DK1470114T3 - Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner - Google Patents

Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner

Info

Publication number
DK1470114T3
DK1470114T3 DK03700408T DK03700408T DK1470114T3 DK 1470114 T3 DK1470114 T3 DK 1470114T3 DK 03700408 T DK03700408 T DK 03700408T DK 03700408 T DK03700408 T DK 03700408T DK 1470114 T3 DK1470114 T3 DK 1470114T3
Authority
DK
Denmark
Prior art keywords
sub
nucleobase
oligomers
side chain
peptide nucleic
Prior art date
Application number
DK03700408T
Other languages
English (en)
Inventor
Sung Kee Kim
Hyunil Lee
Jong Chan Lim
Hoon Choi
Jae Hoon Jeon
Sung Hee Lee
Sang Youl Ahn
Original Assignee
Panagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panagene Inc filed Critical Panagene Inc
Application granted granted Critical
Publication of DK1470114T3 publication Critical patent/DK1470114T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyamides (AREA)
DK03700408T 2002-01-24 2003-01-23 Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner DK1470114T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0004194A KR100464261B1 (ko) 2002-01-24 2002-01-24 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
PCT/IB2003/000164 WO2003062212A1 (en) 2002-01-24 2003-01-23 Peptide nucleic acid oligomers from 1-benzenesulfonyl-3-amino acid side chain-4-(2-nucleobase(acetyl))-piperazin-2-ones

Publications (1)

Publication Number Publication Date
DK1470114T3 true DK1470114T3 (da) 2009-11-02

Family

ID=27607011

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03700408T DK1470114T3 (da) 2002-01-24 2003-01-23 Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner

Country Status (9)

