AU2001296961A1 - 17-beta-hydroxysteroid dehydrogenase-ii inhibitors - Google Patents

17-beta-hydroxysteroid dehydrogenase-ii inhibitors

Info

Publication number
AU2001296961A1
AU2001296961A1 AU2001296961A AU9696101A AU2001296961A1 AU 2001296961 A1 AU2001296961 A1 AU 2001296961A1 AU 2001296961 A AU2001296961 A AU 2001296961A AU 9696101 A AU9696101 A AU 9696101A AU 2001296961 A1 AU2001296961 A1 AU 2001296961A1
Authority
AU
Australia
Prior art keywords
inhibitors
beta
hydroxysteroid dehydrogenase
hydroxysteroid
dehydrogenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296961A
Inventor
Jeremy L. Baryza
Catherine R. Brennan
Soongyu Choi
James H. Cook Jr.
Brian R. Dixon
Paul Erlich
David E Gunn
Peiying Liu
Derek B Lowe
Ian Mcalexander
Aniko M. Redman
William J Scott
Yamin Wang
Jill E. Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharmaceuticals Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of AU2001296961A1 publication Critical patent/AU2001296961A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
AU2001296961A 2000-09-29 2001-09-28 17-beta-hydroxysteroid dehydrogenase-ii inhibitors Abandoned AU2001296961A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23668100P 2000-09-29 2000-09-29
US60236681 2000-09-29
US25743500P 2000-12-22 2000-12-22
US60257435 2000-12-22
PCT/US2001/042430 WO2002026706A2 (en) 2000-09-29 2001-09-28 17-beta-hydroxysteroid dehydrogenase-ii inhibitors

Publications (1)

Publication Number Publication Date
AU2001296961A1 true AU2001296961A1 (en) 2002-04-08

Family

ID=26930016

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296961A Abandoned AU2001296961A1 (en) 2000-09-29 2001-09-28 17-beta-hydroxysteroid dehydrogenase-ii inhibitors

Country Status (4)

Country Link
US (1) US6784167B2 (en)
EP (1) EP1326829A2 (en)
AU (1) AU2001296961A1 (en)
WO (1) WO2002026706A2 (en)

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EP1435353A4 (en) * 2001-10-03 2006-01-04 Nippon Soda Co Novel heterocyclic compound and anti-inflammatory agent
FR2845000B1 (en) * 2002-09-27 2005-05-27 Oreal USE OF A HETEROCYCLIC COMPOUND OR ONE OF ITS SALTS FOR STIMULATING OR INDUCING THE GROWTH OF HAIR AND / OR BRAKING THEIR FALL
US7754709B2 (en) * 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US7465739B2 (en) 2003-06-10 2008-12-16 Solvay Pharmaceuticals B.V. Compounds and their use in therapy
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20100222316A1 (en) * 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
ATE397586T1 (en) * 2004-05-07 2008-06-15 Janssen Pharmaceutica Nv ADAMANTYL PYRROLIDINE-2-ONE DERIVATIVES AS 11-BETA HYDROXYSTEROID DEHYDROGENAS INHIBITORS
NZ551077A (en) * 2004-05-07 2009-05-31 Janssen Pharmaceutica Nv Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
ATE445600T1 (en) * 2004-08-30 2009-10-15 Janssen Pharmaceutica Nv DERIVATIVES OF TRICYCLIC LACTAM AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS
DE602005017159D1 (en) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv OXYSTEROID DEHYDROGENASE INHIBITORS
DE602005018509D1 (en) * 2004-08-30 2010-02-04 Janssen Pharmaceutica Nv N-2-ADAMANTANYL-2-PHENOXY-ACETAMIDE DERIVATIVES AS 11-BETAHYDROXYSTEROID DEHYDROGENASE INHIBITORS
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
US7713979B2 (en) 2004-10-29 2010-05-11 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ATE399546T1 (en) * 2004-12-20 2008-07-15 Lilly Co Eli CYCLOALKYL-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE 1
DE602005008282D1 (en) 2004-12-21 2008-08-28 Lilly Co Eli CYCLOALKYL-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROIDDEHYDROGENASE 1
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
EP1846363B1 (en) * 2005-01-05 2012-04-25 Abbott Laboratories Adamantyl derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20080173809A1 (en) * 2006-07-11 2008-07-24 Excellims Corporation Methods and apparatus for the ion mobility based separation and collection of molecules
US8785848B2 (en) * 2007-07-11 2014-07-22 Excellims Corporation Parallel ion mass and ion mobility analysis
US7435833B2 (en) * 2006-04-07 2008-10-14 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
CA2658215C (en) * 2006-07-07 2013-08-27 Piramal Life Sciences Limited An enantioselective synthesis of pyrrolidines-substituted flavones
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
JP5736098B2 (en) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド Pharmaceutical composition for treating central nervous system disorders
ME03072B (en) 2007-09-10 2019-01-20 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
JP5833011B2 (en) 2009-10-14 2015-12-16 ヤンセン ファーマシューティカ エヌ．ベー． Process for preparing compounds useful as inhibitors of SGLT2
DK2568988T3 (en) 2010-05-11 2016-08-22 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1- (BETA-D-glucopyranosyl) -2-THIENYLMETHYLBENZEN derivatives as inhibitors of SGLT
ES2586846T3 (en) 2011-04-13 2016-10-19 Janssen Pharmaceutica, N.V. Process of preparation of compounds useful as SGLT2 inhibitors
US9035044B2 (en) 2011-05-09 2015-05-19 Janssen Pharmaceutica Nv L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
CN103601715B (en) * 2013-11-22 2015-08-19 沈阳化工大学 A kind of separating and purifying method of 2-(4-fluorophenyl) thiophene
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN106946924A (en) * 2017-05-11 2017-07-14 蚌埠中实化学技术有限公司 A kind of preparation method of 3 Carboxybenzeneboronic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3632589A1 (en) 1985-10-18 1987-04-23 Bayer Ag METHOD FOR PRODUCING (GAMMA) -BUTYROLACTAMES
DE3624102A1 (en) 1986-07-17 1988-01-21 Bayer Ag Substituted pyrrolidones, process for their preparation and their use

Also Published As

Publication number Publication date
EP1326829A2 (en) 2003-07-16
US6784167B2 (en) 2004-08-31
WO2002026706A2 (en) 2002-04-04
WO2002026706A3 (en) 2002-06-13
US20030087952A1 (en) 2003-05-08

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