DK1383526T3 - Immuniseringsterapi til behandling af aterosklerose - Google Patents

Immuniseringsterapi til behandling af aterosklerose

Info

Publication number
DK1383526T3
DK1383526T3 DK02714667T DK02714667T DK1383526T3 DK 1383526 T3 DK1383526 T3 DK 1383526T3 DK 02714667 T DK02714667 T DK 02714667T DK 02714667 T DK02714667 T DK 02714667T DK 1383526 T3 DK1383526 T3 DK 1383526T3
Authority
DK
Denmark
Prior art keywords
treatment
atherosclerosis
immunization therapy
cardiovascular diseases
peptides
Prior art date
Application number
DK02714667T
Other languages
Danish (da)
English (en)
Inventor
Prediman K Shah
Jan Nilsson
Original Assignee
Forskarpatent I Syd Ab
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I Syd Ab, Cedars Sinai Medical Center filed Critical Forskarpatent I Syd Ab
Application granted granted Critical
Publication of DK1383526T3 publication Critical patent/DK1383526T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DK02714667T 2001-04-05 2002-04-05 Immuniseringsterapi til behandling af aterosklerose DK1383526T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
PCT/SE2002/000679 WO2002080954A1 (en) 2001-04-05 2002-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein

Publications (1)

Publication Number Publication Date
DK1383526T3 true DK1383526T3 (da) 2009-03-30

Family

ID=26655437

Family Applications (3)

Application Number Title Priority Date Filing Date
DK02714667T DK1383526T3 (da) 2001-04-05 2002-04-05 Immuniseringsterapi til behandling af aterosklerose
DK10181267.5T DK2295464T3 (en) 2001-04-05 2002-04-05 Peptide-based immunization therapy for the treatment of atherosclerosis targeting ApoB100
DK08151489.5T DK2006301T3 (da) 2001-04-05 2002-04-05 Peptid-baseret immuniseringsterapi til behandling af atherosklerose

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10181267.5T DK2295464T3 (en) 2001-04-05 2002-04-05 Peptide-based immunization therapy for the treatment of atherosclerosis targeting ApoB100
DK08151489.5T DK2006301T3 (da) 2001-04-05 2002-04-05 Peptid-baseret immuniseringsterapi til behandling af atherosklerose

Country Status (18)

Country Link
EP (42) EP2289917A1 (pt)
JP (6) JP2004529143A (pt)
CN (4) CN101284874B (pt)
AT (2) ATE510851T1 (pt)
AU (1) AU2002246484B8 (pt)
BR (1) BR0208685A (pt)
CA (3) CA2827167A1 (pt)
CY (1) CY1108817T1 (pt)
DE (1) DE60230029D1 (pt)
DK (3) DK1383526T3 (pt)
EE (2) EE200700052A (pt)
ES (2) ES2317999T3 (pt)
IL (4) IL158285A0 (pt)
PL (4) PL217858B1 (pt)
PT (1) PT1383526E (pt)
RU (1) RU2296582C2 (pt)
SE (1) SE0103754L (pt)
WO (1) WO2002080954A1 (pt)

