DK1454903T3 - Thiadiazolinderivater til behandling af cancer - Google Patents

Thiadiazolinderivater til behandling af cancer

Info

Publication number
DK1454903T3
DK1454903T3 DK02788786.8T DK02788786T DK1454903T3 DK 1454903 T3 DK1454903 T3 DK 1454903T3 DK 02788786 T DK02788786 T DK 02788786T DK 1454903 T3 DK1454903 T3 DK 1454903T3
Authority
DK
Denmark
Prior art keywords
substituted
unsubstituted
cancer
treatment
unsubstituted lower
Prior art date
Application number
DK02788786.8T
Other languages
Danish (da)
English (en)
Inventor
Chikara Murakata
Kazuhiko Kato
Yoshihisa Ohta
Ryuichiro Nakai
Yoshinori Yamashita
Takeshi Takahashi
Tomohisa Nakano
Yoji Ino
Original Assignee
Kyowa Hakko Kirin Co Ltd
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd, Fujifilm Corp filed Critical Kyowa Hakko Kirin Co Ltd
Application granted granted Critical
Publication of DK1454903T3 publication Critical patent/DK1454903T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK02788786.8T 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer DK1454903T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001377456 2001-12-11
JP2002237399 2002-08-16
PCT/JP2002/012961 WO2003051854A1 (fr) 2001-12-11 2002-12-11 Dérivé de thiadiazolines

Publications (1)

Publication Number Publication Date
DK1454903T3 true DK1454903T3 (da) 2010-11-22

Family

ID=26624996

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07015426.5T DK1847534T3 (da) 2001-12-11 2002-12-11 Thiadiazolin-derivater til behandling af kræft
DK02788786.8T DK1454903T3 (da) 2001-12-11 2002-12-11 Thiadiazolinderivater til behandling af cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK07015426.5T DK1847534T3 (da) 2001-12-11 2002-12-11 Thiadiazolin-derivater til behandling af kræft

Country Status (16)

Country Link
US (4) US7425636B2 (fr)
EP (2) EP1847534B9 (fr)
JP (1) JP4272994B2 (fr)
KR (1) KR100915287B1 (fr)
CN (1) CN100484928C (fr)
AT (2) ATE513821T1 (fr)
AU (1) AU2002354465B2 (fr)
CA (1) CA2469801C (fr)
CY (2) CY1112899T1 (fr)
DE (1) DE60237637D1 (fr)
DK (2) DK1847534T3 (fr)
ES (1) ES2350642T3 (fr)
HK (1) HK1107814A1 (fr)
PT (2) PT1454903E (fr)
SI (2) SI1454903T1 (fr)
WO (1) WO2003051854A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1847534T3 (da) 2001-12-11 2011-08-29 Kyowa Hakko Kirin Co Ltd Thiadiazolin-derivater til behandling af kræft
US7851635B2 (en) * 2003-04-18 2010-12-14 Kyowa Hakko Kirin Co., Ltd. Mitotic kinesin inhibitor
JPWO2004111024A1 (ja) * 2003-06-10 2006-07-20 協和醗酵工業株式会社 チアジアゾリン誘導体
WO2004111023A1 (fr) * 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Derive de 1-oxyde de thiadiazoline
US20070112044A1 (en) * 2003-10-10 2007-05-17 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
WO2005061707A1 (fr) * 2003-12-24 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Procede d'evaluation de la sensibilite d'une cellule cancereuse a l'inhibiteur eg5
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
JP5060285B2 (ja) * 2005-03-22 2012-10-31 協和発酵キリン株式会社 固形腫瘍治療剤
TW200720265A (en) * 2005-03-22 2007-06-01 Kyowa Hakko Kogyo Kk Agent for treatment of hematopoietic tumor
UA95907C2 (en) 2005-05-02 2011-09-26 Эррей Биофарма Инк. Mitotic kinesin inhibitors and methods of use thereof
WO2006137490A1 (fr) * 2005-06-24 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. Agent thérapeutique contre la resténose
DE102005055354A1 (de) * 2005-11-21 2007-10-31 Merck Patent Gmbh Substituierte 5-Phenyl-3,6-dihydro-2-oxo-6H-[1,3,4]thiadiazine
DE102006002065B4 (de) * 2006-01-16 2007-11-29 Infineon Technologies Austria Ag Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
US8324257B2 (en) * 2006-10-03 2012-12-04 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
BRPI0814039A2 (pt) 2007-07-12 2017-10-03 Lilly Co Eli Formulações estáveis de derivados de tiadiazol
WO2009052288A1 (fr) * 2007-10-19 2009-04-23 Schering Corporation Dérivés de 1,3,4-thiadiazole spiro-condensés pour inhiber l'activité de la kinésine ksp

