DE60114419D1 - Neue verwendung von (r)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)-chromane und ihrer physiologisch verträglichen salze - Google Patents

Neue verwendung von (r)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)-chromane und ihrer physiologisch verträglichen salze

Info

Publication number
DE60114419D1
DE60114419D1 DE60114419T DE60114419T DE60114419D1 DE 60114419 D1 DE60114419 D1 DE 60114419D1 DE 60114419 T DE60114419 T DE 60114419T DE 60114419 T DE60114419 T DE 60114419T DE 60114419 D1 DE60114419 D1 DE 60114419D1
Authority
DE
Germany
Prior art keywords
pyridylmethylaminomethyl
chromane
fluoro
phenyl
physiologically compatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60114419T
Other languages
English (en)
Other versions
DE60114419T2 (de
Inventor
Gerd Bartoszyk
Hermann Russ
Christoph Seyfried
Frank Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE60114419D1 publication Critical patent/DE60114419D1/de
Publication of DE60114419T2 publication Critical patent/DE60114419T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60114419T 2000-03-10 2001-02-01 Neue verwendung von (r)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)-chromane und ihrer physiologisch verträglichen salze Expired - Lifetime DE60114419T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00104531 2000-03-10
EP00104531 2000-03-10
PCT/EP2001/001038 WO2001068063A2 (en) 2000-03-10 2001-02-01 Novel use of (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts

Publications (2)

Publication Number Publication Date
DE60114419D1 true DE60114419D1 (de) 2005-12-01
DE60114419T2 DE60114419T2 (de) 2006-07-27

Family

ID=8168017

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60114419T Expired - Lifetime DE60114419T2 (de) 2000-03-10 2001-02-01 Neue verwendung von (r)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)-chromane und ihrer physiologisch verträglichen salze

Country Status (29)

Country Link
US (1) US7928128B2 (de)
EP (2) EP1645273A3 (de)
JP (1) JP4901046B2 (de)
KR (1) KR100830139B1 (de)
CN (1) CN1188123C (de)
AR (1) AR033807A1 (de)
AT (1) ATE307578T1 (de)
AU (2) AU2001230222C1 (de)
BR (1) BR0109119A (de)
CA (1) CA2402402C (de)
CO (1) CO5271686A1 (de)
CZ (1) CZ301807B6 (de)
DE (1) DE60114419T2 (de)
DK (1) DK1299099T3 (de)
ES (1) ES2251460T3 (de)
HK (1) HK1054198B (de)
HU (1) HU229309B1 (de)
ME (1) MEP5608A (de)
MX (1) MXPA02008800A (de)
MY (1) MY136976A (de)
NO (1) NO329583B1 (de)
PL (1) PL200781B1 (de)
RS (1) RS51316B (de)
RU (1) RU2278663C2 (de)
SI (1) SI1299099T1 (de)
SK (1) SK286933B6 (de)
UA (1) UA73981C2 (de)
WO (1) WO2001068063A2 (de)
ZA (1) ZA200208133B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
CA2455621C (en) * 2001-07-26 2010-11-16 Merck Patent Gesellschaft Mit Beschraenkter Haftung Use of (r/s)-(-/+) or (s)-(+)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane for the treatment of extrapyramidal movement disorders
DE60211186T2 (de) * 2001-09-19 2007-01-18 Merck Patent Gmbh Neue verwendung substituierter aminomethylchromane
DE502006003465D1 (de) * 2005-06-21 2009-05-28 Merck Patent Gmbh Feste pharmazeutische zubereitung enthaltend (r)-(-)-2-ä5-(4-fluorophenyl)-3-pyridylmethylaminomethylü-chroman
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
CN108937972A (zh) * 2018-06-08 2018-12-07 青岛大学附属医院 一种多特征融合的就诊用户情绪监控方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2364685C3 (de) 1973-12-27 1978-06-15 Beiersdorf Ag, 2000 Hamburg Phenoxyäthylamine
US4438119A (en) * 1982-12-23 1984-03-20 Mead Johnson & Company Method for alleviation of extrapyramidal motor disorders
CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
DE69123090D1 (de) 1990-07-06 1996-12-19 Yoshitomi Pharmaceutical Kondensierte Thiophenverbindungen und deren Verwendung
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5314888A (en) * 1992-02-21 1994-05-24 Trustees Of Tufts College Veterinary method for treating inappropriate elimination of urine in household pets
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
KR950700073A (ko) 1992-03-11 1995-01-16 마크에스 부틀러 거대 중성 아미노산(LNAA)의 혈장농도의 식사후 변이를 감소시키는 방법 및 조성물(Reducing post-prandial fluctuations in plasma concentrations of large neutral amino acide(LNAA)
DE4226527A1 (de) 1992-08-11 1994-02-17 Merck Patent Gmbh 1,4-Benzodioxanderivate
JPH08503448A (ja) * 1992-12-07 1996-04-16 メレルダウファーマス−ティカルズ インコーポレイテッド ５ｈｔ▲下１▼▲ａ▼受容体アゴニストによる不随意運動の処置
GB9302622D0 (en) 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
AU684730B2 (en) * 1993-11-19 1998-01-08 Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations, The Octahydrobenzo{f}quinoline-based receptor agonists and antagonists
IL114027A (en) 1994-06-08 1999-11-30 Lundbeck & Co As H 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them
FR2723091B1 (fr) * 1994-07-29 1996-11-08 Esteve Labor Dr Tetrahydropyridine-(6,4-hydroxypiperidine) alkylazoles
DE69524528T2 (de) * 1994-10-14 2002-08-01 Merck Patent Gmbh ZNS wirksames (R)-(-)-2-[5-(4-Fluorophenyl)-3-pyridylmethylaminomethyl]chroman
US5502080A (en) * 1994-11-01 1996-03-26 Hitzig; Pietr Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
US5554383A (en) * 1995-04-06 1996-09-10 Trustees Of Tufts College Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
JP4108747B2 (ja) * 1995-07-13 2008-06-25 アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 治療薬としてのピペラジン誘導体
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5756521A (en) * 1996-04-03 1998-05-26 American Home Products Corporation Chroman-2-ylmethylamino derivatives
DE19648384A1 (de) * 1996-11-22 1998-05-28 Merck Patent Gmbh Fluorene, Dibenzofurane und Dibenzothiophene
EP0900792B1 (de) 1997-09-02 2003-10-29 Duphar International Research B.V Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
ATE253058T1 (de) * 1997-09-02 2003-11-15 Duphar Int Res Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
WO1999045906A1 (en) 1998-03-09 1999-09-16 Trustees Of Tufts College Treatment of compulsive behaviours in man and animals
AU753422B2 (en) * 1998-03-17 2002-10-17 Pfizer Products Inc. Bicyclo(2.2.1)heptanes and related compounds
FR2781671A1 (fr) * 1998-07-28 2000-02-04 Synthelabo Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique
UA71590C2 (en) 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit

