DK1435519T3 - Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA - Google Patents

Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA

Info

Publication number
DK1435519T3
DK1435519T3 DK03028919T DK03028919T DK1435519T3 DK 1435519 T3 DK1435519 T3 DK 1435519T3 DK 03028919 T DK03028919 T DK 03028919T DK 03028919 T DK03028919 T DK 03028919T DK 1435519 T3 DK1435519 T3 DK 1435519T3
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DK
Denmark
Prior art keywords
component
protein
protein kinase
pka
luminophore
Prior art date
Application number
DK03028919T
Other languages
English (en)
Inventor
Ole Thastrup
Soeren Tullin
Kurt Scudder
Per Olof Gunnar Arkhammar
Sara Petersen Bjoern
Kasper Almholt
Bernard Robert Terry
Original Assignee
Fisher Bioimage Aps
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Application filed by Fisher Bioimage Aps filed Critical Fisher Bioimage Aps
Application granted granted Critical
Publication of DK1435519T3 publication Critical patent/DK1435519T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DK03028919T 1997-04-07 1998-04-07 Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA DK1435519T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK39297 1997-04-07
PCT/DK1998/000145 WO1998045704A2 (en) 1997-04-07 1998-04-07 A method for extracting quantitative information relating to an influence on a cellular response

Publications (1)

Publication Number Publication Date
DK1435519T3 true DK1435519T3 (da) 2007-06-11

Family

ID=8092994

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03028919T DK1435519T3 (da) 1997-04-07 1998-04-07 Fremgangsmåde til screening af substanser for effekt på cAMP-niveauer baseret på intracellulær translokation af PKA
DK98913541T DK0986753T4 (da) 1997-04-07 1998-04-07 Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98913541T DK0986753T4 (da) 1997-04-07 1998-04-07 Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons

Country Status (11)

Country Link
US (3) US6518021B1 (da)
EP (3) EP0986753B2 (da)
JP (1) JP2001522454A (da)
AT (3) ATE354089T1 (da)
AU (1) AU6820998A (da)
CA (1) CA2286293C (da)
DE (4) DE69837118T2 (da)
DK (2) DK1435519T3 (da)
ES (2) ES2191575T3 (da)
PT (2) PT1199564E (da)
WO (1) WO1998045704A2 (da)

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EP1435519A1 (en) 2004-07-07
EP1199564A2 (en) 2002-04-24
US6518021B1 (en) 2003-02-11
WO1998045704A3 (en) 1999-04-22
ES2191575T3 (es) 2005-02-01
ATE354089T1 (de) 2007-03-15
EP0986753A2 (en) 2000-03-22
EP1199564A3 (en) 2002-05-08
EP0986753B1 (en) 2002-03-27
US8058008B2 (en) 2011-11-15
DE69837118T2 (de) 2007-12-27
ES2173573T3 (es) 2002-10-16
DE69804446D1 (de) 2002-05-02
ATE269975T1 (de) 2004-07-15
US20030082564A1 (en) 2003-05-01
CA2286293A1 (en) 1998-10-15
ATE215227T1 (de) 2002-04-15
DK0986753T3 (da) 2002-07-22
PT1199564E (pt) 2004-10-29
EP0986753B2 (en) 2005-08-10
CA2286293C (en) 2004-04-06
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PT986753E (pt) 2002-09-30
DK0986753T4 (da) 2005-12-19
ES2173573T5 (es) 2006-03-01
DE69804446T2 (de) 2002-11-07
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AU6820998A (en) 1998-10-30
WO1998045704A2 (en) 1998-10-15
EP1199564B1 (en) 2004-06-23
DE69804446T3 (de) 2006-08-24
DE69837118D1 (de) 2007-03-29
US20090023598A1 (en) 2009-01-22
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ES2191575T1 (es) 2003-09-16
JP2001522454A (ja) 2001-11-13

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