Country Link
US (1) US7022851B2 (da)
EP (1) EP1470114B1 (da)
JP (1) JP4394952B2 (da)
KR (1) KR100464261B1 (da)
CN (1) CN100351243C (da)
AT (1) ATE440089T1 (da)
DE (1) DE60328866D1 (da)
DK (1) DK1470114T3 (da)
WO (1) WO2003062212A1 (da)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100464264B1 (ko) * 2002-03-21 2005-01-03 주식회사 파나진 광분해 보호기를 갖는 신규한 ｐｎａ 단량체
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7211668B2 (en) 2003-07-28 2007-05-01 Panagene, Inc. PNA monomer and precursor
WO2005084672A1 (de) * 2004-03-03 2005-09-15 Boehringer Ingelheim International Gmbh Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
ES2852549T3 (es) 2005-02-09 2021-09-13 Sarepta Therapeutics Inc Composición antisentido para tratamiento de la atrofia muscular
EP2236616B1 (en) 2005-06-02 2013-12-18 AdvanDx, Inc. Peptide nucleic acid probes for analysis of microorganisms
KR101072899B1 (ko) 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
US20110111416A1 (en) * 2008-05-06 2011-05-12 Panagene Inc. Peptide Nucleic Acid Probes, Kits and Methods for Expression Profiling of Micrornas
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
CA2764158A1 (en) 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
US8697858B2 (en) 2009-11-13 2014-04-15 Sarepta Therapeutics, Inc. Antisense antiviral compound and method for treating influenza viral infection
WO2011064552A1 (en) 2009-11-30 2011-06-03 Isis Innovation Limited Conjugates for delivery of biologically active compounds
WO2011112516A1 (en) 2010-03-08 2011-09-15 Ico Therapeutics Inc. Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
EP2545173A2 (en) 2010-03-12 2013-01-16 Sarepta Therapeutics, Inc. Antisense modulation of nuclear hormone receptors
EP2563380B1 (en) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
AU2011248489B2 (en) 2010-04-28 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
AU2011248490B2 (en) 2010-04-29 2016-11-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
JP5991963B2 (ja) 2010-04-29 2016-09-14 エータイアー ファーマ， インコーポレイテッド バリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6008841B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ， インコーポレイテッド メチオニルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103096912A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP2566515B1 (en) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
ES2816898T3 (es) 2010-05-13 2021-04-06 Sarepta Therapeutics Inc Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23
WO2011143482A2 (en) 2010-05-14 2011-11-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-trna synthetases
US9034598B2 (en) 2010-05-17 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
CA2800375C (en) 2010-05-27 2021-03-09 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
EP2593125B1 (en) 2010-07-12 2017-11-01 aTyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
EP2889295A1 (en) 2010-08-12 2015-07-01 New York University Oligooxopiperazines and methods of making and using them
WO2012027611A2 (en) 2010-08-25 2012-03-01 Atyr Pharma, Inc. INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF TYROSYL-tRNA SYNTHETASES
US10100305B2 (en) 2011-07-15 2018-10-16 Sarepta Therapeutics, Inc. Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
KR101303699B1 (ko) 2011-07-20 2013-09-09 대한민국 Ｐｎａ 칩을 이용한 다종 식중독균 검출 방법
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
LT2788487T (lt) 2011-12-08 2018-09-10 Sarepta Therapeutics, Inc. Oligonukleotido analogai, nukreipti į žmogaus lmna
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
EP2945631A4 (en) 2013-01-19 2016-06-29 Univ New York OLIGOOXOPIPERAZINES FOR REACTIVATION OF P53
AU2014317961B2 (en) 2013-09-05 2020-07-30 Murdoch University Antisense-induced exon2 inclusion in acid alpha-glucosidase
KR101830700B1 (ko) 2013-11-11 2018-02-21 주식회사 파나진 클램핑 프로브 및 검출 프로브를 이용한 다중 표적핵산 검출방법
US11180481B2 (en) 2014-04-15 2021-11-23 New York University Oxopiperazine helix mimetics as inhibitors of the p53-MDM2 interaction
KR101951172B1 (ko) 2014-11-07 2019-02-22 주식회사 파나진 인유두종바이러스의 유전자형 검출을 위한 ρνα 프로브, 키트 및 방법
US10517898B2 (en) 2014-11-20 2019-12-31 The Regents Of The University Of California Compositions and methods related to hematologic recovery
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
EP3302497A4 (en) 2015-06-01 2019-01-16 Sarepta Therapeutics, Inc. EXCLUSION OF EXON INDUCED PAT TECHNOLOGY ANTISENSE IN COLLAGEN TYPE VII
BR112018003784A2 (pt) 2015-08-24 2018-09-25 Halo-Bio Rnai Therapeutics, Inc. nanopartículas de polinucleotídeo para a modulação da expressão gênica e sua utilização
EP3359668A4 (en) 2015-10-09 2019-06-05 Sarepta Therapeutics, Inc. COMPOSITIONS AND METHODS OF TREATING DUCHENNE MUSCLE DYSTROPHY AND ASSOCIATED ILLNESSES THEREOF
EP3411480A4 (en) 2016-02-02 2020-01-22 Olix Pharmaceuticals, Inc. TREATMENT OF ATOPIC DERMATITIS AND ASTHMA USING RNA COMPLEXES THAT TARGETE IL4R, TRPA1, OR F2RL1
EP3445405A4 (en) 2016-04-18 2019-12-18 Sarepta Therapeutics, Inc. ANTISENSE OLIGOMERS AND METHOD FOR USE THEREOF TO TREAT DISEASES RELATING TO THE ACID ALPHA GLUCOSIDASE GENE
BR112018072279A2 (pt) 2016-04-29 2019-02-12 Sarepta Therapeutics, Inc. análogos de oligonucleotídeo tendo como alvo lmna humana
CA3025575A1 (en) 2016-06-30 2018-01-04 Sarepta Therapeutics, Inc. Exon skipping oligomers for muscular dystrophy
WO2018017814A1 (en) 2016-07-20 2018-01-25 President And Fellows Of Harvard College Peptidoglycan glycosyltransferase inhibitors of sed proteins for treating bacterial infections
WO2018053142A2 (en) 2016-09-14 2018-03-22 President And Fellows Of Harvard College Methods and compositions for modulating erythropoiesis
WO2018112032A1 (en) 2016-12-13 2018-06-21 President And Fellows Of Harvard College Methods and compositions for targeting tumor-infiltrating tregs using inhibitors of ccr8 and tnfrsf8
NZ755416A (en) 2016-12-19 2023-05-26 Sarepta Therapeutics Inc Exon skipping oligomer conjugates for muscular dystrophy
KR102639633B1 (ko) 2016-12-19 2024-02-26 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체
IL267246B2 (en) 2016-12-19 2023-03-01 Sarepta Therapeutics Inc Exon-skipping oligomer conjugates for muscular dystrophy
EP3612215A4 (en) 2017-04-20 2021-05-26 aTyr Pharma, Inc. COMPOSITIONS AND METHODS OF TREATMENT OF Pneumonia
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
US10421728B2 (en) 2017-06-08 2019-09-24 Amrita Vishwa Vidyapeetham Peptide nucleic acid monomer and a preparation method
EA201991450A1 (ru) 2017-09-22 2019-12-30 Сарепта Терапьютикс, Инк. Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
EP3687519A1 (en) 2017-09-28 2020-08-05 Sarepta Therapeutics, Inc. Combination therapies for treating muscular dystrophy
WO2019067975A1 (en) 2017-09-28 2019-04-04 Sarepta Therapeutics, Inc. POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY
WO2019067981A1 (en) 2017-09-28 2019-04-04 Sarepta Therapeutics, Inc. POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY
US11555189B2 (en) 2017-10-18 2023-01-17 Sarepta Therapeutics, Inc. Antisense oligomer compounds
US10758629B2 (en) 2018-05-29 2020-09-01 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
EP3806868A4 (en) 2018-06-13 2022-06-22 Sarepta Therapeutics, Inc. EXON-SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
TW202020153A (zh) 2018-07-27 2020-06-01 美商薩羅塔治療公司 用於肌肉萎縮症之外顯子跳躍寡聚物
US11273137B2 (en) 2018-09-04 2022-03-15 Board Of Trustees Of Michigan State University Methods and compositions to prevent and treat disorders associated with mutations in the ODC1 gene
EP3894558A1 (en) 2018-12-13 2021-10-20 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
KR20210144754A (ko) 2019-03-12 2021-11-30 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 암을 치료하기 위한 방법 및 조성물
US20220193246A1 (en) 2019-04-18 2022-06-23 Sarepta Therapeutics, Inc. Compositions for treating muscular dystrophy
US20220226269A1 (en) 2019-06-12 2022-07-21 President And Fellows Of Harvard College Methods and compositions for modulation of an interspecies gut bacterial pathway for levodopa metabolism
WO2021178556A1 (en) 2020-03-04 2021-09-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for sensitization of tumor cells to immune therapy
WO2021242826A1 (en) 2020-05-27 2021-12-02 The Regents Of The University Of California Compositions and methods for transdifferentiating cells
WO2022056454A2 (en) 2020-09-14 2022-03-17 President And Fellows Of Harvard College Methods and compositions for treating hpv-positive cancers
IL301306A (en) 2020-09-16 2023-05-01 Harvard College Methods of treating an individual who has failed anti-PD-1/anti-PD-L1 therapy
WO2023055774A1 (en) 2021-09-30 2023-04-06 Sarepta Therapeutics, Inc. Antisense oligonucleotides having one or more abasic units
WO2023070086A1 (en) 2021-10-22 2023-04-27 Sarepta Therapeutics, Inc. Morpholino oligomers for treatment of peripheral myelin protein 22 related diseases
WO2023091704A1 (en) 2021-11-18 2023-05-25 Circularis Biotechnologies, Inc. Compositions and methods for production of circular nucleic acid molecules
WO2023150181A1 (en) 2022-02-01 2023-08-10 President And Fellows Of Harvard College Methods and compositions for treating cancer
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2024064237A2 (en) 2022-09-21 2024-03-28 Sarepta Therapeutics, Inc. Dmd antisense oligonucleotide-mediated exon skipping efficiency
WO2024098002A1 (en) 2022-11-04 2024-05-10 Regeneron Pharmaceuticals, Inc. Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
WO2024107765A2 (en) 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
WO2024104914A1 (en) 2022-11-14 2024-05-23 BioNTech SE Rna capping efficiency assay