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SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
PL372925A1 (en) 2001-09-28 2005-08-08 Esperion Therapeutics Inc. Prevention and treatment of restenosis by local administration of drug
WO2004030607A2 (en) * 2002-10-04 2004-04-15 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302312D0 (sv) * 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) * 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) * 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
WO2005097206A2 (en) 2004-04-06 2005-10-20 Cedars-Sinai Medical Center Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano
DE602005020474D1 (de) * 2004-04-15 2010-05-20 Athera Biotechnologies Ab Antikörper gegen Phosphorylcholinkonjugate
EP1676602A1 (en) 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis
GB0517878D0 (en) 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
EP2115466A4 (en) * 2006-12-22 2010-07-28 Abbott Lab HEART CIRCUIT AUTOIMMUNE DISEASE TEST GROUP AND METHOD FOR USE THEREOF
WO2008104194A1 (en) * 2007-02-28 2008-09-04 Bioinvent International Ab Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
DK2208073T3 (da) * 2007-11-05 2020-03-30 Nordic Bioscience As Biokemiske markører til cvd-risikovurdering
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP3021121B1 (en) * 2008-08-15 2018-06-06 Fujikura Kasei Co., Ltd. Polypeptide marker for diagnosis of arteriosclerosis, method for detection of arteriosclerosis by using the maker or the like, and kit for diagnosis of arteriosclerosis
EP2499488A1 (en) * 2009-11-14 2012-09-19 Kuang-Yuh Chyu Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
US8506964B2 (en) 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
WO2012024309A2 (en) 2010-08-18 2012-02-23 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
CN103501806A (zh) * 2010-11-12 2014-01-08 赛达斯西奈医疗中心 用于治疗和/或预防动脉瘤的免疫调节方法和系统
WO2012074725A2 (en) 2010-11-12 2012-06-07 Cedars-Sinai Medical Center Immunomodulatory methods and systems for treatment and/or prevention of hypertension
US20130302362A1 (en) 2010-11-12 2013-11-14 Cedars-Sinai Medical Center Immunomodulatory Compositions, Methods and Systems Comprising Immunogenic Fragments of ApoB-100
ES2732838T3 (es) 2011-08-09 2019-11-26 Athera Biotechnologies Ab Nuevos anticuerpos frente a fosforilcolina
CN103906532B (zh) 2011-08-09 2018-01-26 阿瑟拉生物技术公司 结合磷酰胆碱（pc）和/或pc结合物的抗体
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
US10087234B2 (en) 2012-11-06 2018-10-02 Les Hopitaux Universitaires De Geneve Mimetic peptides
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
CN108135973B (zh) * 2015-05-19 2021-10-19 拉·约拉过敏反应及免疫医学研究所 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
WO2019232081A1 (en) 2018-05-29 2019-12-05 Abcentra, Llc Compositions and methods for treatment of rheumatoid arthritis and accelerated atherosclerosis

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SE0000855D0 (sv) * 2000-03-15 2000-03-15 Karolinska Innovations Ab Antigenic composition useful as a vaccine against atherosclerosis
GB0017641D0 (en) * 2000-07-18 2000-09-06 Medigene Oy Peptides and their use
EP1186299A1 (en) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht The diagnosis, prevention, and/or succesful treatment of atherosclerosis, infectious diseases, and disturbances in the immune system
CA2425513A1 (en) * 2000-10-25 2002-06-20 Vincent Agnello Method of inhibiting infection by hcv, other flaviviridae viruses, and any other virus that complexes to low density lipoprotein or to very low density lipoprotein in blood preventing viral entry into a cell
WO2002042426A2 (en) * 2000-11-10 2002-05-30 University Of Utah Research Foundation Carrier system for specific artery wall gene delivery
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
BR0209572A (pt) * 2001-05-15 2004-07-13 Japan Immunores Lab Co Ltd Peptìdeo reativo com lipoproteìna de alta densidade
WO2003007689A2 (en) * 2001-07-20 2003-01-30 Eidgenoessische Technische Hochschule Zurich (Ethz) Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

