DK1299099T3 - Hidtil ukendt anvendelse af (R)-(-)-2-[5-(4-fluorphenyl)-3-pyridylmethyl-aminomethyl]-chroman og fysiologiske acceptable salte heraf - Google Patents

Hidtil ukendt anvendelse af (R)-(-)-2-[5-(4-fluorphenyl)-3-pyridylmethyl-aminomethyl]-chroman og fysiologiske acceptable salte heraf

Info

Publication number
DK1299099T3
DK1299099T3 DK01902375T DK01902375T DK1299099T3 DK 1299099 T3 DK1299099 T3 DK 1299099T3 DK 01902375 T DK01902375 T DK 01902375T DK 01902375 T DK01902375 T DK 01902375T DK 1299099 T3 DK1299099 T3 DK 1299099T3
Authority
DK
Denmark
Prior art keywords
chroman
pyridylmethyl
aminomethyl
fluorophenyl
acceptable salts
Prior art date
Application number
DK01902375T
Other languages
Danish (da)
English (en)
Inventor
Frank Weber
Gerd Bartoszyk
Hermann Russ
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK1299099T3 publication Critical patent/DK1299099T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK01902375T 2000-03-10 2001-02-01 Hidtil ukendt anvendelse af (R)-(-)-2-[5-(4-fluorphenyl)-3-pyridylmethyl-aminomethyl]-chroman og fysiologiske acceptable salte heraf DK1299099T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00104531 2000-03-10

Publications (1)

Publication Number Publication Date
DK1299099T3 true DK1299099T3 (da) 2006-03-06

Family

ID=8168017

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01902375T DK1299099T3 (da) 2000-03-10 2001-02-01 Hidtil ukendt anvendelse af (R)-(-)-2-[5-(4-fluorphenyl)-3-pyridylmethyl-aminomethyl]-chroman og fysiologiske acceptable salte heraf

Country Status (29)

Country Link
US (1) US7928128B2 (sk)
EP (2) EP1299099B1 (sk)
JP (1) JP4901046B2 (sk)
KR (1) KR100830139B1 (sk)
CN (1) CN1188123C (sk)
AR (1) AR033807A1 (sk)
AT (1) ATE307578T1 (sk)
AU (2) AU2001230222C1 (sk)
BR (1) BR0109119A (sk)
CA (1) CA2402402C (sk)
CO (1) CO5271686A1 (sk)
CZ (1) CZ301807B6 (sk)
DE (1) DE60114419T2 (sk)
DK (1) DK1299099T3 (sk)
ES (1) ES2251460T3 (sk)
HK (1) HK1054198B (sk)
HU (1) HU229309B1 (sk)
ME (1) MEP5608A (sk)
MX (1) MXPA02008800A (sk)
MY (1) MY136976A (sk)
NO (1) NO329583B1 (sk)
PL (1) PL200781B1 (sk)
RS (1) RS51316B (sk)
RU (1) RU2278663C2 (sk)
SI (1) SI1299099T1 (sk)
SK (1) SK286933B6 (sk)
UA (1) UA73981C2 (sk)
WO (1) WO2001068063A2 (sk)
ZA (1) ZA200208133B (sk)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
HUP0402092A3 (en) * 2001-07-26 2010-06-28 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts for preparation of pharmaceutical compositions
PT1427724E (pt) * 2001-09-19 2006-09-29 Merck Patent Gmbh Utilizacao nova de aminometilcromanos substituidos
ATE428416T1 (de) * 2005-06-21 2009-05-15 Merck Patent Gmbh Feste pharmazeutische zubereitung enthaltend (r)- (-)-2-ä5-(4-fluorophenyl)-3- pyridylmethylaminomethylü-chroman
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
CN108937972A (zh) * 2018-06-08 2018-12-07 青岛大学附属医院 一种多特征融合的就诊用户情绪监控方法

