DE60121431D1 - Ein pyridin-n-oxid-derivat und ein prozess zu seiner umsetzung in pharmazeutische wirkstoffe - Google Patents
Ein pyridin-n-oxid-derivat und ein prozess zu seiner umsetzung in pharmazeutische wirkstoffeInfo
- Publication number
- DE60121431D1 DE60121431D1 DE60121431T DE60121431T DE60121431D1 DE 60121431 D1 DE60121431 D1 DE 60121431D1 DE 60121431 T DE60121431 T DE 60121431T DE 60121431 T DE60121431 T DE 60121431T DE 60121431 D1 DE60121431 D1 DE 60121431D1
- Authority
- DE
- Germany
- Prior art keywords
- pyridine
- implementation
- active substances
- oxide
- pharmaceutical active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013543 active substance Substances 0.000 title 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0001583A HUP0001583A2 (hu) | 2000-04-18 | 2000-04-18 | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| HU0001583 | 2000-04-18 | ||
| PCT/HU2001/000046 WO2001079174A1 (en) | 2000-04-18 | 2001-04-17 | A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60121431D1 true DE60121431D1 (de) | 2006-08-24 |
| DE60121431T2 DE60121431T2 (de) | 2007-01-18 |
Family
ID=90001563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60121431T Expired - Lifetime DE60121431T2 (de) | 2000-04-18 | 2001-04-17 | Ein pyridin-n-oxid-derivat und ein prozess zu seiner umsetzung in pharmazeutische wirkstoffe |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7126002B2 (de) |
| EP (1) | EP1274685B1 (de) |
| JP (1) | JP5066638B2 (de) |
| KR (1) | KR100742482B1 (de) |
| CN (1) | CN1216868C (de) |
| AT (1) | ATE332894T1 (de) |
| AU (2) | AU2001254997B2 (de) |
| BG (1) | BG65889B1 (de) |
| BR (1) | BRPI0110184B8 (de) |
| CA (1) | CA2406266C (de) |
| CY (1) | CY1107473T1 (de) |
| CZ (1) | CZ301576B6 (de) |
| DE (1) | DE60121431T2 (de) |
| DK (1) | DK1274685T3 (de) |
| EE (1) | EE05085B1 (de) |
| ES (1) | ES2267758T3 (de) |
| HK (1) | HK1055741A1 (de) |
| HR (1) | HRP20020825A2 (de) |
| HU (1) | HUP0001583A2 (de) |
| IL (2) | IL152337A0 (de) |
| MX (1) | MXPA02010320A (de) |
| NO (1) | NO323535B1 (de) |
| NZ (1) | NZ522017A (de) |
| PL (1) | PL359826A1 (de) |
| PT (1) | PT1274685E (de) |
| RS (1) | RS51003B (de) |
| RU (1) | RU2281282C2 (de) |
| SI (1) | SI1274685T1 (de) |
| SK (1) | SK287606B6 (de) |
| UA (1) | UA75353C2 (de) |
| WO (1) | WO2001079174A1 (de) |
| ZA (1) | ZA200208460B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HU0103939D0 (en) * | 2001-09-27 | 2001-11-28 | Biorex Kutato Fejlesztoe Kft | Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride |
| NZ533795A (en) * | 2002-01-11 | 2006-03-31 | Biorex Kutato Fejlesztoe Kft | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| WO2008039514A1 (en) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| CA2728363C (en) | 2008-06-26 | 2019-02-19 | Orphazyme Aps | Use of hsp70 as a regulator of enzymatic activity |
| AU2011335545A1 (en) | 2010-11-30 | 2013-06-13 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| PT3193840T (pt) | 2014-09-15 | 2021-08-10 | Orphazyme Aps | Formulação de arimoclomol |
| EP3442530A1 (de) | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Hitzeschockproteinen und cholesterinhomöostase |
| KR102254140B1 (ko) | 2016-04-29 | 2021-05-24 | 오르파짐 에이/에스 | 글루코세레브로시다제 연관 장애를 치료하기 위한 아리모클로몰 |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| IL299250A (en) | 2020-06-24 | 2023-02-01 | Kempharm Denmark As | Arimoclomol for the treatment of Gaucher disease |
| EP4247792A1 (de) * | 2020-11-19 | 2023-09-27 | Zevra Denmark A/S | Verfahren zur herstellung von arimoclomolcitrat und zwischenprodukten davon |
| EP4267139A1 (de) | 2020-12-24 | 2023-11-01 | Zevra Denmark A/S | Arimoclomol zur behandlung von morbus niemann pick, typ c, bei patienten mit er-typ-missene-mutationen |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU207988B (en) * | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
-
2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
-
2001
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 EP EP01928133A patent/EP1274685B1/de not_active Expired - Lifetime
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active IP Right Cessation
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
-
2002
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
-
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
-
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60121431D1 (de) | Ein pyridin-n-oxid-derivat und ein prozess zu seiner umsetzung in pharmazeutische wirkstoffe | |
| SE9904505D0 (sv) | Novel compounds | |
| UA44254C2 (uk) | Похідні 4-(заміщеного феніламіно)хіназоліну, спосіб їх одержання, спосіб лікування і фармацевтична композиція | |
| BR0016543A (pt) | Novos derivados de piperidina e piperazina | |
| UY26372A1 (es) | "imidazo-3-il-aminas bicíclicas procedimiento para su preparación y medicamentos que las contienen " | |
| SE9901875D0 (sv) | Novel compounds | |
| BRPI0413094A (pt) | derivados de quinolina e seu uso em terapia | |
| DK0734383T3 (da) | Cykliske amidderivater som neurokinin-A-antagonister | |
| NO20020282D0 (no) | Nytt difenylpiperidinderivat | |
| ATE247645T1 (de) | Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung | |
| FR2842524B1 (fr) | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments | |
| NO995685D0 (no) | Nye glycosylerte ginkgolidderivater, anvendelse derav som medikamenter og farmasöytiske blandinger | |
| DE69813263D1 (de) | Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte | |
| EA200400409A1 (ru) | Новые соединения изохинолина, способ их получения и фармацевтические композиции, содержащие их | |
| MXPA05005340A (es) | Nuevos derivados antagonistas del receptor de la vitronectina, sus procedimientos de preparacion, su aplicacion como medicamentos y los compuestos farmaceuticos que los contienen. | |
| MA28930B1 (fr) | Derives pyridiniques d'indolin-2-one , leur preparation et leur application en therapeutique | |
| NO20034985L (no) | Nye 5-tio-SS-D-xylopyranosid-derivater, fremgangsmåte for fremstilling derav, farmasöytiske blandinger inneholdende dem og den terapeutiskeanvendelse derav | |
| DE69905490D1 (de) | Benzofuranderivate, verfahren zu ihrer herstellung, ihre anwendung als medikament und sie enthaltende pharmazeutische zubereitungen | |
| NO20063353L (no) | 1,2,3,4-tetrahydroisokinolinderivater, fremgangsmate for fremstilling derav og anvendelser derav | |
| SE9803277D0 (sv) | Novel compounds | |
| ATE402178T1 (de) | Substituierte 5,6,6a,11b-tetrahydro-7-oxa-5-aza- benzoäcüfluoren-6-carbonsäurederivate als nmda- antagonisten | |
| DK1165596T3 (da) | 14,15-alfa-methylen-equileninderivater, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse | |
| SE9704835D0 (sv) | New compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: CYTRX CORP., LOS ANGELES, CALIF., US |
|
| 8364 | No opposition during term of opposition |