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE244989C (fr)
US4246225A (en) * 1978-05-25 1981-01-20 Owens-Illinois, Inc. Method for forming tubular plastic articles
US4338449A (en) * 1981-06-15 1982-07-06 Eli Lilly And Company Herbicidal thiadiazolines
US4346225A (en) 1981-06-15 1982-08-24 Eli Lilly And Company Herbicidal 2-methylamino thiadiazolines
US4699913A (en) 1985-06-28 1987-10-13 Ciba-Geigy Corporation Substituted 4,5-dihydro-1,3,4-thiadiazoles useful as insecticides
EP0217519B1 (fr) 1985-08-31 1992-02-05 FISONS plc Inhibiteurs de l'enzyme de conversion de l'angiotensine hétérocycliques à 5 chaînons
DD243930A1 (de) 1985-12-04 1987-03-18 Akad Wissenschaften Ddr Verfahren zur herstellung von neuen 5,5-disubstituierten 4-carbamoyl-4,5-dihydro-1,3,4-thiadiazol-2-yl-harnstoffen
AU4288293A (en) 1992-04-27 1993-11-29 E.I. Du Pont De Nemours And Company Fungicidal 1,3,4-oxadiazines and 1,3,4-thiadiazines
ES2109752T3 (es) * 1994-05-19 1998-01-16 Mitsubishi Chem Corp Medicamento para tratamiento terapeutico y profilactico de enfermedades causadas por hiperplasia de las celulas de los musculos lisos.
JP2798005B2 (ja) 1994-05-19 1998-09-17 三菱化学株式会社 平滑筋細胞増殖に起因する疾患の治療・予防剤
US5814647A (en) 1997-03-04 1998-09-29 Board Of Regents, The University Of Texas System Use of troglitazone and related compounds for the treatment of the climacteric symptoms
US6235762B1 (en) 1998-11-23 2001-05-22 American Cyanamid Company 2-aryl-Δ2-1,3,4-(oxa and thia)diazoline insecticidal and acaricidal agents
JP2000159756A (ja) 1998-11-23 2000-06-13 American Cyanamid Co ２―アリ―ル―δ２―１，３，４―（オキサおよびチア）ジアゾリン殺虫および殺ダニ剤
JP2000204077A (ja) * 1999-01-13 2000-07-25 Warner Lambert Co ジアリ―ルアミン
ES2249060T3 (es) * 1999-01-13 2006-03-16 Warner-Lambert Company Llc Diarilaminas sustituidas con 1-heterociclo.
JP2000229959A (ja) * 1999-02-04 2000-08-22 Sumitomo Pharmaceut Co Ltd Ｓｔａｔ６活性化阻害剤
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
AU774748B2 (en) 1999-10-27 2004-07-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6617115B1 (en) 1999-10-27 2003-09-09 Cytokinetics, Inc. Methods of screening for modulators of cell proliferation
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AU2001234741A1 (en) * 2000-02-04 2001-08-14 Biogen, Inc. Integrin antagonists
US6310716B1 (en) 2000-08-18 2001-10-30 Corning Incorporated Amplifier system with a discrete Raman fiber amplifier module
WO2002056880A1 (fr) 2001-01-19 2002-07-25 Cytokinetics, Inc. Inhibiteurs triphenylmethane de la kinesine
EP1360180A1 (fr) 2001-01-19 2003-11-12 Cytokinetics, Inc. Inhibiteurs de la kinesine a base de phenothiazine
US20040087548A1 (en) * 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6900214B2 (en) 2001-03-29 2005-05-31 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US6809102B2 (en) 2001-03-29 2004-10-26 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
IL158083A0 (en) 2001-03-29 2004-03-28 Bristol Myers Squibb Co A PHARMACEUTICAL COMPOSITION CONTAINING AN Eg5 PROTEIN INHIBITOR
WO2003039460A2 (fr) 2001-11-07 2003-05-15 Merck & Co., Inc. Inhibiteurs de la kinesine mitotique
DK1847534T3 (da) 2001-12-11 2011-08-29 Kyowa Hakko Kirin Co Ltd Thiadiazolin-derivater til behandling af kræft
US6561831B1 (en) 2001-12-27 2003-05-13 Hon Hai Precision Ind. Co., Ltd. Housing of socket connector and conductive terminal thereof
US7745639B2 (en) 2002-03-08 2010-06-29 Merck & Co., Inc. Mitotic kinesin inhibitors
JP2006506401A (ja) * 2002-05-23 2006-02-23 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害薬
US7851635B2 (en) 2003-04-18 2010-12-14 Kyowa Hakko Kirin Co., Ltd. Mitotic kinesin inhibitor
WO2004111023A1 (fr) 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Derive de 1-oxyde de thiadiazoline
JPWO2004111024A1 (ja) 2003-06-10 2006-07-20 協和醗酵工業株式会社 チアジアゾリン誘導体
US20070112044A1 (en) * 2003-10-10 2007-05-17 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
US7449486B2 (en) 2004-10-19 2008-11-11 Array Biopharma Inc. Mitotic kinesin inhibitors and methods of use thereof
JP5060285B2 (ja) 2005-03-22 2012-10-31 協和発酵キリン株式会社 固形腫瘍治療剤
TW200720265A (en) 2005-03-22 2007-06-01 Kyowa Hakko Kogyo Kk Agent for treatment of hematopoietic tumor
WO2006137490A1 (fr) 2005-06-24 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. Agent thérapeutique contre la resténose