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US4438119A (en) * 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
DE3901814A1 (de) 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
DE69123090D1 (de) 1990-07-06 1996-12-19 Yoshitomi Pharmaceutical Kondensierte Thiophenverbindungen und deren Verwendung
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5314888A (en) 1992-02-21 1994-05-24 Trustees Of Tufts College Veterinary method for treating inappropriate elimination of urine in household pets
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
JPH07507058A (ja) * 1992-03-11 1995-08-03 インターニューロン　ファーマシューティカルズ，インコーポレーテッド 大型の中性アミノ酸（ｌｎａａ）の血中濃度の食後変動の低減
DE4226527A1 (de) 1992-08-11 1994-02-17 Merck Patent Gmbh 1,4-Benzodioxanderivate
JPH08503448A (ja) * 1992-12-07 1996-04-16 メレルダウファーマス−ティカルズ インコーポレイテッド ５ｈｔ▲下１▼▲ａ▼受容体アゴニストによる不随意運動の処置
GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
CA2177046A1 (en) * 1993-11-19 1995-05-26 Mark Froimowitz Octahydrobenzo[f]quinoline-based receptor agonists and antagonists
IL114027A (en) 1994-06-08 1999-11-30 Lundbeck & Co As H 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
DK0707007T3 (da) * 1994-10-14 2002-03-18 Merck Patent Gmbh Amino(thio)etherderivater som CNS-aktive midler
US5502080A (en) * 1994-11-01 1996-03-26 Hitzig; Pietr Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
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US5541199A (en) 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
JP4108747B2 (ja) 1995-07-13 2008-06-25 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 治療薬としてのピペラジン誘導体
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DE19648384A1 (de) * 1996-11-22 1998-05-28 Merck Patent Gmbh Fluorene, Dibenzofurane und Dibenzothiophene
EP0900792B1 (en) 1997-09-02 2003-10-29 Duphar International Research B.V Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
DE19751949A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
US6242456B1 (en) 1998-03-09 2001-06-05 Trustees Of Tufts College Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors
NZ506227A (en) * 1998-03-17 2003-06-30 Pfizer Prod Inc Bicyclo[2.2.1]heptanes and their use in treating neurological and psychiatric disorders
FR2781671A1 (fr) * 1998-07-28 2000-02-04 Synthelabo Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique
UA71590C2 (en) 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit

Also Published As

Publication number Publication date
EP1299099B1 (en) 2005-10-26
EP1645273A3 (en) 2006-04-19
KR20030016236A (ko) 2003-02-26
MEP5608A (xx) 2010-02-10
CZ301807B6 (cs) 2010-06-30
ZA200208133B (en) 2004-04-01
AU2001230222C1 (en) 2005-09-22
CN1416344A (zh) 2003-05-07
NO20024291D0 (no) 2002-09-09
PL356428A1 (en) 2004-06-28
CA2402402C (en) 2013-01-22
BR0109119A (pt) 2003-06-03
AR033807A1 (es) 2004-01-07
HU229309B1 (en) 2013-10-28
RS51316B (sr) 2010-12-31
ES2251460T3 (es) 2006-05-01
CA2402402A1 (en) 2001-09-20
SK286933B6 (sk) 2009-07-06
EP1299099A2 (en) 2003-04-09
HK1054198A1 (en) 2003-11-21
CZ20022951A3 (cs) 2003-01-15
CO5271686A1 (es) 2003-04-30
UA73981C2 (en) 2005-10-17
ATE307578T1 (de) 2005-11-15
KR100830139B1 (ko) 2008-05-20
US7928128B2 (en) 2011-04-19
DE60114419T2 (de) 2006-07-27
YU67402A (sh) 2006-01-16
JP4901046B2 (ja) 2012-03-21
RU2002127006A (ru) 2004-03-27
HK1054198B (zh) 2005-05-20
PL200781B1 (pl) 2009-02-27
EP1645273A2 (en) 2006-04-12
JP2004522692A (ja) 2004-07-29
MXPA02008800A (es) 2003-02-12
HUP0300079A2 (en) 2003-05-28
SK12642002A3 (sk) 2003-02-04
NO20024291L (no) 2002-09-09
SI1299099T1 (sl) 2006-04-30
AU3022201A (en) 2001-09-24
CN1188123C (zh) 2005-02-09
US20030181486A1 (en) 2003-09-25
NO329583B1 (no) 2010-11-15
WO2001068063A2 (en) 2001-09-20
AU2001230222B2 (en) 2005-03-17
DE60114419D1 (de) 2005-12-01
MY136976A (en) 2008-12-31
WO2001068063A3 (en) 2002-05-10
RU2278663C2 (ru) 2006-06-27

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DK1408964T3 (da) Hidtil ukendt anvendelse af 2-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman og fysiologisk acceptable salte deraf