NO20025015L - Et pyridin-1-oksidderivat, og fremgangsmåte for dets overföring til farmasöytisk effektive forbindelser - Google Patents
Et pyridin-1-oksidderivat, og fremgangsmåte for dets overföring til farmasöytisk effektive forbindelserInfo
- Publication number
- NO20025015L NO20025015L NO20025015A NO20025015A NO20025015L NO 20025015 L NO20025015 L NO 20025015L NO 20025015 A NO20025015 A NO 20025015A NO 20025015 A NO20025015 A NO 20025015A NO 20025015 L NO20025015 L NO 20025015L
- Authority
- NO
- Norway
- Prior art keywords
- pyridine
- transfer
- pharmaceutically effective
- oxide
- oxide derivative
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0001583A HUP0001583A2 (hu) | 2000-04-18 | 2000-04-18 | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| PCT/HU2001/000046 WO2001079174A1 (en) | 2000-04-18 | 2001-04-17 | A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20025015D0 NO20025015D0 (no) | 2002-10-18 |
| NO20025015L true NO20025015L (no) | 2002-12-16 |
| NO323535B1 NO323535B1 (no) | 2007-06-04 |
Family
ID=90001563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20025015A NO323535B1 (no) | 2000-04-18 | 2002-10-18 | Pyridin-1-oksidderivater, anvendelse av slike for fremstilling av farmasoytisk aktive forbindelser samt fremgangsmater for fremstilling av nevnte farmasoytisk aktive forbindelser. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7126002B2 (no) |
| EP (1) | EP1274685B1 (no) |
| JP (1) | JP5066638B2 (no) |
| KR (1) | KR100742482B1 (no) |
| CN (1) | CN1216868C (no) |
| AT (1) | ATE332894T1 (no) |
| AU (2) | AU5499701A (no) |
| BG (1) | BG65889B1 (no) |
| BR (1) | BRPI0110184B8 (no) |
| CA (1) | CA2406266C (no) |
| CY (1) | CY1107473T1 (no) |
| CZ (1) | CZ301576B6 (no) |
| DE (1) | DE60121431T2 (no) |
| DK (1) | DK1274685T3 (no) |
| EE (1) | EE05085B1 (no) |
| ES (1) | ES2267758T3 (no) |
| HK (1) | HK1055741A1 (no) |
| HR (1) | HRP20020825A2 (no) |
| HU (1) | HUP0001583A2 (no) |
| IL (2) | IL152337A0 (no) |
| MX (1) | MXPA02010320A (no) |
| NO (1) | NO323535B1 (no) |
| NZ (1) | NZ522017A (no) |
| PL (1) | PL359826A1 (no) |
| PT (1) | PT1274685E (no) |
| RS (1) | RS51003B (no) |
| RU (1) | RU2281282C2 (no) |
| SI (1) | SI1274685T1 (no) |
| SK (1) | SK287606B6 (no) |
| UA (1) | UA75353C2 (no) |
| WO (1) | WO2001079174A1 (no) |
| ZA (1) | ZA200208460B (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
| RS60604A (en) | 2002-01-11 | 2006-12-15 | Biorex Kutato Es Feyleszto Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| WO2008039514A1 (en) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| BR122019024895B8 (pt) | 2008-06-26 | 2021-07-27 | Orphazyme As | uso de um agente bioativo capaz de aumentar a concentração intracelular de hsp70 |
| AU2011335545A1 (en) | 2010-11-30 | 2013-06-13 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| BR112017004948A2 (pt) | 2014-09-15 | 2017-12-05 | Orphazyme Aps | formulação farmacêutica. |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| US20190111041A1 (en) | 2016-04-29 | 2019-04-18 | Orphazyme A/S | Arimoclomol for treating glucocerebrosidase associated disorders |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| KR20230035586A (ko) | 2020-06-24 | 2023-03-14 | 켐팜 덴마크 에이/에스 | 고셔병을 치료하기 위한 아리모클로몰 |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
| AU2021405780A1 (en) | 2020-12-24 | 2023-07-06 | Zevra Denmark A/S | Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
-
2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
-
2001
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active IP Right Cessation
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
-
2002
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
-
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
-
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |