DK1443046T3 - Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelse - Google Patents
Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelseInfo
- Publication number
- DK1443046T3 DK1443046T3 DK02772984T DK02772984T DK1443046T3 DK 1443046 T3 DK1443046 T3 DK 1443046T3 DK 02772984 T DK02772984 T DK 02772984T DK 02772984 T DK02772984 T DK 02772984T DK 1443046 T3 DK1443046 T3 DK 1443046T3
- Authority
- DK
- Denmark
- Prior art keywords
- group
- chem
- furoyl
- formula
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001311828 | 2001-10-09 | ||
| PCT/JP2002/010449 WO2003035645A1 (fr) | 2001-10-09 | 2002-10-08 | Nouvelles 4-(2-furoyl)aminopiperidines, intermediaires utilises dans la synthese de ces dernieres, leur procede de production et leur utilisation medicale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1443046T3 true DK1443046T3 (da) | 2009-04-14 |
Family
ID=19130581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02772984T DK1443046T3 (da) | 2001-10-09 | 2002-10-08 | Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelse |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7375115B2 (fr) |
| EP (1) | EP1443046B1 (fr) |
| JP (1) | JP4009251B2 (fr) |
| KR (1) | KR100938369B1 (fr) |
| CN (1) | CN1326853C (fr) |
| AT (1) | ATE417845T1 (fr) |
| BR (1) | BR0213186A (fr) |
| CA (1) | CA2468529C (fr) |
| DE (1) | DE60230437D1 (fr) |
| DK (1) | DK1443046T3 (fr) |
| ES (1) | ES2319879T3 (fr) |
| MX (1) | MXPA04003330A (fr) |
| PT (1) | PT1443046E (fr) |
| WO (1) | WO2003035645A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2325183A1 (fr) * | 2003-05-08 | 2011-05-25 | Kyorin Pharmaceutical Co., Ltd. | 4-(2-Furoyl) Aminopiperidines en tant qu'agents therapeutique contre les démangeaisons. |
| JP2004352714A (ja) * | 2003-05-08 | 2004-12-16 | Kyorin Pharmaceut Co Ltd | 新規な４−（２−フロイル）アミノピペリジン誘導体 |
| WO2005013888A2 (fr) * | 2003-05-14 | 2005-02-17 | Cytokinetics, Inc. | Composes, compositions et procedes |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| AR057959A1 (es) * | 2005-12-01 | 2007-12-26 | Elan Pharm Inc | 5-pirazolpiperidinas-(sustituidas) |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| JP4898287B2 (ja) * | 2006-05-17 | 2012-03-14 | 杏林製薬株式会社 | ［１−［２−［４−［ｎ−（５−メチルピリジン−２−イル）−２−フランカルボキサミド］ピペリジン−１−イル］エチル］シクロヘキシル］アセトヒドロキサム酸の製造方法 |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| KR101506156B1 (ko) | 2007-04-23 | 2015-03-26 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 티아(디아)졸 |
| RU2480462C2 (ru) * | 2007-04-23 | 2013-04-27 | Янссен Фармацевтика Н.В. | Производные пиридина, используемые в качестве быстро диссоциирующихся антагонистов допаминовых рецепторов 2 |
| AU2008240728B2 (en) | 2007-04-23 | 2013-01-10 | Janssen Pharmaceutica N.V. | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
| BRPI0915834A2 (pt) | 2008-07-03 | 2015-11-03 | Janssen Pharmaceutica Nv | 6-(1-piperazinil)-piridazinas substituídas como antagonistas do receptor de 5-ht6 |
| DK2307374T3 (en) | 2008-07-31 | 2017-05-01 | Janssen Pharmaceutica Nv | PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| WO2010135731A1 (fr) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Préparations et procédés pour améliorer ou réduire une presbytie |
| KR20120069710A (ko) * | 2009-09-08 | 2012-06-28 | 교린 세이야꾸 가부시키 가이샤 | ４?(５?메틸피리딘?２?일아미노)피페리딘?１?카복실산 유도체의 제조방법 |
| MX2013003078A (es) * | 2010-09-20 | 2013-09-26 | Kareus Therapeutics Sa | Metodos y composiciones para el tratamiento de diabetes y dislipidemia. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59112984A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | １，４−ベンゾジアゼピン誘導体 |
| US4584303A (en) | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
| US4791112A (en) | 1987-02-02 | 1988-12-13 | The Boc Group, Inc. | N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and methods employing such compounds |
| US4912109A (en) * | 1987-02-02 | 1990-03-27 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds |
| JPH09501404A (ja) * | 1993-05-26 | 1997-02-10 | スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク | 新規化合物 |
-
2002
- 2002-10-08 JP JP2003538161A patent/JP4009251B2/ja not_active Expired - Fee Related
- 2002-10-08 ES ES02772984T patent/ES2319879T3/es not_active Expired - Lifetime
- 2002-10-08 CN CNB028241568A patent/CN1326853C/zh not_active Expired - Fee Related
