CY1108351T1 - Παραγωγα κυκλοαλκυλικης λακταμης ως αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης ι - Google Patents

Παραγωγα κυκλοαλκυλικης λακταμης ως αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης ι

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Publication number
CY1108351T1
CY1108351T1 CY20081101009T CY081101009T CY1108351T1 CY 1108351 T1 CY1108351 T1 CY 1108351T1 CY 20081101009 T CY20081101009 T CY 20081101009T CY 081101009 T CY081101009 T CY 081101009T CY 1108351 T1 CY1108351 T1 CY 1108351T1
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CY
Cyprus
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formula
sup
sub
present
beta
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CY20081101009T
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English (en)
Inventor
Thomas Daniel Aicher
Mark Joseph Chicarelli
Cassandra A Gauthier
Ronald Jay Hinklin
Hongqi Tian
Owen Brendan Wallace
Alexei Pavlovych Krasutsky
John Gordon Allen
Original Assignee
Eli Lilly And Company
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Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1108351T1 publication Critical patent/CY1108351T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου Ι που είναι χρήσιμες ως δυναμικοί και επιλεκτικοί αναστολείς της 11-βήτα υδροξυστεροειδούς αφυδρογονάσης 1. Η παρούσα εφεύρεση παρέχει περαιτέρω μια φαρμακευτική σύνθεση που περιέχει μια ένωση του Τύπου Ι, ή ένα φαρμακευτικό άλας αυτής, και ένα φαρμακευτικώς αποδεκτό φορέα, αραιωτικό, ή έκδοχο. Επιπροσθέτως, οι συνθέσεις της παρούσας εφεύρεσης περιέχουν αυτές τις ενώσεις για την αγωγή μεταβολικού συνδρόμου, διαβήτη, παχυσαρκίας, υπέρτασης, υπερλιπιδαιμίας, άλλων συμπτωμάτων συνδεομένων με υπεργλυκαιμία, και συγγενών διαταραχών. Τύπος Ι όπου το G1 είναι μεθυλένιο ή αιθυλένιο· το L είναι –(C1-C4)αλκυλένιο-, -S-, -CH(OH)-, ή -Ο-· το R0 είναι ο Τύπος II ή ο Τύπος III και οι άλλοι υποκατάστατες ορίζονται όπως στις αξιώσεις.
CY20081101009T 2004-12-20 2008-09-17 Παραγωγα κυκλοαλκυλικης λακταμης ως αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης ι CY1108351T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63748804P 2004-12-20 2004-12-20
EP05854587A EP1830841B1 (en) 2004-12-20 2005-12-16 Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
CY1108351T1 true CY1108351T1 (el) 2014-02-12

Family

ID=36283884

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101009T CY1108351T1 (el) 2004-12-20 2008-09-17 Παραγωγα κυκλοαλκυλικης λακταμης ως αναστολεις της 11-βητα-υδροξυστεροειδους αφυδρογονασης ι

Country Status (11)

Country Link
US (1) US20080214621A1 (el)
EP (1) EP1830841B1 (el)
AT (1) ATE399546T1 (el)
CY (1) CY1108351T1 (el)
DE (1) DE602005007934D1 (el)
DK (1) DK1830841T3 (el)
ES (1) ES2308602T3 (el)
PL (1) PL1830841T3 (el)
PT (1) PT1830841E (el)
SI (1) SI1830841T1 (el)
WO (1) WO2006068992A1 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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JPWO2006104280A1 (ja) * 2005-03-31 2008-09-11 武田薬品工業株式会社 糖尿病の予防・治療剤
CA2646678C (en) 2006-04-21 2014-02-11 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5265521B2 (ja) 2006-04-21 2013-08-14 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としてのビフェニルアミドラクタム誘導体
EA015675B1 (ru) * 2006-04-21 2011-10-31 Эли Лилли Энд Компани Производные циклогексилпиразол-лактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
EA015106B1 (ru) 2006-04-24 2011-06-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1
DK2049475T3 (da) 2006-04-24 2012-03-05 Lilly Co Eli Cyclohexyl-substituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroid dehydrogenase1
ATE473210T1 (de) 2006-04-24 2010-07-15 Lilly Co Eli Substituierte pyrrolidinone als hemmer von 11- beta-hydroxysteroiddehydrogenase 1
BRPI0710875A2 (pt) 2006-04-25 2012-01-10 Lilly Co Eli composto inibidor de 11-beta-hidroxiesteróide desidrogenase 1, composição farmacêutica e intermediário para preparar o dito composto
EA015499B1 (ru) 2006-04-25 2011-08-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид дегидрогеназы типа 1
EP2021337B1 (en) 2006-04-25 2010-01-13 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PT2049513E (pt) 2006-04-28 2012-03-20 Lilly Co Eli Pirrolidinonas substituídas com piperidinilo como inibidores de 11-beta-hidroxiesteróide desidrogenase i
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
WO2009001817A1 (ja) 2007-06-27 2008-12-31 Taisho Pharmaceutical Co., Ltd. １１β－ＨＳＤ１阻害活性を有する化合物
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
CN115260126B (zh) * 2022-07-18 2024-01-30 湖南城市学院 一种带有(s)-联萘基的手性季铵盐及制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001296961A1 (en) * 2000-09-29 2002-04-08 Bayer Pharmaceuticals Corporation 17-beta-hydroxysteroid dehydrogenase-ii inhibitors
TW200307667A (en) * 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
MXPA05003632A (es) * 2002-10-11 2005-06-03 Astrazeneca Ab Derivados de piperidina 1, 4-disustituidos y su uso como inhibidores de 11-beta-hidroesteroide deshidrogenasa humana de tipo 1 (11betahsd1).
TW200508224A (en) * 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
US7169795B2 (en) * 2003-09-30 2007-01-30 Bristol Myers Squibb Company Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
US7687644B2 (en) * 2004-05-07 2010-03-30 Janssen Pharmaceutica Nv Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
ATE419848T1 (de) * 2004-10-29 2009-01-15 Lilly Co Eli Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1

Also Published As

Publication number Publication date
ES2308602T3 (es) 2008-12-01
ATE399546T1 (de) 2008-07-15
US20080214621A1 (en) 2008-09-04
SI1830841T1 (sl) 2008-12-31
DE602005007934D1 (de) 2008-08-14
WO2006068992A1 (en) 2006-06-29
EP1830841B1 (en) 2008-07-02
PL1830841T3 (pl) 2008-12-31
DK1830841T3 (da) 2008-10-13
EP1830841A1 (en) 2007-09-12
PT1830841E (pt) 2008-12-15

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