DK1274685T3 - Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser - Google Patents
Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelserInfo
- Publication number
- DK1274685T3 DK1274685T3 DK01928133T DK01928133T DK1274685T3 DK 1274685 T3 DK1274685 T3 DK 1274685T3 DK 01928133 T DK01928133 T DK 01928133T DK 01928133 T DK01928133 T DK 01928133T DK 1274685 T3 DK1274685 T3 DK 1274685T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridine
- conversion
- pharmaceutically effective
- oxide
- oxide derivative
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0001583A HUP0001583A2 (hu) | 2000-04-18 | 2000-04-18 | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1274685T3 true DK1274685T3 (da) | 2006-11-06 |
Family
ID=90001563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01928133T DK1274685T3 (da) | 2000-04-18 | 2001-04-17 | Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7126002B2 (uk) |
| EP (1) | EP1274685B1 (uk) |
| JP (1) | JP5066638B2 (uk) |
| KR (1) | KR100742482B1 (uk) |
| CN (1) | CN1216868C (uk) |
| AT (1) | ATE332894T1 (uk) |
| AU (2) | AU2001254997B2 (uk) |
| BG (1) | BG65889B1 (uk) |
| BR (1) | BRPI0110184B8 (uk) |
| CA (1) | CA2406266C (uk) |
| CY (1) | CY1107473T1 (uk) |
| CZ (1) | CZ301576B6 (uk) |
| DE (1) | DE60121431T2 (uk) |
| DK (1) | DK1274685T3 (uk) |
| EE (1) | EE05085B1 (uk) |
| ES (1) | ES2267758T3 (uk) |
| HK (1) | HK1055741A1 (uk) |
| HR (1) | HRP20020825A2 (uk) |
| HU (1) | HUP0001583A2 (uk) |
| IL (2) | IL152337A0 (uk) |
| MX (1) | MXPA02010320A (uk) |
| NO (1) | NO323535B1 (uk) |
| NZ (1) | NZ522017A (uk) |
| PL (1) | PL359826A1 (uk) |
| PT (1) | PT1274685E (uk) |
| RS (1) | RS51003B (uk) |
| RU (1) | RU2281282C2 (uk) |
| SI (1) | SI1274685T1 (uk) |
| SK (1) | SK287606B6 (uk) |
| UA (1) | UA75353C2 (uk) |
| WO (1) | WO2001079174A1 (uk) |
| ZA (1) | ZA200208460B (uk) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
| CN1615296A (zh) * | 2002-01-11 | 2005-05-11 | 拜奥列克斯研究发展公司 | 甲脒衍生物及其在治疗血管疾病中的用途 |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| TW200831479A (en) * | 2006-09-26 | 2008-08-01 | Cytrx Corp | Pharmaceutical compositions and methods for treating diseases |
| EP3578195B1 (en) | 2008-06-26 | 2023-08-09 | Zevra Denmark A/S | Use of hsp70 as a regulator of enzymatic activity |
| RU2013125923A (ru) | 2010-11-30 | 2015-01-10 | Орфазиме Апс | СПОСОБЫ УВЕЛИЧЕНИЯ ВНУТРИКЛЕТОЧНОЙ АКТИВНОСТИ Hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| HUE054957T2 (hu) | 2014-09-15 | 2021-10-28 | Orphazyme As | Arimoklomol készítése |
| WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
| HUE052158T2 (hu) | 2016-04-29 | 2021-04-28 | Orphazyme As | Arimoklomol a glükocerebroszidázzal társult rendellenességek kezeléséhez |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| US20230226036A1 (en) | 2020-06-24 | 2023-07-20 | Orphazyme A/S | Arimoclomol for treating gaucher disease |
| IL303026A (en) | 2020-11-19 | 2023-07-01 | Zevra Denmark As | Processes for preparing arimoclomol citrate and its intermediates |
| MX2023007551A (es) | 2020-12-24 | 2023-09-04 | Zevra Denmark As | Arimoclomol para el tratamiento de la enfermedad de niemann pick, tipo c, en pacientes con mutaciones de sentido erroneo de tipo reticulo endoplasmatico (er). |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
-
2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
-
2001
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active IP Right Cessation
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
-
2002
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
-
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
-
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown
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