DK1336605T3 - Substituerede phenolderivater eller salte deraf som inhibitorer af koagulationsfaktor X - Google Patents

Substituerede phenolderivater eller salte deraf som inhibitorer af koagulationsfaktor X

Info

Publication number
DK1336605T3
DK1336605T3 DK01997188T DK01997188T DK1336605T3 DK 1336605 T3 DK1336605 T3 DK 1336605T3 DK 01997188 T DK01997188 T DK 01997188T DK 01997188 T DK01997188 T DK 01997188T DK 1336605 T3 DK1336605 T3 DK 1336605T3
Authority
DK
Denmark
Prior art keywords
salts
coagulation factor
inhibitors
substituted phenol
phenol derivatives
Prior art date
Application number
DK01997188T
Other languages
Danish (da)
English (en)
Inventor
Tsukasa Ishihara
Fukushi Hirayama
Keizo Sugasawa
Takeshi Kadokura
Takeshi Shigenaga
Yuji Koga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of DK1336605T3 publication Critical patent/DK1336605T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Fats And Perfumes (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK01997188T 2000-11-22 2001-11-21 Substituerede phenolderivater eller salte deraf som inhibitorer af koagulationsfaktor X DK1336605T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000356146 2000-11-22
JP2000390321 2000-12-22

Publications (1)

Publication Number Publication Date
DK1336605T3 true DK1336605T3 (da) 2006-06-19

Family

ID=26604464

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01997188T DK1336605T3 (da) 2000-11-22 2001-11-21 Substituerede phenolderivater eller salte deraf som inhibitorer af koagulationsfaktor X

Country Status (17)

