04-26 2013-05-22 Atyr医药公司 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
CN103118693B (zh) 2010-04-29 2017-05-03 Atyr 医药公司 与缬氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
US8986680B2 (en) 2010-04-29 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
EP2566496B1 (en) 2010-05-03 2018-02-28 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
WO2011140267A2 (en) 2010-05-04 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
CA3090304A1 (en) 2010-05-13 2011-11-17 Sarepta Therapeutics, Inc. Antisense modulation of interleukins 17 and 23 signaling
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011256366C1 (en) 2010-05-17 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
US8791121B2 (en) 2010-08-12 2014-07-29 New York University Oligooxopiperazines and methods of making and using them
WO2012027611A2 (en) 2010-08-25 2012-03-01 Atyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
AU2012284259A1 (en) 2011-07-15 2014-03-06 Sarepta Therapeutics, Inc. Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
KR101303699B1 (ko) 2011-07-20 2013-09-09 대한민국 Pna 칩을 이용한 다종 식중독균 검출 방법
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
JP6132849B2 (ja) 2011-12-08 2017-05-31 サレプタ セラピューティクス, インコーポレイテッド ヒトlmnaを標的とするオリゴヌクレオチド類似体を使用する早老性ラミノパシーを処置するための方法
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
AU2014207311A1 (en) 2013-01-19 2015-08-20 New York University Oligooxopiperazines for p53 reactivation
CN105793422B (zh) 2013-09-05 2020-03-03 萨罗塔治疗公司(美国) 酸性α-葡糖苷酶中反义诱导的外显子2纳入
KR101830700B1 (ko) 2013-11-11 2018-02-21 주식회사 파나진 클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법
US11180481B2 (en) 2014-04-15 2021-11-23 New York University Oxopiperazine helix mimetics as inhibitors of the p53-MDM2 interaction
KR101951172B1 (ko) 2014-11-07 2019-02-22 주식회사 파나진 인유두종바이러스의 유전자형 검출을 위한 ρνα 프로브, 키트 및 방법
WO2016081808A1 (en) 2014-11-20 2016-05-26 The Regents Of The University Of California Compositions and methods related to hematologic recovery
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
EP3851531A1 (en) 2015-06-01 2021-07-21 Sarepta Therapeutics, Inc. Antisense-induced exon exclusion in type vii collagen
BR112018003784A2 (pt) 2015-08-24 2018-09-25 Halo-Bio Rnai Therapeutics, Inc. nanopartículas de polinucleotídeo para a modulação da expressão gênica e sua utilização
CN108699555A (zh) 2015-10-09 2018-10-23 萨勒普塔医疗公司 用于治疗杜兴肌营养不良和相关病症的组合物和方法
US10358648B2 (en) 2016-02-02 2019-07-23 Olix Pharmaceuticals, Inc. Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1
AU2017254106B2 (en) 2016-04-18 2024-07-11 Sarepta Therapeutics, Inc. Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
CN109477109B (zh) 2016-04-29 2022-09-23 萨勒普塔医疗公司 靶向人lmna的寡核苷酸类似物
MX2018016052A (es) 2016-06-30 2019-05-02 Sarepta Therapeutics Inc Oligomeros de omision de exon para distrofia muscular.
WO2018017814A1 (en) 2016-07-20 2018-01-25 President And Fellows Of Harvard College Peptidoglycan glycosyltransferase inhibitors of sed proteins for treating bacterial infections
WO2018053142A2 (en) 2016-09-14 2018-03-22 President And Fellows Of Harvard College Methods and compositions for modulating erythropoiesis
WO2018112032A1 (en) 2016-12-13 2018-06-21 President And Fellows Of Harvard College Methods and compositions for targeting tumor-infiltrating tregs using inhibitors of ccr8 and tnfrsf8
MX2019006879A (es) 2016-12-19 2019-08-01 Sarepta Therapeutics Inc Conjugados de oligomeros de omision de exon para distrofia muscular.
KR102552428B1 (ko) 2016-12-19 2023-07-06 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체
KR102639633B1 (ko) 2016-12-19 2024-02-26 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체
JP2020517638A (ja) 2017-04-20 2020-06-18 エータイアー ファーマ, インコーポレイテッド 肺の炎症を治療するための組成物および方法
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
US10421728B2 (en) 2017-06-08 2019-09-24 Amrita Vishwa Vidyapeetham Peptide nucleic acid monomer and a preparation method
EA201991450A1 (ru) 2017-09-22 2019-12-30 Сарепта Терапьютикс, Инк. Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
US20200248178A1 (en) 2017-09-28 2020-08-06 Sarepta Therapeutics, Inc. Combination therapies for treating muscular dystrophy
US20200254002A1 (en) 2017-09-28 2020-08-13 Sarepta Therapeutics, Inc. Combination therapies for treating muscular dystrophy
EP3687577A1 (en) 2017-09-28 2020-08-05 Sarepta Therapeutics, Inc. Combination therapies for treating muscular dystrophy
EP3697910A4 (en) 2017-10-18 2021-07-14 Sarepta Therapeutics, Inc. ANTISENSE OLIGOMERIC COMPOUNDS
US10758629B2 (en) 2018-05-29 2020-09-01 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
EP3806868A4 (en) 2018-06-13 2022-06-22 Sarepta Therapeutics, Inc. EXON-SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
TW202020153A (zh) 2018-07-27 2020-06-01 美商薩羅塔治療公司 用於肌肉萎縮症之外顯子跳躍寡聚物
US11273137B2 (en) 2018-09-04 2022-03-15 Board Of Trustees Of Michigan State University Methods and compositions to prevent and treat disorders associated with mutations in the ODC1 gene
SG11202104960PA (en) 2018-12-13 2021-06-29 Sarepta Therapeutics Inc Exon skipping oligomer conjugates for muscular dystrophy
CN114040799A (zh) 2019-03-12 2022-02-11 哈佛大学校长及研究员协会 治疗癌症的方法和组合物
EP3955966A1 (en) 2019-04-18 2022-02-23 Sarepta Therapeutics, Inc. Compositions for treating muscular dystrophy
US20220226269A1 (en) 2019-06-12 2022-07-21 President And Fellows Of Harvard College Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism
EP4114946A1 (en) 2020-03-04 2023-01-11 Regeneron Pharmaceuticals, Inc. Methods and compositions for sensitization of tumor cells to immune therapy
EP4157264A4 (en) 2020-05-27 2024-06-19 The Regents of the University of California COMPOSITIONS AND METHODS FOR TRANSDIFFERENTIATION OF CELLS
WO2022056454A2 (en) 2020-09-14 2022-03-17 President And Fellows Of Harvard College Methods and compositions for treating hpv-positive cancers
WO2022060986A2 (en) 2020-09-16 2022-03-24 President And Fellows Of Harvard College Methods of treating an individual that has failed an anti-pd-1/anti-pd-l1 therapy
EP4392558A1 (en) 2021-09-30 2024-07-03 Sarepta Therapeutics, Inc. Antisense oligonucleotides having one or more abasic units
WO2023070086A1 (en) 2021-10-22 2023-04-27 Sarepta Therapeutics, Inc. Morpholino oligomers for treatment of peripheral myelin protein 22 related diseases
WO2023091704A1 (en) 2021-11-18 2023-05-25 Circularis Biotechnologies, Inc. Compositions and methods for production of circular nucleic acid molecules
WO2023150181A1 (en) 2022-02-01 2023-08-10 President And Fellows Of Harvard College Methods and compositions for treating cancer
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2024064237A2 (en) 2022-09-21 2024-03-28 Sarepta Therapeutics, Inc. Dmd antisense oligonucleotide-mediated exon skipping efficiency
US20240182561A1 (en) 2022-11-04 2024-06-06 Regeneron Pharmaceuticals, Inc. Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
US20240173426A1 (en) 2022-11-14 2024-05-30 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
WO2024104914A1 (en) 2022-11-14 2024-05-23 BioNTech SE Rna capping efficiency assay