- 2002-10-08 BR BR0213186-2A patent/BR0213186A/pt not_active IP Right Cessation
- 2002-10-08 US US10/492,065 patent/US7375115B2/en not_active Expired - Fee Related
- 2002-10-08 EP EP02772984A patent/EP1443046B1/fr not_active Expired - Lifetime
- 2002-10-08 KR KR1020047005180A patent/KR100938369B1/ko not_active IP Right Cessation
- 2002-10-08 WO PCT/JP2002/010449 patent/WO2003035645A1/fr active Application Filing
- 2002-10-08 AT AT02772984T patent/ATE417845T1/de active
- 2002-10-08 DE DE60230437T patent/DE60230437D1/de not_active Expired - Lifetime
- 2002-10-08 CA CA2468529A patent/CA2468529C/fr not_active Expired - Fee Related
- 2002-10-08 MX MXPA04003330A patent/MXPA04003330A/es active IP Right Grant
- 2002-10-08 DK DK02772984T patent/DK1443046T3/da active
- 2002-10-08 PT PT02772984T patent/PT1443046E/pt unknown
-
2008
- 2008-03-20 US US12/077,687 patent/US20080194826A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080194826A1 (en) | 2008-08-14 |
| WO2003035645A1 (fr) | 2003-05-01 |
| CN1582286A (zh) | 2005-02-16 |
| ATE417845T1 (de) | 2009-01-15 |
| JP4009251B2 (ja) | 2007-11-14 |
| CA2468529A1 (fr) | 2003-05-01 |
| PT1443046E (pt) | 2009-02-26 |
| JPWO2003035645A1 (ja) | 2005-02-10 |
| EP1443046B1 (fr) | 2008-12-17 |
| DE60230437D1 (de) | 2009-01-29 |
| EP1443046A1 (fr) | 2004-08-04 |
| ES2319879T3 (es) | 2009-05-14 |
| US7375115B2 (en) | 2008-05-20 |
| EP1443046A4 (fr) | 2005-11-16 |
| KR20040039495A (ko) | 2004-05-10 |
| KR100938369B1 (ko) | 2010-01-22 |
| US20050085508A1 (en) | 2005-04-21 |
| BR0213186A (pt) | 2004-08-10 |
| CN1326853C (zh) | 2007-07-18 |
| MXPA04003330A (es) | 2004-07-08 |
| CA2468529C (fr) | 2011-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1443046T3 (da) | Nye 4-(2-furoyl)-amino-piperidiner, mellemprodukter til deres syntese, fremgangsmåde til deres fremstilling og deres medicinske anvendelse | |
| DE69501947D1 (de) | SUBSTITUIERTE AROMATISCHE VERBINDUNGEN ALS c. AMP PHOSPHODIESTERASE-UND TNF-HEMMER | |
| HUT76476A (en) | Morpholine and thiomorpholine derivatives, process for the preparation thereof and pharmaceutical compositions containing them | |
| NO20050054L (no) | Nye, kondenserte imidazolderivater | |
| ATE182583T1 (de) | 4-(aryl-substituierte)-piperidine als neurokinin- receptor antagonisten | |
| EP1400518A4 (fr) | Derives de composes heterocycliques et medicaments | |
| DE60235396D1 (de) | 3-amido-1,2-benzisoxazolderivate, herstellungsverfahren und deren verwendung | |
| NO20073019L (no) | Pyrasolonforbindelser som metabotrope glutamatreseptor-antagonister for behandlingen av nevrotiske og psykiatriske lidelser | |
| CY1108351T1 (el) | Παραγωγα κυκλοαλκυλικης λακταμης ως αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης ι | |
| NO981858L (no) | Fenyletanolamin-forbindelser anvendelige som <beta>3 agonist, fremgangsmÕte for fremstilling av disse og mellomprodukter i fremstilling av dem | |
| NO20025641D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
| DE602004031722D1 (de) | Kondensierte bizyklisch substituierte amine als histamin 3 rezeptor liganden | |
| NO20025640D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
| TW200616997A (en) | The preparation method for 6-substituted-1-methyl-1h-benzoimidazol derivatives and their preparation imtermediates | |
| WO1999062893A3 (fr) | Nouveaux antagonistes de la neurokinine, leur procede de production et compositions pharmaceutiques contenant ces composes | |
| NO20052491L (no) | Nye vitronektinresepotr antagonistderivater, fremgangsmate til deres fremstilling, anvendelse derav som legemidler og farmasoytiske sammensetninger som inneholder de samme | |
| DK0518118T3 (da) | 7-Oxabicycloheptyl-substituerede, heterocycliske amid-prostaglandin-analoger, anvendelige ved behandlingen af thrombotiske og vasospastiske sygdomme | |
| DK0630893T3 (da) | N,N'-disubstitueret amidderivat | |
| ES2012687A6 (es) | Procedimiento de preparacion de derivados 1,4-dihidro-piridinas. | |
| EA199900608A1 (ru) | Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов | |
| DK0911336T3 (da) | Pyridoncarboxylsyrederivater og mellemprodukter til deres fremstilling | |
| AU7332996A (en) | Therapeutics for thrombocytopenia | |
| HK1096670A1 (en) | Pyrrolo-pyrazine derivatives useful as cb1-modulators | |
| NZ218034A (en) | Benzopyrando(2,3-c)pyrrole derivatives, intermediates and pharmaceutical compositions |