Also Published As

Publication number Publication date
EP2289931A1 (en) 2011-03-02
EP2147929A3 (en) 2010-04-14
EP2295459A1 (en) 2011-03-16
CY1108817T1 (el) 2014-04-09
JP5613890B2 (ja) 2014-10-29
EP2147930A2 (en) 2010-01-27
ES2317999T3 (es) 2009-05-01
AU2002246484B8 (en) 2007-06-14
WO2002080954A1 (en) 2002-10-17
EP2289923A1 (en) 2011-03-02
PL400308A1 (pl) 2012-12-17
EP2289932A1 (en) 2011-03-02
EP2295463A1 (en) 2011-03-16
EP2006301A1 (en) 2008-12-24
EP2289934A1 (en) 2011-03-02
AU2002246484B2 (en) 2007-04-19
EP2147928A2 (en) 2010-01-27
EP2147680A2 (en) 2010-01-27
DE60230029D1 (de) 2009-01-08
IL158285A0 (en) 2004-05-12
EP2289915A1 (en) 2011-03-02
SE0103754L (sv) 2002-10-06
ATE415423T1 (de) 2008-12-15
JP2011063598A (ja) 2011-03-31
ATE510851T1 (de) 2011-06-15
EP2289917A1 (en) 2011-03-02
EP2006301B1 (en) 2011-05-25
EP2305707A1 (en) 2011-04-06
EP2289914A1 (en) 2011-03-02
JP2008169215A (ja) 2008-07-24
EP2147930A3 (en) 2010-04-14
EP2289927A1 (en) 2011-03-02
RU2003132443A (ru) 2005-02-27
EP2289926A1 (en) 2011-03-02
EP2289925A1 (en) 2011-03-02
EP1918300A3 (en) 2009-06-17
CN103122031B (zh) 2015-07-22
CA2443223A1 (en) 2002-10-17
EP2289913A1 (en) 2011-03-02
CN1505525B (zh) 2012-11-07
EP2295461A1 (en) 2011-03-16
IL158285A (en) 2009-12-24
RU2296582C2 (ru) 2007-04-10
PL215401B1 (pl) 2013-12-31
EP2289919A1 (en) 2011-03-02
DK2006301T3 (da) 2011-09-12
EP2147680A3 (en) 2010-04-14
EP2289916A1 (en) 2011-03-02
EP2289933A1 (en) 2011-03-02
EP2295462A1 (en) 2011-03-16
CA2443223C (en) 2013-11-26
ES2546293T3 (es) 2015-09-22
EP2147928A3 (en) 2010-04-14
DK2295464T3 (en) 2015-08-17
JP5300819B2 (ja) 2013-09-25
EP2289928A1 (en) 2011-03-02
CN101486766A (zh) 2009-07-22
EP2289934B1 (en) 2013-11-13
EP2289930A1 (en) 2011-03-02
EP2305706A1 (en) 2011-04-06
EP2289918A1 (en) 2011-03-02
PL367301A1 (en) 2005-02-21
EP2289920A1 (en) 2011-03-02
IL195356A0 (en) 2009-08-03
BR0208685A (pt) 2004-03-30
EP2295458A1 (en) 2011-03-16
EP2289921A1 (en) 2011-03-02
EP2295464A1 (en) 2011-03-16
JP5270456B2 (ja) 2013-08-21
CA2606839C (en) 2015-06-09
CN101284874A (zh) 2008-10-15
EP2305708A1 (en) 2011-04-06
JP5300820B2 (ja) 2013-09-25
EE200300487A (et) 2004-02-16
EP2289912A1 (en) 2011-03-02
EP1383526A1 (en) 2004-01-28
CN101284874B (zh) 2012-10-03
EP2289924A1 (en) 2011-03-02
EE200700052A (et) 2008-08-15
PT1383526E (pt) 2009-02-27
JP2013144687A (ja) 2013-07-25
EP2295464B1 (en) 2015-06-03
EP2289935A1 (en) 2011-03-02
JP2004529143A (ja) 2004-09-24
SE0103754D0 (sv) 2001-11-09
PL217858B1 (pl) 2014-08-29
CN1505525A (zh) 2004-06-16
EP2147929A2 (en) 2010-01-27
EP2295457A1 (en) 2011-03-16
JP2011068654A (ja) 2011-04-07
AU2002246484A1 (en) 2002-10-21
EP1918300A2 (en) 2008-05-07
CN103122031A (zh) 2013-05-29
CA2827167A1 (en) 2002-10-17
EP2295460A1 (en) 2011-03-16
EP2289929A1 (en) 2011-03-02
JP2009191078A (ja) 2009-08-27
EP1383526B1 (en) 2008-11-26
CA2606839A1 (en) 2002-10-17
IL188286A0 (en) 2008-03-20
EP2289922A1 (en) 2011-03-02
EP2295460B1 (en) 2015-06-03

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