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204870A (en) * 1978-07-25 1980-05-27 Eastman Kodak Company Photographic products and processes employing novel nondiffusible heterocyclyazonaphthol dye-releasing compounds
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
AU646966B2 (en) * 1991-08-23 1994-03-10 Takeda Chemical Industries Ltd. 2-piperazinone compounds, their production and use
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ,インコーポレーテッド Pna−dnaキメラと、このキメラ合成用のpnaシントン
DE19620170A1 (de) * 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
AUPO008396A0 (en) * 1996-05-27 1996-06-20 Fujisawa Pharmaceutical Co., Ltd. New piperazine compounds
AU2298899A (en) * 1998-02-05 1999-08-23 Takeda Chemical Industries Ltd. Sulfonamide derivatives, process for producing the same and utilization thereof
DE69933770D1 (de) 1998-07-09 2006-12-07 Biocept Inc Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung
KR20030009903A (ko) * 2001-07-24 2003-02-05 삼성정밀화학 주식회사 주쇄 2-아미노에틸글리신의 1차 아미노기가p-니트로페닐설포닐에톡시카르보닐기로 보호된 펩타이드핵산 단량체의 제조방법
KR20030042180A (ko) * 2001-11-21 2003-05-28 주식회사 파나진 펩타이드 핵산의 골격을 제조하는 방법
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법