Country Link
US (2) US7504417B2 (pl)
EP (1) EP1336605B1 (pl)
JP (1) JP3903920B2 (pl)
KR (1) KR100863923B1 (pl)
CN (1) CN1283626C (pl)
AT (1) ATE323071T1 (pl)
AU (2) AU2002224064B2 (pl)
CA (1) CA2424522C (pl)
DE (1) DE60118774T2 (pl)
DK (1) DK1336605T3 (pl)
ES (1) ES2260336T3 (pl)
HU (1) HUP0400558A3 (pl)
MX (1) MXPA03003572A (pl)
PL (1) PL204898B1 (pl)
PT (1) PT1336605E (pl)
RU (1) RU2276137C2 (pl)
WO (1) WO2002042270A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
PL369772A1 (pl) * 2002-01-31 2005-05-02 Morphochem Aktiengesellschaft Für Kombinatorischechemie Związki hamujące aktywność czynnika XA
GB0226930D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
CA2554686A1 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Compounds
RU2392275C2 (ru) * 2004-02-18 2010-06-20 Астразенека Аб Бензамидные производные и их применение в качестве активирующих глюкокиназу агентов
TW200600086A (en) 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
BRPI0516595A (pt) * 2004-10-16 2008-09-23 Astrazeneca Ab processo para fabricar um composto, e, composto
GB0423043D0 (en) * 2004-10-16 2004-11-17 Astrazeneca Ab Compounds
EP1847527A4 (en) 2005-02-02 2009-04-08 Ajinomoto Kk NEW BENZAMIDINE DERIVATIVE
WO2006125958A1 (en) * 2005-05-24 2006-11-30 Astrazeneca Ab 2-phenyl substituted imidazol [4 , 5b] pyridine/ pyrazine and purine derivatives as glucokinase modulators
TW200714597A (en) * 2005-05-27 2007-04-16 Astrazeneca Ab Chemical compounds
US20080234273A1 (en) * 2005-07-09 2008-09-25 Mckerrecher Darren Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes
KR101346902B1 (ko) * 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
US20110053910A1 (en) * 2005-07-09 2011-03-03 Mckerrecher Darren 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
US9202182B2 (en) * 2005-08-11 2015-12-01 International Business Machines Corporation Method and system for analyzing business architecture
TW200734304A (en) * 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
TW200738621A (en) 2005-11-28 2007-10-16 Astrazeneca Ab Chemical process
TW200825063A (en) * 2006-10-23 2008-06-16 Astrazeneca Ab Chemical compounds
TW200825060A (en) * 2006-10-26 2008-06-16 Astrazeneca Ab Chemical compounds
AU2007336016A1 (en) * 2006-12-21 2008-06-26 Astrazeneca Ab Novel crystalline compound useful as GLK activator
JP2010120852A (ja) * 2007-03-09 2010-06-03 Daiichi Sankyo Co Ltd 新規なジアミド誘導体
WO2008135524A2 (en) * 2007-05-02 2008-11-13 Boehringer Ingelheim International Gmbh Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments
EP2311810A4 (en) 2008-07-11 2012-04-04 Ajinomoto Kk AMIDINE DERIVATIVE
EA201100097A1 (ru) 2008-08-04 2011-10-31 Астразенека Аб Производные пиразоло[3,4]пиримидин-4-ила и их применения для лечения диабета и ожирения
TW201021832A (en) * 2008-09-30 2010-06-16 Astellas Pharma Inc Pharmaceutical composition for oral administration
GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
GB0902406D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Crystalline polymorphic form
AR076221A1 (es) * 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
AR076220A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivados de pirazol [4,5 - e] pirimidina
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04304012A (ja) * 1991-03-31 1992-10-27 Sony Corp フイルタ回路
US5417200A (en) * 1994-01-25 1995-05-23 Wasielewski; John J. Lantern cooker
WO1996016940A1 (fr) 1994-12-02 1996-06-06 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive d'amidinonaphtyle ou sel de celui-ci
IL133625A0 (en) * 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
WO1999000126A1 (en) * 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
US6313122B1 (en) 1997-06-26 2001-11-06 Eli Lilly And Company Antithrombotic agents
DE69830504T2 (de) 1997-06-26 2006-03-16 Eli Lilly And Co., Indianapolis Antithrombotische mitteln
WO1999032477A1 (en) 1997-12-19 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
WO1999037643A1 (fr) 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
ATE272633T1 (de) 1998-12-23 2004-08-15 Lilly Co Eli Aromatische amiden
CA2358091A1 (en) * 1998-12-23 2000-07-06 Eli Lilly And Company Antithrombotic amides
ES2196917T3 (es) 1998-12-23 2003-12-16 Lilly Co Eli Amidas heteroaromaticas como inhibidores del factor xa`.
JP4390024B2 (ja) 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
CZ2002959A3 (cs) 1999-09-17 2002-07-17 Millennium Pharmaceuticals, Inc. Inhibitory faktoru Xa
ES2316383T3 (es) 1999-09-17 2009-04-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
CA2401778C (en) 2000-02-29 2010-12-21 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
ATE374765T1 (de) 2000-07-27 2007-10-15 Lilly Co Eli Substituierte heterocyclische amide
AU2001297648A1 (en) 2000-11-28 2002-08-28 Eli Lilly And Company Substituted carboxamides as inhibitors of factor xa

Also Published As

Publication number Publication date
RU2276137C2 (ru) 2006-05-10
CN1283626C (zh) 2006-11-08
JPWO2002042270A1 (ja) 2004-03-25
ES2260336T3 (es) 2006-11-01
CA2424522C (en) 2009-12-29
US20040077555A1 (en) 2004-04-22
JP3903920B2 (ja) 2007-04-11
WO2002042270A1 (fr) 2002-05-30
EP1336605A1 (en) 2003-08-20
DE60118774D1 (de) 2006-05-24
HUP0400558A2 (hu) 2004-06-28
CA2424522A1 (en) 2003-03-31
DE60118774T2 (de) 2007-03-15
ATE323071T1 (de) 2006-04-15
EP1336605A4 (en) 2004-01-28
PT1336605E (pt) 2006-06-30
EP1336605B1 (en) 2006-04-12
KR20030060944A (ko) 2003-07-16
AU2406402A (en) 2002-06-03
PL360710A1 (pl) 2004-09-20
MXPA03003572A (es) 2003-07-14
US7786106B2 (en) 2010-08-31
AU2002224064B2 (en) 2005-12-08
HUP0400558A3 (en) 2010-03-29
PL204898B1 (pl) 2010-02-26
US20090137498A1 (en) 2009-05-28
CN1476433A (zh) 2004-02-18
KR100863923B1 (ko) 2008-10-17
US7504417B2 (en) 2009-03-17

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