DK1461426T3 - Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression - Google Patents

Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression

Info

Publication number
DK1461426T3
DK1461426T3 DK02787465T DK02787465T DK1461426T3 DK 1461426 T3 DK1461426 T3 DK 1461426T3 DK 02787465 T DK02787465 T DK 02787465T DK 02787465 T DK02787465 T DK 02787465T DK 1461426 T3 DK1461426 T3 DK 1461426T3
Authority
DK
Denmark
Prior art keywords
product
interest
gene expression
rna polymerase
production
Prior art date
Application number
DK02787465T
Other languages
Danish (da)
English (en)
Inventor
Steen Troels Jorgensen
Jens Toenne Andersen
Niels Banke
Preben Nielsen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of DK1461426T3 publication Critical patent/DK1461426T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK02787465T 2001-12-29 2002-12-20 Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression DK1461426T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101972 2001-12-29
DKPA200200274 2002-02-21
PCT/DK2002/000886 WO2003055996A1 (fr) 2001-12-29 2002-12-20 Mutants de l'arn polymerase eubacterienne ayant une production de produit modifiee

Publications (1)

Publication Number Publication Date
DK1461426T3 true DK1461426T3 (da) 2008-05-19

Family

ID=26069122

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02787465T DK1461426T3 (da) 2001-12-29 2002-12-20 Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression

Country Status (9)

Country Link
US (4) US20050095669A1 (fr)
EP (1) EP1461426B1 (fr)
JP (3) JP4741186B2 (fr)
CN (2) CN101851599B (fr)
AT (1) ATE383419T1 (fr)
AU (1) AU2002351750A1 (fr)
DE (1) DE60224579T2 (fr)
DK (1) DK1461426T3 (fr)
WO (1) WO2003055996A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4997420B2 (ja) * 2006-03-28 2012-08-08 花王株式会社 変異微生物
JP6139139B2 (ja) * 2012-01-11 2017-05-31 国立大学法人 岡山大学 変異型ＲＮＡポリメラーゼβ−サブユニット遺伝子
KR101594156B1 (ko) * 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
JP7025325B2 (ja) * 2015-10-30 2022-02-24 ダニスコ・ユーエス・インク タンパク質発現の増強およびその方法
CN106244714B (zh) * 2016-09-23 2019-09-24 山西大学 一种巨大芽孢杆菌特异性检测的基因芯片
US11407983B2 (en) * 2018-08-07 2022-08-09 Cj Cheiljedang Corporation Nucleic acid molecules comprising a variant RpoC coding sequence
CN111118091A (zh) * 2018-10-31 2020-05-08 宁夏乙征生物工程有限公司 一种抗菌肽的生产方法
WO2022094445A1 (fr) * 2020-11-02 2022-05-05 University Of Stuttgart Souches bactériennes à génome modifié pour bioprocédés à grande échelle
CN112608911B (zh) * 2020-12-18 2022-07-05 湖州中科工业生物技术中心 一种rna聚合酶突变体及其应用
WO2023247514A1 (fr) 2022-06-22 2023-12-28 Novozymes A/S Expression de mannanase recombinée

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090393A1 (fr) * 2000-05-24 2001-11-29 Novozymes A/S Procede pour augmenter le nombre de copies de gene dans une cellule hote et cellule hote resultante
EP1239040A3 (fr) * 2001-02-16 2003-01-08 Degussa AG Mutations du gène rpoB derivées des souches de Corynebacterium glutamicum productrices de L-lysine et procédé pour la préparation de L-lysine

Also Published As

Publication number Publication date
US20090317865A1 (en) 2009-12-24
CN101851599A (zh) 2010-10-06
CN1610740A (zh) 2005-04-27
DE60224579D1 (de) 2008-02-21
JP2011155977A (ja) 2011-08-18
JP5876460B2 (ja) 2016-03-02
US20050095669A1 (en) 2005-05-05
US20150147783A1 (en) 2015-05-28
US20130122548A1 (en) 2013-05-16
AU2002351750A1 (en) 2003-07-15
CN1610740B (zh) 2010-05-26
ATE383419T1 (de) 2008-01-15
EP1461426B1 (fr) 2008-01-09
CN101851599B (zh) 2016-01-20
WO2003055996A1 (fr) 2003-07-10
JP4741186B2 (ja) 2011-08-03
EP1461426A1 (fr) 2004-09-29
JP2005512595A (ja) 2005-05-12
DE60224579T2 (de) 2008-12-24
JP2014042530A (ja) 2014-03-13

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