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204870A (en) * 1978-07-25 1980-05-27 Eastman Kodak Company Photographic products and processes employing novel nondiffusible heterocyclyazonaphthol dye-releasing compounds
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
JP2001518054A (ja) * 1995-06-07 2001-10-09 パーセプティブ バイオシステムズ，インコーポレーテッド Ｐｎａ−ｄｎａキメラと、このキメラ合成用のｐｎａシントン
DE19620170A1 (de) * 1996-05-20 1997-11-27 Wolfgang Prof Dr Dr Pfleiderer Nucleosid-Derivate mit photolabilen Schutzgruppen
AUPO008396A0 (en) * 1996-05-27 1996-06-20 Fujisawa Pharmaceutical Co., Ltd. New piperazine compounds
EP1054005A4 (en) * 1998-02-05 2003-02-05 Takeda Chemical Industries Ltd SULFAMIDE DERIVATIVES, THEIR PRODUCTION PROCESS AND THEIR USE
WO2000002899A1 (en) 1998-07-09 2000-01-20 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
KR20030009903A (ko) * 2001-07-24 2003-02-05 삼성정밀화학 주식회사 주쇄 ２－아미노에틸글리신의 １차 아미노기가ｐ－니트로페닐설포닐에톡시카르보닐기로 보호된 펩타이드핵산 단량체의 제조방법
KR20030042180A (ko) * 2001-11-21 2003-05-28 주식회사 파나진 펩타이드 핵산의 골격을 제조하는 방법
KR20030084444A (ko) * 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법