Also Published As

Publication number Publication date
WO2001068063A2 (en) 2001-09-20
CN1416344A (zh) 2003-05-07
UA73981C2 (en) 2005-10-17
JP4901046B2 (ja) 2012-03-21
SK12642002A3 (sk) 2003-02-04
KR20030016236A (ko) 2003-02-26
EP1299099A2 (de) 2003-04-09
CA2402402C (en) 2013-01-22
US20030181486A1 (en) 2003-09-25
RU2002127006A (ru) 2004-03-27
MEP5608A (xx) 2010-02-10
AU3022201A (en) 2001-09-24
BR0109119A (pt) 2003-06-03
MXPA02008800A (es) 2003-02-12
DK1299099T3 (da) 2006-03-06
CZ301807B6 (cs) 2010-06-30
NO329583B1 (no) 2010-11-15
CA2402402A1 (en) 2001-09-20
RS51316B (sr) 2010-12-31
CN1188123C (zh) 2005-02-09
AR033807A1 (es) 2004-01-07
AU2001230222C1 (en) 2005-09-22
DE60114419T2 (de) 2006-07-27
MY136976A (en) 2008-12-31
WO2001068063A3 (en) 2002-05-10
CZ20022951A3 (cs) 2003-01-15
ATE307578T1 (de) 2005-11-15
NO20024291L (no) 2002-09-09
EP1645273A2 (de) 2006-04-12
PL356428A1 (en) 2004-06-28
US7928128B2 (en) 2011-04-19
JP2004522692A (ja) 2004-07-29
CO5271686A1 (es) 2003-04-30
ZA200208133B (en) 2004-04-01
ES2251460T3 (es) 2006-05-01
SI1299099T1 (sl) 2006-04-30
HK1054198B (zh) 2005-05-20
RU2278663C2 (ru) 2006-06-27
KR100830139B1 (ko) 2008-05-20
HK1054198A1 (en) 2003-11-21
SK286933B6 (sk) 2009-07-06
HU229309B1 (en) 2013-10-28
YU67402A (sh) 2006-01-16
PL200781B1 (pl) 2009-02-27
NO20024291D0 (no) 2002-09-09
HUP0300079A2 (en) 2003-05-28
AU2001230222B2 (en) 2005-03-17
EP1299099B1 (de) 2005-10-26
EP1645273A3 (de) 2006-04-19

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