DK1461426T3 - Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression - Google Patents

Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression

Info

Publication number
DK1461426T3
DK1461426T3 DK02787465T DK02787465T DK1461426T3 DK 1461426 T3 DK1461426 T3 DK 1461426T3 DK 02787465 T DK02787465 T DK 02787465T DK 02787465 T DK02787465 T DK 02787465T DK 1461426 T3 DK1461426 T3 DK 1461426T3
Authority
DK
Denmark
Prior art keywords
product
interest
gene expression
rna polymerase
production
Prior art date
Application number
DK02787465T
Other languages
English (en)
Inventor
Steen Troels Jorgensen
Jens Toenne Andersen
Niels Banke
Preben Nielsen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of DK1461426T3 publication Critical patent/DK1461426T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1247—DNA-directed RNA polymerase (2.7.7.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK02787465T 2001-12-29 2002-12-20 Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression DK1461426T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101972 2001-12-29
DKPA200200274 2002-02-21
PCT/DK2002/000886 WO2003055996A1 (en) 2001-12-29 2002-12-20 Eubacterial rna-polymerase mutants with altered product production

Publications (1)

Publication Number Publication Date
DK1461426T3 true DK1461426T3 (da) 2008-05-19

Family

ID=26069122

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02787465T DK1461426T3 (da) 2001-12-29 2002-12-20 Eubakterielle RNA-polymerasemutanter til forbedret heterolog genekspression

Country Status (9)

Country Link
US (4) US20050095669A1 (da)
EP (1) EP1461426B1 (da)
JP (3) JP4741186B2 (da)
CN (2) CN1610740B (da)
AT (1) ATE383419T1 (da)
AU (1) AU2002351750A1 (da)
DE (1) DE60224579T2 (da)
DK (1) DK1461426T3 (da)
WO (1) WO2003055996A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4997420B2 (ja) * 2006-03-28 2012-08-08 花王株式会社 変異微生物
JP6139139B2 (ja) * 2012-01-11 2017-05-31 国立大学法人 岡山大学 変異型ＲＮＡポリメラーゼβ−サブユニット遺伝子
KR101594156B1 (ko) 2013-06-25 2016-02-15 씨제이제일제당 주식회사 Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법
KR20180069057A (ko) * 2015-10-30 2018-06-22 다니스코 유에스 인크. 향상된 단백질 발현 및 이의 방법
CN106244714B (zh) * 2016-09-23 2019-09-24 山西大学 一种巨大芽孢杆菌特异性检测的基因芯片
JP7296449B2 (ja) * 2018-08-07 2023-06-22 シージェイ チェイルジェダング コーポレイション 変異体ＲｐｏＣコード配列を含む核酸分子
CN111118091A (zh) * 2018-10-31 2020-05-08 宁夏乙征生物工程有限公司 一种抗菌肽的生产方法
EP4237540A1 (en) * 2020-11-02 2023-09-06 University of Stuttgart Genome-modified bacterial strains for large scale bioprocesses
CN112608911B (zh) * 2020-12-18 2022-07-05 湖州中科工业生物技术中心 一种rna聚合酶突变体及其应用
WO2023247514A1 (en) 2022-06-22 2023-12-28 Novozymes A/S Recombinant mannanase expression

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090393A1 (en) * 2000-05-24 2001-11-29 Novozymes A/S Method for increasing gene copy number in a host cell and resulting host cell
EP1239040A3 (de) * 2001-02-16 2003-01-08 Degussa AG Mutationen im rpoB-Gen L-Lysin produzierender Corynebacterium glutamicum-Stämme und Verfahren zur Herstellung von L-Lysin

Also Published As

Publication number Publication date
AU2002351750A1 (en) 2003-07-15
ATE383419T1 (de) 2008-01-15
US20130122548A1 (en) 2013-05-16
CN1610740B (zh) 2010-05-26
US20150147783A1 (en) 2015-05-28
US20090317865A1 (en) 2009-12-24
WO2003055996A1 (en) 2003-07-10
EP1461426B1 (en) 2008-01-09
JP2014042530A (ja) 2014-03-13
CN101851599B (zh) 2016-01-20
JP2005512595A (ja) 2005-05-12
JP2011155977A (ja) 2011-08-18
DE60224579D1 (de) 2008-02-21
JP5876460B2 (ja) 2016-03-02
EP1461426A1 (en) 2004-09-29
JP4741186B2 (ja) 2011-08-03
DE60224579T2 (de) 2008-12-24
US20050095669A1 (en) 2005-05-05
CN101851599A (zh) 2010-10-06
CN1610740A (zh) 2005-04-27

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