Also Published As

Publication number Publication date
US20030195332A1 (en) 2003-10-16
WO2003062212A1 (en) 2003-07-31
CN100351243C (zh) 2007-11-28
CN1642923A (zh) 2005-07-20
ATE440089T1 (de) 2009-09-15
JP2005538928A (ja) 2005-12-22
DE60328866D1 (de) 2009-10-01
JP4394952B2 (ja) 2010-01-06
US7022851B2 (en) 2006-04-04
KR20030063848A (ko) 2003-07-31
EP1470114A1 (en) 2004-10-27
KR100464261B1 (ko) 2005-01-03
EP1470114B1 (en) 2009-08-19
EP1470114A4 (en) 2005-05-11

Similar Documents

Publication Publication Date Title
DK1470114T3 (da) Peptid-nukleinsyre-oligomerer fra 1-benzensulfonyl-3-aminosyre sidekæde-4-(2-nucleobase(acetyl))-piperazin-2-oner
ATE447569T1 (de) Pna-monomer und vorstufe
DK2174936T3 (da) Pna-monomer og prækursor
NO20062267L (no) Hepatitt C virus inhibitorer
NO20044807L (no) Heratitt C virus inhibitorer
YU57603A (sh) Inhibitori fosfodiesteraze 4
NO20062185L (no) Hepatitt C virus-inhibitorer
DK1501507T3 (da) Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet
TW200602322A (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
WO2002048157A3 (en) Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
HUP0202450A2 (hu) N-heterociklusos származékok mint NOS inhibitorok
HUP0402235A2 (hu) 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények
CY1110284T1 (el) Παραγωγα της 2-αμινο-4-πυριδυλομεθυλο-θειαζολινης και η χρηση τους ως αναστολεις της επαγωγιμης συνθασης νο
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
HUP0003425A2 (hu) 2-(4-Aril- vagy heteroaril-piperazin-ilmetil)-1H-indol-származékok és a vegyületeket tartalmazó gyógyászati készítmények
DE602004020730D1 (de) Pharmazeutisches verfahren und damit hergestellte verbindungen
BR0007890A (pt) Compostos de uracila e uso dos mesmos
DK1706414T3 (da) Fremgangsmåde til fluorcytidinderivater
EA200400690A1 (ru) Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
DK1644389T3 (da) Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
JP2002501043A5 (da)
ATE412628T1 (de) N- (1-dimethylaminocycloalkyl)methyl benzamid- derivate
NO971687D0 (no) Diazepinoindoler som forsfodiesterase IV-inhibitorer
DK1446393T3 (da) Derivater af 2-amino-thiazolin og fremstilling heraf som inhibitorer af inducerbar NO-syntase
DE60125053D1 (de) Cephem verbindungen und diese enthaltende esbl nachweisreagenzien