Also Published As

Publication number Publication date
AU2002354465A1 (en) 2003-06-30
ATE480527T1 (de) 2010-09-15
CN1617864A (zh) 2005-05-18
EP1454903A1 (fr) 2004-09-08
CA2469801A1 (fr) 2003-06-26
AU2002354465B2 (en) 2008-11-20
SI1454903T1 (sl) 2010-12-31
SI1847534T1 (sl) 2011-10-28
PT1847534E (pt) 2011-08-01
US7759371B2 (en) 2010-07-20
CN100484928C (zh) 2009-05-06
EP1847534B9 (fr) 2012-03-21
ES2350642T3 (es) 2011-01-25
KR20040072649A (ko) 2004-08-18
JP4272994B2 (ja) 2009-06-03
DK1847534T3 (da) 2011-08-29
US7902234B2 (en) 2011-03-08
EP1454903B9 (fr) 2011-10-05
US20060074113A1 (en) 2006-04-06
EP1847534A2 (fr) 2007-10-24
EP1847534B1 (fr) 2011-06-22
WO2003051854A1 (fr) 2003-06-26
EP1454903B1 (fr) 2010-09-08
EP1847534A3 (fr) 2008-09-24
CY1112899T1 (el) 2016-04-13
EP1454903A4 (fr) 2005-12-21
JPWO2003051854A1 (ja) 2005-04-28
HK1107814A1 (en) 2008-04-18
PT1454903E (pt) 2010-11-09
DE60237637D1 (de) 2010-10-21
CY1111816T1 (el) 2015-10-07
US20100240716A1 (en) 2010-09-23
US20080207706A1 (en) 2008-08-28
KR100915287B1 (ko) 2009-09-03
ATE513821T1 (de) 2011-07-15
US7425636B2 (en) 2008-09-16
US20070213380A1 (en) 2007-09-13
CA2469801C (fr) 2011-06-21

Similar Documents

Publication Publication Date Title
CY1111816T1 (el) Παραγωγο θειαδιαζολινης για την θεραπεια του καρκινου
NO20012617D0 (no) Kinolin- og kinzolinderivater
NO20004485L (no) Sykloalkenderivater, deres fremstilling og anvendelse
HK1158637A1 (en) Mitotic kinesin inhibitor m
TR200201205T2 (tr) N-ikame edilmiş karbamoiloksialkil-azolyum türevleri.
TR200403436T2 (tr) Kristalin 1-metilkarbapenem türevleri.
ATE315550T1 (de) Fungizide phenylamidinderivative
NO20025035D0 (no) Oksadiazolderivater som har anticancer-effekter
EP1671957A4 (fr) Derives de thiadiazoline
DE69623497T2 (de) 1-methylcarbapenem-derivate
ATE283840T1 (de) Chondrogonese promotoren und indolin-2-on derivate
ATE320417T1 (de) Naphthimidobenzamid-derivate
DK1433480T3 (da) Lægemiddel indeholdende pyrimidin-derivat
ATE262522T1 (de) Benzimidazolverbindungen
HUP0202237A2 (hu) Amin, módosított pszeudomicin vegyületek, azokat tartalmazó gyógyászati készítmény és alkalmazásuk
MX9704976A (es) Derivados de 1,2,3-benzotiadiazol.
EP1251129A4 (fr) Derives de la pyrimidine a effet anti-tumoral