Also Published As

Publication number Publication date
JP4394952B2 (ja) 2010-01-06
CN1642923A (zh) 2005-07-20
EP1470114B1 (en) 2009-08-19
ATE440089T1 (de) 2009-09-15
JP2005538928A (ja) 2005-12-22
DE60328866D1 (de) 2009-10-01
EP1470114A1 (en) 2004-10-27
WO2003062212A1 (en) 2003-07-31
KR20030063848A (ko) 2003-07-31
KR100464261B1 (ko) 2005-01-03
CN100351243C (zh) 2007-11-28
EP1470114A4 (en) 2005-05-11
US20030195332A1 (en) 2003-10-16
US7022851B2 (en) 2006-04-04

Similar Documents

Publication Publication Date Title
DK1470114T3 (da) Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner
ATE447569T1 (de) Pna-monomer und vorstufe
DK2174936T3 (da) Pna-monomer og prækursor
NO20062267L (no) Hepatitt C virus inhibitorer
NO20044807L (no) Heratitt C virus inhibitorer
NO20062339L (no) Hepatitt C virus-inhibitoerer
YU57603A (sh) Inhibitori fosfodiesteraze 4
NO20062185L (no) Hepatitt C virus-inhibitorer
WO2005061458A3 (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
DK1501507T3 (da) Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet
WO2002048157A3 (en) Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
HUP0202450A2 (hu) N-heterociklusos származékok mint NOS inhibitorok
CY1111349T1 (el) Καρβαμιδικες ενωσεις προς χρηση στη θεραπεια του πονου
CY1110284T1 (el) Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
BR0007890A (pt) Compostos de uracila e uso dos mesmos
DK1706414T3 (da) Fremgangsmåde til fluorcytidinderivater
EA200400690A1 (ru) Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
DK1644389T3 (da) Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
JP2002501043A5 (zh)
DK1446393T3 (da) Derivater af 2-amino-thiazolin og fremstilling heraf som inhibitorer af inducerbar NO-syntase
ATE412628T1 (de) N- (1-dimethylaminocycloalkyl)methyl benzamid- derivate
NO971687D0 (no) Diazepinoindoler som forsfodiesterase IV-inhibitorer
DE60125053D1 (de) Cephem verbindungen und diese enthaltende esbl nachweisreagenzien
HUP0204516A2 (en) Synergistic fungicidal composition and its use